LOCUS       NM_011782               8104 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            5 (Adamts5), mRNA.
ACCESSION   NM_011782 XM_917529
VERSION     NM_011782.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8104)
  AUTHORS   Feng,W., Hong,N., Wu,Y., Huang,J., Zhang,Q., Liu,G., Qian,Z.,
            Chen,Y., Jin,L., Ding,X., Zhao,P., Chen,A.F. and Yu,Y.
  TITLE     Deficiency of Sox7 leads to congenital aortic stenosis via abnormal
            valve remodeling
  JOURNAL   J Mol Cell Cardiol 199, 81-94 (2025)
   PUBMED   39746830
REFERENCE   2  (bases 1 to 8104)
  AUTHORS   Chen,T., Liu,S., Yang,Z., Feng,S., Fang,W., Lu,X. and Li,J.
  TITLE     Investigation roles of Adamts1 and Adamts5 in scleral fibroblasts
            under hypoxia and mice with form-deprived myopia
  JOURNAL   Exp Eye Res 247, 110026 (2024)
   PUBMED   39122105
  REMARK    GeneRIF: Investigation roles of Adamts1 and Adamts5 in scleral
            fibroblasts under hypoxia and mice with form-deprived myopia.
REFERENCE   3  (bases 1 to 8104)
  AUTHORS   Mead,T.J., Bhutada,S., Foulcer,S.J., Peruzzi,N., Nelson,C.M.,
            Seifert,D.E., Larkin,J., Tran-Lundmark,K., Filmus,J. and Apte,S.S.
  TITLE     Combined genetic-pharmacologic inactivation of tightly linked
            ADAMTS proteases in temporally specific windows uncovers distinct
            roles for versican proteolysis and glypican-6 in cardiac
            development
  JOURNAL   Matrix Biol 131, 1-16 (2024)
   PUBMED   38750698
  REMARK    GeneRIF: Combined genetic-pharmacologic inactivation of tightly
            linked ADAMTS proteases in temporally specific windows uncovers
            distinct roles for versican proteolysis and glypican-6 in cardiac
            development.
REFERENCE   4  (bases 1 to 8104)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8104)
  AUTHORS   Liu,Z., Lu,T., Ma,L., Zhang,Y. and Li,D.
  TITLE     DNA demethylation of promoter region orchestrates SPI-1-induced
            ADAMTS-5 expression in articular cartilage of osteoarthritis mice
  JOURNAL   J Cell Physiol 239 (2), e31170 (2024)
   PUBMED   38149721
  REMARK    GeneRIF: DNA demethylation of promoter region orchestrates
            SPI-1-induced ADAMTS-5 expression in articular cartilage of
            osteoarthritis mice.
REFERENCE   6  (bases 1 to 8104)
  AUTHORS   Richards,J.S., Hernandez-Gonzalez,I., Gonzalez-Robayna,I.,
            Teuling,E., Lo,Y., Boerboom,D., Falender,A.E., Doyle,K.H.,
            LeBaron,R.G., Thompson,V. and Sandy,J.D.
  TITLE     Regulated expression of ADAMTS family members in follicles and
            cumulus oocyte complexes: evidence for specific and redundant
            patterns during ovulation
  JOURNAL   Biol Reprod 72 (5), 1241-1255 (2005)
   PUBMED   15659705
  REMARK    GeneRIF: ADAMTS1, ADAMTS4, and ADAMTS5 are expressed in patterns
            that relate to the expression pattern of versican in granulosa
            cells of small follicles, expanded cumulus cell-oocyte complexes,
            and endothelial cells of the ovary.
REFERENCE   7  (bases 1 to 8104)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 8104)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 8104)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
REFERENCE   10 (bases 1 to 8104)
  AUTHORS   Abbaszade,I., Liu,R.Q., Yang,F., Rosenfeld,S.A., Ross,O.H.,
            Link,J.R., Ellis,D.M., Tortorella,M.D., Pratta,M.A., Hollis,J.M.,
            Wynn,R., Duke,J.L., George,H.J., Hillman,M.C. Jr., Murphy,K.,
            Wiswall,B.H., Copeland,R.A., Decicco,C.P., Bruckner,R., Nagase,H.,
            Itoh,Y., Newton,R.C., Magolda,R.L., Trzaskos,J.M., Burn,T.C. et al.
  TITLE     Cloning and characterization of ADAMTS11, an aggrecanase from the
            ADAMTS family
  JOURNAL   J Biol Chem 274 (33), 23443-23450 (1999)
   PUBMED   10438522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC163107.3, AK044746.1 and
            AC126936.4.
            
            On Feb 9, 2007 this sequence version replaced NM_011782.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded
            protein are protected from surgery-induced osteoarthritis and
            antigen-induced arthritis. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.213468.1, AF140673.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1779              AC163107.3         122457-124235       c
            1780-4513           AK044746.1         2-2735
            4514-4844           AC163107.3         84527-84857         c
            4845-8104           AC126936.4         174526-177785       c
FEATURES             Location/Qualifiers
     source          1..8104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 48.34 cM"
     gene            1..8104
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 5"
                     /db_xref="GeneID:23794"
                     /db_xref="MGI:MGI:1346321"
     exon            1..1962
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             859..3651
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 5; implantin; aggrecanase-2; a
                     disintegrin-like and metallopeptidase (reprolysin type)
                     with thrombospondin type 1 motif, 5 (aggrecanase-2)"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 5 preproprotein"
                     /protein_id="NP_035912.2"
                     /db_xref="CCDS:CCDS28288.1"
                     /db_xref="GeneID:23794"
                     /db_xref="MGI:MGI:1346321"
                     /translation="MRLEWAPLLLLLLLLSASCLSLAADSPAAAPAQDKTRQPQAAAA
                     AAEPDQPQGEETRERGHLQPLAGQRRSGGLVQNIDQLYSGGGKVGYLVYAGGRRFLLD
                     LERDDTVGAAGSIVTAGGGLSASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAV
                     KHARYTLKPLLRGSWAEYERIYGDGSSRILHVYNREGFSFEALPPRASCETPASPSGP
                     QESPSVHSRSRRRSALAPQLLDHSAFSPSGNAGPQTWWRRRRRSISRARQVELLLVAD
                     SSMARMYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLTDKDTSLEVSKNA
                     ATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPER
                     SCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGTTEDKRLMSSILTSIDASK
                     PWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVC
                     PGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRVCLQGKCVDKTKKKYYSTSS
                     HGNWGSWGPWGQCSRSCGGGVQFAYRHCNNPAPRNSGRYCTGKRAIYRSCSVTPCPPN
                     GKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSP
                     KVTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIIGTFNK
                     KSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKTGEYLINGKYMISTSETI
                     IDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKALDVRYSFFVPKKTT
                     QKVNSVISHGSNKVGPHSTQLQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCL
                     LSQRPSAFKQCLLKKC"
     exon            1963..2095
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2263
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2547
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2731
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2907
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3083
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..8104
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4549..4554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="hexamer: AAGAAA"
     polyA_site      4554
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="major polyA site"
     regulatory      6651..6656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="hexamer: AATATA"
     polyA_site      6675
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="major polyA site"
     polyA_site      6830
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="major polyA site"
     polyA_site      6858
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
     regulatory      7812..7817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      7833
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
     regulatory      7938..7943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
                     /note="hexamer: AATAAA"
     polyA_site      7960
                     /gene="Adamts5"
                     /gene_synonym="9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11;
                     ADMP-2; ASMP-2"
ORIGIN      
        1 gaaattgcca ttgcaggatg gcacgccgct ataaattcat tgtcccacct cctcgcatct
       61 tcacagcgcc tgagccgctc tccgcgcccg tagcagccga ctggggatga tcccgggcgg
      121 gaggacgcgg caacggaagg gaccgggacg cgccgcctcg ctggctctcc gcaggccgcc
      181 tcctagcttt tgattttaaa catttttagg tgtttccttt gcttgctttc tttccttttc
      241 ttttctcccg tctcatttct ccctgccttc gggttccagc ggagccgagg aagccctgag
      301 aataagaaag gaagtgggtc ggagcttgga agctttgcag cccgccagcc ccgggcttcg
      361 agggggcggg agcggacgcg caccagttgc gggccagcgc ggtcgccctt cttactctct
      421 tagctcgttt gttttgatct gtttgtgcaa agatcttgtc tgcgttgggc ctctctcctt
      481 ttttgtattt ggttgctctc cacctcttgg cttttactcc caccaacacc accctttatt
      541 taattttttt tcttttattt tatttaaaat ttttcttcct ccgtctcttg gacctccatt
      601 ccaaacattt tccaaaccaa caaagaaaaa gttctcacag tggcaccggt gccaggccag
      661 gctggctctc tgctgcggat tccccctacc ctttcctgga cacttgactc aaccttgcac
      721 gccagtgtgt agagtgtgcg gctgtgggtg ggtgggtggg agggcgagcc ccccaccccc
      781 gcccctgaaa cttctatagc aaatagcaag catccagcta gactcagtcg cgcagcccct
      841 cccggcgggc agcgcactat gcggctcgag tgggcgccct tgttgctgct actgctgctg
      901 ctgagcgcgt cctgcctgtc cctggccgct gacagccccg ccgcggcacc tgcccaggat
      961 aaaaccaggc agcctcaggc tgcagcagcg gccgccgagc cggaccagcc gcagggggag
     1021 gaaacacggg agcgaggcca tttacaaccc ttggccgggc agcgcaggag cggcgggctg
     1081 gtccagaata tagaccaact ctactctggc ggtggcaaag tgggctacct tgtctacgcg
     1141 ggcggccgga ggttcctgct ggacctggag agagatgaca cagtgggtgc tgctggtagc
     1201 atcgttactg caggaggagg gctgagcgca tcctctggcc accggggtca ctgtttctac
     1261 agaggcaccg tggacggcag ccctcgatcc ctagctgtct ttgacctctg cgggggtctc
     1321 gatggcttct ttgcagtcaa gcatgcgcgc tacactctaa agccactcct gcgtgggtcc
     1381 tgggcagagt atgaacgaat ttatggggat ggatcttccc gcatcctgca tgtctacaac
     1441 cgcgagggct ttagcttcga ggccctgccg ccacgcgcca gttgcgagac tcctgcatcc
     1501 ccatctgggc cccaagagag cccctcggtg cacagtagat ctaggagacg ctcagcgctg
     1561 gccccgcagc tgctggacca ctcagctttc tcgccatctg ggaacgcggg acctcagact
     1621 tggtggaggc gtaggcgccg ttccatctcc agggcccgcc aggtggagct cctcttggtg
     1681 gctgactcgt ccatggccag gatgtatggg cggggcctgc agcattacct gctgaccctg
     1741 gcctccatcg ccaacaggct gtacagtcat gcaagcattg agaaccacat ccgcctggcg
     1801 gtggtgaagg tggtggtgct gacggacaag gacacgagtc tggaggtgag caagaatgcg
     1861 gccacgaccc tcaagaactt ttgcaaatgg cagcaccaac ataaccagct aggggatgat
     1921 cacgaagagc actacgatgc agccatcctg ttcacccgag aggatttatg tgggcatcat
     1981 tcatgtgaca ccctgggaat ggcagacgtt gggaccatat gttctccgga gcgcagctgt
     2041 gcagtgattg aagatgatgg cctccatgca gccttcactg tggctcatga aattgggcat
     2101 ctacttggcc tttctcatga cgattccaaa ttctgtgaag agaacttcgg tactacagaa
     2161 gacaagcgtt taatgtcttc aatccttacc agcatcgatg catccaagcc ctggtccaaa
     2221 tgcacgtcag ccaccatcac agaattcctg gatgatggtc atggtaattg tttgctagac
     2281 ctaccacgga agcagatttt gggtcccgag gaactcccag gacagaccta cgatgccacc
     2341 cagcagtgca acttgacatt tgggcctgag tactcggtgt gccctggcat ggatgtctgt
     2401 gcgcggctgt ggtgtgctgt ggtgcgccaa ggccaaatgg tgtgtctgac caagaagctg
     2461 ccggctgtgg agggcactcc ctgtgggaag ggaagagtct gccttcaagg caaatgtgtg
     2521 gacaaaacta agaaaaaata ttactcgaca tcaagccatg gaaattgggg gtcctggggc
     2581 ccctggggtc agtgttctcg ctcatgcggg ggaggagtgc agtttgccta ccgccattgt
     2641 aataaccctg cacctcgaaa cagtggccgc tactgcacag ggaagagggc catataccgt
     2701 tcctgcagtg ttacaccctg cccacccaat ggtaaatctt ttcgccatga gcagtgtgaa
     2761 gccaaaaatg gctatcagtc tgatgcaaaa ggagtcaaaa catttgtaga atgggttccc
     2821 aaatatgcag gtgtcctgcc ggcagatgtg tgcaagctta cctgcagagc taagggcaca
     2881 ggctactatg tggtcttttc tccaaaggtt acggatggga ctgaatgcag gccgtacagc
     2941 aactctgtgt gtgtccgagg acggtgtgtg agaactggat gtgacggcat tattggctca
     3001 aagctacaat atgacaagtg tggagtgtgc ggaggggata actccagttg tacaaagatt
     3061 atcggaacct tcaataaaaa aagcaagggt tatactgacg ttgtgaggat ccctgaagga
     3121 gcaacccaca taaaagtccg acagttcaaa gccaaagacc agactagatt cactgcctac
     3181 ttagccctga agaagaaaac tggcgagtac cttatcaatg gcaagtacat gatttccact
     3241 tcagagacca tcatcgacat caatggtacc gtcatgaact acagtggatg gagccacaga
     3301 gatgattttt tacatgggat gggctattca gccacaaaag aaatcctgat cgtgcagatc
     3361 cttgccacag acccaactaa agcgctagac gtccgttaca gcttttttgt tcccaagaag
     3421 accactcaaa aagtaaactc tgtcatcagc catggcagca acaaggtggg accacactct
     3481 acacagctgc agtgggtgac aggtccatgg ctggcctgct ccaggacctg tgacacaggc
     3541 tggcacacta ggaccgtgca gtgccaggat ggaaacagga aattagctaa aggatgcctt
     3601 ctctctcaga ggccttctgc atttaagcaa tgtctgctga agaaatgtta gcctgtggtt
     3661 tactctaatg cacaaaaaaa caacaggagg atcatcgcag atacagctgt ggtgaagaca
     3721 aggcctaccc aaagcacaga aagtcatgcc ttcatgtcat tgtcaccacg agtcgaatta
     3781 tgggcagaat ctgctctctg cgaccaaaag gtttactcta cttggtgtaa tgatggtgac
     3841 cttggaataa agaaaacgtg agggtcatgg aacatccctg ggcctacaca aaggagacac
     3901 acaatgatga atgtagaatc ggggacattt gaagatggca gagaagtctt gtcacctacc
     3961 tcttatagaa tgtcttcaaa gacatcgtga tcatgttcag ccatgacaca cagcttattt
     4021 ttactgtttg taaatgcatc cgcccttagt atgtcacttt ataaacttgg tcctattaat
     4081 atatacacat gtgtaaatac aatatatata tttgaccaaa gtaggtctgc agctatttca
     4141 actactattt tccagaaaga gctgaagaag atttactgga aattaagaac ttgctgctgt
     4201 taaataaaac tttgtatatt gtcagcctgc aggagataac attttagtca aaaaaaaaaa
     4261 aaaaagaaaa aaaagaaaaa gaaaagaaaa agaaagaaac cattttgaca gcaagcacct
     4321 tctgtgaagt tctaaaaagg gaaaggatct gcgtgtgtct ggtcatttaa acacatattc
     4381 agttctgtgt actctagagt ttgacggtct gtatattttt caggcagcca agccaagtta
     4441 ttgtatcatt tgggtgtaga aactgtgttt tcctgtgtat atgtgatcaa tatccaaggg
     4501 tctaaaagtt agcttgcttg tattggaatt taaaacaaca acaacaaaaa gaaatatgtc
     4561 actgtgtttt caatttgtat tttcacaact gcttcctttt ctatggctcc tggttcatat
     4621 ctcacagtgt gtagggatca tagagaacac gcagagccgc aagctgtctg tcacatccag
     4681 cttccgcagt aatggctcac ctctgctcag ccagggttta aaatgtgttt gtggttgctt
     4741 gtttgttttt cctgagggtg ggaagatgta tgttctgtat tggctgggtc taacagtaat
     4801 attaaaatca tttcgtattt agcctcatct tgaacgagca atcggatcag ttcaactaat
     4861 tcaagaaacc aaactagtta gcacttaaaa gactgtttcc acaccatagg caattatctc
     4921 ataatttaca aaatataagc atatgtctgc tgtattagag aatttctgct ctcagaaggc
     4981 gtttgtctct accagtgagt atgtaagtga tggaatataa gtggtttcag gaagtctttt
     5041 acctgcacaa gaaggtcgca cacgcttaat gataatcata atctccttta actactcact
     5101 gaaaggcccc cctccgataa ttcaaataat atgacgtggt tttattccac tggcatttct
     5161 tttttcttcg taaaaatctg caaagtaaat tgttttacac aaattctata gtgaccatac
     5221 caaatgtgcc tactgtgaaa gatttgcata gaaggatttt gagaaatcct ctctggaatt
     5281 ccactaaatg tatgagagtt tatttttatt ataggatatt ttaatataaa taactatgta
     5341 attgatgact ccatatcaca ttgatttcag tgggacagaa aaagaatgca atcctactta
     5401 ggtttgtttg tttgtttgtt tgttttaaga gattattttg tgaaacagac caatgccctc
     5461 ccaaaccagt catcatccat tggcttctca cagcctggtc tttttacatc aagaaatgca
     5521 gactatacag aacttgtagc ctatattggg tgcaggtctc caaatataga gcagggagtt
     5581 catttagtca aattggtcat aagacaaaaa attaaatctc acgttgctta tttaactgta
     5641 cagagagaat aaatagtata atgcaacttt ctccaatttc taaaaacaat ataagccaag
     5701 tagttccaat ttgacaaaat tcttattttg ttttttgttg tggttatatt aaaaaaaata
     5761 aatgaagagt aaatgtgatt atctcctact ctgcttccct ctatgatcat catagttttt
     5821 tttaataata ttttcactgg gttactttcc ctataataat cgagttttat acttcacact
     5881 gaaatcatcc taaggagggt aaacggataa accactaatc tatgtctaga gggattttct
     5941 ttatgtttta aaaagactat tcctacattg acaggggaat gtatataaat ctcctgagga
     6001 aagaaacaca gcaaactgag agtcagaaat ctgaagtgtc acagagggaa agagaaattg
     6061 agtgtgggag gagaaaccga tattaaattc caattcattc agttagattc tgtgctgtgt
     6121 ttgccatctt cccggttgtg tatcttgaat cgttaaagac cttggattta agatggtgaa
     6181 taaaggtggg gaaacagaac aaggcagtgc tctggttaca aaatgtctaa ccttgcttgc
     6241 ataaaaaaat tattccagag tgagtgtcag tgcaaaagag cccagagtga aacagtacct
     6301 tgatctatca gaacagcaaa tgccacctta aaaccccctt attgcttgaa agtataagga
     6361 catggttata gtgtatttaa cagactcaac atctattgcc ttcctgtgga aacagtttta
     6421 aactaacagt tgagggatga atcacaaaca aacagaataa gaagttgcag cactgaaaac
     6481 taagtaattt attgtttttg caactgccat gtgaatttct gtgatgaaat tatttattct
     6541 tatttaacaa aaattatgtg caaaatctta tatttgaaat gttttgctgt tgtccttttt
     6601 ttaatttatg cttcttgttt gtgtataaag tgcactttgt gagtttatat aatatacagc
     6661 actggtggct ttgtatttct tttttacaga aggctttctg tgtggaacag gtgtatgtgt
     6721 gtatattccg catgtatttt cagtctgcca ctctcttaaa ttttaaagga acattgatca
     6781 ctatgttaat aggtcattta aataccaata acattggctt tttcagatca tgagttttaa
     6841 aaatgtgtat tcaatccagc aagttgcaac tggtttttaa ctagaggaca tatatacctt
     6901 aggaacatct caacagaagc taagacacaa tggagaacag ggtttgaaac aggcatagca
     6961 cacaggaggc tgaaggagga agattatgaa cttaagagtt gtctgggagc catagcaggc
     7021 ccctagtttg gtggaagaaa tagaatcagt ttcagtcaca tcactgataa ttatatacaa
     7081 ggagacttaa atttattata tgcatgttat agacacataa cttctaagtg attaaagaat
     7141 gataaataca aactcttaca gctttagaaa cagcttccca caaaaacagt gtctgagcct
     7201 ctgctgtctg tagagattct agagatgatc tcaaatgaaa gtggatttgt gtatttctaa
     7261 taccagtcat aaccttgtct atgggtgtaa gtgcacataa caaagtaaga ctttttacta
     7321 ctactatcag accagagtgg taggacatgg gacaagcagg aacaactctg gtaacaacag
     7381 ctcatttgtg agtgagactg tgcggtccag gtctagaaat aaagtcaagc actcttggcc
     7441 ccactgtata agtcattggg tcaagccctg gctccgatgt tcctccatta ataacttcct
     7501 tgttagcaaa ttaacaaggt cagtcagtgc aaccagcagg gaacataggc aggttcagaa
     7561 atccagggtg tgcactatga ctgcagctca ttgttagaaa tatgatgaat acaatgctta
     7621 attctactct gagttgagaa ccctgcaaaa cagccatact gtgctaatac cactcatcta
     7681 tttacactga aacatgggac cgtacaaatg cattacattt tttattattt catggctaca
     7741 aaataaaaga aataaccaca agagcaaaat aggtcaaagc agatgcaaaa tcatattaag
     7801 gaagttttat cattaaaaca cagagaaaag gcacttgtat ggtttctgta ttattatttt
     7861 ctttggccaa cagtctacag ttgcaaagaa tcaaacaaat agatcagcct aaccgaatag
     7921 tttggtaaaa atgtggtaat aaacccttat taatgtgaaa tataggcatg gcttattgaa
     7981 tcatatcacc acaaaacata gcaatctata atcaacccat taattctatt caatcaaaca
     8041 atgaggacac attgcaatac aggtccattc attattaagc taatgcacag gaataaaaat
     8101 cagt
//
