LOCUS       NM_001081401            7579 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            3 (Adamts3), transcript variant 2, mRNA.
ACCESSION   NM_001081401 XM_978433
VERSION     NM_001081401.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7579)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 7579)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   3  (bases 1 to 7579)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 7579)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7579)
  AUTHORS   Neupane,S., Goto,J., Berardinelli,S.J., Ito,A., Haltiwanger,R.S.
            and Holdener,B.C.
  TITLE     Hydrocephalus in mouse B3glct mutants is likely caused by defects
            in multiple B3GLCT substrates in ependymal cells and subcommissural
            organ
  JOURNAL   Glycobiology 31 (8), 988-1004 (2021)
   PUBMED   33909046
REFERENCE   6  (bases 1 to 7579)
  AUTHORS   Bui,H.M., Enis,D., Robciuc,M.R., Nurmi,H.J., Cohen,J., Chen,M.,
            Yang,Y., Dhillon,V., Johnson,K., Zhang,H., Kirkpatrick,R.,
            Traxler,E., Anisimov,A., Alitalo,K. and Kahn,M.L.
  TITLE     Proteolytic activation defines distinct lymphangiogenic mechanisms
            for VEGFC and VEGFD
  JOURNAL   J Clin Invest 126 (6), 2167-2180 (2016)
   PUBMED   27159393
REFERENCE   7  (bases 1 to 7579)
  AUTHORS   Janssen,L., Dupont,L., Bekhouche,M., Noel,A., Leduc,C., Voz,M.,
            Peers,B., Cataldo,D., Apte,S.S., Dubail,J. and Colige,A.
  TITLE     ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and
            regulates placental angiogenesis
  JOURNAL   Angiogenesis 19 (1), 53-65 (2016)
   PUBMED   26446156
  REMARK    GeneRIF: an ADAMTS3 knockout mouse (Adamts3(-/-)) model was created
            to determine in vivo the actual functions of ADAMTS3.
REFERENCE   8  (bases 1 to 7579)
  AUTHORS   van Berlo,J.H., Elrod,J.W., van den Hoogenhof,M.M., York,A.J.,
            Aronow,B.J., Duncan,S.A. and Molkentin,J.D.
  TITLE     The transcription factor GATA-6 regulates pathological cardiac
            hypertrophy
  JOURNAL   Circ Res 107 (8), 1032-1040 (2010)
   PUBMED   20705924
REFERENCE   9  (bases 1 to 7579)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   10 (bases 1 to 7579)
  AUTHORS   Le Goff,C., Somerville,R.P., Kesteloot,F., Powell,K., Birk,D.E.,
            Colige,A.C. and Apte,S.S.
  TITLE     Regulation of procollagen amino-propeptide processing during mouse
            embryogenesis by specialization of homologous ADAMTS proteases:
            insights on collagen biosynthesis and dermatosparaxis
  JOURNAL   Development 133 (8), 1587-1596 (2006)
   PUBMED   16556917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102039.8, AC102056.17 and AC156611.10.
            
            On Apr 8, 2010 this sequence version replaced NM_001081401.1.
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            exon in the coding region compared to variant 1. The resulting
            protein (isoform 2) is shorter but has the same N- and C-termini
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158105.1, SRR9219380.63352.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC102039.8         64563-65075
            514-541             AC102039.8         66335-66362
            542-948             AC102039.8         86192-86598
            949-1105            AC102056.17        119452-119608       c
            1106-1305           AC156611.10        183350-183549       c
            1306-1389           AC156611.10        172353-172436       c
            1390-1546           AC156611.10        170307-170463       c
            1547-1652           AC156611.10        169498-169603       c
            1653-1796           AC156611.10        169001-169144       c
            1797-1929           AC156611.10        168346-168478       c
            1930-2043           AC156611.10        166887-167000       c
            2044-2189           AC156611.10        164630-164775       c
            2190-2365           AC156611.10        163335-163510       c
            2366-2499           AC156611.10        162103-162236       c
            2500-2623           AC156611.10        159900-160023       c
            2624-2704           AC156611.10        156446-156526       c
            2705-2868           AC156611.10        154735-154898       c
            2869-3034           AC156611.10        152996-153161       c
            3035-3167           AC156611.10        148472-148604       c
            3168-3375           AC156611.10        146008-146215       c
            3376-3493           AC156611.10        144838-144955       c
            3494-7579           AC156611.10        135537-139622       c
FEATURES             Location/Qualifiers
     source          1..7579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.32 cM"
     gene            1..7579
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 3"
                     /db_xref="GeneID:330119"
                     /db_xref="MGI:MGI:3045353"
     exon            1..513
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..4056
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 3"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 3 isoform 2 precursor"
                     /protein_id="NP_001074870.1"
                     /db_xref="CCDS:CCDS39140.1"
                     /db_xref="GeneID:330119"
                     /db_xref="MGI:MGI:3045353"
                     /translation="MVFLSLWLIAASLVEVRTSADGQAGTDEMVQIDLPTKRYREYEL
                     VTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEHLFFNVTAFGRDFHLRLKPNTHFI
                     APGAVVEWHETAPRPGNTTDPRNSHLHGSASEGSWRSEPLQTSCAYVGDIMDIPGTSV
                     AISNCDGLAGMIKSDDEEYFIEPLERGKQMDEENGRIHVVYKRSAVEQPPRDVSEDVY
                     HRESDLEGLDDLGTVYSNIGQQLNKTMRRRRHTGENDYNIEVLLGVDDSVVRFHGKEH
                     VQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCR
                     WACQQQKTDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSS
                     AFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYI
                     HSYDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCS
                     HPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRT
                     CGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHF
                     DYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRG
                     ECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARH
                     VLIQEDEASPHVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHTD
                     GPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQ
                     CSEPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQECTHPVWAADEW
                     EHCSRSCGSSGNQLRTVRCLQPLQDGTNRSVHSKYCLGDRPESRRPCNRVPCPAQWKT
                     GSWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRPCQLPPCNDEPCLGDKSIFCQM
                     EVLARYCSIPGYNKLCCESCSKRSGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTP
                     FLPSSSGTRAEKKSLSSFSSMANPNADAAFRASSRASADFPRKRAHQAGRKTLESVPS
                     SSSIKTDHLRPASPVAAAPSPAISDSIGASPQTRTPKKDDAKSVSRRHPTRSTASER"
     exon            514..541
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            542..948
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1105
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1305
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1389
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1546
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1652
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1796
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1929
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2043
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2189
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2365
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2499
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2623
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2704
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2868
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3034
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3167
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3375
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3493
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3494..7579
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6539..6544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6560
                     /gene="Adamts3"
                     /gene_synonym="1100001H14Rik; 6330442E02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctttctcccg ctcgctgggc tccggctccc acttctcccc gccgctgcgc tcccgggacc
       61 cgagccgtct ccgtgcttag cctaggcggc ccacggtgct ccgagagcct cgcaaaagca
      121 gctccggggt agagagtggg acgccccggt cccttccccc gctcgggtca gcctctgccc
      181 ggctcgcagc acctctggct ccctcactgt cggcttggga ggacagggtg agaaggtgaa
      241 gtggaaagga ccgacagggc acggggccag gcgcacagct cacgttgcct tttcattgag
      301 caaagcccaa gataattttt taaaagctct gcacgccccc cactccttcc attttctttg
      361 cgcttttaaa ggaaacttat tttggggtgc tttgcgctgg ggtagctgct ttgcccagta
      421 gttgcgaagt acactcgact cgtgatggtg ttcctgtcac tttggttgat agcagcctct
      481 ctggtagagg ttaggacatc agctgatgga caagctggta ctgacgaaat ggtgcaaata
      541 gatttaccaa caaagagata cagagagtat gagctggtga caccagttag cacgaatcta
      601 aaaggacatt atctttccca tattctttct gcaaatcaca aaaagaggtc acccagggac
      661 gtgtcatcta actcagagca tttgttcttc aacgtcacgg catttggaag agattttcat
      721 cttcgactga agccaaacac tcacttcata gctcctgggg ctgtggtgga atggcatgag
      781 acagctccaa ggcctgggaa taccactgac cccagaaaca gccatctaca cggaagtgct
      841 tcagaaggaa gctggagatc agagcctttg cagaccagct gtgcctatgt tggtgacatc
      901 atggacattc caggaacctc tgttgccatt agcaactgtg atggtctggc tgggatgata
      961 aagagcgatg atgaagagta tttcattgaa cccttggaga gagggaagca gatggatgaa
     1021 gaaaatggaa ggattcacgt tgtctacaag agatcagcag tggagcagcc tcccagagat
     1081 gtatctgaag acgtctacca cagggagtcg gacctggaag gccttgacga tctaggtaca
     1141 gtttacagca acattggcca gcagctgaac aagacaatgc ggcgccgcag acacacggga
     1201 gagaacgatt acaacatcga ggtgcttctg ggagtggatg actctgtggt ccgtttccat
     1261 ggcaaagagc atgtccaaaa ttacctcctc accctgatga acattgtaaa tgaaatctac
     1321 cacgatgagt ccctcggagt gcatataaat gtggtcctgg tacgaatgat tatgcttggt
     1381 tatgcaaagt ccatcagtct catcgaaagg ggaaacccgt ccaggagcct ggagaacgtg
     1441 tgccgatggg cttgccagca acagaaaact gatcccaacc acgccgaaca ccatgatcac
     1501 gcaattttct taaccaggca agactttggg cctgctggaa tgcaaggata tgctcctgtc
     1561 actggcatgt gtcacccagt gagaagttgc accctgaatc atgaagatgg tttttcatct
     1621 gcttttgtag tagcccatga aactggccat gtgttgggca tggagcatga cgggcaaggc
     1681 aatcggtgtg gcgatgagac tgccatgggc agtgtcatgg cgccactagt gcaagctgcc
     1741 ttccatcgtt atcactggtc cagatgcagc ggtcaggaac tgaaacgata catccattcc
     1801 tatgactgcc tccttgatga cccctttgaa cacgactggc ccaaactccc agaacttccc
     1861 ggaattaatt actccatgga tgagcaatgc cgttttgact ttggcgttgg ctacaagatg
     1921 tgtactgcgt tccgaacctt tgacccatgt aaacagctat ggtgcagcca ccctgataac
     1981 ccatacttct gtaagaccaa gaaggggccc ccactcgacg ggactgagtg tgctgctggc
     2041 aagtggtgct ataaaggaca ctgcatgtgg aagaatgcta accagcaaaa gcaagatggc
     2101 aactgggggt cgtggaccaa atttggctcc tgttctagga catgtggaac cggtgttcgt
     2161 tttagaacac gccaatgcaa taatcccacg cccatcaatg gtgggcagga ctgccctggt
     2221 gttaattttg agtaccagct ttgtaataca gaagaatgcc aaaagcactt tgaggacttc
     2281 agggcccagc agtgccaaca gcgtaactca cactttgact accagaatac caaacaccac
     2341 tggctgccgc atgaacatcc cgactccaag aaaagatgcc atctttactg tcagtccaaa
     2401 gagactgggg atgttgctta catgaaacaa ctggtgcacg acggaacgcg atgctcttac
     2461 aaagatccat acagcatatg tgtgcgagga gaatgtgtga aagtgggctg tgatagagaa
     2521 atcggctcca acaaggttga ggataagtgt ggggtctgtg gaggggacaa ttcccactgt
     2581 cgaactgtga aagggacatt taccaggaca cccaggaaac ttgggtacct taagatgttt
     2641 gatatacccc ctggggctag acatgtgtta atccaagaag acgaggcttc tcctcatgtt
     2701 cttgccatta agaatcaagc cacaggtcac tacattttaa atggcaaagg ggaggaagcc
     2761 aagtcacgga ccttcataga tcttggtgtg gagtgggatt acaacattga agatgacatt
     2821 gaaaccctcc acacagatgg cccgctacat gaccccgtta ttgttctgat catacctcag
     2881 gagaacgaca cgcgctccag cctgacgtat aagtacatca tccacgaaga ctcggtgcca
     2941 acgatcaaca gcaacaacgt catccaggag gagctggata ccttcgagtg ggcgctgaag
     3001 agctggtctc agtgctccga gccctgtggc ggaggattcc agtatacgaa atatggatgc
     3061 cgaaggaaaa gcgacagtaa aatggttcac cgcagtttct gcgaggtcaa taaaaagcca
     3121 aaacccatca gacgcatgtg caacattcag gagtgcacac acccggtctg ggcagcggat
     3181 gaatgggagc actgtagcag aagctgtggc agctccggga accagctgcg caccgtgcgc
     3241 tgcctccagc cactgcagga tggcaccaac cgctcggtgc acagcaagta ctgcctggga
     3301 gaccgtcctg agagccgccg gccctgtaac agagtgccct gtccagctca gtggaaaaca
     3361 ggatcctgga atgagtgttc agtgacctgc ggtgagggaa cagaggtgag acaggttctg
     3421 tgcaggactg gagaccactg tgatggagaa aagcccgagt ctgtcagacc ctgccagctg
     3481 cctccctgta atgatgagcc atgtttgggt gacaagtcca tattctgtca aatggaggtg
     3541 ctagcaagat actgctccat accagggtat aacaagttat gctgcgaatc atgtagcaag
     3601 cgcagtggta ccctgcctcc gccatacctt caagaagctg ctgaaatcca cagtgatgct
     3661 atctttggcc ctagtgacct ccctaggtcc ctagtcatgc ctacaccctt cctcccttcc
     3721 tcctcaggga cccgtgctga gaagaaatcc ttgagtagct tctcttccat ggcaaacccc
     3781 aatgcggatg ctgccttcag agccagcagc agagctagtg ctgacttccc ccggaagaga
     3841 gcacatcagg ctggaagaaa gactctggag tcagtgccat cctcctcatc cataaagact
     3901 gatcaccttc gtcccgcctc ccctgtggct gctgccccct cccctgctat cagcgattca
     3961 ataggtgctt ctccccagac aagaacccca aagaaagatg atgcaaagag tgttagcagg
     4021 agacatccga ccaggtcaac agcctcagag agatgagaaa gcagactagt ggagctagag
     4081 gtcaaaggga aacctggacc gcctccctcc ctgcatggtg catacagctt gttaaaaagt
     4141 ggtactctcc acaaaaggtt tactcgcgtc ctctgtccat ggaaggaccg gaagtgctgg
     4201 ttcacttttt agttgcttcc atcttcctcc tgttccacat cgacttgttt accagaatcc
     4261 attagaagaa agcgccaaag actgtttttc agaaggaaag agcccagctg cagtggcccc
     4321 tgccttagaa tgtcctcagt tgggaaacta aggcaagatg gtggccactc gcccgcccgt
     4381 tcagggacag ccaggaacaa ctctccccag aacaaaagaa aaaatggaaa gggttgctct
     4441 ctaaggaaga aaagagccta gagccgattg tgcatatcag ctgttctgtt catttgttgg
     4501 tttttttttt ttttttttaa gttacagtta agaataaccc aaacaaatgc cagtggttta
     4561 cgcttcaaga aattttggaa ataattctta gacttgtatt cctatttatc tatattagaa
     4621 atactgtatg agcaaatttg caactgtcgt gtaaattctg tacattgcag aaatcagtat
     4681 tattttaaaa gatgttctca aatgattgtt tactatctta catttctgga tgttctaggg
     4741 tgcctgccat tgagcattgc cttatgtggc gttccatgag ttgattttga agccgactag
     4801 gatgaagaag ttgggattac atctactgat aatatacaga gggcttgcca tttgtcatct
     4861 gttgacactg ccgatgtgca ggtgactcat ttaatccact gccttccttt cttgcaacaa
     4921 agggaacggg aacagcctct caatgtgttt gtgcacacag gctgcagtga ctaagcttgc
     4981 acaagacaaa gcccaacctt cttgccatca catcaaaggg catcgtggcg atgcgcaaca
     5041 tctcagtgat gcccagttcg tgtgctatca gctgtacttg atattctgtg atcaccacag
     5101 atgggttgtg tgtgttcttt catagctgag aagaatatca tcagtctagg actgacactt
     5161 gagtacgtga gtgctttgag agcaagttca aggaagagtc ttcgtcgcgg ttgagatatt
     5221 tattttctgc atggttcata tctaaatgtt cccagtcaca atgcatcgga ctgcagtgcc
     5281 aggctggtag ttctgttagt gaccaacatg ttcacatgaa gccagaaatg ctccctccag
     5341 gggctggatg tatagtactt gtatatagga cacagatctg aagatattta ttttaagagt
     5401 tgattttttt ttcttgatag tctttttatg tctttaatat tgacactaat atcaatgaca
     5461 ttttagtaaa ctagagagac ataattagag gtgtgtgcta tgttctgtga agaaaggaca
     5521 agtttaaacc aagcacacag ccaactcaaa gaactaaaat tgaacagatt cttaccgtta
     5581 aaaaaggaca aatttggcag aacttgattg gatccaggac ctcccacatg ttaagccagc
     5641 actccattgc tgagccgaat cttttatatt ttaatacagg atctccctaa gttacctagg
     5701 caggccttga acttgtgatc cacttgccac aacctcccaa gaggctgaga ttacaggcaa
     5761 agcttgtgtt aaatatttac attctttaag tagtcgatac agagttaatg acttgatccc
     5821 cttcaagggt gcataaaata gtcaggaatt cagctagctg tttaataaat aatgcattag
     5881 gaacatttct aaagcccggt gaagtggtgc atacctgtca tcccagcaat tcagaagctg
     5941 aggcaggagg attactatga gtgtacagcc agcctgggcc atgtaacaag actctgcttc
     6001 aaacaaaacc tattttaagt atgtaatgag taattcctat gttacacttt aaagacaaaa
     6061 gtgttgtgag catgcttcgg aagtcatttt ctaaacatgt ctagaaagcc attacgcaga
     6121 ctaaagtaga gatgcatcat cctttcaaag cacagactgg gaaggccttt gtgttataac
     6181 catcataagt caacagccta agctatgact caatacctcg aaacaattgc tgctacttca
     6241 tgcaaggatt ttaaatgtcg agttaggtga tttcctgata gttcaatcat ccctgagcct
     6301 taaaatgttc tctctcttga aagcttcatc agaatgaaat tctctctagt ttgcttgggt
     6361 gtacacatat ctggtccaca gggaacctga agatggtcac acacatacac ctcccataag
     6421 atgtaaatat tccttccact ttctacctat gcgctttttt tttctactaa gctgaaaaag
     6481 ttccttttta tcaaggtgta cactactgat gctgttggtt gtattgggaa cacatagcaa
     6541 taaaaaaacg tgaaagagga gactcggcct gatcttgact ttcttgctgg tttccttatg
     6601 cctgtgggga tgcatccttt cctccaatca agtgaaacaa taacctttca ctggagatgc
     6661 tagagagagt ctccacactt ttaaagatgc taagaagcca tgggaggtgg attgtgcgga
     6721 agtctttccc ttagaactag gcaagagaag aacaataagg ctgatgatag aatgaagaaa
     6781 agagagcttc ctcctctgcc ccaccccact gtgaaatctc agagtggctg agatgcctaa
     6841 caacttagta ccatgaatac ctgagagctg ggggcggggg atgggggtgg ggagggcgat
     6901 tttccatcgg actcaggaca gcaaggagga gcagaacacc acagtgagtg gatagccttt
     6961 tattatctaa agagagggct ggggtgcaga tgccagtttg aagggcaaaa caggcagaat
     7021 cgagtttaac ctccacctgc cacctcatac ccatgccacc tcaggtgact tctctgatgt
     7081 tcagtttctt cagcaatgac agggacagca gagctctgac agtccagtga aaatgaagta
     7141 acacaagtac tgagcacagc gcctcccagt ggacatcgaa ccactatcta tatcatcccc
     7201 cccccaactt cactgtacag ttgaaccata gctgacctct ggtgtctggc tacttcagaa
     7261 tcagaactgc ttgcccacgt gggtaaacag gatggtttgg gaaatctcaa gaacagcgac
     7321 tttataagtt gatacaagga actcaatata aatgctctcc agtcactgtt gaggattttg
     7381 agcttcttct atccatctgc ctcttccaga caatgatcaa actaagtggc cagcaagcac
     7441 tattcccgag aacttggctg atggtgtctc aatacggttg gcagcatggg ttcccataca
     7501 tttatctcat ccacataatt tgcagtcagc agcaaaacca ttcttctaga cacactttgt
     7561 agtttcttta tgaagaagc
//
