LOCUS       NM_172845               6311 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            4 (Adamts4), mRNA.
ACCESSION   NM_172845
VERSION     NM_172845.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6311)
  AUTHORS   Li,M.D., Lu,J.W., Zhang,F., Lei,W.J., Pan,F., Lin,Y.K., Ling,L.J.,
            Myatt,L., Wang,W.S. and Sun,K.
  TITLE     ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in
            the amnion at parturition
  JOURNAL   Commun Biol 7 (1), 301 (2024)
   PUBMED   38461223
  REMARK    GeneRIF: ADAMTS4 is a crucial proteolytic enzyme for versican
            cleavage in the amnion at parturition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6311)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6311)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6311)
  AUTHORS   Zhu,L., Duan,W., Yang,B. and Wang,L.
  TITLE     Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse
            hepatic I/R injury in an age-independent manner
  JOURNAL   Int J Med Sci 20 (12), 1562-1569 (2023)
   PUBMED   37859693
  REMARK    GeneRIF: Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in
            mouse hepatic I/R injury in an age-independent manner.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6311)
  AUTHORS   Jiang,C., Qiu,W., Yang,Y., Huang,H., Dai,Z.M., Yang,A., Tang,T.,
            Zhao,X. and Qiu,M.
  TITLE     ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination
            by Cleaving NG2 Proteoglycan and Attenuating PDGFRalpha Signaling
  JOURNAL   J Neurosci 43 (24), 4405-4417 (2023)
   PUBMED   37188512
  REMARK    GeneRIF: ADAMTS4 Enhances Oligodendrocyte Differentiation and
            Remyelination by Cleaving NG2 Proteoglycan and Attenuating
            PDGFRalpha Signaling.
REFERENCE   6  (bases 1 to 6311)
  AUTHORS   Somerville,R.P., Longpre,J.M., Apel,E.D., Lewis,R.M., Wang,L.W.,
            Sanes,J.R., Leduc,R. and Apte,S.S.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
REFERENCE   7  (bases 1 to 6311)
  AUTHORS   Glasson,S.S., Askew,R., Sheppard,B., Carito,B.A., Blanchet,T.,
            Ma,H.L., Flannery,C.R., Kanki,K., Wang,E., Peluso,D., Yang,Z.,
            Majumdar,M.K. and Morris,E.A.
  TITLE     Characterization of and osteoarthritis susceptibility in
            ADAMTS-4-knockout mice
  JOURNAL   Arthritis Rheum 50 (8), 2547-2558 (2004)
   PUBMED   15334469
REFERENCE   8  (bases 1 to 6311)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 6311)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
REFERENCE   10 (bases 1 to 6311)
  AUTHORS   Tortorella,M.D., Burn,T.C., Pratta,M.A., Abbaszade,I., Hollis,J.M.,
            Liu,R., Rosenfeld,S.A., Copeland,R.A., Decicco,C.P., Wynn,R.,
            Rockwell,A., Yang,F., Duke,J.L., Solomon,K., George,H.,
            Bruckner,R., Nagase,H., Itoh,Y., Ellis,D.M., Ross,H., Wiswall,B.H.,
            Murphy,K., Hillman,M.C. Jr., Hollis,G.F., Newton,R.C.,
            Magolda,R.L., Trzaskos,J.M. and Arner,E.C.
  TITLE     Purification and cloning of aggrecanase-1: a member of the ADAMTS
            family of proteins
  JOURNAL   Science 284 (5420), 1664-1666 (1999)
   PUBMED   10356395
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084821.26, AK083534.1 and
            AC087229.27.
            
            On Jul 13, 2016 this sequence version replaced NM_172845.2.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active zinc-dependent aggrecanase enzyme that degrades cartilage.
            [provided by RefSeq, Jul 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028364.1, AK157287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AC084821.26        95107-95399         c
            294-3595            AK083534.1         1-3302
            3596-6311           AC087229.27        4925-7640
FEATURES             Location/Qualifiers
     source          1..6311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.28 cM"
     gene            1..6311
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 4"
                     /db_xref="GeneID:240913"
                     /db_xref="MGI:MGI:1339949"
     exon            1..1341
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1665
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1798
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1969
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2256
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2443
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2619
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2795
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..6311
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3941..3946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /note="hexamer: AATAAA"
     polyA_site      3959
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /note="major polyA site"
     polyA_site      3992
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
     regulatory      4516..4521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /note="hexamer: AGTAAA"
     polyA_site      4537
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
     regulatory      6280..6285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /note="hexamer: AATAAA"
     polyA_site      6301
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
ORIGIN      
        1 cagctgaggg ctgatggtgg gatttgggaa aaaagatgtg tcatcagctg gctcagtgcc
       61 ttaaatgcat ctgcttgcta gagattccct tcccctgggc aagtcccttc cctccccccc
      121 cccttctttt ttaaggaaaa aagaaaacca ctaaggtctt tgggaagcaa tgatacatcc
      181 tccatccttc agagtcccag tgaccaagct tctggctgag tggcttacag atctgccact
      241 cacacacaga gggcggttct ggatgcttaa aagagctgga ggggagagag gctggggaga
      301 acccggggaa gacccacaga tacacagaaa cgagagagac agaagaggag agagacagag
      361 acaaagagac agcagcagga ggaggaggag gaggaggcaa agacagggcg agcactgagg
      421 caaagccaga cagctgagca gagggagaag ccaaggagtc acagacaaag acctgggaca
      481 gaaaggcaaa ggaggaagtt ttggagcaga aagaacccgt gggcactttt cctgagccca
      541 ggggctgttt tctttttcat cttctctgaa agtccctagc ccatttaaaa actttgcctc
      601 agattttggc acaagcccca aagcccttct ggctttaacg aggagccttc cacagttagg
      661 gtgtggagca ttttggtgcc gcagatggcc tcaatccatc ccagctgcag cccgggtacc
      721 atgtcccaga tgggcttgca tcccaggagg ggcttgactg ggcactggct gcaaagattc
      781 caaccctgct tgccgcttca cactgtgcag tggcggaggc tgctgctgct ggccttcctc
      841 ctgtccttag cgtggcccgc cagccccctc ccccgggagg aggagatcgt gtttccagag
      901 aagctcaatg gcagtagcat cctacctgga tcaggcgttc ctgccaggct gctgtaccga
      961 ttgccagcct ttggggagat gttgctacta gaactagaac aggaccctgg ggtgcaggta
     1021 gagggtttga ctgtacagta cctgggccag gcacctgaga tgctgggtgg ggcagagcca
     1081 ggtacctacc tgactggcac catcaatgga gatccggagt cggtggcatc tctgcactgg
     1141 gacgggggag ccctattagg ggtactgcag taccgtgggg ccgaactcca cctccagcct
     1201 ctggaaggag gcgcccttaa ctctgctggg ggaccggggg ctcacatcct acgccggaag
     1261 agtcctgcca gcagccaagg tcccatgtgc accgtcaagg ctccttctgg gagcccgagt
     1321 cccatttccc gcagaaccaa gcgcttcgct tctctgagta gattcgtgga gacactggtg
     1381 gtagcagatg acaagatggc agcattccat ggtacagggt taaagcgcta cctgctgacg
     1441 gttatggcag ctgccgctaa agcctttaaa cacccaagca tccgaaaccc tgtcaacttg
     1501 gtggtgacgc gcctggtgat cctggggtcc ggccaggaag ggccccaagt ggggccaagt
     1561 gccgcccaga ccctacgcag cttctgcacc tggcagcggg gcctcaacac ccctaacgac
     1621 tcagatcctg accactttga cacagccatt ctgttcaccc ggcaggacct gtgtggggtc
     1681 tccacttgtg acaccctggg tatggctgat gtgggcacag tgtgtgatcc agctaggagc
     1741 tgtgctattg tggaagatga tgggctccag tcagccttca ctgctgctca tgaactgggc
     1801 catgtcttca acatgctcca tgataactcc aagccatgca ctaacttgaa tgggcagggg
     1861 ggttcctctc gccatgtcat ggctcctgtc atggcccatg tggaccctga agagccctgg
     1921 tcgccctgca gtgcccgatt catcactgac ttcctggaca atggttatgg gcactgcctc
     1981 ttagacaaac cggaggctcc cctccatcta ccagcgactt ttcctggcaa ggactatgac
     2041 gctgaccgcc aatgccaact gaccttcggt cctgactcaa gccattgtcc acagctgcca
     2101 ccgccctgtg ctgccctctg gtgctctggc cacctcaatg gccatgccat gtgccagacg
     2161 aagcactcac cttgggctga tggcactccc tgcgggtctt cacaggcctg catgggtggc
     2221 cgctgtctgc acgtggacca gctcaaggac ttcaatgttc ctcaggctgg aggctggggc
     2281 ccctggggac catggggtga ctgctccagg acttgtgggg gtggtgtcca gttctcctcc
     2341 cgggattgca cgaggcccgt cccccggaac ggtggcaagt attgtgaggg ccgccggact
     2401 cgcttccgct cctgcaacac ggagaactgc ccacacggct cagcattgac cttccgtgaa
     2461 gagcagtgtg ctgcctacaa ccaccgaacc gacctcttca agagctttcc agggcccatg
     2521 gactgggttc cgcgctacac aggtgtggcc cctcgagacc aatgcaaact cacctgccag
     2581 gcccgggcac tgggctacta ctacgtattg gagccccggg tggcagatgg gactccctgc
     2641 tccccagaca cctcctctgt ctgtgtccag ggccgctgta tccatgctgg ctgtgaccgg
     2701 atcattggct ccaaaaagaa atttgacaag tgcatggtgt gcggcgggga tggctctcgc
     2761 tgcagcaagc agtcgggctc cttcaaaaaa ttcaggtatg gatacagcga tgtggtcacg
     2821 atccctgcgg gggccaccca tatccttgta cggcagcagg gggggtctgg tctcaagagc
     2881 atctacctgg ccctgaagct ttctgacggt tcttacgccc tcaatggtga atacacgctg
     2941 atgccctccc caacagatgt ggttcttcct ggggcagtca gcttgcgcta cagcggagcc
     3001 acagcagcct cagagacact gtctggacat gggccgctgg cccagccctt gacgctgcaa
     3061 gtcctggtgg ctggcaaccc acagaatgca cgtctgcggt acagtttctt tgtcccgcgg
     3121 ccagtccctt caacaccacg ccctcctccc caagactggc tgcaacgcag ggcagagata
     3181 ctgaagatcc ttcggaagcg tccctgggca ggccggaaat aacctcactg tcccggctgc
     3241 cctttttggg cgccggggcc tcggactcat ctgggagaat gagcaggctt ctgcaactgc
     3301 ctcctgctaa aacacagtag ggaggtgtag agggtgagat ctgcctgcct cactgcccca
     3361 aaccgcaggc tggccctgcc ctggcttcct gccctgggag gcagtgatgt cttggtgaat
     3421 ggaaaggggc taggtgacag taccctatct actaaactgc cccctctacc ctgcaggtca
     3481 caggaggaat ggggggaaga cagggtgggt cctgggccct agttgtattt atttggtatt
     3541 tattcatttt tatttagcac caggaaaggg gactagggtc ttggggaaac tcacccatta
     3601 tagccctaac ctagctatga aatccagggt gttggtgaca aatatgagtg gtgtgtgtgt
     3661 gtgtgtgtgt gtgtgtgtgt gtgtttatgt atgaggtaca acctgccctg ctttcctctc
     3721 cctaattttt ttttttttct gggaaaagga aagtcaaagg taggactgcc ttcagggagt
     3781 aagggatgat tgtgttttta aattgaagtt tgctatttat atgctctttt tggagtcaga
     3841 caaatgtggg ttatattctg gccccgcatc tttgagcatt agttttctca tgtgccaata
     3901 ataatccctt agaaattggt tgtaaggatt aaatgatgtt aataaagaac tagcatagag
     3961 cctctcactc agtaggtgct caaggaatgg cagctgctgc tcctgtggtc cttgttctcc
     4021 cagtcaccct ccacagaggc tctgccaggc actcgaagtc cacaaggatt catgtcactt
     4081 gtgcctatct ttagtcccag gctcaggacc ttcggttggc aggaccctgt ttaggatttg
     4141 gagagagttc agactctcag atggccatct tgtctattac ttctgtaggc acgtaagcac
     4201 ctgcagcaga cataataaac acttggcaaa gatagtcaac aagaacatga aggtacaaga
     4261 acagaaccca acaactccct ggacacaaac aggagcttag ttgtaagaat ggcggaaggg
     4321 gcagagaagg gatgatgtaa tagcatcctg gcattccagg agctggtgga tctgaacttg
     4381 agttagggtt cagcatctta ttacctgggt gatgttgggc aagtgctgat aagtgacctt
     4441 ggagtacaag tctgtggaat ggggccagta ataactgctc tgacagcatt gctctgtgct
     4501 caaggatttt caaacagtaa aggccgttgt aacaggagag gtgacctttg tggtgacaga
     4561 ctgggacagt gactccagaa tcaatcaaag taagcccaac caacatctag gaatggaatt
     4621 caatgagagg aacaggatgt ggtctggtat tgcctaataa tcaacaaagc aaagcaaagc
     4681 caaaaaaaaa aaaaaaaatc ctacaagagt ggagccatct gtcaatctgt ccagtggtgg
     4741 cggaatgcga ggaccagcac tggctgaaat ggatctccct tccttgaggg gtaacctagt
     4801 cagtcttatg tgcgtcaggg actggcgaaa gtgtcagtgg agaatttcac atgctaagtg
     4861 gcaaatgcag agcttctagg attgtggaag ggactgaatg ctgaggtagg aaggagctgt
     4921 aggttaggaa gaccctgagg tgagggtgga ctgtggagac actaaaggca tcttgctctg
     4981 ccaaaggaga gtaggggtga gagggggaga ggcaggcaca gagggcaagg ctgtttgtgt
     5041 gctgtattca ttgggaccag gcttggctgg tcaagttcta aacgaggcag ggcagagcgt
     5101 tgtagagtgc tctgtgcctt acaccagcaa gcacagtggc tgctctctct gcaggcttga
     5161 gggaagggct ggctacactc ctctctttag cgtgcattgc tctcactccc atgcttgctc
     5221 tctgatgtgg gccttgtggt gcttctacca accaggcagg gggaggcagc aacaggacag
     5281 tggcatcttc agttgcttca tctcagtggt aagattggac caacagtatg tttatggaac
     5341 ttaatactat gaactcacgg tacaagcaga gctttgttga agtgaaggta aaacacaaat
     5401 gatatacggc cgtgtcctta aagagctcac actgcatcct gggggagggg ggaggttgtg
     5461 cagcacatgt ccacaaagag agtcaagggt cagtctgagg agctataaga taaaggcaaa
     5521 atggactttg tgaagcttga gccttgtacc tgagcaccag ggctcaggaa ggaggaacgt
     5581 gatttgggct ttgggaagtg ggtcattatg gtaacgcttc tcacatttct ttgaggttct
     5641 tggcaattta ctttgtaagt cactgtcata tgttatttta aagaaaaacc actttgttca
     5701 ccaggtaggg ttcttactgg cacgaagaaa ttttctcctt gggaggtaga aacagatggg
     5761 tcggaatttc aaggctatcc tccgtggcaa catcatagca taaaggccag tttggttaca
     5821 tggaactttg tctcaaaaga ggagggggct ggagagatgg ctcagaggtt aagagcactg
     5881 accacttttc cagaggtcct gagttcaatt cccagcaacc acatggtggc tcacaaccat
     5941 ctgtaatgag atctgacgcc ctcttctggt gtgtctgaac acagtgacta tgtactcata
     6001 taaataaata aaatctttaa aaaaaaaaag aggaggagga ggaggaggag gaggtagaga
     6061 attttgaagg ctagagagat gctcagccgt taagagtact ggctgctcct ccagagaacc
     6121 tgagtttgag tgccagcacc catacggcag ctcacaacca tttgcaactc cagttccagg
     6181 gaatcaatac tcccttttgt tctctgtggg tacttaggca cgcacgtggt gcatagacat
     6241 acatgcagac agaacactga tatccacaaa gtgtaaataa ataaagaaaa attaaaaaac
     6301 attgagttta a
//
