LOCUS       NM_172466               5769 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            18 (Adamts18), transcript variant 1, mRNA.
ACCESSION   NM_172466
VERSION     NM_172466.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5769)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 5769)
  AUTHORS   Wang,L., He,L., Yi,W., Wang,M., Xu,F., Liu,H., Nie,J., Pan,Y.H.,
            Dang,S. and Zhang,W.
  TITLE     ADAMTS18-fibronectin interaction regulates the morphology of liver
            sinusoidal endothelial cells
  JOURNAL   iScience 27 (7), 110273 (2024)
   PUBMED   39040056
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5769)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5769)
  AUTHORS   Nie,J., Dang,S., Zhu,R., Lu,T. and Zhang,W.
  TITLE     ADAMTS18 deficiency associates extracellular matrix dysfunction
            with a higher risk of HER2-positive mammary tumorigenesis and
            metastasis
  JOURNAL   Breast Cancer Res 26 (1), 19 (2024)
   PUBMED   38287441
  REMARK    GeneRIF: ADAMTS18 deficiency associates extracellular matrix
            dysfunction with a higher risk of HER2-positive mammary
            tumorigenesis and metastasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5769)
  AUTHORS   Wang,L., Sun,M., Zhang,Q., Dang,S. and Zhang,W.
  TITLE     ADAMTS18 regulates early branching morphogenesis of lacrimal gland
            and has a significant association with the risk of dry eye in mice
  JOURNAL   Exp Eye Res 218, 109020 (2022)
   PUBMED   35240198
  REMARK    GeneRIF: ADAMTS18 regulates early branching morphogenesis of
            lacrimal gland and has a significant association with the risk of
            dry eye in mice.
REFERENCE   6  (bases 1 to 5769)
  AUTHORS   Aldahmesh,M.A., Khan,A.O., Mohamed,J.Y., Alkuraya,H., Ahmed,H.,
            Bobis,S., Al-Mesfer,S. and Alkuraya,F.S.
  TITLE     Identification of ADAMTS18 as a gene mutated in Knobloch syndrome
  JOURNAL   J Med Genet 48 (9), 597-601 (2011)
   PUBMED   21862674
  REMARK    GeneRIF: Adamts18 is expressed in the lens and retina in the
            developing murine eye.
REFERENCE   7  (bases 1 to 5769)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   8  (bases 1 to 5769)
  AUTHORS   Li,Z., Nardi,M.A., Li,Y.S., Zhang,W., Pan,R., Dang,S., Yee,H.,
            Quartermain,D., Jonas,S. and Karpatkin,S.
  TITLE     C-terminal ADAMTS-18 fragment induces oxidative platelet
            fragmentation, dissolves platelet aggregates, and protects against
            carotid artery occlusion and cerebral stroke
  JOURNAL   Blood 113 (24), 6051-6060 (2009)
   PUBMED   19218546
REFERENCE   9  (bases 1 to 5769)
  AUTHORS   Stankunas,K., Hang,C.T., Tsun,Z.Y., Chen,H., Lee,N.V., Wu,J.I.,
            Shang,C., Bayle,J.H., Shou,W., Iruela-Arispe,M.L. and Chang,C.P.
  TITLE     Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment
            for myocardial morphogenesis
  JOURNAL   Dev Cell 14 (2), 298-311 (2008)
   PUBMED   18267097
REFERENCE   10 (bases 1 to 5769)
  AUTHORS   Holmberg,M., Leonardsson,G. and Ny,T.
  TITLE     The species-specific differences in the cAMP regulation of the
            tissue-type plasminogen activator gene between rat, mouse and human
            is caused by a one-nucleotide substitution in the cAMP-responsive
            element of the promoters
  JOURNAL   Eur J Biochem 231 (2), 466-474 (1995)
   PUBMED   7543410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108856.20 and AC125463.4.
            
            On Apr 5, 2022 this sequence version replaced NM_172466.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140876.1, BC094674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AC108856.20        60138-60494
            358-448             AC108856.20        60597-60687
            449-762             AC108856.20        63713-64026
            763-1045            AC108856.20        130919-131201
            1046-1239           AC108856.20        133432-133625
            1240-1323           AC108856.20        133864-133947
            1324-1483           AC108856.20        135657-135816
            1484-1589           AC108856.20        137740-137845
            1590-1727           AC108856.20        141698-141835
            1728-1881           AC108856.20        144508-144661
            1882-1977           AC108856.20        154222-154317
            1978-2126           AC108856.20        157632-157780
            2127-2299           AC108856.20        165672-165844
            2300-2430           AC125463.4         209651-209781       c
            2431-2554           AC125463.4         208393-208516       c
            2555-2799           AC125463.4         207536-207780       c
            2800-2941           AC125463.4         185206-185347       c
            2942-3068           AC125463.4         184014-184140       c
            3069-3273           AC125463.4         180435-180639       c
            3274-3456           AC125463.4         177767-177949       c
            3457-3663           AC125463.4         176034-176240       c
            3664-3811           AC125463.4         174113-174260       c
            3812-5769           AC125463.4         167982-169939       c
FEATURES             Location/Qualifiers
     source          1..5769
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 59.65 cM"
     gene            1..5769
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 18"
                     /db_xref="GeneID:208936"
                     /db_xref="MGI:MGI:2442600"
     exon            1..357
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..3927
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 18; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 18; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 18"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 18 isoform a precursor"
                     /protein_id="NP_766054.2"
                     /db_xref="CCDS:CCDS40485.1"
                     /db_xref="GeneID:208936"
                     /db_xref="MGI:MGI:2442600"
                     /translation="MECALLCLCALRAAGPGPPWGPAGLGRLAKALQLCCFCCASVAV
                     ALASDSGSSGGSGLNDDYVFVVPVEVDSGGSYISHDILHHRKRRSAHGASNSLHYRVS
                     AFGQDLHLELKPSAILSSHFRVQVLGKDGASETREPEVPQCLYQGFIRNDSSSSVAVS
                     TCAGLSGLIRTRDNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEKRVRWYQDYP
                     GSQRTYPGHSPSHTPPASQSQEPEYSHRRWQKRHFCGRRKKYAPKPPAEDAYLRFDEY
                     GGTGRPRRSAGKSQNGLNVETLVVADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGTI
                     GSDINIVVVSLILLEEEPEGLLINHHADQSLNSFCQWQSALVGKNGKRHDHAILLTGF
                     DICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEG
                     NPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKYPD
                     KLPGQIYDADMQCKWQFGAKAKLCSLGVMKDICKSLWCHRVGHRCETKFMPAAEGTAC
                     GLSMWCRQGQCVKLGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCSNPKPQYG
                     GKYCPGSSRIYKLCNINPCPENSLDFRAQQCAEYNNKPFRGWLYRWKPYTKVEEEDRC
                     KLYCKAENFEFFFAMSGKVKDGTPCSPHRNDVCIDGICELVGCDHELGSKAVSDACGV
                     CKGDNSTCKFYKGLYLSQHKANEYYPVVTIPAGARSIEIQELQLSSSYLAVRSLSQKY
                     YLTGGWSIDWPGDFTFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILTQGKNPGIAW
                     KYALPKVMNVTQPATKRYHHTWRTVQSDCSVTCGGGYISIKAICLRDQHTQVNSSFCS
                     VRTKPATEPKICNAFSCPAYWLPGEWSACSKSCAGGQQSRKIRCVQKKPFQKEEAVLH
                     SLCPVSTPTQVQVCNSHACPPEWSPSPWSQCSKTCGRGVRRREVLCKSPAAETLPESL
                     CSSSPRPEAQEGCVLGRCPKNNRLQWIASAWSECSATCGLGVRKRELKCVEKTLQGKL
                     ITFPERRCRNIKKPSLELEEACNQRTCPVYSMAVASWYSSPWQQCTVTCGGGVQTRSV
                     HCMQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKKDDPSCVDFFSWCHLVPQHGVCNH
                     KFYGKQCCRSCTRKS"
     exon            358..448
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            449..762
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1045
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1239
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1323
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1483
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1589
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1727
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1881
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1977
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2126
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2299
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2430
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2554
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2799
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2941
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3068
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3273
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3456
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3663
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3811
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..5769
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5743..5748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5769
                     /gene="Adamts18"
                     /gene_synonym="9630038L21; ADAMTS21; E130314N14Rik"
                     /note="major polyA site"
ORIGIN      
        1 aatcactctg ataccgacaa gcgcccagac ccgcgagcat caccaacaga gtttcatagc
       61 cacaggcgct gcagaccggg ctctggcaga gctccctaca ccccgaagca cctcaggccc
      121 gcgaggctag agcagggagg aggctcgcag gctctcgtgc tgccatgtga gcggcggcgg
      181 ccactcgcac ctggcgccac acctggggct ccgctgcccg cgggggacaa tgcgcgcctg
      241 ccacagtcac cgcgtccgca cctgaccatg gagtgcgccc tcctgtgctt gtgcgccctc
      301 cgggccgcag gtcccgggcc gccgtggggg cccgcgggac tggggcgtct ggccaaggca
      361 ctccagctgt gctgcttctg ctgtgcttcg gtggccgtcg ccttagccag tgacagcggc
      421 agcagcggtg gcagcggatt aaatgatgat tacgtctttg tcgtgccagt agaagtggac
      481 tcgggcgggt catatatttc acacgacatt ttgcaccaca ggaaaaggcg atcggcacac
      541 ggtgccagca actccctgca ctaccgagtt tcagcatttg gacaggatct acatttagag
      601 cttaagccct cggcgatctt gagcagtcac tttagagtcc aagtacttgg aaaggacggt
      661 gcttcagaga ctcgggagcc tgaggtaccg cagtgtttgt atcagggatt tatcagaaat
      721 gacagctcgt cctctgtggc tgtgtctacg tgtgccggct tgtcaggtct gataaggacc
      781 cgagacaatg aattcctcat ctcaccgcta cctcagctgc tggcccagga acacaactat
      841 agctcgcctg caggccacca tcctcacgtc ctgtacaaaa ggacagcaga gaagagggtc
      901 agatggtacc aagactaccc tggctcccag cggacatatc ctggtcactc cccaagtcac
      961 actccccctg cctcccagag ccaagagcca gagtacagcc atcgaaggtg gcaaaagcgg
     1021 catttttgtg gacgacgcaa gaaatatgcc cccaagcctc ctgcagagga cgcctatcta
     1081 cgctttgacg aatatggagg cacagggcgg cccagacggt cagctggaaa gtcacaaaat
     1141 ggtctcaatg tggagaccct tgttgtggca gatgccaaga tggtggagaa gcacggcaag
     1201 gatgacgtca ccacgtacat tctcacagtc atgaacatgg tttctagcct gttcaaagat
     1261 gggaccattg gaagcgacat aaacattgtg gttgtgagcc taattctgct ggaagaagaa
     1321 cctgaaggac tgctgatcaa tcaccatgca gaccagtctc taaacagctt ctgtcagtgg
     1381 cagtcagctc ttgtgggaaa gaatggcaag agacacgacc acgccatcct cctcacagga
     1441 tttgacattt gttcctggaa gaacgaacca tgtgacacac taggatttgc tcctatcagt
     1501 ggcatgtgca gtaagtaccg aagctgtacc atcaatgaag acacaggact tggcctggcc
     1561 ttcaccattg cgcatgagtc agggcacaac tttggcatgg ttcatgatgg tgaaggcaat
     1621 ccctgcagga aagcagaagg caacatcatg tcacccacac tgactggaaa caatggggtg
     1681 ttttcatggt cgtcctgcag ccgacagtat ctaaagaaat tcctcagtac accgcaggct
     1741 ggctgtctgg tggatgagcc caagcaaacg ggacagtata aatatccgga caaactcccg
     1801 ggacagattt atgatgccga catgcaatgt aagtggcaat ttggagccaa agccaagctg
     1861 tgcagccttg gggttatgaa ggacatttgc aagtcactct ggtgccaccg cgtgggccac
     1921 agatgtgaaa ccaagttcat gcctgcagca gaggggaccg cttgtggctt gagtatgtgg
     1981 tgtcggcaag gccagtgtgt aaagctcgga gaactagggc cccggcccat ccatggccag
     2041 tggtctgcct ggtcgaagtg gtcagaatgt tctcgcactt gcggcggagg agtcaagttc
     2101 caggagagac actgtagtaa ccccaagcct cagtatggtg gcaagtactg tccaggatct
     2161 agccgcatct acaagctgtg caacattaac ccttgtcctg agaatagctt ggatttccgt
     2221 gcccaacagt gtgcagagta taacaacaag cccttccgtg gatggttgta ccgttggaaa
     2281 ccctacacaa aagttgaaga ggaagatcga tgtaaactct actgcaaggc ggagaacttt
     2341 gagtttttct ttgccatgtc tggcaaggtg aaagatggga cgccttgttc cccacacaga
     2401 aatgacgtct gcatcgatgg gatttgtgaa ctggtgggat gtgaccatga gcttggctct
     2461 aaggcggttt ctgatgcatg tggtgtttgc aaaggcgata actcaacttg caagttttat
     2521 aagggcctgt acctcagtca gcacaaagca aatgagtatt accctgtggt caccatcccc
     2581 gctggggccc gaagcattga gattcaggag ttgcagcttt cttccagcta tcttgctgtt
     2641 cgaagcctca gtcaaaagta ttacctcaca gggggctgga gcatcgactg gccaggggac
     2701 ttcaccttcg cagggaccac gtttgaatac cagcgttcct ttaaccgccc tgaacgactg
     2761 tatgcaccag gacccacgaa tgagacgctg gtctttgaaa ttctgacaca aggcaagaat
     2821 ccggggatcg cttggaagta tgcacttccc aaggtcatga atgtaactca gccagccacc
     2881 aagagatacc accacacctg gcgcacagtg cagtctgact gctcagtcac ctgcggtgga
     2941 ggttatataa gcatcaaggc catttgctta cgagatcaac acacccaagt caattcctca
     3001 ttctgcagtg taagaaccaa gccagcaaca gagcccaaga tatgcaacgc tttctcctgc
     3061 ccagcctatt ggttgccagg ggagtggagc gcatgcagca agtcctgtgc cggcggccag
     3121 cagagccgca agatacggtg tgtgcagaag aagcccttcc agaaagagga ggccgtgctg
     3181 cactccctct gtccagtgag cacgcccact caggttcaag tctgcaacag ccatgcctgc
     3241 cctccagagt ggagccccag cccctggtct cagtgttcca agacctgtgg acgaggcgtg
     3301 aggaggcgtg aggtcctttg taaaagccct gcagcggaga cactccccga gagcctgtgc
     3361 tccagcagcc ccagacccga ggcacaggag ggctgtgtgc tgggacggtg ccccaaaaac
     3421 aacaggctcc agtggattgc ctctgcatgg agtgagtgtt ctgcaacctg tggcttgggt
     3481 gtgaggaaga gagaactgaa atgcgttgag aagaccttgc aggggaaact aataacattc
     3541 ccggagcgga gatgccgcaa cattaagaag ccaagcctgg aactggaaga agcctgcaac
     3601 caaaggactt gcccagtgta cagcatggcg gtggcgagct ggtattcatc accatggcaa
     3661 cagtgcacag taacctgcgg gggaggagtc cagactcgct ctgtccactg catgcagcaa
     3721 ggccggcctt cctcaagttg tctgctccat cagaagcctc cggtgctcag agcctgtaac
     3781 accaacttct gtccagctcc tgaaaagaaa gatgacccat cttgcgtgga tttcttcagc
     3841 tggtgtcacc tggtccctca gcacggagtc tgcaaccaca aattttatgg aaagcagtgc
     3901 tgtagatcat gcacaaggaa gagctgatct tggggtctcc tcaccctcct cagaccaaga
     3961 ccttacccgt ccatctctag gtcttcgtat caagactaca aaccacagag gaaatcccat
     4021 agggtttaaa gaatggacag atagccactc tccttcttag ttgacccctg gaaacacatg
     4081 gtactctaaa gcacttgaca atgagaagcg acgacaaatc taactaagaa aaaaaaaata
     4141 gcctttggtt tgcactgtga ttcagaagac gagagatgga ttgtactgag ataagtcaag
     4201 ttttcatttt gacaaagtgg gaacttcgtt gactttggga caggtcttgt tcccacatat
     4261 gtactcttga acatcaaagg attcaacagc aaagacatct atttttaaca gagtctgtaa
     4321 ggtctcattc aggtcaagga ctgagactca gagccatcgc atacagggat ggaattctgc
     4381 ctaacagttg cttggaatct cttgtgtcaa actcttgaca ccaaatggtg ctcagtgggc
     4441 gcttgctgct ggactggcaa gcttcatctt atgtttttta tttttgtgtg ttgttgtttt
     4501 tatttgattt caagtatatt ctgcctagaa tgagtctcca agactgaaat taacaacttg
     4561 aaacatattc ccaagtaaca ttctagaggc agggtcacat ggacgattta agtcctccat
     4621 ggaattcaaa ttcatacccg aaggggacaa agtgtccaat actgatgatg cctttcatgc
     4681 gacatcaacc tcgtaacttg gtgcttattc cctgctcttt gagaagaact ggtgacatgt
     4741 tcacttttgg taaaaatagg tgctcactgg tgaaatagca tgcttgaagg agggacaagc
     4801 ccaccattta taacgctcca cacatattat cggaatgctt agaaaattaa aggctgcctg
     4861 cctgtggttt tttttttttt tttttcctcc ttccaactga caagtttcaa tttgccccag
     4921 gacttggtca acaaggaaaa atagaataaa aataaaataa aacacagtgg ctagagaaaa
     4981 atccgtcttc ttgcgacatt aataaattac aactcacaga gatctttcca tgagtaacag
     5041 catttcacca cgtctcagat gagagtttcg atcgtcggga gccagctgtt gatgggcatt
     5101 aacaagctta aaattgctct caattggaaa agtaccgtgc ttttttgcca aaaccaaagt
     5161 aacttaaaag attgtgacct cccctgtaat tctttgagaa gtagctctac agggcttgtt
     5221 tatatgatac gattctacgc cccccccaaa aaaagcttct ttgatgaatg tacactcaaa
     5281 ttttactgct tcttggaggc ttggttcaaa caggggtttg ccagctcagc agaactagtg
     5341 agacagtggt ctgttaaatt taacagcctt ctttgtccct atcccagtgg caaccatgag
     5401 ctcttgtatg ccatggaaat gaagaataac agcttggcct tcttagattg gtctttcagt
     5461 agccattttg atatggggag aaaaacaaaa caaaacaacc acactatcat ttccctggct
     5521 ctatgaaaag tgggaagtta tttgacttta tataattatc actttattat tttatgggaa
     5581 agaattaatt tattaatagc ctattcttac gtgttctcac ctctcttctc tgagtaaatg
     5641 atattctgag ggaaaatgtt gaattaaaaa aaaaaaacat gggttataga gaaaaaaaag
     5701 tcaaaatata tgtgtaatat ttaattattt tataagtttt ataataaagt attctgtttc
     5761 tttgtcttt
//
