LOCUS       NP_766433                833 aa            linear   ROD 18-MAR-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 4
            preproprotein [Mus musculus].
ACCESSION   NP_766433
VERSION     NP_766433.2
DBSOURCE    REFSEQ: accession NM_172845.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 833)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (residues 1 to 833)
  AUTHORS   Li,M.D., Lu,J.W., Zhang,F., Lei,W.J., Pan,F., Lin,Y.K., Ling,L.J.,
            Myatt,L., Wang,W.S. and Sun,K.
  TITLE     ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in
            the amnion at parturition
  JOURNAL   Commun Biol 7 (1), 301 (2024)
   PUBMED   38461223
  REMARK    GeneRIF: ADAMTS4 is a crucial proteolytic enzyme for versican
            cleavage in the amnion at parturition.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 833)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 833)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 833)
  AUTHORS   Zhu,L., Duan,W., Yang,B. and Wang,L.
  TITLE     Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse
            hepatic I/R injury in an age-independent manner
  JOURNAL   Int J Med Sci 20 (12), 1562-1569 (2023)
   PUBMED   37859693
  REMARK    GeneRIF: Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in
            mouse hepatic I/R injury in an age-independent manner.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 833)
  AUTHORS   Somerville,R.P., Longpre,J.M., Apel,E.D., Lewis,R.M., Wang,L.W.,
            Sanes,J.R., Leduc,R. and Apte,S.S.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
REFERENCE   7  (residues 1 to 833)
  AUTHORS   Glasson,S.S., Askew,R., Sheppard,B., Carito,B.A., Blanchet,T.,
            Ma,H.L., Flannery,C.R., Kanki,K., Wang,E., Peluso,D., Yang,Z.,
            Majumdar,M.K. and Morris,E.A.
  TITLE     Characterization of and osteoarthritis susceptibility in
            ADAMTS-4-knockout mice
  JOURNAL   Arthritis Rheum 50 (8), 2547-2558 (2004)
   PUBMED   15334469
REFERENCE   8  (residues 1 to 833)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (residues 1 to 833)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
REFERENCE   10 (residues 1 to 833)
  AUTHORS   Tortorella,M.D., Burn,T.C., Pratta,M.A., Abbaszade,I., Hollis,J.M.,
            Liu,R., Rosenfeld,S.A., Copeland,R.A., Decicco,C.P., Wynn,R.,
            Rockwell,A., Yang,F., Duke,J.L., Solomon,K., George,H.,
            Bruckner,R., Nagase,H., Itoh,Y., Ellis,D.M., Ross,H., Wiswall,B.H.,
            Murphy,K., Hillman,M.C. Jr., Hollis,G.F., Newton,R.C.,
            Magolda,R.L., Trzaskos,J.M. and Arner,E.C.
  TITLE     Purification and cloning of aggrecanase-1: a member of the ADAMTS
            family of proteins
  JOURNAL   Science 284 (5420), 1664-1666 (1999)
   PUBMED   10356395
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084821.26, AK083534.1 and
            AC087229.27.
            
            On Jul 13, 2016 this sequence version replaced NP_766433.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active zinc-dependent aggrecanase enzyme that degrades cartilage.
            [provided by RefSeq, Jul 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028364.1, AK157287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.28 cM"
     Protein         1..833
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 4 preproprotein"
                     /EC_number="3.4.24.82"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 4; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 4; aggrecanase-1; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 4"
                     /calculated_mol_wt=84356
     sig_peptide     1..49
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=5732
     Region          55..177
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Site            63
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BNJ2.2)"
     Region          180..204
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BNJ2.2)"
     Region          188..195
                     /region_name="Cysteine switch. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BNJ2.2)"
     mat_peptide     209..833
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 4. /id=PRO_0000029167"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BNJ2.2)"
                     /calculated_mol_wt=67714
     Region          214..421
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            299
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BNJ2.2)"
     Site            order(357..358,361,367)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          435..503
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          527..571
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          574..681
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          682..833
                     /region_name="Spacer"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BNJ2.2)"
     Region          683..798
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     CDS             1..833
                     /gene="Adamts4"
                     /gene_synonym="ADAM-TS4; ADAMTS-2; ADMP-1"
                     /coded_by="NM_172845.3:721..3222"
                     /db_xref="CCDS:CCDS15485.2"
                     /db_xref="GeneID:240913"
                     /db_xref="MGI:MGI:1339949"
ORIGIN      
        1 msqmglhprr gltghwlqrf qpclplhtvq wrrllllafl lslawpaspl preeeivfpe
       61 klngssilpg sgvparllyr lpafgemlll eleqdpgvqv egltvqylgq apemlggaep
      121 gtyltgting dpesvaslhw dggallgvlq yrgaelhlqp leggalnsag gpgahilrrk
      181 spassqgpmc tvkapsgsps pisrrtkrfa slsrfvetlv vaddkmaafh gtglkryllt
      241 vmaaaakafk hpsirnpvnl vvtrlvilgs gqegpqvgps aaqtlrsfct wqrglntpnd
      301 sdpdhfdtai lftrqdlcgv stcdtlgmad vgtvcdpars caiveddglq saftaahelg
      361 hvfnmlhdns kpctnlngqg gssrhvmapv mahvdpeepw spcsarfitd fldngyghcl
      421 ldkpeaplhl patfpgkdyd adrqcqltfg pdsshcpqlp ppcaalwcsg hlnghamcqt
      481 khspwadgtp cgssqacmgg rclhvdqlkd fnvpqaggwg pwgpwgdcsr tcgggvqfss
      541 rdctrpvprn ggkycegrrt rfrscntenc phgsaltfre eqcaaynhrt dlfksfpgpm
      601 dwvprytgva prdqckltcq aralgyyyvl eprvadgtpc spdtssvcvq grcihagcdr
      661 iigskkkfdk cmvcggdgsr cskqsgsfkk frygysdvvt ipagathilv rqqggsglks
      721 iylalklsdg syalngeytl mpsptdvvlp gavslrysga taasetlsgh gplaqpltlq
      781 vlvagnpqna rlrysffvpr pvpstprppp qdwlqrraei lkilrkrpwa grk
//
