LOCUS       NM_177431               7964 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus a disintegrin-like and metallopeptidase (reprolysin
            type) with thrombospondin type 1 motif, 20 (Adamts20), transcript
            variant 1, mRNA.
ACCESSION   NM_177431 XM_894046
VERSION     NM_177431.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7964)
  AUTHORS   Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M,
            Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I and
            Fujiwara H.
  TITLE     Tracing the origin of hair follicle stem cells
  JOURNAL   Nature 594 (7864), 547-552 (2021)
   PUBMED   34108685
REFERENCE   2  (bases 1 to 7964)
  AUTHORS   Holdener BC, Percival CJ, Grady RC, Cameron DC, Berardinelli SJ,
            Zhang A, Neupane S, Takeuchi M, Jimenez-Vega JC, Uddin SMZ, Komatsu
            DE, Honkanen R, Dubail J, Apte SS, Sato T, Narimatsu H, McClain SA
            and Haltiwanger RS.
  TITLE     ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT
            in mouse model of Peters plus syndrome
  JOURNAL   Hum Mol Genet 28 (24), 4053-4066 (2019)
   PUBMED   31600785
  REMARK    GeneRIF: Results provide compelling evidence that ADAMTS9 and
            ADAMTS20 were differentially sensitive to B3GLCT inactivation and
            suggest that the developmental defects in PTRPLS result from
            disruption of a subset of highly sensitive POFUT2/B3GLCT targets
            such as ADAMTS20.
            Erratum:[Hum Mol Genet. 2020 Oct 10;29(17):2986-2987. PMID:
            32533185]
REFERENCE   3  (bases 1 to 7964)
  AUTHORS   Nandadasa S, Kraft CM, Wang LW, O'Donnell A, Patel R, Gee HY, Grobe
            K, Cox TC, Hildebrandt F and Apte SS.
  TITLE     Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical
            role in ciliary vesicle growth during ciliogenesis
  JOURNAL   Nat Commun 10 (1), 953 (2019)
   PUBMED   30814516
  REMARK    GeneRIF: ADAMTS9 or ADAMTS20 mutagenesis impaired neural and yolk
            sac ciliogenesis, leading to morphogenetic anomalies resulting from
            impaired hedgehog signaling, which is transduced by primary cilia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7964)
  AUTHORS   Silver DL, Hou L, Somerville R, Young ME, Apte SS and Pavan WJ.
  TITLE     The secreted metalloprotease ADAMTS20 is required for melanoblast
            survival
  JOURNAL   PLoS Genet 4 (2), e1000003 (2008)
   PUBMED   18454205
  REMARK    GeneRIF: Adamts20 mutations in belted (bt) mice cause white
            spotting of the dorsal and ventral torso, indicative of defective
            neural crest (NC)-derived melanoblast development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7964)
  AUTHORS   Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA,
            Apte SS, Pavan WJ and Beier DR.
  TITLE     A defect in a novel ADAMTS family member is the cause of the belted
            white-spotting mutation
  JOURNAL   Development 130 (19), 4665-4672 (2003)
   PUBMED   12925592
  REMARK    GeneRIF: Results suggest that the role of ADAMTS proteases,
            including ADAMTS20, in the regulation of cell migration has been
            conserved in mammalian development.
REFERENCE   6  (bases 1 to 7964)
  AUTHORS   Llamazares M, Cal S, Quesada V and Lopez-Otin C.
  TITLE     Identification and characterization of ADAMTS-20 defines a novel
            subfamily of metalloproteinases-disintegrins with multiple
            thrombospondin-1 repeats and a unique GON domain
  JOURNAL   J Biol Chem 278 (15), 13382-13389 (2003)
   PUBMED   12562771
  REMARK    GeneRIF: This protein is identified and characterized and its
            relation to other disintegrins and thrombospondin 1 repeats is
            examined.
            Erratum:[J Biol Chem. 2018 Jul 27;293(30):11785. PMID: 30054291]
REFERENCE   7  (bases 1 to 7964)
  AUTHORS   Somerville RP, Longpre JM, Jungers KA, Engle JM, Ross M, Evanko S,
            Wight TN, Leduc R and Apte SS.
  TITLE     Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS
            subfamily related to Caenorhabditis elegans GON-1
  JOURNAL   J Biol Chem 278 (11), 9503-9513 (2003)
   PUBMED   12514189
  REMARK    GeneRIF: ADAMTS-9 and ADAMTS-20 have an identical modular
            structure, are distinct in possessing 15 thrombospondin type I
            repeats and a unique C-terminal domain, and have a similar gene
            structure
REFERENCE   8  (bases 1 to 7964)
  AUTHORS   Sekiguchi M, Shimai K, Guo H and Nowakowski RS.
  TITLE     Cytoarchitectonic abnormalities in hippocampal formation and
            cerebellum of dreher mutant mouse
  JOURNAL   Brain Res Dev Brain Res 67 (1), 105-112 (1992)
   PUBMED   1638738
REFERENCE   9  (bases 1 to 7964)
  AUTHORS   Beier DR, Morton CC, Leder A, Wallace R and Leder P.
  TITLE     Perinatal lethality (ple): a mutation caused by integration of a
            transgene into distal mouse chromosome 15
  JOURNAL   Genomics 4 (4), 498-504 (1989)
   PUBMED   2744761
REFERENCE   10 (bases 1 to 7964)
  AUTHORS   MAYER,T.C. and MALTBY,E.L.
  TITLE     AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL
            SPOTTING AND BELTED MOUSE EMBRYOS
  JOURNAL   Dev Biol 9, 269-286 (1964)
   PUBMED   14138974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084382.2, AK090358.1,
            AC084384.1 and AK142029.1.
            
            [WARNING] On May 16, 2023 this sequence was replaced by
            NM_177431.6.
            
            On Jul 27, 2016 this sequence version replaced NM_177431.4.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active protease. Certain mutations in this gene cause defective
            development of neural crest-derived melanoblasts resulting in a
            'belted' phenotype that is characterized by white spots in the
            lumbar region. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY189815.1, BC121792.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               AC084382.2         136167-136518
            353-714             AC084382.2         136967-137328
            715-877             AC084382.2         145743-145905
            878-1116            AC084382.2         160554-160792
            1117-1761           AK090358.1         1083-1727
            1762-1866           AC084384.1         26435-26539
            1867-2012           AC084384.1         27826-27971
            2013-2194           AC084384.1         29547-29728
            2195-2331           AC084384.1         29827-29963
            2332-2449           AC084384.1         31585-31702
            2450-2545           AC084384.1         34493-34588
            2546-2712           AC084384.1         36787-36953
            2713-2842           AC084384.1         37103-37232
            2843-2969           AC084384.1         41915-42041
            2970-3083           AC084384.1         44112-44225
            3084-4530           AK142029.1         2-1448
            4531-4698           AC084384.1         83939-84106
            4699-4872           AC084384.1         89157-89330
            4873-5043           AC084384.1         89832-90002
            5044-5244           AC084384.1         91612-91812
            5245-5374           AC084384.1         92565-92694
            5375-5469           AC084384.1         92895-92989
            5470-5561           AC084384.1         93076-93167
            5562-5695           AC084384.1         93621-93754
            5696-5787           AC084384.1         95554-95645
            5788-5892           AC084384.1         102326-102430
            5893-7964           AC084384.1         105251-107322
FEATURES             Location/Qualifiers
     source          1..7964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 48.2 cM"
     gene            1..7964
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /note="a disintegrin-like and metallopeptidase (reprolysin
                     type) with thrombospondin type 1 motif, 20"
                     /db_xref="GeneID:223838"
                     /db_xref="MGI:MGI:2660628"
     exon            1..352
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            353..714
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            715..877
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1116
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1200
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1325
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1366
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1472
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1619
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1761
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1866
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2012
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2194
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2331
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2449
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2545
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2712
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2842
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2969
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3180
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3345
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3510
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3630
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3738
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3903
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4194
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4356
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4530
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            4531..4698
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            4699..4872
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            4873..5043
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            5044..5244
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            5245..5374
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..5469
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..5561
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            5562..5695
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            5696..5787
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            5788..5892
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            5893..7964
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgagcgct tcccagggtg gcgcgggagc gcggggcgcg cgggcctgag agagccaggc
       61 gggcagcgcg cgatgaggca gcggcgccgg gagcggggac tggcggcggg gcgaggcgag
      121 ccggggtgca gtcccgggtg ctcaggaggc tgctgagacg ccgcggagaa ccgctagagc
      181 gcggaggagg gcagcggagc tcggggagcc ggcggccctg gggcggcctc ccagtcggga
      241 tcccctcccc tgtgtgcagc catgcgggtg gccaagtggc tgaccgggtt gctctgcccg
      301 atctcgctcc ttctcactgg gtcctgggaa gttcgtttcc acccacgaca ggaagccctg
      361 gtgaagactc tggcctccta cgaagtggtg acccccacgc gggtcaatga gttcggagac
      421 gtgtttcccc agaaccggca tttcagccgg aagaaacgta gctccggggt gccggagcct
      481 cctccgttca ggacccacta ccgaatcagc gcctacgggc agctcttcca gctgaacctg
      541 agcgctgatg cggccttcct ggctgcaggc tacactgagg tgcacttggg gaccccggta
      601 cctggaccag gcgggcgcag cacggagtcc ccagacctgc gccactgttt ctaccgtggc
      661 caggtcaacg cgcgagagga ccacactgct gtcttcagtc tctgtggagg actgatgggg
      721 acattcaaag caaatgatgg ggagtatttc ttagaaccag tcctgagggc cgatgggagt
      781 gcgcatgacg atgaccacaa caagccacat ctgatctaca gacaggaatt aaagaggaac
      841 tcctttgcgc ggtctcacaa gccttgtgaa gtttcagaaa atcaaatgga gaaaactgct
      901 ttgccctctc agagctccag aaacacgact ggagatgttg atatcgaaga ggaagcggtg
      961 ttcagattgg aaggcgaacg gagccagtta cattccagga ataagcgttt tttatcatac
     1021 ccaagatacg tggaagttat ggttacagcc gatgctaaga tggttcacca tcatgggcag
     1081 aatttgcagc actatgttct gacactgatg tcgattgttg ctgcaatcta caaggattcc
     1141 agcattggga accttatcaa tatagtgatt gtgaaattag ttgtgattca cagtgaacag
     1201 gaaggaccag tgatcagttt taacgcagcc accacgttac gcaacttttg cttatggcaa
     1261 cagagtcaga atgtcccgga tgatgctcac ccctcccacc atgacactgc tgtcctcatc
     1321 actagggaag acatttgcgg agctaaagag aaatgcgaca cgttaggctt agcagagcta
     1381 ggcaccctgt gtgatccttc acggagctgc tccattagcg aagagaacgg gctgagcgcc
     1441 gccttcacca tcgcccatga gcttggacac gtgtttaatg ttccacacga cgacagcttt
     1501 aaatgtaaag aagccggaat taaacatcag tatcacgtca tggccccgac tctaaattac
     1561 cacacgagtc cttggacctg gtcagcatgc agtcagaagc atatcacaga atttctagac
     1621 actggtcatg gagaatgcct tcttgacaaa cccaacggga gaacatatga cctgtctcca
     1681 cagcttccgg gctccgtgta cgatgggaac aggcagtgtg agctcatgtt tggccctgga
     1741 tcacaagtgt gtccctactt gaagcactgc cgacgtctgt ggtgcacgag tgcagaaggc
     1801 gtccacaagg gctgtcgcac acagcacatg ccgctggcag atgggacgag ctgtggtccc
     1861 gggatgcact gccaccgtgg gctgtgtgtg accagggaca tggagacccg tcctgtggat
     1921 ggcgagtggg gaccatgggg accctacagc tcgtgttcaa ggacatgcgg aggtggaatc
     1981 aagagcacag cccggctctg tgaccggccc gagccacgaa acggaggaag gtactgtgtg
     2041 ggccgcagga tgaaatttcg atcatgtaat actgattcat gtccaaaagg caagcgagac
     2101 ttccgagaaa agcaatgctc cgacttcgac ggtaaacatt tcgacatcaa cggcctcccc
     2161 cccaatgtga ggtggcttcc gaagtacagc gggattgccg taaaagatcg ctgtaaactc
     2221 tattgccggg tcgctgggac taccagcttc taccagctga aggacagagt tgctgatggg
     2281 acaccctgtg ggacggaaac taacgacatc tgtgtccagg gcctctgtcg gcaagctggc
     2341 tgtgatcacg tgttaaactc caaggccaag agagacaagt gtggagtgtg tggtggtgac
     2401 aactcttcgt gccagaccct ggcaggtgtc ttcaacagtg cccattacgg ttacaatgtg
     2461 gttgtaaaga tccctgcggg ggctacaaac attgaaatcc ttcagcacag ctattctgga
     2521 agaccagaag atgacaacta tctcgcatta tctgacactc aagggaactt tctcctgaat
     2581 ggaaactttg ttgtaagtat ggcgaagaaa gagatcaaca tccagggtgc tgttttcgaa
     2641 tacagcgggt caaacaactc gattgaaaga attaacagca cggaccggct ggaggcggag
     2701 ctcgttctgc aggtgttgtg tgtgggtaat ttatacaacc ctgacgtgcg ctattccttc
     2761 aacatcccca ttgaggagag gagcaatctg ttctcctggg atccatacgg gccgtggcaa
     2821 gactgtacca aaatgtgcca aggtcttcat agaagaaaaa ttgcctgcgt ccgtaagagc
     2881 gaccatgcag ttgtatctga ccacaattgt ggccacttac cgatgccact gtttgtgact
     2941 gaaaagtgca atatggactg tgaactcagg tggcacatca ttgggaaaag cgactgctca
     3001 tcccagtgtg gccaaggata cagaacccta gacgttcact gcatgaagta ctcggttcat
     3061 aaaggacagg ctgtcccagt aggagatcag tactgtggtg accagctcaa gcctcccagc
     3121 cgagagccat gccatggcag ctgtgttttg acaaggtggc attattcaga gtggtcccag
     3181 tgttctagga gttgtggcgg cggtgacaag actcgggaat cctactgcgt aaatggcttt
     3241 ggccaccgcc ttgctgaaag cgagtgtcgg gagcttccgc gggtggtgct ggagaactgc
     3301 aatgaatttc cgtgtcccag ctgggcaacg agtgagtgga gtgagtgtcc tgtcacatgt
     3361 ggaaaaggaa tgaagcagcg acaggtttgg tgtcagctga gtgaagaccc catgagggat
     3421 ggtttctgta atgccagtac caagcccgag tcgctgagac cctgtgagct ccgtgcgtgc
     3481 gcttcttggc atgtaggacc gtgggggtct tgcacggcca cctgtggaca tggatatcag
     3541 atgcgtgctg ttaagtgtat cagtgagata tttggcacca tgctagatga cagagagtgc
     3601 ccgcaagcca gccggccaag tgacagacag gactgtatat tggcaccttg cctggctatt
     3661 ccagaagtgg gggccacctc cttaccagcc attcccctgg gaagggcagc acagtggcgc
     3721 catggatcgt ggaccccatg ctctgtgtcc tgtggaagag gcagtcaggc ccgttatgtg
     3781 agctgccggg atgctcatga tgaagtggca gatgagtcga attgtgccca cttgcctcga
     3841 cctgctgcgg tgtctctctg cttcagccct tgtggagagt ggcaagcagg ggactggtca
     3901 ccatgttcag cctcctgtgg acatgggaaa accacccgac gtgttttatg cgtgaactac
     3961 caccaactgg tcgatgagag ttactgtgac ccggaaggcc gtcctgtgac tgaacaagaa
     4021 tgtagcctgg cagcctgccc acccttatac agccgagctc ccagctcctc tgagcagcca
     4081 agccacgttc ccagcagaaa tgttccatta actcacaaac caggagagaa tcaagatcag
     4141 ggggcccagc tgtcaatcag aggaaaccag tggagaacag gcccttgggg agcatgctcc
     4201 agaagctgcg ccggtggtct tcagcacagg gctgtggtct gccaggatga agacgggcga
     4261 agcgctactt cctgtgatgg gtcctccaag cccccagagt caaggcactg tggctccgga
     4321 ccttgtccgc actggaatta tggggactgg ggagaatgca cacaaacctg tggtggaggg
     4381 gtaaaatcaa gatttgtgat ctgtcagttt cccaatggcc aaatgacaca ggaacacagc
     4441 tgtgaactgc ccaagccacc tagcatgatg cagtgtcacc tgcacgcctg ccctgaagat
     4501 gtgtcctggt atcggggacc atggaagtcg tgctcagctt cctgtggtaa aggtgtaaag
     4561 taccgggagg ttctttgtat tgatcaattc caaaggaaat tagaagaaaa atattgcagt
     4621 catttgcata aacctcgaac tcacaaagct tgcagatcgg gacgatgccc ttcatggaag
     4681 gccaataaat ggaaggagtg ctctgtgacc tgtgggtcag gggtgcagca gagggaggtg
     4741 tactgcaggc tgagaggcac tggtcgagtg tctgaagaca tgtgtgatcc atccacccgg
     4801 cctcaggggc agcggcagtg ctggcgtcag gactgcatga ggtaccagtg gacgacagga
     4861 gactggctag attgttcaac atcgtgtaag aaaaaagaga cctatcggct ggtgaaatgt
     4921 gtgaatgagc aaaacgtaca agccaatgaa agtctctgtg accctttaac gaagccgctt
     4981 tcaatcaaaa aatgcaggaa ccctcactgc aagtactcgg tggttacagg agactcgtcg
     5041 cagtgtgcag gtaactgtgg gttcacttcc ccacagaaga ttacatactg cactaagatc
     5101 cagtcctcta agaagcatac gttccatcag cttcggcctg tcgtctatgg ggaatgtccg
     5161 gtgataccgt ctcctcaggc gtacaaatgc gaccttagaa gctgtctgca tgtagccact
     5221 tggaaagtgg gaaaatggag caagtgctca gtaacttgtg gaattgggat aatggagaga
     5281 agagtagcat gcaggactga gaacggttgg cccagtgact tatgtttaaa gcgtttaaag
     5341 ccagatgccc aaaagaaatg ttatgccaat gactgtaaat tactaaccac ctgcaaggaa
     5401 ctccaagtta caaacaatgt taccaaggat ggtgactatg accttaacgt caggggaaga
     5461 atattgaaga tccattgctc aggcatgcag ctggagaacc ctagagaata tttaccactg
     5521 gtcaaaagtg aagacaactt ttcagaaata tacggcctta gacttcaaaa tccctatgaa
     5581 tgccccttca acggaagcag gaggccagac tgtgcgtgtg aaaacgacta cctacctgcc
     5641 gggtacactg tttttagcaa agtgagagtg gatctcgaat ccatgcaaat caaaactgca
     5701 gatcttcttt tttcccagac actatctgga aaggcagttc catttgctac agctggggac
     5761 tgctacagcg ctgccagatg cccacagggg cagttcagca tcaacttagc aggaactggg
     5821 atgaagatat ccaacacagc aaagtggctc gctcagggga ggtatgcctc tgtcatcatc
     5881 cacaggtccc aagacggaac caaagtctac ggcagatgcg gagggttctg tggaaagtgc
     5941 attcctcaca tggctacggg gctctcaatt caagtactgt gaacgtccaa ggcttggaag
     6001 gaccgtgaag ggggattgct ctgtgaaaac acaggcgtcg gtgctcctct ctcacccctg
     6061 gcttcccgag acttccatat tcaaaccttt ctttgggtgc tcattggggt ttcagaccac
     6121 ttcatgttta taggttttaa agaggaactt aacggacatc ccactccaat caggctcact
     6181 cttaaacatc ataatttatt atagggaata caagcaaaac gtttgaatgg attataccaa
     6241 gaaaatattg ctggtcaaag cttggactgt taaacagaca tacaaaatac atctccaatc
     6301 agcttcctac gttacagcga agtgttattg tgattgttaa aatggagaaa ataagaatca
     6361 gtgaatatga aattaataat tatatcaaat aagcatattc ttttttctga tatgattttg
     6421 attcattgtc ttattctttt ttctttaatt ttatctatgg attttggtgc ttcaataaaa
     6481 atggttctaa aatataatac gtttttcctt aaaaagttgt gcttatgtta agtattaaat
     6541 agaaaacttt gtggcaaaca gagaagacag atgttgggat ttgagtttta aggcctacct
     6601 ctatttacgt atgagcagta tattgttttt ataatgtttg tgtgccatta tgcctttata
     6661 actcatatat gtaactaccc ttaaaaccta ttttcttaac gtgaaatacc ttttttgcta
     6721 gccagataga aagacggagg ttcttaaaat tctgatgatc caaagttttg attctgtttt
     6781 cctgacccct cccctacttc aaaataattc actagagatt atgtggtggg ggtggggttc
     6841 tctagaacaa aagttctcaa cctgtgagtc tcaacccctt ggggatctaa tgacccttcc
     6901 acaggagtca cctatgacca ttggaaagca cgggtattta cattactatt cataacagta
     6961 gcaaaattaa agttatggat tagcaacaaa ataattttat agttgggggt caatacagca
     7021 taagtggctg tttttaaaga gtcacagtat taggaaggtt gagagccatt gttctaaagg
     7081 aacagggtag ataacactat taaaggggtt tattggattg gattatacag tctaaattct
     7141 ccaataataa ttgtctttac actggagagc tggatgccat agctgtctca atcgggtact
     7201 aaacagcctt agcttgccag agcggagcga tgccagagcg gtgatggcag agccatgatg
     7261 ctggtcttca gtccatgtgg gaaagctgaa aagctgaagt cagagggaaa tgacgacggt
     7321 ctagtcagcg tgcgcaccca caagacagta aaagaagcag gaaaagagca aaggcttgct
     7381 ctcccacagt tagggcgcgt cttcttcaca gtggacctaa cgggacagtc ctgcacaggt
     7441 gcccagacgg cctgcttagt ggacacgttc agatcctgct gcgctgaaga tcagtggtaa
     7501 ccatcacgga gaagctcagc tcctgtctac tggggcgttc tcaaacatga gtgaatttaa
     7561 aaatttgcca ctatagacag attctcagga attaagggat tatttttcat gtgcgtaact
     7621 taattgtgtg ttatacgctg ataggatttt aaaaagcaaa ataataaata ttttcccatg
     7681 ccggcctgcc ctataaacaa aaacatggga tttgctaatt catttcaaca gtaaatatca
     7741 gtgtactagt tttaccttca aggtgttttt ctcccaaata tttgctagag atgtaaaagg
     7801 cgccagagga agtcggtgcg catgcggtca aacacttgca gaactctgaa tcagagggga
     7861 gattatgcaa atcggtcagg cattaagtca gaatgtctaa tgtttcccat taaatgtttc
     7921 atctgttatt aaagccgtgt aatttataaa catctaaata aaaa
//
