LOCUS       NM_001081020            6792 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            6 (Adamts6), transcript variant 1, mRNA.
ACCESSION   NM_001081020 XM_001002065
VERSION     NM_001081020.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6792)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6792)
  AUTHORS   Werren,E.A., LaForce,G.R., Srivastava,A., Perillo,D.R., Li,S.,
            Johnson,K., Baris,S., Berger,B., Regan,S.L., Pfennig,C.D., de
            Munnik,S., Pfundt,R., Hebbar,M., Jimenez-Heredia,R.,
            Karakoc-Aydiner,E., Ozen,A., Dmytrus,J., Krolo,A., Corning,K.,
            Prijoles,E.J., Louie,R.J., Lebel,R.R., Le,T.L., Amiel,J.,
            Gordon,C.T., Boztug,K., Girisha,K.M., Shukla,A., Bielas,S.L. and
            Schaffer,A.E.
  TITLE     TREX tetramer disruption alters RNA processing necessary for
            corticogenesis in THOC6 Intellectual Disability Syndrome
  JOURNAL   Nat Commun 15 (1), 1640 (2024)
   PUBMED   38388531
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6792)
  AUTHORS   Ross,J.A., Arcos-Villacis,N., Battey,E., Boogerd,C., Orellana,C.A.,
            Marhuenda,E., Swiatlowska,P., Hodzic,D., Prin,F., Mohun,T.,
            Catibog,N., Tapia,O., Gerace,L., Iskratsch,T., Shah,A.M. and
            Stroud,M.J.
  TITLE     Lem2 is essential for cardiac development by maintaining nuclear
            integrity
  JOURNAL   Cardiovasc Res 119 (11), 2074-2088 (2023)
   PUBMED   37067297
REFERENCE   4  (bases 1 to 6792)
  AUTHORS   Mead,T.J., Martin,D.R., Wang,L.W., Cain,S.A., Gulec,C., Cahill,E.,
            Mauch,J., Reinhardt,D., Lo,C., Baldock,C. and Apte,S.S.
  TITLE     Proteolysis of fibrillin-2 microfibrils is essential for normal
            skeletal development
  JOURNAL   Elife 11, e71142 (2022)
   PUBMED   35503090
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6792)
  AUTHORS   Cao,M., Ouyang,J., Guo,J., Lin,S. and Chen,S.
  TITLE     Metalloproteinase Adamts16 Is Required for Proper Closure of the
            Optic Fissure
  JOURNAL   Invest Ophthalmol Vis Sci 59 (3), 1167-1177 (2018)
   PUBMED   29625437
REFERENCE   6  (bases 1 to 6792)
  AUTHORS   San Agustin,J.T., Klena,N., Granath,K., Panigrahy,A., Stewart,E.,
            Devine,W., Strittmatter,L., Jonassen,J.A., Liu,X., Lo,C.W. and
            Pazour,G.J.
  TITLE     Genetic link between renal birth defects and congenital heart
            disease
  JOURNAL   Nat Commun 7, 11103 (2016)
   PUBMED   27002738
  REMARK    Erratum:[Nat Commun. 2016 Jun 08;7:11910. PMID: 27273704]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6792)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   8  (bases 1 to 6792)
  AUTHORS   Cheverud,J.M., Lawson,H.A., Bouckaert,K., Kossenkov,A.V.,
            Showe,L.C., Cort,L., Blankenhorn,E.P., Bedelbaeva,K.,
            Gourevitch,D., Zhang,Y. and Heber-Katz,E.
  TITLE     Fine-mapping quantitative trait loci affecting murine external ear
            tissue regeneration in the LG/J by SM/J advanced intercross line
  JOURNAL   Heredity (Edinb) 112 (5), 508-518 (2014)
   PUBMED   24569637
REFERENCE   9  (bases 1 to 6792)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   10 (bases 1 to 6792)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030315.1, AK044528.1, AC154830.2 and AK034499.1.
            
            On May 15, 2016 this sequence version replaced NM_001081020.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164133,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AK030315.1         1-36
            37-1817             AK044528.1         2-1782
            1818-2514           AK044528.1         1920-2616
            2515-2638           AC154830.2         107652-107775       c
            2639-3022           AK044528.1         2617-3000
            3023-4343           AK034499.1         370-1690
            4344-5125           AK030315.1         5244-6025
            5126-5126           AC154830.2         41581-41581         c
            5127-5413           AK030315.1         6027-6313
            5414-5414           AC154830.2         41293-41293         c
            5415-6015           AK030315.1         6315-6915
            6016-6638           AK030315.1         6917-7539
            6639-6792           AK030315.1         7541-7694
FEATURES             Location/Qualifiers
     source          1..6792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.42 cM"
     gene            1..6792
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 6"
                     /db_xref="GeneID:108154"
                     /db_xref="MGI:MGI:1347348"
     exon            1..166
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            167..544
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..3801
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 6; a
                     disintegrin-like and metallopeptidase (reprolysin type)
                     with thrombospondin type 1 motif, 6"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 6 precursor"
                     /protein_id="NP_001074489.1"
                     /db_xref="CCDS:CCDS36773.1"
                     /db_xref="GeneID:108154"
                     /db_xref="MGI:MGI:1347348"
                     /translation="MEISWKTLTWILSLIMASSEFYSDHRLSYSSQEEFLTYLEHYQL
                     TIPIRVDQNGAFLSFTVKNDKHSRRRRSMDLLDPQQAVSKLFFKLSAYGKHFHLNLTL
                     NTNFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQHSTTKVALSNCVGLHGIIAT
                     EDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSTLQQQHIYDHSHCGVSDLTGSGKP
                     WWLNKTSSFPSLPPINDTHIHHRKRRSVSTERFVETLVVADKMMVGYHGRKDIEHYIL
                     SVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILS
                     HQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINED
                     IGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRD
                     YITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCR
                     ELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGSWSL
                     WGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQC
                     ADFDSMPFRGKHYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDI
                     CINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPR
                     GSVHIEVREVSMSKNYIALKSEGDDYYINGAWTIDWPRKFDVSGTAFHYKRPTDEPES
                     LEALGPTSENLIVMVLLQEQNLGIRYKFNVPIVRTGSGDNEVGFMWTYQPWAECSATC
                     AGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKT
                     CDGGMRTRAVLCIRKVGPSEEETLDYGDCLTHRPVEKESCNNQSCPPQWVALDWSECT
                     PKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRCPPPRWVTGDWGQC
                     SAQCGLGQQMRTVQCLSYTGQASVDCPETVRPPSMQQCDSKCDSTPLSSTEECKDVNK
                     VAYCPLVLKFKFCSRAYFRQMCCKTCQGH"
     exon            545..909
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1078
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1290
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1374
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1520
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1564
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1670
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1817
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1959
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2067
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2213
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2277
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2380
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2514
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2638
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2719
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2883
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3022
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3152
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3357
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3534
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3691
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..6792
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6765..6770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /note="hexamer: AATAAA"
     polyA_site      6791
                     /gene="Adamts6"
                     /gene_synonym="A930019D11Rik; ADAM-TS6; b2b1879.1Clo;
                     b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo"
                     /note="major polyA site"
ORIGIN      
        1 tctctctctc tctctctctc tctctctctc tctctcactc tctgtgttgt gtctgcgcgc
       61 gcgtgcgtgc tttatggcaa gaagtgagtt tcactaaact cacattacag atagaaatct
      121 tttaaactct agtctactcg tggatgtaaa attccggggc ttacaggtta aaaagtggcc
      181 accatattta agtgacctat cactctgagc ttggctaatg aaaaaatttc atcatcgtta
      241 ttttcttcat ttttggattg gaaaaatgaa tccagacata gaagaaagtg caagatgttg
      301 gggaagagta cttgttaaac agtggagtat ctaacaactt atttacaaga aggattaaag
      361 aattaaaatt gttatgcttc gatattggta tgctattgac tctctagctc ataggtagcc
      421 ctccaaaaac attcagtttt ccaaattatg gaaatttcgt ggaaaacgtt gacttggatt
      481 ctgagcctca tcatggcctc atcggaattt tatagtgacc acagactttc atatagttct
      541 caagaggaat tcctgactta tcttgaacac taccagctaa ctattccaat aagagttgac
      601 caaaatggag cttttctcag ctttactgtg aaaaatgata aacactcaag aagaagacgg
      661 agtatggacc ttcttgatcc acagcaggca gtgtctaaat tattttttaa actttcagcc
      721 tatggcaagc actttcacct aaacttgact ctcaatacaa attttgtgtc caaacatttt
      781 acagtagagt attgggggaa agatggaccc cagtggaaac atgatttttt agacaactgt
      841 cactacacag gatacttgca agatcaacat agtacaacta aagtggcttt aagcaactgt
      901 gttggattgc atggtattat tgctacagaa gatgaagaat attttattga gcctctaaag
      961 aatactacag aggattccaa acattttagt tatgaaaatg gccatcctca tgttatttac
     1021 aaaaagtcta ctcttcagca acaacatatc tatgatcatt ctcattgtgg ggtttcagat
     1081 ctcacaggaa gtggcaaacc ttggtggctg aataagacat catcttttcc ttctttacca
     1141 ccaattaatg acacacatat tcatcacaga aagagaagat ctgtgagcac tgagagattt
     1201 gtggagactt tagtagtggc agacaaaatg atggtgggct accatggccg taaagacatt
     1261 gaacattata ttttaagtgt gatgaatatt gttgccaaac tttatcgtga ctccagtcta
     1321 ggaaacgttg tgaatattat agtggctcgc ttaattgttc tcactgaaga tcagccaaac
     1381 ttggagataa accatcatgc agacaagtcc ctcgatagct tctgtaaatg gcagaaatcc
     1441 attctctccc accaaagtga tggaaacacc attccagaaa atgggattgc ccaccacgat
     1501 aatgcagttc ttattactag atatgatatc tgcacgtata aaaacaagcc ctgtggaaca
     1561 ctgggcttag cctctgtggc tggaatgtgt gagcctgaaa ggagctgcag cattaatgaa
     1621 gacattggcc taggctcggc ttttaccatc gcacatgaga ttggtcacaa ttttggtatg
     1681 aaccatgatg gaattggaaa ttcttgtggg acgaaaggtc atgaggcagc aaaacttatg
     1741 gcagctcata ttactgcaaa taccaatccc ttctcctggt ctgcctgcag cagagactac
     1801 atcaccagct ttctagattc aggccgtggt acttgccttg ataatgagcc tccaaagcgt
     1861 gactttcttt atccagctgt ggccccaggt caggtgtatg atgctgatga acaatgtcgt
     1921 ttccagtatg gagcaacatc ccgccaatgc aaatatgggg aagtgtgtag agagctctgg
     1981 tgcctcagca aaagcaaccg ctgtgtcacc aacagtattc cagctgctga ggggacactg
     2041 tgtcagactg ggaatattga gaaagggtgg tgttatcagg gagattgtgt tccttttggc
     2101 acatggcccc agagtattga tgggggctgg ggttcctggt cactgtgggg cgagtgcagt
     2161 aggacctgcg gaggaggtgt ctcctcgtct ctaagacact gtgacagtcc agcaccttca
     2221 ggaggtggga aatattgcct tggtgaaagg aaacgctacc gctcttgcaa cacagatcca
     2281 tgccctttgg gttcccgaga ttttcgagaa aaacagtgtg cagactttga cagtatgcct
     2341 ttccggggaa agcattataa ctggaaaccc tatactggag gtggggtaaa accttgtgca
     2401 ttaaattgcc tggctgaagg ctataatttc tacacagagc gagctcctgc tgtgatagat
     2461 gggacacagt gcaatgcaga ctcactggat atctgtatca atggagaatg caagcacgta
     2521 ggttgtgata atattttggg atctgatgct agggaagata ggtgccgagt ctgtggtggg
     2581 gatggaagca cctgtgatgc cattgaaggg ttcttcaatg actcattgcc cagaggaggt
     2641 tatatggaag tggttcagat accaagaggc tctgttcata ttgaagtaag agaagtttcc
     2701 atgtcaaaaa attacattgc tttaaaatct gaaggggatg attactacat taatggtgcc
     2761 tggactattg actggcctag gaaatttgat gtttcgggga cagcttttca ctacaagaga
     2821 ccgacagatg aaccagaatc cttggaagct ctaggaccca cctctgagaa cctcattgta
     2881 atggttctac tccaagaaca gaatttggga attaggtaca agttcaatgt tcccatcgtt
     2941 cgtactggca gtggagataa tgaagttggc ttcatgtgga cttatcagcc ctgggcggag
     3001 tgctctgcta cttgtgctgg aggtgtccaa agacaagaag tggtctgtaa aagattggat
     3061 gacaactcca ttgtccagaa caatttctgt gatcctgaca gtaagccacc tgaaaatcaa
     3121 agagcctgca acactgagcc ttgcccacct gaatggttca ttggagactg gttggagtgc
     3181 agcaagactt gtgatggtgg gatgcgcaca agggccgtgc tctgcatcag gaaagttgga
     3241 ccttctgaag aggaaacact ggactacggc gactgcttaa cacaccggcc tgtggagaaa
     3301 gagtcctgca acaaccagtc atgtccacct cagtgggtag ctttggactg gtccgaatgt
     3361 actcctaaat gtggttcagg attcaagcat cggattgttc tgtgcaagag cagtgacctt
     3421 tctaaaacat tcccagctgc acaatgtcca gaggagagca agcctcctgc tcgcatccgc
     3481 tgcagtctgg gccgctgccc tcctccccgc tgggtgacag gagactgggg ccagtgctct
     3541 gctcagtgtg gtcttggaca acaaatgaga actgtccagt gcctttccta tactggacag
     3601 gcgtctgttg actgtccaga aactgtccgg cctccatcca tgcagcagtg tgacagcaaa
     3661 tgtgatagca cccctctctc cagtactgaa gagtgcaaag atgtgaacaa agtggcttat
     3721 tgcccactgg tgctgaagtt caagttctgc agtcgagcat acttcagaca gatgtgttgt
     3781 aagacctgcc aaggacactg acccgcagaa agccagagag tcctgtcatt tcatcgtgga
     3841 aatgcgtcca tcaaagagaa ccacccagag gaagtggatg gatgtcctta caaaagcatt
     3901 accctgtgga aaatgtaacc actggtcagc cccagctgac aggatttcaa tattatttta
     3961 acttctgtga agtgggattt attgatccaa agtgctggac acggtatcag gagggactgc
     4021 cagatctgag agatccaaac aacacaggaa acttgcttac tgtggagcgt ttgtgttctt
     4081 tcgagtaaat ctaacagcct gtttacctcc ctggaccatt aagataattt ttattatgga
     4141 cttagcaatg acactgaatc catttgtatt taagactgtt taaaatgtag ttattatgac
     4201 ttggttaact atgaaagtag aagagattca gaattcttaa gtcatagctt aaaaatattt
     4261 actactcttt atcacaccac aatagcacca cgatttaaat tataaaatgg gctttaaact
     4321 gtaatttaag aaacaattat aaatcaaaag taatgaaagt gtgtattatt tttctttgtc
     4381 ccactcagtt tccttaggaa taacccctgt tctgagcact gctgtgagcc atgtataaac
     4441 tctattaaac agtgagggac ttggtttgaa gctgcgcagc aattgctgca gctgtgcaag
     4501 tctataaact cagtgctaag agtctgtggc caacttgcca ttgtgcaagg gaggctgaga
     4561 tttccattaa aactttaaga gaaaaacatt tcaatttcat gcagaagcca gacctaaggc
     4621 atggcagaga ctgaagcacc aggcccttgc agccgtcagt gggatgcctt atttgagtca
     4681 ccgagactcc ttcgtgttta catccccacc agccacagat cagcttctgc cctgctcggc
     4741 tgttgcatgc atggtgagct tatggagatg atgccatgcg gaaagataag ctggcttagt
     4801 aataaccagg caggcccttt accatttgct gacagtccga tgggttccag atgtcccttc
     4861 tttgatatgg tagaagggca tttatttata tgagagcaag tgtatacgtg tgtgtatgtg
     4921 tgtgtgtgtg cagacattcc tgagtgggga aacaggtgag tttgcttgca tataaatgtg
     4981 ctgtttctgt gagttttaaa gtagggaagg ataacaacca aagaagaaaa gctccatgaa
     5041 gaaagatcac aaactataag tttagaagtc acataatttt tatagatatt ctaaatggca
     5101 gttaaatgtg aaacccggtt tcctaggcga gtcaggctct aaaggcatac cttacagaac
     5161 tgaaatgact cgcgtgggcc ttcccacctt cacgcttcac acgttgccat caaaagattc
     5221 aacaactaga ttgtttaagg gttcttgttt atgttaatgc ttcgtacttg aacacttgta
     5281 gcgtgtagta ggttgttggt gaatgtgctt tgtgtcaagc acacctcctt agtccttcac
     5341 gtatgtgccc cgtacacaca gcatcatcga aaacacaaac taaatggcta cttggtaaca
     5401 aagaaaatat tttcatttaa gagcatgtct cacttatcta ccactgtgct ctgaagctag
     5461 attttggtgt gtcacctatg tggtgacctt agaaaggctg tcaccaaagg cctcctcagc
     5521 ttcttgcttg ctatgtacag gtggcctgga tgttagccca cactccagtg tgaccagcca
     5581 tatcttcatt ccctgcttct ttctcagtat catcccctaa gttctccaga ggaggctatc
     5641 agtgatacaa agcatatggt caagccctcc atctgactgc cctgagaaga ccagcctaag
     5701 taccatccca gccattccac taaaggaagg caacacatgg gagcctggcc cagacttgaa
     5761 ttcccttggt ccttttcaaa ggacagttaa cttggtgcta atgtgccctg gtaaaatata
     5821 ggaagactgg gtgatcgctg aggcagttta caataggctt gctacccaga cctaattttt
     5881 tgtaccaaca ttaatattaa atcatgctta tattccaaga agatatccta caatacttgt
     5941 aaaaagctgt atttacctca cttggaagct aacatcgcaa gggctgaccc ccacaggtac
     6001 tgtgcagttc ctgcctctgc tactgctagg gtaagagatc agtctatgct ctctccagga
     6061 agtgcattgg cacagtggac aggctactgc tgaggggagc acggccttcc atggggaaac
     6121 aaagcgtggt ttaacaggat tcaacattct caaagtagac tctgaattta aacttgagca
     6181 ggttacacaa aatgaagagc atcttccata acacattaca atgccactgc tactgcagcc
     6241 atctctgtcc tccgtggtaa cagtgggatc agcagcggag gctgggctgc cctggcaggc
     6301 actccaaatg ttgtgagcta tattgactac ttagggtacc agggtaccca tggctaggag
     6361 cagtgtctgc cactggtata aaggcctacc aaaataggaa tgtcaaatat acccaaatga
     6421 ttgaacccct aaaggcaggt atgatttccc aatagaccat ttcattagga atttatatgt
     6481 atttgagtga atgtcttata ggtatcgtta ataatacaga acaaaattac ctttgtatta
     6541 ttgtgatagc ttgttgctta ttattttata ctcagtatta atgtggtaca ctgttactat
     6601 ttttgctttt gtaaattata ttctaattta ttgccatgtt tcctaacacc tgtcctttat
     6661 tcattctcct gctcgtaatg aaaatgaaag tcattgtaac acttgatgga gtgaaatttc
     6721 ataccaggca cagatttttt tttaacatag ataattcagt aaataataaa aacttcagct
     6781 tgtaaaaata at
//
