LOCUS       NM_001326351            5496 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            7 (Adamts7), transcript variant 4, mRNA.
ACCESSION   NM_001326351 XM_006510758
VERSION     NM_001326351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5496)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 5496)
  AUTHORS   Sharifi,M.A., Wierer,M., Dang,T.A., Milic,J., Moggio,A., Sachs,N.,
            von Scheidt,M., Hinterdobler,J., Muller,P., Werner,J., Stiller,B.,
            Aherrahrou,Z., Erdmann,J., Zaliani,A., Graettinger,M.,
            Reinshagen,J., Gul,S., Gribbon,P., Maegdefessel,L., Bernhagen,J.,
            Sager,H.B., Mann,M., Schunkert,H. and Kessler,T.
  TITLE     ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation
            of TIMP-1
  JOURNAL   Circ Res 133 (8), 674-686 (2023)
   PUBMED   37675562
  REMARK    GeneRIF: ADAMTS-7 Modulates Atherosclerotic Plaque Formation by
            Degradation of TIMP-1.
REFERENCE   3  (bases 1 to 5496)
  AUTHORS   Gong,Z., Huang,J., Wang,D., Yang,S., Ma,Z., Fu,Y., Ma,Q. and
            Kong,W.
  TITLE     ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and
            dissection in mice
  JOURNAL   J Mol Med (Berl) 101 (3), 237-248 (2023)
   PUBMED   36662289
  REMARK    GeneRIF: ADAMTS-7 deficiency attenuates thoracic aortic aneurysm
            and dissection in mice.
REFERENCE   4  (bases 1 to 5496)
  AUTHORS   Ma,Z., Mao,C., Jia,Y., Yu,F., Xu,P., Tan,Y., Zou,Q.H., Zhou,X.J.,
            Kong,W. and Fu,Y.
  TITLE     ADAMTS7-Mediated Complement Factor H Degradation Potentiates
            Complement Activation to Contributing to Renal Injuries
  JOURNAL   J Am Soc Nephrol 34 (2), 291-308 (2023)
   PUBMED   36735376
  REMARK    GeneRIF: ADAMTS7-Mediated Complement Factor H Degradation
            Potentiates Complement Activation to Contributing to Renal
            Injuries.
REFERENCE   5  (bases 1 to 5496)
  AUTHORS   Jaiswal,A.K. and Mishra,A.
  TITLE     ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and
            Th2 Immune Responses
  JOURNAL   Lung 200 (3), 305-313 (2022)
   PUBMED   35503474
  REMARK    GeneRIF: ADAMTS7 Attenuates House Dust Mite-Induced Airway
            Inflammation and Th2 Immune Responses.
REFERENCE   6  (bases 1 to 5496)
  AUTHORS   Lai,Y., Bai,X., Zhao,Y., Tian,Q., Liu,B., Lin,E.A., Chen,Y.,
            Lee,B., Appleton,C.T., Beier,F., Yu,X.P. and Liu,C.J.
  TITLE     ADAMTS-7 forms a positive feedback loop with TNF-alpha in the
            pathogenesis of osteoarthritis
  JOURNAL   Ann Rheum Dis 73 (8), 1575-1584 (2014)
   PUBMED   23928557
  REMARK    GeneRIF: ADAMTS-7 and TNF-alpha form a positive feedback loop in
            the regulation of cartilage degradation and osteoarthritis
            progression.
REFERENCE   7  (bases 1 to 5496)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   8  (bases 1 to 5496)
  AUTHORS   Bai,X.H., Wang,D.W., Kong,L., Zhang,Y., Luan,Y., Kobayashi,T.,
            Kronenberg,H.M., Yu,X.P. and Liu,C.J.
  TITLE     ADAMTS-7, a direct target of PTHrP, adversely regulates
            endochondral bone growth by associating with and inactivating GEP
            growth factor
  JOURNAL   Mol Cell Biol 29 (15), 4201-4219 (2009)
   PUBMED   19487464
  REMARK    GeneRIF: Findings demonstrate that ADAMTS-7, a direct target of
            PTHrP signaling, negatively regulates endochondral bone formation
            by associating with and inactivating GEP chondrogenic growth
            factor.
REFERENCE   9  (bases 1 to 5496)
  AUTHORS   Somerville,R.P., Longpre,J.M., Apel,E.D., Lewis,R.M., Wang,L.W.,
            Sanes,J.R., Leduc,R. and Apte,S.S.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
  REMARK    GeneRIF: ADAMTS7B has a domain organization with a total of eight
            thrombospondin type 1 repeats in its ancillary domain. Of these,
            seven are arranged in two distinct clusters that are separated by a
            mucin domain
REFERENCE   10 (bases 1 to 5496)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY347798.1, BC076575.1,
            CB246893.1, AC140392.3 and BC058991.1.
            
            On May 15, 2016 this sequence version replaced XM_006510758.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active, zinc-dependent enzyme that degrades cartilage oligomeric
            matrix protein. The deficiency of the encoded protein decreases
            atherosclerosis in genetically hyperlipidemic mice and in response
            to vascular injury. Alternative splicing results in multiple
            transcript variants encoding different isoforms, some of which may
            undergo similar processing. [provided by RefSeq, May 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on the transcript AY551090.1. An
            unsupported intron in the 3' coding region of this transcript was
            replaced with sequence from the reference genome assembly.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.9220.1,
                                           SRR9219380.72908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               BY347798.1         1-146
            147-1782            BC076575.1         1-1636
            1783-2098           CB246893.1         42-357
            2099-3075           BC076575.1         1807-2783
            3076-3201           AC140392.3         211025-211150
            3202-5083           BC076575.1         2784-4665
            5084-5496           BC058991.1         3930-4342
FEATURES             Location/Qualifiers
     source          1..5496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.46 cM"
     gene            1..5496
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 7"
                     /db_xref="GeneID:108153"
                     /db_xref="MGI:MGI:1347346"
     exon            1..337
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..5241
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /EC_number="3.4.24.-"
                     /note="isoform 4 preproprotein is encoded by transcript
                     variant 4; a disintegrin and metalloproteinase with
                     thrombospondin motifs 7; COMPase; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 7; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 7"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform 4 preproprotein"
                     /protein_id="NP_001313280.1"
                     /db_xref="CCDS:CCDS85708.1"
                     /db_xref="GeneID:108153"
                     /db_xref="MGI:MGI:1347346"
                     /translation="MHRGPSLLLILCALASRVLGPASGLVTEGRAGLDIVHPVRVDAG
                     GSFLSYELWPRVLRKRDVSTTQASSAFYQLQYQGRELLFNLTTNPYLMAPGFVSEIRR
                     HSTLGHAHIQTSVPTCHLLGDVQDPELEGGFAAISACDGLRGVFQLSNEDYFIEPLDG
                     VSAQPGHAQPHVVYKHQGSRKQAQQGDSRPSGTCGMQVPPDLEQQREHWEQQQQKRRQ
                     QRSVSKEKWVETLVVADSKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHISIV
                     RLIILEDEEKDLKITHHAEETLKNFCRWQKNINIKGDDHPQHHDTAILLTRKDLCASM
                     NQPCETLGLSHVSGLCHPQLSCSVSEDTGMPLAFTVAHELGHSFGIQHDGTGNDCESI
                     GKRPFIMSPQLLYDRGIPLTWSRCSREYITRFLDRGWGLCLDDRPSKDVIALPSVLPG
                     VLYDVNHQCRLQYGSHSAYCEDMDDVCHTLWCSVGTTCHSKLDAAVDGTSCGKNKWCL
                     KGECVPEGFQPEAVDGGWSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGER
                     KRSQLCNLPACPPDRPSFRHTQCSQFDGMLYKGKLHKWVPVPNDDNPCELHCRPSNSS
                     NTEKLRDAVVDGTPCYQSRISRDICLNGICKNVGCDFVIDSGAEEDRCGVCRGDGSTC
                     QTVSRTFKETEGQGYVDIGLIPAGAREILIEEVAEAANFLALRSEDPDKYFLNGGWTI
                     QWNGDYRVAGTTFTYARKGNWENLTSPGPTSEPVWIQLLFQEKNPGVHYQYTIQRDSH
                     DQVRPPEFSWHYGPWSKCTVTCGTGVQRQSLYCMERQAGVVAEEYCNTLNRPDERQRK
                     CSEEPCPPRWWAGEWQPCSRSCGPEGLSRRAVFCIRSMGLDEQRALELSACEHLPRPL
                     AETPCNRHVICPSTWGVGNWSQCSVTCGAGIRQRSVLCINNTDVPCDEAERPITETFC
                     FLQPCQYPMYIVDTGASGSGSSSPELFNEVDFIPNQLAPRPSPASSPKPVSISNAIDE
                     EELDPPGPVFVDDFYYDYNFINFHEDLSYGSFEEPHPDLVDNGGWTAPPHIRPTESPS
                     DTPVPTAGALGAEAEDIQGSWSPSPLLSEASYSPPGLEQTSINPLANFLTEEDTPMGA
                     PELGFPSLPWPPASVDDMMTPVGPGNPDELLVKEDEQSPPSTPWSDRNKLSTDGNPLG
                     HTSPALPQSPIPTQPSPPSISPTQASPSPDVVEVSTGWNAAWDPVLEADLKPGHGELP
                     STVEVASPPLLPMATVPGIWGRDSPLEPGTPTFSSPELSSQHLKTLTMPGTLLLTVPT
                     DLRSPGPSGQPQTPNLEGTQSPGLLPTPARETQTNSSKDPEVQPLQPSLEEDGDPADP
                     LPARNASWQVGNWSQCSTTCGLGAIWRLVSCSSGNDEDCTLASRPQPARHCHLRPCAA
                     WRTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCQPGPTKPPNRQLCGTQPCLP
                     WYTSSWRECSEACGGGEQQRLVTCPEPGLCEESLRPNNSRPCNTHPCTQWVVGPWGQC
                     SAPCGGGVQRRLVRCVNTQTGLAEEDSDLCSHEAWPESSRPCATEDCELVEPPRCERD
                     RLSFNFCETLRLLGRCQLPTIRAQCCRSCPPLSRGVPSRGHQRVARR"
     exon            338..693
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            694..859
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1038
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1122
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1247
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1397
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1544
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1689
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1782
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1928
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2098
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2232
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2353
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2598
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2734
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2861
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3075
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..4446
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..4599
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..4773
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4774..4920
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4921..5083
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5084..5472
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5447..5452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /note="hexamer: CATAAA"
     polyA_site      5470
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /note="major polyA site"
ORIGIN      
        1 ttttctttct ttctttcttt ctttcttttt tttttcctgg gcttctcgct ctctttcttt
       61 gcctcggcag ctggctgagg gggcgggcct tgcagtcttt gttgccggag gagcgagtgc
      121 agctgcccgg cggctagagt caggacccgg accttgggaa gagtttaaag ccaggcatgt
      181 cctgagtcgg acccaggccc ggctgggacg caacggcgta gacgaaggag tgcacagggg
      241 tcgtcctgcg gccaccccgt ccgggccatg caccgtggtc cgagtctcct cctgatcctg
      301 tgcgctctgg cgtcccgcgt cctcggacct gcatcaggtc ttgtgactga gggccgggcg
      361 ggtttggaca tcgtgcaccc ggtgcgagtg gatgctggag gctccttcct gtcctatgag
      421 ctgtggccac gggtgctgcg caagcgcgat gtgtccacca cgcaggcttc gtctgctttc
      481 taccagctgc agtaccaagg gcgggaactg cttttcaact tgaccaccaa cccttatctg
      541 atggctcccg gctttgtgag tgagattcga cgtcacagca ctttaggcca tgcgcacatc
      601 caaaccagtg tcccaacctg ccatttgctt ggtgatgtcc aggacccgga gctggaagga
      661 ggctttgcag ccattagcgc ctgcgatggc ctaagaggtg tgttccagct ctccaatgag
      721 gactacttca ttgagcctct ggatggagtt tcagctcagc ctggacatgc ccagccccat
      781 gtggtataca agcaccaagg ctctaggaag caggcccagc agggtgactc aaggccttca
      841 ggcacctgtg ggatgcaagt gcccccagat ctggagcagc agcgagaaca ttgggaacag
      901 cagcagcaga aacggaggca gcagcgatca gtcagcaaag agaagtgggt ggagaccctg
      961 gtagtggctg attccaagat ggtcgagtac catgggcagc cgcaagtgga gagctatgtg
     1021 ctgacgatca tgaacatggt ggctggactc tttcatgatc caagcattgg gaaccccatt
     1081 cacatcagca ttgtgcgcct tatcatactg gaagacgagg agaaggactt aaagatcaca
     1141 caccatgccg aagagactct gaagaacttc tgtaggtggc agaagaacat taacataaag
     1201 ggggatgacc acccacagca ccatgacact gccatcctgc tcaccaggaa ggatttgtgt
     1261 gcgtccatga accagccatg tgaaaccctg ggcctgtctc atgtgtctgg cttgtgccac
     1321 cctcagctca gctgtagcgt cagtgaggat actggcatgc cactggcctt cactgtggcc
     1381 cacgagctag gacacagttt tggcattcag catgacggca ccggcaatga ctgtgaatcc
     1441 attgggaaac ggcctttcat catgtctcca cagctcctgt atgacagagg cattcctctt
     1501 acctggtccc gatgcagccg cgagtacatc accaggttcc ttgaccgtgg gtggggcctg
     1561 tgcttagatg accgtccatc caaggatgtc attgcactcc cctcggtgtt gcccggtgtc
     1621 ctgtatgatg tgaaccacca gtgccgcctt cagtatgggt ctcactctgc ctactgtgag
     1681 gacatggatg atgtctgcca cacactatgg tgctctgtgg ggaccacctg tcactccaag
     1741 ctggatgcgg ctgtggatgg cacgagctgt gggaagaata agtggtgtct caaaggagag
     1801 tgcgtccctg agggcttcca gcccgaggcg gtggacggtg gctggtccgg ttggagtgcc
     1861 tggtctgact gctcgaggag ctgtggcgtg ggtgtacgga gttctgaacg acagtgcacg
     1921 cagcctgtgc ctaagaacag aggcaagtac tgtgtggggg agaggaagcg gtcccagctc
     1981 tgcaacctgc cagcctgccc gccggaccgt ccctctttcc gtcacaccca gtgtagccag
     2041 tttgatggca tgctgtacaa gggcaagctc cataaatggg tgcctgtgcc caatgacgac
     2101 aacccctgtg agctgcactg ccggccttcc aactcctcca atacagagaa gctgagggat
     2161 gctgtggtgg atggcacccc ttgctaccaa agccgcatca gccgtgacat ctgcctcaac
     2221 ggcatctgta agaacgtggg ctgcgacttt gtgattgact ctggtgctga ggaggaccgc
     2281 tgtggcgtgt gccgggggga tggctctact tgccagactg tgagcaggac cttcaaggag
     2341 actgaaggcc aggggtatgt ggatataggg ctgatcccag ccggagccag agagattctt
     2401 attgaggagg tggctgaggc tgccaacttc ctggccctgc ggagtgagga cccagataag
     2461 tacttcctca atggaggctg gaccatccag tggaatggag actaccgagt ggcaggcact
     2521 accttcacct atgcacggaa gggcaactgg gagaatctca catccccagg ccccaccagt
     2581 gagcctgtct ggatccagct gctgttccag gagaagaacc ctggggtaca ctaccagtat
     2641 accatccaga gggacagcca tgatcaagtc cgaccacctg agttctcctg gcattatggg
     2701 ccctggagca agtgcacggt cacttgtggc acaggcgtgc agaggcagag cttatactgc
     2761 atggagaggc aggctggggt tgttgctgag gaatactgta acactctaaa tcggcccgat
     2821 gaacgccaga gaaaatgcag tgaggagccc tgtcccccca ggtggtgggc aggggagtgg
     2881 cagccatgtt cccgatcctg cgggcccgaa ggcctctctc gccgggctgt gttctgcata
     2941 cgtagtatgg ggctggatga gcagcgtgct cttgagctat ctgcctgcga acatcttccc
     3001 cgtcccctgg ctgaaacccc gtgcaaccgt catgtaatct gtccttccac ttggggtgtg
     3061 gggaactggt ctcagtgctc tgtgacatgt ggagctggca ttcggcaacg aagtgtcctc
     3121 tgcatcaaca acactgatgt cccctgtgat gaagctgagc gaccaataac tgagaccttt
     3181 tgttttctgc aaccctgcca gtatcccatg tacatagtgg acacaggtgc ctctggaagc
     3241 ggctcctcca gccccgagct cttcaatgag gttgacttca tcccgaacca gctggcccca
     3301 cgaccttccc cagcatcctc acccaagccg gtcagcatca gcaacgctat tgatgaggag
     3361 gaactagatc cgccagggcc cgtgtttgtg gatgatttct attatgacta caatttcatt
     3421 aacttccatg aagacctgtc ctatgggtcc tttgaagaac cccatccaga cctggttgat
     3481 aatgggggtt ggacagcacc acctcacatc agacccactg aatctccctc agatacccca
     3541 gtacctactg caggggctct tggagctgag gcagaagaca ttcagggatc ttggtctcct
     3601 agccccttac tcagtgaggc tagctattcc ccaccaggat tagagcagac ctccatcaac
     3661 cccctggcca atttcttgac tgaggaagat actcccatgg gggcccctga acttggattc
     3721 cccagcttgc cctggccccc tgcttcagtt gatgatatga tgacacctgt tggccctgga
     3781 aaccctgatg agttgctagt gaaagaagat gagcagagcc caccatccac tccatggtct
     3841 gataggaaca aactttctac agatggtaac cccttgggtc atacatcccc tgccctgccc
     3901 caaagcccta tccccacaca gccctctcca ccctccatca gtcctaccca agcttctccg
     3961 agtcctgatg tggtggaggt gtcgacagga tggaatgcgg cctgggaccc tgtgctagag
     4021 gctgacctga agcccggaca cggtgagctg ccgtccactg tggaggtggc ttctcctcca
     4081 cttcttccca tggccactgt gccaggcatc tggggcaggg acagccctct tgaaccagga
     4141 acgcctacct tttccagccc agaactgagc tcacagcacc taaaaactct gacaatgcct
     4201 gggaccttgc ttttgacagt accaactgac ctgaggagcc cgggaccatc gggccagcca
     4261 cagaccccta accttgaggg aacccagagc cctgggttgc tgcctacacc agctcgggag
     4321 actcaaacta acagtagcaa ggaccccgag gtccagcctt tgcagcccag cctagaggag
     4381 gatggtgacc ccgcagatcc actgcctgcc aggaatgcca gctggcaagt aggaaactgg
     4441 agccagtgtt ccaccacctg tggcctgggc gccatctgga ggctagtgag ctgcagctct
     4501 ggcaatgacg aggactgcac cctcgctagc cgtccccagc ctgcccgcca ttgtcatctg
     4561 aggccctgtg ctgcctggcg cacgggcaac tggagtaagt gctctcgaaa ctgtggtgga
     4621 ggttcctcta caagggatgt acagtgtgtg gatacacggg acctccggcc actgcggccc
     4681 tttcactgcc agcccgggcc taccaagcca cccaaccgtc agctctgtgg gacccagccc
     4741 tgcctcccct ggtacacctc ctcctggaga gagtgttccg aggcttgtgg tggtggtgaa
     4801 cagcagcgac tggtgacatg tccagagcca gggctctgtg aggagtcgct gagacccaac
     4861 aacagcaggc cctgcaacac ccacccctgc acacagtggg tggtagggcc ctggggtcag
     4921 tgctcagccc cctgcggtgg tggtgttcag cggcgtctgg tcagatgtgt gaacactcag
     4981 accggcttgg cagaggaaga cagtgacctg tgtagccatg aggcgtggcc tgagagctca
     5041 cggccatgtg ccactgagga ctgtgaactg gttgaacccc cacgttgtga gcgggatcgc
     5101 ctgtccttca atttctgtga gacgctgcgc ctgctgggcc gctgccagct gcccaccatc
     5161 cgcgctcagt gctgccgttc atgtccccca ctcagtcgtg gtgtcccttc ccgaggccat
     5221 cagcgggtag ccagacggta aaccgaggaa ggcaccatta gaatgcacag actgaccctt
     5281 gacacacaga cctcagtgcc ccaccacagg ctgcggtgga gccccctgct cctcgtgccc
     5341 taacggtgct aaccccaccc ctgcacggtg gcaggctggg gacccccttt cctttcagaa
     5401 aaggtatttt tttattctaa cagtttgcac atttgttatt attttacata aatgagtatc
     5461 taccctttca gaaaaaaaaa aaaaaaaaaa aaaaaa
//
