LOCUS       NM_001164785            6988 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus a disintegrin-like and metallopeptidase (reprolysin
            type) with thrombospondin type 1 motif, 20 (Adamts20), transcript
            variant 2, mRNA.
ACCESSION   NM_001164785
VERSION     NM_001164785.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6988)
  AUTHORS   Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M,
            Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I and
            Fujiwara H.
  TITLE     Tracing the origin of hair follicle stem cells
  JOURNAL   Nature 594 (7864), 547-552 (2021)
   PUBMED   34108685
REFERENCE   2  (bases 1 to 6988)
  AUTHORS   Holdener BC, Percival CJ, Grady RC, Cameron DC, Berardinelli SJ,
            Zhang A, Neupane S, Takeuchi M, Jimenez-Vega JC, Uddin SMZ, Komatsu
            DE, Honkanen R, Dubail J, Apte SS, Sato T, Narimatsu H, McClain SA
            and Haltiwanger RS.
  TITLE     ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT
            in mouse model of Peters plus syndrome
  JOURNAL   Hum Mol Genet 28 (24), 4053-4066 (2019)
   PUBMED   31600785
  REMARK    GeneRIF: Results provide compelling evidence that ADAMTS9 and
            ADAMTS20 were differentially sensitive to B3GLCT inactivation and
            suggest that the developmental defects in PTRPLS result from
            disruption of a subset of highly sensitive POFUT2/B3GLCT targets
            such as ADAMTS20.
            Erratum:[Hum Mol Genet. 2020 Oct 10;29(17):2986-2987. PMID:
            32533185]
REFERENCE   3  (bases 1 to 6988)
  AUTHORS   Nandadasa S, Kraft CM, Wang LW, O'Donnell A, Patel R, Gee HY, Grobe
            K, Cox TC, Hildebrandt F and Apte SS.
  TITLE     Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical
            role in ciliary vesicle growth during ciliogenesis
  JOURNAL   Nat Commun 10 (1), 953 (2019)
   PUBMED   30814516
  REMARK    GeneRIF: ADAMTS9 or ADAMTS20 mutagenesis impaired neural and yolk
            sac ciliogenesis, leading to morphogenetic anomalies resulting from
            impaired hedgehog signaling, which is transduced by primary cilia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6988)
  AUTHORS   Silver DL, Hou L, Somerville R, Young ME, Apte SS and Pavan WJ.
  TITLE     The secreted metalloprotease ADAMTS20 is required for melanoblast
            survival
  JOURNAL   PLoS Genet 4 (2), e1000003 (2008)
   PUBMED   18454205
  REMARK    GeneRIF: Adamts20 mutations in belted (bt) mice cause white
            spotting of the dorsal and ventral torso, indicative of defective
            neural crest (NC)-derived melanoblast development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6988)
  AUTHORS   Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA,
            Apte SS, Pavan WJ and Beier DR.
  TITLE     A defect in a novel ADAMTS family member is the cause of the belted
            white-spotting mutation
  JOURNAL   Development 130 (19), 4665-4672 (2003)
   PUBMED   12925592
  REMARK    GeneRIF: Results suggest that the role of ADAMTS proteases,
            including ADAMTS20, in the regulation of cell migration has been
            conserved in mammalian development.
REFERENCE   6  (bases 1 to 6988)
  AUTHORS   Llamazares M, Cal S, Quesada V and Lopez-Otin C.
  TITLE     Identification and characterization of ADAMTS-20 defines a novel
            subfamily of metalloproteinases-disintegrins with multiple
            thrombospondin-1 repeats and a unique GON domain
  JOURNAL   J Biol Chem 278 (15), 13382-13389 (2003)
   PUBMED   12562771
  REMARK    GeneRIF: This protein is identified and characterized and its
            relation to other disintegrins and thrombospondin 1 repeats is
            examined.
            Erratum:[J Biol Chem. 2018 Jul 27;293(30):11785. PMID: 30054291]
REFERENCE   7  (bases 1 to 6988)
  AUTHORS   Somerville RP, Longpre JM, Jungers KA, Engle JM, Ross M, Evanko S,
            Wight TN, Leduc R and Apte SS.
  TITLE     Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS
            subfamily related to Caenorhabditis elegans GON-1
  JOURNAL   J Biol Chem 278 (11), 9503-9513 (2003)
   PUBMED   12514189
  REMARK    GeneRIF: ADAMTS-9 and ADAMTS-20 have an identical modular
            structure, are distinct in possessing 15 thrombospondin type I
            repeats and a unique C-terminal domain, and have a similar gene
            structure
REFERENCE   8  (bases 1 to 6988)
  AUTHORS   Sekiguchi M, Shimai K, Guo H and Nowakowski RS.
  TITLE     Cytoarchitectonic abnormalities in hippocampal formation and
            cerebellum of dreher mutant mouse
  JOURNAL   Brain Res Dev Brain Res 67 (1), 105-112 (1992)
   PUBMED   1638738
REFERENCE   9  (bases 1 to 6988)
  AUTHORS   Beier DR, Morton CC, Leder A, Wallace R and Leder P.
  TITLE     Perinatal lethality (ple): a mutation caused by integration of a
            transgene into distal mouse chromosome 15
  JOURNAL   Genomics 4 (4), 498-504 (1989)
   PUBMED   2744761
REFERENCE   10 (bases 1 to 6988)
  AUTHORS   MAYER,T.C. and MALTBY,E.L.
  TITLE     AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL
            SPOTTING AND BELTED MOUSE EMBRYOS
  JOURNAL   Dev Biol 9, 269-286 (1964)
   PUBMED   14138974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084382.2, AK090358.1,
            AC084384.1, AK142029.1 and AI450842.1.
            
            [WARNING] On May 16, 2023 this sequence was replaced by
            NM_001164785.2.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active protease. Certain mutations in this gene cause defective
            development of neural crest-derived melanoblasts resulting in a
            'belted' phenotype that is characterized by white spots in the
            lumbar region. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (2)
            has a distinct C-terminus and is shorter than isoform 1. This
            isoform (2) may undergo proteolytic processing similar to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY189816.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               AC084382.2         136167-136518
            353-714             AC084382.2         136967-137328
            715-877             AC084382.2         145743-145905
            878-1116            AC084382.2         160554-160792
            1117-1761           AK090358.1         1083-1727
            1762-1866           AC084384.1         26435-26539
            1867-2012           AC084384.1         27826-27971
            2013-2194           AC084384.1         29547-29728
            2195-2331           AC084384.1         29827-29963
            2332-2449           AC084384.1         31585-31702
            2450-2545           AC084384.1         34493-34588
            2546-2712           AC084384.1         36787-36953
            2713-2842           AC084384.1         37103-37232
            2843-2969           AC084384.1         41915-42041
            2970-3083           AC084384.1         44112-44225
            3084-5260           AK142029.1         2-2178
            5261-6971           AK142029.1         2180-3890
            6972-6988           AI450842.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..6988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 48.2 cM"
     gene            1..6988
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /note="a disintegrin-like and metallopeptidase (reprolysin
                     type) with thrombospondin type 1 motif, 20"
                     /db_xref="GeneID:223838"
                     /db_xref="MGI:MGI:2660628"
     exon            1..352
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..4539
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; a disintegrin and metalloproteinase with
                     thrombospondin motifs 20"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 20 isoform 2 precursor"
                     /protein_id="NP_001158257.1"
                     /db_xref="CCDS:CCDS49711.1"
                     /db_xref="GeneID:223838"
                     /db_xref="MGI:MGI:2660628"
                     /translation="MRVAKWLTGLLCPISLLLTGSWEVRFHPRQEALVKTLASYEVVT
                     PTRVNEFGDVFPQNRHFSRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAA
                     GYTEVHLGTPVPGPGGRSTESPDLRHCFYRGQVNAREDHTAVFSLCGGLMGTFKANDG
                     EYFLEPVLRADGSAHDDDHNKPHLIYRQELKRNSFARSHKPCEVSENQMEKTALPSQS
                     SRNTTGDVDIEEEAVFRLEGERSQLHSRNKRFLSYPRYVEVMVTADAKMVHHHGQNLQ
                     HYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQQ
                     SQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLS
                     AAFTIAHELGHVFNVPHDDSFKCKEAGIKHQYHVMAPTLNYHTSPWTWSACSQKHITE
                     FLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNRQCELMFGPGSQVCPYLKHCRRLWC
                     TSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEWGPWGPYSSCS
                     RTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSDFDG
                     KHFDINGLPPNVRWLPKYSGIAVKDRCKLYCRVAGTTSFYQLKDRVADGTPCGTETND
                     ICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAGVFNSAHYGYNVVVKIPAG
                     ATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGSN
                     NSIERINSTDRLEAELVLQVLCVGNLYNPDVRYSFNIPIEERSNLFSWDPYGPWQDCT
                     KMCQGLHRRKIACVRKSDHAVVSDHNCGHLPMPLFVTEKCNMDCELRWHIIGKSDCSS
                     QCGQGYRTLDVHCMKYSVHKGQAVPVGDQYCGDQLKPPSREPCHGSCVLTRWHYSEWS
                     QCSRSCGGGDKTRESYCVNGFGHRLAESECRELPRVVLENCNEFPCPSWATSEWSECP
                     VTCGKGMKQRQVWCQLSEDPMRDGFCNASTKPESLRPCELRACASWHVGPWGSCTATC
                     GHGYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPCLAIPEVGATSLPAIPL
                     GRAAQWRHGSWTPCSVSCGRGSQARYVSCRDAHDEVADESNCAHLPRPAAVSLCFSPC
                     GEWQAGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDPEGRPVTEQECSLAACPPL
                     YSRAPSSSEQPSHVPSRNVPLTHKPGENQDQGAQLSIRGNQWRTGPWGACSRSCAGGL
                     QHRAVVCQDEDGRSATSCDGSSKPPESRHCGSGPCPHWNYGDWGECTQTCGGGVKSRF
                     VICQFPNGQMTQEHSCELPKPPSMMQCHLHACPEDVSWYRGPWKSVR"
     exon            353..714
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            715..877
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1116
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1200
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1325
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1366
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1472
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1619
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1761
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1866
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2012
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2194
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2331
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2449
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2545
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2712
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2842
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2969
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3180
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3345
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3510
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3630
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3738
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3903
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4194
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4356
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..6980
                     /gene="Adamts20"
                     /gene_synonym="Adamst20; bt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgagcgct tcccagggtg gcgcgggagc gcggggcgcg cgggcctgag agagccaggc
       61 gggcagcgcg cgatgaggca gcggcgccgg gagcggggac tggcggcggg gcgaggcgag
      121 ccggggtgca gtcccgggtg ctcaggaggc tgctgagacg ccgcggagaa ccgctagagc
      181 gcggaggagg gcagcggagc tcggggagcc ggcggccctg gggcggcctc ccagtcggga
      241 tcccctcccc tgtgtgcagc catgcgggtg gccaagtggc tgaccgggtt gctctgcccg
      301 atctcgctcc ttctcactgg gtcctgggaa gttcgtttcc acccacgaca ggaagccctg
      361 gtgaagactc tggcctccta cgaagtggtg acccccacgc gggtcaatga gttcggagac
      421 gtgtttcccc agaaccggca tttcagccgg aagaaacgta gctccggggt gccggagcct
      481 cctccgttca ggacccacta ccgaatcagc gcctacgggc agctcttcca gctgaacctg
      541 agcgctgatg cggccttcct ggctgcaggc tacactgagg tgcacttggg gaccccggta
      601 cctggaccag gcgggcgcag cacggagtcc ccagacctgc gccactgttt ctaccgtggc
      661 caggtcaacg cgcgagagga ccacactgct gtcttcagtc tctgtggagg actgatgggg
      721 acattcaaag caaatgatgg ggagtatttc ttagaaccag tcctgagggc cgatgggagt
      781 gcgcatgacg atgaccacaa caagccacat ctgatctaca gacaggaatt aaagaggaac
      841 tcctttgcgc ggtctcacaa gccttgtgaa gtttcagaaa atcaaatgga gaaaactgct
      901 ttgccctctc agagctccag aaacacgact ggagatgttg atatcgaaga ggaagcggtg
      961 ttcagattgg aaggcgaacg gagccagtta cattccagga ataagcgttt tttatcatac
     1021 ccaagatacg tggaagttat ggttacagcc gatgctaaga tggttcacca tcatgggcag
     1081 aatttgcagc actatgttct gacactgatg tcgattgttg ctgcaatcta caaggattcc
     1141 agcattggga accttatcaa tatagtgatt gtgaaattag ttgtgattca cagtgaacag
     1201 gaaggaccag tgatcagttt taacgcagcc accacgttac gcaacttttg cttatggcaa
     1261 cagagtcaga atgtcccgga tgatgctcac ccctcccacc atgacactgc tgtcctcatc
     1321 actagggaag acatttgcgg agctaaagag aaatgcgaca cgttaggctt agcagagcta
     1381 ggcaccctgt gtgatccttc acggagctgc tccattagcg aagagaacgg gctgagcgcc
     1441 gccttcacca tcgcccatga gcttggacac gtgtttaatg ttccacacga cgacagcttt
     1501 aaatgtaaag aagccggaat taaacatcag tatcacgtca tggccccgac tctaaattac
     1561 cacacgagtc cttggacctg gtcagcatgc agtcagaagc atatcacaga atttctagac
     1621 actggtcatg gagaatgcct tcttgacaaa cccaacggga gaacatatga cctgtctcca
     1681 cagcttccgg gctccgtgta cgatgggaac aggcagtgtg agctcatgtt tggccctgga
     1741 tcacaagtgt gtccctactt gaagcactgc cgacgtctgt ggtgcacgag tgcagaaggc
     1801 gtccacaagg gctgtcgcac acagcacatg ccgctggcag atgggacgag ctgtggtccc
     1861 gggatgcact gccaccgtgg gctgtgtgtg accagggaca tggagacccg tcctgtggat
     1921 ggcgagtggg gaccatgggg accctacagc tcgtgttcaa ggacatgcgg aggtggaatc
     1981 aagagcacag cccggctctg tgaccggccc gagccacgaa acggaggaag gtactgtgtg
     2041 ggccgcagga tgaaatttcg atcatgtaat actgattcat gtccaaaagg caagcgagac
     2101 ttccgagaaa agcaatgctc cgacttcgac ggtaaacatt tcgacatcaa cggcctcccc
     2161 cccaatgtga ggtggcttcc gaagtacagc gggattgccg taaaagatcg ctgtaaactc
     2221 tattgccggg tcgctgggac taccagcttc taccagctga aggacagagt tgctgatggg
     2281 acaccctgtg ggacggaaac taacgacatc tgtgtccagg gcctctgtcg gcaagctggc
     2341 tgtgatcacg tgttaaactc caaggccaag agagacaagt gtggagtgtg tggtggtgac
     2401 aactcttcgt gccagaccct ggcaggtgtc ttcaacagtg cccattacgg ttacaatgtg
     2461 gttgtaaaga tccctgcggg ggctacaaac attgaaatcc ttcagcacag ctattctgga
     2521 agaccagaag atgacaacta tctcgcatta tctgacactc aagggaactt tctcctgaat
     2581 ggaaactttg ttgtaagtat ggcgaagaaa gagatcaaca tccagggtgc tgttttcgaa
     2641 tacagcgggt caaacaactc gattgaaaga attaacagca cggaccggct ggaggcggag
     2701 ctcgttctgc aggtgttgtg tgtgggtaat ttatacaacc ctgacgtgcg ctattccttc
     2761 aacatcccca ttgaggagag gagcaatctg ttctcctggg atccatacgg gccgtggcaa
     2821 gactgtacca aaatgtgcca aggtcttcat agaagaaaaa ttgcctgcgt ccgtaagagc
     2881 gaccatgcag ttgtatctga ccacaattgt ggccacttac cgatgccact gtttgtgact
     2941 gaaaagtgca atatggactg tgaactcagg tggcacatca ttgggaaaag cgactgctca
     3001 tcccagtgtg gccaaggata cagaacccta gacgttcact gcatgaagta ctcggttcat
     3061 aaaggacagg ctgtcccagt aggagatcag tactgtggtg accagctcaa gcctcccagc
     3121 cgagagccat gccatggcag ctgtgttttg acaaggtggc attattcaga gtggtcccag
     3181 tgttctagga gttgtggcgg cggtgacaag actcgggaat cctactgcgt aaatggcttt
     3241 ggccaccgcc ttgctgaaag cgagtgtcgg gagcttccgc gggtggtgct ggagaactgc
     3301 aatgaatttc cgtgtcccag ctgggcaacg agtgagtgga gtgagtgtcc tgtcacatgt
     3361 ggaaaaggaa tgaagcagcg acaggtttgg tgtcagctga gtgaagaccc catgagggat
     3421 ggtttctgta atgccagtac caagcccgag tcgctgagac cctgtgagct ccgtgcgtgc
     3481 gcttcttggc atgtaggacc gtgggggtct tgcacggcca cctgtggaca tggatatcag
     3541 atgcgtgctg ttaagtgtat cagtgagata tttggcacca tgctagatga cagagagtgc
     3601 ccgcaagcca gccggccaag tgacagacag gactgtatat tggcaccttg cctggctatt
     3661 ccagaagtgg gggccacctc cttaccagcc attcccctgg gaagggcagc acagtggcgc
     3721 catggatcgt ggaccccatg ctctgtgtcc tgtggaagag gcagtcaggc ccgttatgtg
     3781 agctgccggg atgctcatga tgaagtggca gatgagtcga attgtgccca cttgcctcga
     3841 cctgctgcgg tgtctctctg cttcagccct tgtggagagt ggcaagcagg ggactggtca
     3901 ccatgttcag cctcctgtgg acatgggaaa accacccgac gtgttttatg cgtgaactac
     3961 caccaactgg tcgatgagag ttactgtgac ccggaaggcc gtcctgtgac tgaacaagaa
     4021 tgtagcctgg cagcctgccc acccttatac agccgagctc ccagctcctc tgagcagcca
     4081 agccacgttc ccagcagaaa tgttccatta actcacaaac caggagagaa tcaagatcag
     4141 ggggcccagc tgtcaatcag aggaaaccag tggagaacag gcccttgggg agcatgctcc
     4201 agaagctgcg ccggtggtct tcagcacagg gctgtggtct gccaggatga agacgggcga
     4261 agcgctactt cctgtgatgg gtcctccaag cccccagagt caaggcactg tggctccgga
     4321 ccttgtccgc actggaatta tggggactgg ggagaatgca cacaaacctg tggtggaggg
     4381 gtaaaatcaa gatttgtgat ctgtcagttt cccaatggcc aaatgacaca ggaacacagc
     4441 tgtgaactgc ccaagccacc tagcatgatg cagtgtcacc tgcacgcctg ccctgaagat
     4501 gtgtcctggt atcggggacc atggaagtcg gtacgatagt tatagtaggc ttatgaccac
     4561 gttcctttta cttgaatttc ctctttgtaa gtggaaaaat tcataactat cttgcatctg
     4621 attactgctt ctgaaagctg accatcaact gtcctggtgt gtttattgaa gtcgatattt
     4681 tgagcaggaa ttcattcaag tactgtaatt acatatgtgt aatggtttta tatgtattta
     4741 tatgtgaatt ttgaactaat ggagatgctt tctttcatta cacctctgac cttcactcca
     4801 attaatcaga tttgtgcaca atgttaacat tccacttgta aggctatgtc ttgtttgagt
     4861 ttattatggt tatatgtggc ttttgtctgt gcctagccaa taactgatct aaaaccaaat
     4921 aacattcttt taaaatttgc ctcctcactg ttaaattgtt ttgtttagaa atgtgaagat
     4981 agtgaagaca aagacatttg cttacataaa aattgttcat agttaaatgc atcataggaa
     5041 actacgactt atgtagtaat ttactatgaa tatccatttt ccaccgtgtg gacgtactgt
     5101 gggttaggaa tatattactt ttccatgttt tgaatcatag tcgaaactca tagatagtgc
     5161 tcataagtat tttctctaat atttttcaaa tatctagtcg ggagtataat taatacatga
     5221 gtatattgaa attagcatat tatcaccttt tttttttttt agatcatgaa aaaaatgagt
     5281 atttaccttc cagataaaat ctagatttga ggcagcgatc tatttgtaac taaactcata
     5341 aaccgagaca ttctgtccca aatggggaga aagctagcca gtacctgggg accagccagt
     5401 acctggggac ctggatctgg cggctttgct tctgagctcc atggtgctat tttcctgtga
     5461 gggagtggat aagcttgaag catccacctg cctctccgct tcctgatagg tgctgcaata
     5521 cctcactgtg atgatgctga gctaagattt tcatcaggga tacgtgtgct ggctgttttc
     5581 atatgccata agccttactg gtactcagtg aagtcatttg ttccttacca tctgcggcgg
     5641 atgctacacc acagcggttg agctgactct gccagccaca atggtggaaa tatttactat
     5701 caggccattt cttagaaggt tttgctgaga ccttggtgga cagaaaggca tgtctaaagt
     5761 acaggacaga aacttacttt aagtcatagg catcagcatg gccatgttct gtaggagtta
     5821 ggcatccaca ggggcttcca cctggtattt tgaacactct gcagttctaa acttacccag
     5881 cgtggtatat gcatttgtct atgtactgca ctggaatatc tgaccctgta ttccagagat
     5941 gtgtgtgcat agaccatgcc gtaactgaga aacccggatg cctattatgt cctctgcacg
     6001 agcagccctt caacctcaca gaaatagtca gtcaagaaaa cgatccccaa gcttccagag
     6061 cagtaaggga ggattgcaga gatcttcagt gtgtaccaca caactgtttc aaacgcagct
     6121 aaccgagtaa tctttgcact agtggaagac tgtaatatct ttatatattt tgataatttg
     6181 aaaatgaagt ttttttttta aatcgcgata aatgtttatg ccagaatttt tttttacaaa
     6241 cctatttatt tgcatgtgta aagatatata tcattagagt acctggattt ctgtaattat
     6301 atgaagaata tttatttttt caattagtct tttatattaa aaggactcag gggatctgag
     6361 gttttgttat caaaaccagg tatatataaa tatatttttt gactctttca gtgttgctta
     6421 cagattagcc aaatttcaga atacctctta gaatacatta gattagtact ctttcatgac
     6481 tgacatgaat gtcaatagac cctgctcatc cagttagaaa actaagggaa tatatgtgta
     6541 tatacacaaa tgaatgacaa cactgaacct ttttattgta aaggaaagta aaaagacagt
     6601 gagtaaagtc atgattaaaa tattttagaa aaaaattgaa aatattctta acttttcttc
     6661 atgttctgag aaatcttgtg ttgtaataac agaaagaata aatgaattgt aatccatgct
     6721 tgttaattga ataactgcat ctttgtaatc agccaatgtg aatggactgt atctttacat
     6781 acgatgtgtg tcaatgtgct gtcgttacgc tttgcataat gtatatgtat gctgtattat
     6841 tatcccttgt gtcagtacct aaatgtttta agcaactgac aaaccttatg ctggaacgaa
     6901 tggcccctct ccttggtgct gtttgtctta gtaacaggct gttgatgtct cttattaaaa
     6961 agctaactgt ggaaagtgaa aaaaaaaa
//
