LOCUS       NM_175643               7265 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            2 (Adamts2), mRNA.
ACCESSION   NM_175643
VERSION     NM_175643.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7265)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 7265)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 7265)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
  REMARK    GeneRIF: ADAMTS2 promotes radial migration by activating TGF-beta
            signaling in the developing neocortex.
REFERENCE   4  (bases 1 to 7265)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7265)
  AUTHORS   Carter,E.P., Yoneten,K.K., Gavara,N., Tyler,E.J., Gauthier,V.,
            Murray,E.R., Ten Dijke,P., Cameron,A.J., Pearce,O. and Grose,R.P.
  TITLE     Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast
            differentiation and function
  JOURNAL   J Pathol 262 (1), 90-104 (2024)
   PUBMED   37929635
  REMARK    GeneRIF: Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast
            differentiation and function.
REFERENCE   6  (bases 1 to 7265)
  AUTHORS   Kesteloot,F., Desmouliere,A., Leclercq,I., Thiry,M., Arrese,J.E.,
            Prockop,D.J., Lapiere,C.M., Nusgens,B.V. and Colige,A.
  TITLE     ADAM metallopeptidase with thrombospondin type 1 motif 2
            inactivation reduces the extent and stability of carbon
            tetrachloride-induced hepatic fibrosis in mice
  JOURNAL   Hepatology 46 (5), 1620-1631 (2007)
   PUBMED   17929299
  REMARK    GeneRIF: The extent of liver fibrosis is reduced in
            ADAMTS2-deficient mice in comparison with their wild type
            littermates.
REFERENCE   7  (bases 1 to 7265)
  AUTHORS   Le Goff,C., Somerville,R.P., Kesteloot,F., Powell,K., Birk,D.E.,
            Colige,A.C. and Apte,S.S.
  TITLE     Regulation of procollagen amino-propeptide processing during mouse
            embryogenesis by specialization of homologous ADAMTS proteases:
            insights on collagen biosynthesis and dermatosparaxis
  JOURNAL   Development 133 (8), 1587-1596 (2006)
   PUBMED   16556917
REFERENCE   8  (bases 1 to 7265)
  AUTHORS   Kobielak,A. and Fuchs,E.
  TITLE     Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma
            in skin
  JOURNAL   Proc Natl Acad Sci U S A 103 (7), 2322-2327 (2006)
   PUBMED   16452166
REFERENCE   9  (bases 1 to 7265)
  AUTHORS   Li,S.W., Arita,M., Fertala,A., Bao,Y., Kopen,G.C., Langsjo,T.K.,
            Hyttinen,M.M., Helminen,H.J. and Prockop,D.J.
  TITLE     Transgenic mice with inactive alleles for procollagen N-proteinase
            (ADAMTS-2) develop fragile skin and male sterility
  JOURNAL   Biochem J 355 (Pt 2), 271-278 (2001)
   PUBMED   11284712
REFERENCE   10 (bases 1 to 7265)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645639.17, CJ068037.1,
            AL645611.9, AK040370.1 and AL627215.12.
            
            On Mar 30, 2013 this sequence version replaced NM_175643.2.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin repeats) family of
            proteinases that is involved in the proteolytic processing of
            procollagens. The encoded protein precursor is proteolytically
            processed to generate a mature, zinc-dependent enzyme. Mice lacking
            the encoded protein develop abnormal lungs, fragile skin and male
            sterility. [provided by RefSeq, Aug 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046456.1, SRR7652917.938917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL645639.17        56015-56018
            5-464               CJ068037.1         1-460
            465-610             AL645639.17        57416-57561
            611-770             AL645639.17        121921-122080
            771-973             AL645611.9         4576-4778
            974-1057            AL645611.9         24106-24189
            1058-1214           AL645611.9         40627-40783
            1215-1256           AL645611.9         42724-42765
            1257-3738           AK040370.1         1-2482
            3739-7265           AL627215.12        3965-7491
FEATURES             Location/Qualifiers
     source          1..7265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.78 cM"
     gene            1..7265
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 2"
                     /db_xref="GeneID:216725"
                     /db_xref="MGI:MGI:1347356"
     exon            1..215
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..3721
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /EC_number="3.4.24.14"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 2; procollagen I/II amino
                     propeptide-processing enzyme; procollagen N-endopeptidase;
                     procollagen N-proteinase; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 2; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 2; a
                     disintegrin and metalloproteinase with thrombospondin
                     repeats"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 2 preproprotein"
                     /protein_id="NP_783574.1"
                     /db_xref="CCDS:CCDS24636.1"
                     /db_xref="GeneID:216725"
                     /db_xref="MGI:MGI:1347356"
                     /translation="MDPPAGAARRLLCPALLLLLLPPPPLLLLPPPPASVRLVAATEP
                     PGGPPGQGAERILAVPVRTDAQGRLVSHVVSLETAGAGVRARRAALDQTSGLPGGAAQ
                     DPGGRLFYNLTVFGRDLHLRLRPNARLVAPGATVEWQGETGDTRVEPLLGSCLYVGDV
                     ADLPKASSVALSNCDGLAGLIRMEEEEFFIEPLEKGQTDQEAEQGRVHVVYRRPPTPK
                     PPPVSEPQALDTGVSQGNLDSLSRALGVLEERINSSRRRVRRHATDDDYNIEVLLGVD
                     DSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSHAKSMSLIEIG
                     NPSQSLENVCRWAYLQQKPDTDHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRS
                     CTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWS
                     RCSQQELSRYLHSYDCLRDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFR
                     TFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGNWG
                     AWTPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCNPQDCPNSLADFR
                     EEQCQQWDLYFEHGDVQHHWLPHEHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCS
                     YKDAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYI
                     KMFEIPAGARHLLIQEADTTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMGVEWEY
                     RNEDERETLQTIGPLHGTITVLVIPEGDTRISLTYKYMIHEDSLNVDDNNVLEDDAVR
                     HEWALKKWSPCSKPCGGGSQFTKYGCRRRLDSKMVHRAFCSALAKPKAIRRACNPQEC
                     SQPVWVTGEWEPCTQSCGRTGMQVRSVRCIQPLHNNTTRSVHTKHCNDHRPESRRACN
                     RELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDNFGVCREERPETARICRLAPCP
                     RNGSDPSKKSYVVQWLSRPDPDSPIQKISSKDQCQGDKSMFCRMEVLSRYCSIPSYNK
                     LCCKSCNPPRNLSNTEDGGVEPPPGKHNDIDVFMPTLPGPTVATQVQPSPGPPLEAPL
                     NVSSTNATEDHPETNAVDVPYKIHGVDEEVPSPNLIPRRPSLYVKTRNQRIQELINAV
                     QRKEKPGKF"
     exon            216..610
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            611..770
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            771..973
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1057
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1214
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1320
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1464
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1597
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1711
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1857
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2033
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2167
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2291
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2372
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2539
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2699
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2832
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..3040
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3170
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3260
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..7265
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3720..3725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /note="hexamer: AATAAA"
     regulatory      3726..3731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /note="hexamer: AATAGA"
     polyA_site      3741
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
     polyA_site      3745
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /note="major polyA site"
     regulatory      7238..7243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
                     /note="hexamer: ATTAAA"
     polyA_site      7265
                     /gene="Adamts2"
                     /gene_synonym="ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP;
                     PCINP; pNPI"
ORIGIN      
        1 cccagatgtg ggctgggcag cgcgcgggga actttcgcgc cggctgcgag tgcggggccc
       61 cggctgcggt cgggctgcca tggatccgcc ggcgggagcc gctcgccgcc tgctctgccc
      121 cgctctactg ctgctgctgc tgccgccgcc gcctctcctg ctgctgccgc cgccgcccgc
      181 gagcgtccgg ctcgtcgccg ccaccgagcc cccaggcggg cccccggggc aaggagccga
      241 gcgcatcctg gcggtgccgg tgcgcactga cgcccagggc cgcttggtgt cccacgtggt
      301 gtctttggag acggccgggg cgggggtacg agcccgcaga gctgccctgg accagacctc
      361 gggcttgccc ggaggcgctg ctcaggaccc tggaggacgc cttttctaca acctcacagt
      421 attcggccga gacctgcacc tgcggctgcg gcccaacgcc cggctcgtgg ctccgggggc
      481 caccgtggag tggcagggtg agacgggtga cacccgagtg gagcccctgc ttgggagctg
      541 tctctacgtt ggagacgtgg cagacttacc taaagcctcc tcggtggcgc tcagtaactg
      601 tgatgggctg gctggtctga tccggatgga ggaggaggag ttctttatcg aacctctgga
      661 gaaggggcag acggatcagg aggctgaaca aggccgagtg catgtggtat atcgccgacc
      721 gcccactccc aagccccctc ctgtgagcga accacaggct ctggacacag gagtctccca
      781 gggcaacctg gacagcctca gcagagccct aggcgtcctg gaggagcgca tcaacagctc
      841 acggcggagg gtgcgcaggc atgccacgga cgatgactac aacattgagg tcctgctggg
      901 tgtggatgac tcggtggtcc agttccatgg gaaggagcac gtgcagaagt acctgctgac
      961 actcatgaac attgtcaacg aaatctacca tgatgagtcg ttgggggccc acatcaatgt
     1021 ggtgctggtg aggattatcc tgctgagcca cgcaaagtcc atgagcctca ttgagattgg
     1081 aaacccctct cagagtctgg agaatgtctg ccgatgggcc tacctccagc agaagccgga
     1141 cacagaccac gatgagtacc acgaccatgc catctttctc acacggcagg attttgggcc
     1201 ctcgggcatg caaggctatg ctcccgtcac cgggatgtgc caccctgtcc gcagctgtac
     1261 tctgaaccat gaagatggct tctcctcggc atttgtggtg gctcacgaga cgggccatgt
     1321 gctgggcatg gagcatgacg ggcaaggcaa ccgctgcggt gacgaggtgc ggctgggcag
     1381 catcatggcc cccctggtac aggctgcctt ccatcgcttc cactggtccc gctgcagcca
     1441 gcaggagctc agccgctacc tgcattccta tgactgcctg cgggatgatc ccttcgccca
     1501 cgactggcca gcattgcctc aactcccagg gcttcactat tccatgaacg agcagtgtcg
     1561 ctttgacttt ggcctgggtt acatgatgtg cactgcgttc cggaccttcg acccctgcaa
     1621 acagctctgg tgcagccacc cagacaaccc ctacttttgc aagacaaaga agggtcctcc
     1681 actggatggt actatgtgtg cgcctggcaa gcactgcttc aaaggccact gcatctggct
     1741 gacacccgat atcctcaaac gagacggcaa ctggggtgcc tggactccgt ttggctcctg
     1801 ctcacgcacc tgtggcacag gcgtgaagtt caggacccgc cagtgtgaca acccacatcc
     1861 agccaatggg ggccgcacct gctcgggcct ggcctatgac ttccagctct gcaaccccca
     1921 ggactgtccc aattccctgg ctgacttccg ggaggagcag tgtcagcagt gggacctgta
     1981 ctttgagcac ggtgatgtcc agcaccactg gctgcctcat gagcaccggg atgccaagga
     2041 gagatgccac ctctactgtg agtccaagga gacaggggag gtggtgtcta tgaagcgcat
     2101 ggtgcacgat ggaacacgct gctcctacaa ggacgccttc agcctgtgtg tgcgtgggga
     2161 ctgcaggaaa gtgggatgtg atggggtgat cgggtcccgt aagcaggaag acaagtgtgg
     2221 cgtgtgtgga ggcgacaaca cccactgtaa agtggtgaag ggcacattca cgaggtcacc
     2281 gaggaaacaa gattacatca agatgtttga gatccccgca ggagccagac acctgctcat
     2341 ccaggaggcc gacaccacca gccaccatct gtctgtcaag aacctggaga caggcaagtt
     2401 catcttaaat gaagagaacc acttggaccc caattctaga tccttcattg ccatgggtgt
     2461 ggagtgggaa tacaggaacg aggacgagag ggagacgctg cagaccatag gcccactcca
     2521 cggaaccatc accgtgctgg ttattcctga aggagacacc aggatctcac tgacatacaa
     2581 atacatgatt cacgaggact ccctcaatgt tgacgacaac aatgtcctgg aagatgatgc
     2641 tgtgcgccac gagtgggccc tgaagaagtg gtctccctgc tccaagccct gcggtggagg
     2701 gtcccagttc actaagtatg gctgccgccg gaggttggac agcaagatgg tacaccgagc
     2761 cttctgcagt gccctcgcca agcccaaggc catccgacga gcctgcaacc ctcaggagtg
     2821 ctcccagcct gtgtgggtca ccggtgaatg ggagccttgt actcaaagct gtgggcgaac
     2881 tggcatgcag gtgcgctccg tccgctgtat acaacctctg cacaacaaca ccacccgctc
     2941 cgtgcacacc aaacactgca acgatcaccg tcccgagagc cgccgggcct gcaaccgtga
     3001 gctctgccct gggcggtggc gggctgggtc ctggtcccag tgttcggtaa cctgtggcaa
     3061 cggcacccag gaacggccag tgctctgtcg cactgcagat gataattttg gtgtctgccg
     3121 ggaggagcga ccggagacgg caaggatctg caggcttgca ccctgtcccc gaaacggctc
     3181 agatccctcc aagaagagct acgtggttca gtggctgtcc cggcctgatc ctgactcacc
     3241 tatccagaag atctcgtcaa aggaccagtg ccaaggcgac aagtcaatgt tctgtaggat
     3301 ggaagtcttg tctcgctact gctccatccc cagctacaac aagctttgct gcaagtcctg
     3361 caacccgccc cgaaacctca gcaacacaga ggacggaggt gtggagcctc ctcccgggaa
     3421 gcacaatgac atcgatgtgt tcatgcccac actcccgggg cccactgtag ctacacaggt
     3481 gcagccttct ccggggcctc ctttggaggc tcccctcaat gtctctagca ccaatgccac
     3541 tgaagatcac ccagaaacca atgctgtgga tgtcccctac aaaatccatg gtgtggatga
     3601 agaggtcccg tctcctaacc tgatccctcg acggccaagc ctgtatgtaa agacaaggaa
     3661 ccaaagaatc caggagctca ttaatgcagt gcagaggaaa gagaagccgg gaaagttcta
     3721 ataaaaatag aaagattcgc atcaacagcc tttccccttg cttatagata tattccccaa
     3781 gttagcaaat cctgtgtttg tggaaaatga agccaaaaac cctgcttcca agaaggtttg
     3841 gaatgcatgg aaaatggtac aaaagaatat attggggtgg gtgggggcat gtgacaatca
     3901 gcctaacatg tattttccag gttaggaatg acctcaatcg aggcaggcag atttcttagt
     3961 tcgaggtcgg cctggtctac aaagtgagtt ccaggacagc cagggctaca cagagaaacc
     4021 ctgtctcgag aaaccaaaaa gaaaagaaaa agaaaaaaaa aaaggaatga cctaaatctt
     4081 gcggtgatct taagtggaga gtggacagga atattcaagt tccctagttt cttatcaatg
     4141 atgggaggtc aagggggatg actcccagag agaaaaattt tgctccaact tactaagcaa
     4201 tggttgagaa ccttcatttc cttgatgatg accagtcccc agacaaagag atgagaccgc
     4261 tggggactct taggtgacag gtgacatagt gttttattta tagatcaatt gccaggttga
     4321 gtacaactaa gtggaggtca tgagtcaaac caaccccaag ggccaggcag aggataggat
     4381 aagtgtggta accagtagta tagggctctg atcaatcaga gaagaaagcc cacctagagc
     4441 tgttggtggg ctttagccat ggctgccagt gtgacatata gcttccctac aagccgagcc
     4501 ttgtcatagg ttgcacttcc agatacctct gtttcctgtc ctcagaatcc tttaagttgt
     4561 ggggctgagg tcacccagga atttcaggtc tagctccacc tggctccaac cacaggtttc
     4621 cgttttaact actaactacc tggtgcagtt tcaaaacctg gtgctcaaaa tgtgtgcggt
     4681 gttttgatct ctgctgagca ggggctgtgc atctatctag ttctttccag gaaattgatg
     4741 agattctgta atggggggat tcgagggcag ttctgaacaa gagccattgg gtcaaaggcg
     4801 gcaaggacca cttctctctt ctccacttca ccatggcctt acttgctgcc cctacccatg
     4861 gctgtggtag aagagtcgca ctattcttct ctgatagcct gggctaaaag acccagtgag
     4921 gaagaatgat ggagtcatcc actctgctgg gatgacccaa catgtggtcc aagaaccagg
     4981 actctctctt tcctagagtc ccagttctgc caccatggtg gtagattgcc aggctgtggg
     5041 gcctcaggtt ccgagaatgg gttttgccta tggtctgacc ttgcccctgc ccacctccaa
     5101 cctttagatg ttctagaacg tggcaatctg gtctgcaatc tgacgtacag ggtgggaggt
     5161 gggagcccca ctttaccttt ttctttagaa gctcagatga cttttgtttg gggtagaatg
     5221 gtgtttggtg agtatattag tcagggtcct ctagagtcac aggacttatg gatagtctct
     5281 atatagtaaa ggaatttatt gatgacttac agtctgtagt ccaattccca acaatggttc
     5341 agtagtgaat ggaagtccaa ggatctagca gttgctcagt tccacatggc aagtaggcca
     5401 aagagcgaga gaggcaactc ccttattcca atgtccttat atggcctcca gcagaaggtg
     5461 tagcccagat taaaggtgtg tgccaccaca cctttaatcc caatgacctt gaactcagag
     5521 atcccgctgt cttaatcttc tggagtgcat agccactatg cctcaagatc tccataccaa
     5581 gatccaggtc agaaacttct atcttctagc ctccagataa gggtcactgg tgagccttcc
     5641 aattctggat tgtagttcat tccagatata gtcaagttga caaccaggaa tagacactac
     5701 agtgagccag atatgaatgg gaggaaaatg ggagggagga agggaagggt gacaggaggg
     5761 tggtgggcaa aggcgtattt gctggcattt tgtgagcatg ctactccagt gccccacacc
     5821 ttagtaagac ctaagggcat gttagtgctc tagctgggcc cagcctggcc agaattctaa
     5881 ggcttctcct ctgtgtcctc atcaactgta gatctaagat tcatcttcct tattgacatt
     5941 ccccagccct tcgcagaatt tagggtgctg agacttgggt tgacaccatt gtggctgctc
     6001 ctccattaaa ttttgaggtg ctctgtatgc ttgtgtgaac ttgtgtgtgt gtgtgtgtgt
     6061 gtgtgcgcgc gcgcgcgctg gggagaggtg tctgtgtgaa tgatctatgg aaagaagtca
     6121 gagcatagac accagataaa gatggtgctt aaccttcctc ccagaaggta gccagaccct
     6181 cttaccatcc attcctctgc ccccacccga ccctgcactg ctccagctcc caaagaacca
     6241 aactgggaaa tgtcccttta ctacccctcc tggtatgtgg ttgagagcaa ttctgttctc
     6301 cttccccctt gtaagctggg agtgaatccc atggctggcc cgcatttgtt gaatccaggt
     6361 cagcagggtt tactcctggg ctaaagaact gagtacttct tgtttgagtc tgtggtagaa
     6421 tgtagaggaa atgttctgga ctagtactag ttgggatgac tgagtttacc cattctaagg
     6481 gctgtgggat agtaacactc cattgtcaga tcctagcaaa tcacagaagc cccacatggg
     6541 acagccccag caagacagcc ttgagggaga caacatcctt ggtgcgttgg gccatgtacc
     6601 gcgaggcctc tccagagtta gtggtgctca tacacgtgtg gctaaggaac acagtgtcca
     6661 ctgggctcag agaagctgcg catgcccgag catgggagga tggtttggag aatgcttgga
     6721 aacaaccctc agcttcccat gaagctctta tttctggggt gttcctcaga ggcaggtagg
     6781 tgtcctctga aggcaggtag gtgtcctttg aaggcaggta ggtgtcctct gaaggcaggt
     6841 aggtgtcctc tgaaggtttc cggcacgacg tagtcaccca gactgtcctg catcacccag
     6901 aaaaatatga ggcacctggg agtcgttctt cattcccagg gaggtcaggc cacatttaaa
     6961 gaggcccttt cggaaacccc gtggaatctt gtatataagc ctctcatttg tattttacaa
     7021 gttttctttc ttggtctgtt ttaagtatat aaatggtgct tagtaccaat gttggtctga
     7081 ggtaacattc tgactctatt tactcctgtg tgacacgtgg ctgccaagtg ggggccaaac
     7141 acggtgctca acttaaatca cagaatttta tctgacaaca gccatcgatg cattttcgtt
     7201 ctgtatagca aaaactgact ccttattttc gtaacttatt aaagtgtctg tggttttgca
     7261 aatca
//
