LOCUS       NM_001033877            6043 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            17 (Adamts17), mRNA.
ACCESSION   NM_001033877 XM_133542 XM_896893 XM_896905 XM_896917 XM_907743
VERSION     NM_001033877.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6043)
  AUTHORS   Mead TJ, Martin DR, Wang LW, Cain SA, Gulec C, Cahill E, Mauch J,
            Reinhardt D, Lo C, Baldock C and Apte SS.
  TITLE     Proteolysis of fibrillin-2 microfibrils is essential for normal
            skeletal development
  JOURNAL   Elife 11, e71142 (2022)
   PUBMED   35503090
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6043)
  AUTHORS   Neupane S, Berardinelli SJ, Cameron DC, Grady RC, Komatsu DE,
            Percival CJ, Takeuchi M, Ito A, Liu TW, Nairn AV, Moremen KW,
            Haltiwanger RS and Holdener BC.
  TITLE     O-fucosylation of thrombospondin type 1 repeats is essential for
            ECM remodeling and signaling during bone development
  JOURNAL   Matrix Biol 107, 77-96 (2022)
   PUBMED   35167946
REFERENCE   3  (bases 1 to 6043)
  AUTHORS   Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M,
            Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I and
            Fujiwara H.
  TITLE     Tracing the origin of hair follicle stem cells
  JOURNAL   Nature 594 (7864), 547-552 (2021)
   PUBMED   34108685
REFERENCE   4  (bases 1 to 6043)
  AUTHORS   Oichi T, Taniguchi Y, Soma K, Oshima Y, Yano F, Mori Y, Chijimatsu
            R, Kim-Kaneyama JR, Tanaka S and Saito T.
  TITLE     Adamts17 is involved in skeletogenesis through modulation of
            BMP-Smad1/5/8 pathway
  JOURNAL   Cell Mol Life Sci 76 (23), 4795-4809 (2019)
   PUBMED   31201465
  REMARK    GeneRIF: Adamts17 is involved in skeletal formation by modulating
            BMP-Smad1/5/8 pathway, possibly through inhibiting the
            incorporation of fibrillin-2 into microfibrils. Delayed terminal
            differentiation of Adamts17-/- chondrocytes, observed both in
            primary chondrocyte and primordial metatarsal culture.
            Erratum:[Cell Mol Life Sci. 2019 Oct 16;:. PMID: 31620828]
REFERENCE   5  (bases 1 to 6043)
  AUTHORS   Dubail J and Apte SS.
  TITLE     Insights on ADAMTS proteases and ADAMTS-like proteins from
            mammalian genetics
  JOURNAL   Matrix Biol 44-46, 24-37 (2015)
   PUBMED   25770910
  REMARK    Review article
REFERENCE   6  (bases 1 to 6043)
  AUTHORS   Naba A, Clauser KR, Hoersch S, Liu H, Carr SA and Hynes RO.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   7  (bases 1 to 6043)
  AUTHORS   Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M,
            Haltiwanger RS and Holdener BC.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   8  (bases 1 to 6043)
  AUTHORS   Morales J, Al-Sharif L, Khalil DS, Shinwari JM, Bavi P, Al-Mahrouqi
            RA, Al-Rajhi A, Alkuraya FS, Meyer BF and Al Tassan N.
  TITLE     Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular
            myopia, ectopia lentis, glaucoma, spherophakia, and short stature
  JOURNAL   Am J Hum Genet 85 (5), 558-568 (2009)
   PUBMED   19836009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053131.1, CF741491.1, CX769149.1, AC119810.8, CN530432.1,
            BG085304.2 and CO043544.1.
            
            On Jun 1, 2007 this sequence version replaced NM_001033877.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1670              AK053131.1         2-1671
            1671-1822           CF741491.1         413-564
            1823-1943           CX769149.1         526-646
            1944-1983           AC119810.8         71632-71671
            1984-1992           AC119810.8         77182-77190
            1993-2686           CN530432.1         1-694
            2687-2987           BG085304.2         263-563
            2988-3125           AC119810.8         154660-154797
            3126-3303           AC119810.8         177281-177458
            3304-5505           AC119810.8         179620-181821
            5506-6043           CO043544.1         1-538               c
FEATURES             Location/Qualifiers
     source          1..6043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 36.26 cM"
     gene            1..6043
                     /gene="Adamts17"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 17"
                     /db_xref="GeneID:233332"
                     /db_xref="MGI:MGI:3588195"
     exon            1..177
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..3470
                     /gene="Adamts17"
                     /note="disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 17; a
                     disintegrin-like and metallopeptidase (reprolysin type)
                     with thrombospondin type 1 motif, 17"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 precursor"
                     /protein_id="NP_001029049.2"
                     /db_xref="CCDS:CCDS21349.2"
                     /db_xref="GeneID:233332"
                     /db_xref="MGI:MGI:3588195"
                     /translation="MCDGTLLPPLVLSLLLLVWGLDPGTAVGDAAADVEVVLPRRLRP
                     EDVHLQLLPGAAGLRRWRRPRASPGGHRAGQGERALLLHLPAFGRDLYLQLHRDLRFL
                     SPGFEVEEAGVSGRSGHPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLEQEQV
                     FIQPLNSSGGPFIGREHLIRRKWASTPSPATEVEGPRQRCKVVTEKKPRKDHLSRDWR
                     ERRNAIRLTNEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHRSLGIKIN
                     IQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDTPPV
                     DAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHN
                     LGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLITD
                     PRSQHALRLPHKLPGMHYSANEQCQILFGTNATFCKNMEHLMCAGLWCLVEGDTSCKT
                     KLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSLWSAWSMCSRTCGTGARFRQR
                     KCDNPPPGPGGTHCQGASVEHAACEKLPCPKGVPSFRDQQCQAHDRLSSKKRGLLTAV
                     VVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYEADLCVYGRCQKIGCDGIIGSAA
                     KEDRCGVCSGDGKTCRVVKGDFSHSRGTGYIEAVVIPVGARRIRVVEDKPAHSFLALK
                     DSSKRSINSDWKIELPGEFQIAGTTVRYVRRGLWEKFSAKGPTTVPLHLMVLLFHDQN
                     YGIHYEYTIPVNQSSENQSEPAKPQDALFLWTHSGWEGCSVQCGGGERRTIVSCTRIV
                     NKTTTLVNDSDCPQASRPEPQVRRCNSHPCQSRWVTGQWSPCSATCEKGVQHREVTCV
                     YQLQNGTHVTTRPIYCSEPRPTPVQSCEGQDCLSIWEASEWSECSANCGKGIQKRTVT
                     CTNSQGKCDASTRPKAEEECEDYSGCYEWKTGDWSKCSSTCGKGLQSRVVQCMHKLTG
                     RHGSECPTLSKPAAYRQCHQEVCNEKINVNTITSPRLAALTYKCTRDQWTVYCRVIRE
                     KNLCQDMRWYQRCCQTCRDFYADKMRQPPSPPSS"
     exon            178..548
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            549..714
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            715..884
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            885..968
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1126
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1170
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1276
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1417
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1568
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1670
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1816
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1983
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2111
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2232
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2313
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2471
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2631
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2767
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2972
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3125
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3303
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..6029
                     /gene="Adamts17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actttttcca aaggctgcag ggctgcactc cggttggctt cgccgcctcg cgagtccctg
       61 ctctatcact acagtcttgg gggctgctgg tcccaagtac catgtgtgac ggcaccctgc
      121 tgccccctct cgtcctgtcc ttgctgctgc tggtgtgggg gctggacccg ggcacagctg
      181 tcggcgacgc ggcggccgac gtggaggtgg tgctcccgag gcggctgcgc cccgaggacg
      241 tgcacctgca gttgctgccg ggagcagcgg ggctccggcg gtggcggcga ccgcgagcat
      301 ctccaggtgg ccatcgagca gggcaaggag agcgcgccct gctactgcac ctgccggcct
      361 ttgggcgcga cctatacctg cagctgcatc gcgacctgcg tttcctgtcc ccaggcttcg
      421 aggtggagga ggcgggtgtc tcggggcgca gcggacatcc tgccgagctg tgcttctact
      481 ccggacgagt cctgggccac ccgggctccc tcgtctccct cagcgcctgc ggcgccgccg
      541 gcggcctggt tggcctcatc cagcttgagc aggagcaagt tttcatccag cccctcaact
      601 cctcaggggg cccattcatt ggaagagagc atctgatcag acgcaaatgg gcctccaccc
      661 ccagccctgc tacggaggtg gagggaccga ggcagcgctg caaagtagtg acagaaaaga
      721 agcccaggaa ggaccatctg tctcgggact ggagggaaag gaggaatgcc atccggctca
      781 ccaacgaaca cacagtggag accctggtgg tggccgatgc cgacatggtg cagtaccacg
      841 gggcagaggc tgcacaaaga ttcatcctca ctgtcatgaa catggtatac aacatgtttc
      901 agcacaggag ccttgggatt aaaattaaca ttcaagtcac caagctggtc cttctgagac
      961 aacgccccgc caagttatcc attgggcacc atggtgagcg gtccctggag agcttctgtc
     1021 actggcagaa tgaggagtat ggaggagcac gctaccttgg caataaccag gtgccaggag
     1081 gcaaggatga tacacctcct gtggatgctg ctgtatttgt gaccaggaca gatttctgcg
     1141 ttcacaaaga tgaaccttgc gacactgttg gaattgctta cttaggaggc gtgtgcagtg
     1201 ctaagaggaa atgtgtgctc gccgaagaca atggtctcaa tttggccttt accatcgcac
     1261 atgaactggg ccacaacctg gggatgaacc atgatgacga ccactcatct tgtgctggcc
     1321 ggtcgcacat catgtccgga gagtgggtaa aaggacggaa tcccagcgac ctctcttggt
     1381 catcctgtag tcgagatgac cttgagaact ttctcaaatc caaagtcagt acatgtttac
     1441 tgatcactga tcccaggagc cagcatgccc tgcgccttcc acacaagctg ccaggcatgc
     1501 actacagcgc caacgagcag tgccagattc tgtttggcac caatgctacc ttctgcaaaa
     1561 acatggagca tttgatgtgt gctgggctgt ggtgcctggt agagggagac acatcctgca
     1621 agaccaagct ggaccctccc ctggatggca ctgaatgtgg agcagacaag tggtgccggg
     1681 ctggagagtg tgtgagcaag acgcccatcc cagagcacgt ggacggggac tggagtctgt
     1741 ggagcgcctg gagcatgtgc agccgaacct gtggtacagg agcgcgattc cggcagagga
     1801 aatgtgacaa ccccccccct ggacctggtg gcacacactg ccagggtgcc agcgtagaac
     1861 atgctgcctg tgagaagctg ccctgcccca agggtgtgcc cagcttccgg gaccagcagt
     1921 gccaagccca tgaccgactg agcagcaaga agagaggcct gttgacagca gtggtggttg
     1981 atgataaacc ctgtgaactc tactgttcac ccctcgggaa ggagtccccg ctgctggtgg
     2041 ctgacagggt cctggatggc acaccctgtg gaccctacga ggctgacctc tgcgtgtatg
     2101 gcagatgcca gaaaattgga tgtgacggca tcatcggatc tgcggctaaa gaagataggt
     2161 gtggtgtctg cagcggggat ggcaagacct gccgtgtggt gaagggtgac ttcagccact
     2221 cccgggggac aggttatatc gaagcggttg tcattccggt tggagctcgg cggatccgtg
     2281 tggtggaaga caaacctgct cacagcttcc tggctctcaa agattccagt aagagatcca
     2341 tcaacagcga ctggaagata gaactccctg gagagttcca gattgcaggt acaaccgtcc
     2401 gctacgtgag gagaggcttg tgggagaagt tctcagccaa gggacccacc acagtgccgc
     2461 tgcatctgat ggtgctgtta tttcatgacc agaattacgg aattcattat gagtacacca
     2521 tacctgtaaa ccagagttca gaaaaccaga gtgagcccgc caagccacaa gatgctctgt
     2581 tcctctggac ccacagcggc tgggaagggt gcagtgtgca gtgtggagga ggagaacgca
     2641 ggactatcgt atcatgcaca cggattgtta acaagactac aaccctggtg aatgacagtg
     2701 actgccccca agcaagccgc cctgagcccc aggtccgacg gtgtaactct cacccatgcc
     2761 agtcccggtg ggtgactggt cagtggagcc cctgctcagc gacctgtgag aagggcgtgc
     2821 agcatcggga ggtgacttgc gtgtaccagc tccagaacgg cacacacgtc actactcggc
     2881 ccatctactg ctcagaaccc cggccaacac cggtacagag ctgtgaaggc caggactgcc
     2941 tgtctatctg ggaggcttca gagtggtcag agtgctctgc caactgcggc aaagggatcc
     3001 aaaaacggac tgtgacatgt accaactccc aagggaaatg tgacgcgtcc acaaggccga
     3061 aagcagagga ggagtgcgag gactactctg gctgctatga gtggaaaacg ggggactggt
     3121 ctaagtgctc gtccacctgt gggaaggggc ttcagtcaag agtggtccag tgtatgcaca
     3181 agctcactgg acgccatggc agtgagtgcc cgactctctc aaagccagca gcctacagac
     3241 agtgccacca ggaggtctgc aacgagaaga tcaatgtgaa caccatcacc tcccctcgcc
     3301 ttgccgctct gacctacaaa tgcactcggg accagtggac ggtgtactgc cgggtcatcc
     3361 gagagaagaa cctctgccag gatatgcgat ggtaccagcg ctgctgccag acctgtaggg
     3421 acttctacgc agataagatg cgccagccgc cctctccacc aagctcgtga cggatagacg
     3481 gcacagtgct tgctcagtgc tctgactcaa ggtctgaggc gtggcagtta gtgagtggag
     3541 agccctcaac ctatccaaaa agcacaccag ccctgcagcc aggaccccca aagcactgct
     3601 ctgctcccac aataaggcca cctcaagaat ccagttgcct agagctagag agtgcacttg
     3661 acattgccat tagtcctttg aacgtaatat attcttaaca gtcactggat ggctttctaa
     3721 ggaaaaacga cacaagagtc atcaaataat tttaatttcc aagctacaca cacacacaca
     3781 cacacacaca gagagagaga gagagagaaa gagagagaga gagagagaga gagagagaga
     3841 gagagaacac atttagtgct tctactctgg ctttctgttg acatttgaat tcctcgggct
     3901 cgggcttgat gtagctttgt ggaaacgaga taccacatta gaagccgctc tgtcctgaga
     3961 gcgacgacgc cctgaccaac cacctctgct aatggcttct ctggaagagg ggtgagctgc
     4021 cttcctacga atccgagaat caagacttgg tctctgccca tctcaaaaaa acgtagtctc
     4081 gaaaatcctt agaaattgtc ttaggaatct tgcccctgag agtttgaatc taaatagccc
     4141 aacaagaaat ccaatgctac gccactctgc ccgccacctg tgtgggagaa cgtgtccaaa
     4201 gagctagatt taggaaggaa tctgcttttc agagctcaac tgtgtatccc acagggagac
     4261 ataggagcct ctcttcaagg tgctatgaaa cgggacatgc atggtccacg ggttgcctcc
     4321 tgacatgaag gcgccctcag cttcctcagg ggtgtgccgg ctcccagtct gcctccaggc
     4381 acatccactc tggcctgcac tccctagggc tttgtacctt atatacatgc tacaccttgg
     4441 caacgtagct ttcattgaca ttggcctttc ctctgaaggt aggatgatgt ttggcacatc
     4501 tgaggacaca catcagtcct gggttctgca gcataaggct tgattgactt cagtatctgg
     4561 acacagggaa gatgtgccag gactcgtgga ggaacaccat atggctgaaa ttgctacaca
     4621 tccatgaagc cgccttctag ccaatgtgcc acgattagca ccttcattga tcatcactgt
     4681 cgttactgac ccatctggat gtgccatgga aaggtcctct cttccattcc catgccgtca
     4741 ctctcaccac agaacttaac catttccaga aggctagaga agtgccagac tgactcttca
     4801 agaacaaacc agcctgatag actcgaggct gccctgggag gccggctttg ctctgcctct
     4861 cagagggttt tcatgggtgc ttatgaacca ccttgagaag cccatcttct cctggtgtca
     4921 gacggaagct ctcacctcgg ccagtttcca tgggctcatc tttaagtgct tcttgattta
     4981 ttactggtgc tgtttctatt tttcttttgg gtttttattc tgttttgatt tttactagcc
     5041 catcacatag acgtggtcag ggtggcagga aatttgtttg gttccacttg aactgagaaa
     5101 ggagtactga gaagactcct taggtgctcg gagagtgtca ggatgaagtc acccactggt
     5161 tgtcacccca gtgttgtgct aaacactgcc ccccagctca ggcctggtca ccagcacact
     5221 ccctacacta ttttgaaaac ccacaaattc cagggagctt cagaggcaga ggggaaggtg
     5281 ctgtcaattt tccctttgcc caacagcttc tgttagctta cccaaagaca ttcatatttt
     5341 agagacagat caatgagagc accagcatag ccatctcaga gggtcacaca atcttccttg
     5401 tggacctgca gaggcaaacc gagacagagc aagtccccat aggtatgcac tgtccctggt
     5461 gcctctgatg tcccccccac caccaccacc acacacaccc cccctgcagc cataaacgtt
     5521 aaacccctca cgcatgcgct ttcccagcaa gtgctggcat cgtcacctta aactccacca
     5581 cgatttcatt ctgccatcgg agctctgggg ccacaatggt gatgcccctg tgttaaaccc
     5641 atactgtcac ttaagtactg taccctcatg gtcccacaga tgtgtcccta gtgtctctca
     5701 gtcttatggt gctattcaca ctggtgcaag acaaaccact ctccgttgtc tgtggcttga
     5761 cagatcagaa cacagaaaag gagctgtggt ggtgacctct aacctctgct cttttgccat
     5821 tttaaagtca aatgtatata gttcccacga gctaacttac actcagtact gtatctgtgg
     5881 gttctgtctt gtgttgtttt actttggggt gctggttatg aaagaacgca gaagaggaga
     5941 ggataaacaa tggatgccat ttagacatga aaaactcacc atttcgttgg gagcaagttg
     6001 aacatgtgta ataaaatgtt tttccataaa aaaaaaaaaa aaa
//
