LOCUS       NM_001164786            1964 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus a disintegrin-like and metallopeptidase (reprolysin
            type) with thrombospondin type 1 motif, 20 (Adamts20), transcript
            variant 3, mRNA.
ACCESSION   NM_001164786
VERSION     NM_001164786.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M,
            Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I and
            Fujiwara H.
  TITLE     Tracing the origin of hair follicle stem cells
  JOURNAL   Nature 594 (7864), 547-552 (2021)
   PUBMED   34108685
REFERENCE   2  (bases 1 to 1964)
  AUTHORS   Holdener BC, Percival CJ, Grady RC, Cameron DC, Berardinelli SJ,
            Zhang A, Neupane S, Takeuchi M, Jimenez-Vega JC, Uddin SMZ, Komatsu
            DE, Honkanen R, Dubail J, Apte SS, Sato T, Narimatsu H, McClain SA
            and Haltiwanger RS.
  TITLE     ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT
            in mouse model of Peters plus syndrome
  JOURNAL   Hum Mol Genet 28 (24), 4053-4066 (2019)
   PUBMED   31600785
  REMARK    GeneRIF: Results provide compelling evidence that ADAMTS9 and
            ADAMTS20 were differentially sensitive to B3GLCT inactivation and
            suggest that the developmental defects in PTRPLS result from
            disruption of a subset of highly sensitive POFUT2/B3GLCT targets
            such as ADAMTS20.
            Erratum:[Hum Mol Genet. 2020 Oct 10;29(17):2986-2987. PMID:
            32533185]
REFERENCE   3  (bases 1 to 1964)
  AUTHORS   Nandadasa S, Kraft CM, Wang LW, O'Donnell A, Patel R, Gee HY, Grobe
            K, Cox TC, Hildebrandt F and Apte SS.
  TITLE     Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical
            role in ciliary vesicle growth during ciliogenesis
  JOURNAL   Nat Commun 10 (1), 953 (2019)
   PUBMED   30814516
  REMARK    GeneRIF: ADAMTS9 or ADAMTS20 mutagenesis impaired neural and yolk
            sac ciliogenesis, leading to morphogenetic anomalies resulting from
            impaired hedgehog signaling, which is transduced by primary cilia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1964)
  AUTHORS   Silver DL, Hou L, Somerville R, Young ME, Apte SS and Pavan WJ.
  TITLE     The secreted metalloprotease ADAMTS20 is required for melanoblast
            survival
  JOURNAL   PLoS Genet 4 (2), e1000003 (2008)
   PUBMED   18454205
  REMARK    GeneRIF: Adamts20 mutations in belted (bt) mice cause white
            spotting of the dorsal and ventral torso, indicative of defective
            neural crest (NC)-derived melanoblast development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1964)
  AUTHORS   Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA,
            Apte SS, Pavan WJ and Beier DR.
  TITLE     A defect in a novel ADAMTS family member is the cause of the belted
            white-spotting mutation
  JOURNAL   Development 130 (19), 4665-4672 (2003)
   PUBMED   12925592
  REMARK    GeneRIF: Results suggest that the role of ADAMTS proteases,
            including ADAMTS20, in the regulation of cell migration has been
            conserved in mammalian development.
REFERENCE   6  (bases 1 to 1964)
  AUTHORS   Llamazares M, Cal S, Quesada V and Lopez-Otin C.
  TITLE     Identification and characterization of ADAMTS-20 defines a novel
            subfamily of metalloproteinases-disintegrins with multiple
            thrombospondin-1 repeats and a unique GON domain
  JOURNAL   J Biol Chem 278 (15), 13382-13389 (2003)
   PUBMED   12562771
  REMARK    GeneRIF: This protein is identified and characterized and its
            relation to other disintegrins and thrombospondin 1 repeats is
            examined.
            Erratum:[J Biol Chem. 2018 Jul 27;293(30):11785. PMID: 30054291]
REFERENCE   7  (bases 1 to 1964)
  AUTHORS   Somerville RP, Longpre JM, Jungers KA, Engle JM, Ross M, Evanko S,
            Wight TN, Leduc R and Apte SS.
  TITLE     Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS
            subfamily related to Caenorhabditis elegans GON-1
  JOURNAL   J Biol Chem 278 (11), 9503-9513 (2003)
   PUBMED   12514189
  REMARK    GeneRIF: ADAMTS-9 and ADAMTS-20 have an identical modular
            structure, are distinct in possessing 15 thrombospondin type I
            repeats and a unique C-terminal domain, and have a similar gene
            structure
REFERENCE   8  (bases 1 to 1964)
  AUTHORS   Sekiguchi M, Shimai K, Guo H and Nowakowski RS.
  TITLE     Cytoarchitectonic abnormalities in hippocampal formation and
            cerebellum of dreher mutant mouse
  JOURNAL   Brain Res Dev Brain Res 67 (1), 105-112 (1992)
   PUBMED   1638738
REFERENCE   9  (bases 1 to 1964)
  AUTHORS   Beier DR, Morton CC, Leder A, Wallace R and Leder P.
  TITLE     Perinatal lethality (ple): a mutation caused by integration of a
            transgene into distal mouse chromosome 15
  JOURNAL   Genomics 4 (4), 498-504 (1989)
   PUBMED   2744761
REFERENCE   10 (bases 1 to 1964)
  AUTHORS   MAYER,T.C. and MALTBY,E.L.
  TITLE     AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL
            SPOTTING AND BELTED MOUSE EMBRYOS
  JOURNAL   Dev Biol 9, 269-286 (1964)
   PUBMED   14138974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084382.2 and AK090358.1.
            
            [WARNING] On May 16, 2023 this sequence was replaced by
            NM_001164786.2.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active protease. Certain mutations in this gene cause defective
            development of neural crest-derived melanoblasts resulting in a
            'belted' phenotype that is characterized by white spots in the
            lumbar region. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (3) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (3)
            has a distinct C-terminus and is shorter than isoform 1. This
            isoform (3) may undergo proteolytic processing similar to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090358.1, AK145288.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               AC084382.2         136167-136518
            353-714             AC084382.2         136967-137328
            715-877             AC084382.2         145743-145905
            878-1116            AC084382.2         160554-160792
            1117-1964           AK090358.1         1083-1930
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 48.2 cM"
     gene            1..1964
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /note="a disintegrin-like and metallopeptidase (reprolysin
                     type) with thrombospondin type 1 motif, 20"
                     /db_xref="GeneID:223838"
                     /db_xref="MGI:MGI:2660628"
     exon            1..352
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1815
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; a disintegrin and metalloproteinase with
                     thrombospondin motifs 20"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 20 isoform 3 precursor"
                     /protein_id="NP_001158258.1"
                     /db_xref="GeneID:223838"
                     /db_xref="MGI:MGI:2660628"
                     /translation="MRVAKWLTGLLCPISLLLTGSWEVRFHPRQEALVKTLASYEVVT
                     PTRVNEFGDVFPQNRHFSRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAA
                     GYTEVHLGTPVPGPGGRSTESPDLRHCFYRGQVNAREDHTAVFSLCGGLMGTFKANDG
                     EYFLEPVLRADGSAHDDDHNKPHLIYRQELKRNSFARSHKPCEVSENQMEKTALPSQS
                     SRNTTGDVDIEEEAVFRLEGERSQLHSRNKRFLSYPRYVEVMVTADAKMVHHHGQNLQ
                     HYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQQ
                     SQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLS
                     AAFTIAHELGHVFNVPHDDSFKCKEAGIKHQYHVMAPTLNYHTSPWTWSACSQKHITE
                     FLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNRQCELMFGPGSQVCPYLVGETLPIS
                     LKKKTTWKS"
     exon            353..714
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            715..877
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1116
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1200
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1325
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1366
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1472
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1619
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1964
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgagcgct tcccagggtg gcgcgggagc gcggggcgcg cgggcctgag agagccaggc
       61 gggcagcgcg cgatgaggca gcggcgccgg gagcggggac tggcggcggg gcgaggcgag
      121 ccggggtgca gtcccgggtg ctcaggaggc tgctgagacg ccgcggagaa ccgctagagc
      181 gcggaggagg gcagcggagc tcggggagcc ggcggccctg gggcggcctc ccagtcggga
      241 tcccctcccc tgtgtgcagc catgcgggtg gccaagtggc tgaccgggtt gctctgcccg
      301 atctcgctcc ttctcactgg gtcctgggaa gttcgtttcc acccacgaca ggaagccctg
      361 gtgaagactc tggcctccta cgaagtggtg acccccacgc gggtcaatga gttcggagac
      421 gtgtttcccc agaaccggca tttcagccgg aagaaacgta gctccggggt gccggagcct
      481 cctccgttca ggacccacta ccgaatcagc gcctacgggc agctcttcca gctgaacctg
      541 agcgctgatg cggccttcct ggctgcaggc tacactgagg tgcacttggg gaccccggta
      601 cctggaccag gcgggcgcag cacggagtcc ccagacctgc gccactgttt ctaccgtggc
      661 caggtcaacg cgcgagagga ccacactgct gtcttcagtc tctgtggagg actgatgggg
      721 acattcaaag caaatgatgg ggagtatttc ttagaaccag tcctgagggc cgatgggagt
      781 gcgcatgacg atgaccacaa caagccacat ctgatctaca gacaggaatt aaagaggaac
      841 tcctttgcgc ggtctcacaa gccttgtgaa gtttcagaaa atcaaatgga gaaaactgct
      901 ttgccctctc agagctccag aaacacgact ggagatgttg atatcgaaga ggaagcggtg
      961 ttcagattgg aaggcgaacg gagccagtta cattccagga ataagcgttt tttatcatac
     1021 ccaagatacg tggaagttat ggttacagcc gatgctaaga tggttcacca tcatgggcag
     1081 aatttgcagc actatgttct gacactgatg tcgattgttg ctgcaatcta caaggattcc
     1141 agcattggga accttatcaa tatagtgatt gtgaaattag ttgtgattca cagtgaacag
     1201 gaaggaccag tgatcagttt taacgcagcc accacgttac gcaacttttg cttatggcaa
     1261 cagagtcaga atgtcccgga tgatgctcac ccctcccacc atgacactgc tgtcctcatc
     1321 actagggaag acatttgcgg agctaaagag aaatgcgaca cgttaggctt agcagagcta
     1381 ggcaccctgt gtgatccttc acggagctgc tccattagcg aagagaacgg gctgagcgcc
     1441 gccttcacca tcgcccatga gcttggacac gtgtttaatg ttccacacga cgacagcttt
     1501 aaatgtaaag aagccggaat taaacatcag tatcacgtca tggccccgac tctaaattac
     1561 cacacgagtc cttggacctg gtcagcatgc agtcagaagc atatcacaga atttctagac
     1621 actggtcatg gagaatgcct tcttgacaaa cccaacggga gaacatatga cctgtctcca
     1681 cagcttccgg gctccgtgta cgatgggaac aggcagtgtg agctcatgtt tggccctgga
     1741 tcacaagtgt gtccctactt ggtaggagaa actctaccta tttctttgaa aaaaaaaact
     1801 acctggaagt catagcgaga atgtacttca aaatatgcat ttattcttga atggaagatg
     1861 gattaggtgg tgttccctag aaatgacccc aaacaatgaa aaccaaaact aatggtgtgc
     1921 tcagtgttat gctagctact tccaaataaa tattgctcac cctc
//
