LOCUS       NM_175506               5067 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            19 (Adamts19), mRNA.
ACCESSION   NM_175506
VERSION     NM_175506.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5067)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5067)
  AUTHORS   Mead,T.J., Martin,D.R., Wang,L.W., Cain,S.A., Gulec,C., Cahill,E.,
            Mauch,J., Reinhardt,D., Lo,C., Baldock,C. and Apte,S.S.
  TITLE     Proteolysis of fibrillin-2 microfibrils is essential for normal
            skeletal development
  JOURNAL   Elife 11, e71142 (2022)
   PUBMED   35503090
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5067)
  AUTHORS   Koli,S., Labelle-Dumais,C., Zhao,Y., Paylakhi,S. and Nair,K.S.
  TITLE     Identification of MFRP and the secreted serine proteases PRSS56 and
            ADAMTS19 as part of a molecular network involved in ocular growth
            regulation
  JOURNAL   PLoS Genet 17 (3), e1009458 (2021)
   PUBMED   33755662
  REMARK    GeneRIF: Identification of MFRP and the secreted serine proteases
            PRSS56 and ADAMTS19 as part of a molecular network involved in
            ocular growth regulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5067)
  AUTHORS   Wunnemann,F., Ta-Shma,A., Preuss,C., Leclerc,S., van Vliet,P.P.,
            Oneglia,A., Thibeault,M., Nordquist,E., Lincoln,J.,
            Scharfenberg,F., Becker-Pauly,C., Hofmann,P., Hoff,K., Audain,E.,
            Kramer,H.H., Makalowski,W., Nir,A., Gerety,S.S., Hurles,M.,
            Comes,J., Fournier,A., Osinska,H., Robins,J., Puceat,M.,
            Elpeleg,O., Hitz,M.P. and Andelfinger,G.
  CONSRTM   MIBAVA Leducq Consortium principal investigators
  TITLE     Loss of ADAMTS19 causes progressive non-syndromic heart valve
            disease
  JOURNAL   Nat Genet 52 (1), 40-47 (2020)
   PUBMED   31844321
  REMARK    GeneRIF: Loss of ADAMTS19 causes progressive non-syndromic heart
            valve disease.
REFERENCE   5  (bases 1 to 5067)
  AUTHORS   Sandireddy,R., Cibi,D.M., Gupta,P., Singh,A., Tee,N., Uemura,A.,
            Epstein,J.A. and Singh,M.K.
  TITLE     Semaphorin 3E/PlexinD1 signaling is required for cardiac
            ventricular compaction
  JOURNAL   JCI Insight 4 (16), 125908 (2019)
   PUBMED   31434798
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5067)
  AUTHORS   Vegvari,A., Szabo,Z., Szanto,S., Nesterovitch,A.B., Mikecz,K.,
            Glant,T.T. and Adarichev,V.A.
  TITLE     Two major interacting chromosome loci control disease
            susceptibility in murine model of spondyloarthropathy
  JOURNAL   J Immunol 175 (4), 2475-2483 (2005)
   PUBMED   16081819
REFERENCE   7  (bases 1 to 5067)
  AUTHORS   Bouma,G.J., Albrecht,K.H., Washburn,L.L., Recknagel,A.K.,
            Churchill,G.A. and Eicher,E.M.
  TITLE     Gonadal sex reversal in mutant Dax1 XY mice: a failure to
            upregulate Sox9 in pre-Sertoli cells
  JOURNAL   Development 132 (13), 3045-3054 (2005)
   PUBMED   15944188
REFERENCE   8  (bases 1 to 5067)
  AUTHORS   Bouma,G.J., Hart,G.T., Washburn,L.L., Recknagel,A.K. and
            Eicher,E.M.
  TITLE     Using real time RT-PCR analysis to determine multiple gene
            expression patterns during XX and XY mouse fetal gonad development
  JOURNAL   Gene Expr Patterns 5 (1), 141-149 (2004)
   PUBMED   15533830
REFERENCE   9  (bases 1 to 5067)
  AUTHORS   Menke,D.B., Koubova,J. and Page,D.C.
  TITLE     Sexual differentiation of germ cells in XX mouse gonads occurs in
            an anterior-to-posterior wave
  JOURNAL   Dev Biol 262 (2), 303-312 (2003)
   PUBMED   14550793
REFERENCE   10 (bases 1 to 5067)
  AUTHORS   Menke,D.B. and Page,D.C.
  TITLE     Sexually dimorphic gene expression in the developing mouse gonad
  JOURNAL   Gene Expr Patterns 2 (3-4), 359-367 (2002)
   PUBMED   12617826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ092717.1, AY135183.1 and
            AC132242.2.
            
            On Jul 27, 2016 this sequence version replaced NM_175506.3.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. This gene is
            predominantly expressed in the ovary with lower levels of
            expression observed in kidney, heart, skeletal muscle, lung and
            testis. The encoded preproprotein undergoes proteolytic processing
            to generate an active protease. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY135183.1, BC150736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               CJ092717.1         1-401
            402-3179            AY135183.1         1-2778
            3180-3180           AC132242.2         87982-87982
            3181-5067           AY135183.1         2780-4666
FEATURES             Location/Qualifiers
     source          1..5067
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 33.78 cM"
     gene            1..5067
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 19"
                     /db_xref="GeneID:240322"
                     /db_xref="MGI:MGI:2442875"
     exon            1..532
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            533..1182
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1348
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1521
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1605
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1763
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1807
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1913
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2054
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2205
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2307
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2438
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2611
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2739
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2860
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2941
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3099
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3253
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3389
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3594
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3747
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3925
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..5067
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5040..5045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5058
                     /gene="Adamts19"
                     /gene_synonym="4831407I23Rik; D230034E10Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagctctgc aaccgcaagc cgtccaaact cgtgcgcccg ccacgctccg cgcgggtgcg
       61 ggcggcgaat ctgggctggg accgtactgc tccgctggtc cggaggccgc cctgcctgcc
      121 gccccgcgcc tcctggctct tggcggactg cgggtctgtc ccacggggct ccagccgggc
      181 ctggaaactc ctgcactgtt cagagctcag caagtcgact catcacctaa ttcgctgggg
      241 agctggagcg cagagagccg gggcgctgct ggccgctcct ccccacccca gccccgcccg
      301 ggctctggga gtcagagttc gccccccctc cgccccccac ccctggcaga caaagggcct
      361 gggcacagtc gccgcctggc cgccgacgct ccggggaggc tgctgcgtgc gctgtggatc
      421 gcgcgggagg cgcgcgcagt ggagatgggc ccggagatgc gcctgactcg catctgctgc
      481 tgctgctgcc tcctctacca gctaggcttc ctgtcgcatg ggaccacctc agggttgcag
      541 ctcaccccgg atctcgagga atgggaagtc gtgtttcctg cactctggcg ccgggagtcg
      601 ctgaacgcca cgggcctcag cgggggcagc tcagacccgg gatccgggcg cagctctggg
      661 ggcggcggcc gggggcaggc ttcgggcagc tcgcgggagg tgcgctcggt ggcccgagca
      721 ccgcaggaag aagccaccag aggccaatct gagccctggt tcgggtctcc cctggagcca
      781 ggtgctgagg acgaggagga actcgaatct caggagctgc ctcggggatc cagcggagat
      841 actgccctgt cctcgggaac cccggcctcg tggcagcctc ctctgccccc gcaacggccc
      901 tcgtccccgc cccctgccca gcaagaggaa cccagcgcgg aggaggtgct gttgcggatc
      961 ccggccctct cccgggacct gtacctgctg ctccggagag atggccgctt cctggcgcag
     1021 cgcttcgcag tggagcagtg gcccaaacca ggtcccgatc ccacccgggc aacggctgac
     1081 cctggctctt ccttgctgcc agatgcctcc tgcttttaca ccgggacagt gctgcgccat
     1141 cctggctctc tggcctcttt cagcacctgt ggaggtggcc tgatgggctt tatacagctc
     1201 aatgaggact tcctattcat tgagccattc aatgatacaa tggccatcat aggtcacccg
     1261 caccgtttat acaggcagaa gaggtccaca gaggaaaaag taacagagaa ctcagctgtt
     1321 caccgccatc actgtggtgt catttcagat aaaggaagac caaggtctaa aaaaatagca
     1381 gacaacagac gagaaaaacg gtattcctac aaattatccc aggaatacaa catcgagacc
     1441 gtagtagttg cagaccctgc aatggtttcc taccacggag cagatgcagc caggagattc
     1501 attctgacaa tcctaaatat ggtttttaac cttttccagc acaagagtct gggtgtgcag
     1561 gtcaacctcc gtgtgctaaa gctcattctc ctccatgaaa caccagcaga tctgtatatt
     1621 gggcaccacg gagagaaaat gctggagagt ttttgtaagt ggcagcacga agagtttggc
     1681 cggaggaatg atgtgcattt ggagatgtcg accagctggg gagaagacat tgctgcggtg
     1741 gatgcagcta ttcttataac aaggaaagat ttctgtgtgc acaaagatga gccatgtgac
     1801 actgtgggta ttgcttactt gaatggaatg tgtagtgaaa agaggaagtg tattattgct
     1861 gaagacaacg gcctgaacct tgcgtttaca atcgctcatg aaatgggtca caacatgggc
     1921 atcaaccatg acaatgacca cccatcctgt gctgatggtc ttcatatcat gtctggtgaa
     1981 tggatcaaag gacaaaatct tggtgatgtt tcatggtcca ggtgcagcaa ggaggatctg
     2041 gaaagatttc tcaggtcaaa ggccagtagc tgcttgttgc atacagatcc gcagagtctc
     2101 agttcggtgc tggttccctc aaaattgcca gggatggctt acactgcaga cgaacagtgc
     2161 cagatcctct ttgggcctct ggcttctttt tgtcaagaga tgcagcatgt tatctgcact
     2221 ggtttgtggt gcaaagtgga gggggaagca gagtgcagga ccaagctgga cccaccaatg
     2281 gatgggactg actgcgaccc tggcaagtgg tgtaaggctg gagaatgcac ccgcaggact
     2341 cctgcacccg agcacttggc tggagagtgg agcccgtgga gttcctgtag tcgaagttgc
     2401 agttctgggg tcagcagtcg agagcgcaag tgtcctgggc taggttctga agcaagggat
     2461 tgtaatggcc ccagaaaaca atacagaata tgtgagaatc caccttgtcc tgcaggtttg
     2521 cctggattca gagactggca atgtcaggcc tatagtgtta gaacttcgta cccaaagcat
     2581 gcacttcagt ggcaagctgt cttcgatgaa gaaaaaccat gtgccttgtt ttgctctcct
     2641 gttggaaaag aacagcctgt tcttctatca gaaaaagtga tggatggaac ttcttgtgga
     2701 tatcagggac tagatatatg tgcaaatggc aggtgccaga aagctggttg tgatggttta
     2761 ctggggtctc ttgccaggga agatcattgt ggtgtttgta acggcaatgg aaagtcatgc
     2821 aaagtcatta aaggcgattt taatcacacc agaggggcag gttatgtaga agttctggtg
     2881 atacctgctg gagcgagaag aatcaaagtt gtggaggaaa agccggcaca tagcttctta
     2941 gctcttcgag atgccagtaa gcagtctata aacagtgact ggaagataga acattctgga
     3001 gcattcagtc tggctggaac tacagtacat tacttaagac gaggcctgtg ggagaagatc
     3061 tctgccaaag gtcccacaac cacacctttg catctcctgg tactcctatt tcaagatcag
     3121 aattacggtc ttcactatga atatactgtt ccatcagacc ctcttccaga caatcagagt
     3181 tctaaggagc cggggcccct cttcatgtgg acacacgcag gctggggcga ttgcaatgcc
     3241 acgtgtggag gaggagagag gaagacaatg gtgtcctgca caaaaatcat gagcaagaat
     3301 atcagccttg tggacaacaa gaaatgcaag gacttgacca aaccagagcc acagattcga
     3361 aagtgcaatg aacaaccttg tcaaacaagg tggatgatga cagaatggac cacgtgttca
     3421 cgaacctgtg gaaaaggagt ccagagtaga caagtggcct gtacccagca gctggaaaat
     3481 ggaaccctga ttagagcctg ggagagggac tgcctagggc caaagcccgc aactgtgcaa
     3541 cgctgtgagg gtcaggactg catgacggtg tgggaggccg gagtgtggtc ggagtgctca
     3601 gtgaagtgtg gcaaaggtgt gcggcatcgc accgtgaggt gcactaaccc gagaaaaaag
     3661 tgcgtcctct ccaccagacc cagggaggcc gaggactgtg aggattactc caaatgctac
     3721 gtgtggcgag taggtgactg gtctaagtgc tccattacct gtggcaaagg catgcagtct
     3781 cgtgttatcc agtgcatgca taagatcaca ggaagacacg gaaatgaatg cttttcttcg
     3841 gagaaacctg cagcctacag gccatgtcac cttcagccct gtaatgagaa aattaatgta
     3901 aatacaataa catcaccaag actggctgcc ctgaccttca agtgcctggg agaccagtgg
     3961 ccagtgtact gcagagtgat ccgggagaag aatctttgcc aggacatgcg gtggtaccaa
     4021 cgatgctgtg agacttgcag ggacttctat gcccaaaagc tacagcagaa gagttgacct
     4081 ctgacaggct ggctgactgg ctcatagctt ttttttttgc tattgcatta tttataaaca
     4141 tacacactag catgtttttc agaccaaata ttatcagatt acatataatt taatcaaatt
     4201 aatttatttg cctgccaggc atctaatgtg gtgtttgttt tggacataca aacattttga
     4261 ttttatacta tgaggcttca taaataattt tatatgaatg agtaagttgg gtctagtaaa
     4321 ctaataagaa aaaaagaaat gatttctttt cattgagggc tgtctctaag gtgctatttt
     4381 tctctccacc aaaaccatta agttatcgag tgtgtacact accttagcat gatagcttag
     4441 ctatgtatgc agaaaatgat gtattttctt gtgtcctgct gcagaatctg cccattttct
     4501 gttaatggca ggagatgtgt aaacagaaca aacctcacag tcttgaagag tttgagagaa
     4561 tgtattatga atttgattca gatttttaga ggcgagcata ggagatattc tactgtaacg
     4621 atacctttat attaataatg gaaaagtcaa gacagagact ttgatcctgt tggtgaacat
     4681 gcacttgaac acagcactgt gagcctgatg cactgtatcg atgtacactg aatcaccatt
     4741 gcgctgttgg tgaaggtgta gagaagctgt gacggaagtg gcagctccct ataacacctg
     4801 tattattgta acatgccatt agactggctt ttaaaaggta tttcaaacag agaaaacatg
     4861 gatccaccca gatctttcca tcccctagca gtcttatgaa agaggatcgt acttcaactc
     4921 acaattcata tgagcaatgg tagtaaatat tttttttcct tcttttcccc taggaaataa
     4981 gaaaatgaga ttcagataat attttgatag tttcattgtg ttttttttcc ttttaaagaa
     5041 ataaaattat aattctctga aacattc
//
