LOCUS       NP_038934                905 aa            linear   ROD 01-AUG-2024
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 8
            isoform 1 preproprotein [Mus musculus].
ACCESSION   NP_038934 XP_919656
VERSION     NP_038934.2
DBSOURCE    REFSEQ: accession NM_013906.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 905)
  AUTHORS   Feng,W., Bais,A., He,H., Rios,C., Jiang,S., Xu,J., Chang,C.,
            Kostka,D. and Li,G.
  TITLE     Single-cell transcriptomic analysis identifies murine heart
            molecular features at embryonic and neonatal stages
  JOURNAL   Nat Commun 13 (1), 7960 (2022)
   PUBMED   36575170
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 905)
  AUTHORS   Omura,J., Satoh,K., Kikuchi,N., Satoh,T., Kurosawa,R., Nogi,M.,
            Ohtsuki,T., Al-Mamun,M.E., Siddique,M.A.H., Yaoita,N., Sunamura,S.,
            Miyata,S., Hoshikawa,Y., Okada,Y. and Shimokawa,H.
  TITLE     ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension
            and Right Ventricular Failure: A Possible Novel Therapeutic Target
  JOURNAL   Circ Res 125 (10), 884-906 (2019)
   PUBMED   31556812
  REMARK    GeneRIF: ADAMTS8 deletion reduced pulmonary artery smooth muscle
            cell proliferation with AMPK up-regulation.
REFERENCE   3  (residues 1 to 905)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   4  (residues 1 to 905)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   5  (residues 1 to 905)
  AUTHORS   Rossier,J., Bernard,A., Cabungcal,J.H., Perrenoud,Q., Savoye,A.,
            Gallopin,T., Hawrylycz,M., Cuenod,M., Do,K., Urban,A. and Lein,E.S.
  TITLE     Cortical fast-spiking parvalbumin interneurons enwrapped in the
            perineuronal net express the metallopeptidases Adamts8, Adamts15
            and Neprilysin
  JOURNAL   Mol Psychiatry 20 (2), 154-161 (2015)
   PUBMED   25510509
  REMARK    GeneRIF: This study demonstrated that Cortical fast-spiking
            parvalbumin interneurons enwrapped in the perineuronal net express
            the metallopeptidases Adamts8 in mice.
REFERENCE   6  (residues 1 to 905)
  AUTHORS   Stankunas,K., Hang,C.T., Tsun,Z.Y., Chen,H., Lee,N.V., Wu,J.I.,
            Shang,C., Bayle,J.H., Shou,W., Iruela-Arispe,M.L. and Chang,C.P.
  TITLE     Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment
            for myocardial morphogenesis
  JOURNAL   Dev Cell 14 (2), 298-311 (2008)
   PUBMED   18267097
REFERENCE   7  (residues 1 to 905)
  AUTHORS   Wagsater,D., Bjork,H., Zhu,C., Bjorkegren,J., Valen,G., Hamsten,A.
            and Eriksson,P.
  TITLE     ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in
            macrophage-rich areas of human atherosclerotic plaques
  JOURNAL   Atherosclerosis 196 (2), 514-522 (2008)
   PUBMED   17606262
  REMARK    GeneRIF: ADAMTS-4 expression was upregulated during the development
            of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
REFERENCE   8  (residues 1 to 905)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   9  (residues 1 to 905)
  AUTHORS   Georgiadis,K.E., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on
            mouse chromosome 9 and human chromosome 11
  JOURNAL   Genomics 62 (2), 312-315 (1999)
   PUBMED   10610729
REFERENCE   10 (residues 1 to 905)
  AUTHORS   Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S.,
            Lombardo,M. and Iruela-Arispe,M.L.
  TITLE     METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a
            new family of proteins with angio-inhibitory activity
  JOURNAL   J Biol Chem 274 (33), 23349-23357 (1999)
   PUBMED   10438512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT025653.7 and AK043875.1.
            
            On Nov 9, 2006 this sequence version replaced NP_038934.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. This gene is
            expressed in mouse lung, heart and macrophage-rich areas of
            atherosclerotic plaques. The encoded preproprotein undergoes
            proteolytic processing to generate an active, zinc-dependent
            aggrecanase enzyme. This gene is located adjacent to a related
            ADAMTS gene on chromosome 9. [provided by RefSeq, May 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF175282.1, SRR6116558.193540.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.49 cM"
     Protein         1..905
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 8 isoform 1 preproprotein"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 8; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 8; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 8"
                     /calculated_mol_wt=95889
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3053
     Region          41..150
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          139..163
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P57110.1)"
     Region          186..225
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P57110.1)"
     mat_peptide     229..905
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 8. /id=PRO_0000029181"
                     /note="propagated from UniProtKB/Swiss-Prot (P57110.1)"
                     /calculated_mol_wt=74703
     Region          234..441
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(378..379,382,388)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Site            415
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57110.1)"
     Region          455..529
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Site            480
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57110.1)"
     Site            506
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57110.1)"
     Region          545..597
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          603..705
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Site            615
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57110.1)"
     Region          706..847
                     /region_name="Spacer"
                     /note="propagated from UniProtKB/Swiss-Prot (P57110.1)"
     Region          707..825
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          852..903
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          877..905
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P57110.1)"
     CDS             1..905
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /coded_by="NM_013906.3:276..2993"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS22946.1"
                     /db_xref="GeneID:30806"
                     /db_xref="MGI:MGI:1353468"
ORIGIN      
        1 mlrdptttgw ppllllllql pppplvcgap agpgtgaqas elvvptrlpg saselafhls
       61 afgqgfvlrl apdasflape fkierlggss aaaggepglr gcffsgtvng ereslaamsl
      121 crglsgsfll ageeftiqpq gagdsldqph rlqrwgpgqr redpglaaae vfplpqglew
      181 evemgngqgq ersdneedrk qdkegllket edsrkvpppf gsktrskrfv searfvetll
      241 vadasmaafy gtdlqnhilt vmsmaariyk hpsirnsvnl vvvkvlivee egwgpevsdn
      301 ggltlrnfcs wqrrfnkpsd rhpehydtai lftrqnfcgk geqcdtlgma dvgticdpdk
      361 scsvikdegl qaaytlahel ghvlsmphdd skpcvrlfgp mgkyhmmapf fihvnktlpw
      421 spcsavylte llddghgdcl ldaptsvlpl ptglpghstl yeldqqckqi fgpdfrhcpn
      481 tsvedicvql wcrhrdsdep ichtkngsll wadgtpcgpg hlcldgscvl kedvenpkav
      541 vdgdwgpwrp wgqcsrtcgg giqfsnrecd npmpqnggrf clgervkyqs cnteecppng
      601 ksfreqqcek ynaynhtdld gnflqwvpky sgvsprdrck lfcrargrse fkvfeakvid
      661 gtlcgpdtls icvrgqcvka gcdhvvnspk kldkcgvcgg kgtacrkisg sftpfsygyn
      721 divtipagat nidvkqrshp gvrndgsyla lktangqyll ngnlaisaie qdilvkgtil
      781 kysgsmatle rlqsfqalpe pltvqlltvs gevfppkvry tffvpndmdf svqnskerat
      841 tniiqslpsa ewvlgdwsec pstcrgswqr rtvecrdpsg qasdtcdeal kpedakpcgs
      901 qpcpl
//
