LOCUS       NM_172053               4987 bp    mRNA    linear   ROD 27-JUN-2023
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            16 (Adamts16), transcript variant 1, mRNA.
ACCESSION   NM_172053
VERSION     NM_172053.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4987)
  AUTHORS   Yang N, Zhang Q, Ye S, Lu T, Sun M, Wang L, Wang M, Pan YH, Dang S
            and Zhang W.
  TITLE     Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult
            Mice
  JOURNAL   J Dent Res 101 (2), 226-234 (2022)
   PUBMED   34323105
REFERENCE   2  (bases 1 to 4987)
  AUTHORS   Yao Y, Hu C, Song Q, Li Y, Da X, Yu Y, Li H, Clark IM, Chen Q and
            Wang QK.
  TITLE     ADAMTS16 activates latent TGF-beta, accentuating fibrosis and
            dysfunction of the pressure-overloaded heart
  JOURNAL   Cardiovasc Res 116 (5), 956-969 (2020)
   PUBMED   31297506
  REMARK    GeneRIF: ADAMTS16 activates latent TGF-beta, accentuating fibrosis
            and dysfunction of the pressure-overloaded heart.
REFERENCE   3  (bases 1 to 4987)
  AUTHORS   Livermore C, Warr N, Chalon N, Siggers P, Mianne J, Codner G,
            Teboul L, Wells S and Greenfield A.
  TITLE     Male mice lacking ADAMTS-16 are fertile but exhibit testes of
            reduced weight
  JOURNAL   Sci Rep 9 (1), 17195 (2019)
   PUBMED   31748609
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4987)
  AUTHORS   Rutledge EA, Parvez RK, Short KM, Smyth IM and McMahon AP.
  TITLE     Morphogenesis of the kidney and lung requires branch-tip directed
            activity of the Adamts18 metalloprotease
  JOURNAL   Dev Biol 454 (2), 156-169 (2019)
   PUBMED   31242448
REFERENCE   5  (bases 1 to 4987)
  AUTHORS   Zhu R, Pan YH, Sun L, Zhang T, Wang C, Ye S, Yang N, Lu T,
            Wisniewski T, Dang S and Zhang W.
  TITLE     ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the
            Levels of Depression-like Behaviors in Mice
  JOURNAL   Neuroscience 399, 53-64 (2019)
   PUBMED   30579834
REFERENCE   6  (bases 1 to 4987)
  AUTHORS   Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M,
            Hoodless PA, Jones SJ, Marra MA and Helgason CD.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 4987)
  AUTHORS   Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK,
            Carpenter DA, Johnson DK, Rinchik EM and Culiat CT.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   8  (bases 1 to 4987)
  AUTHORS   Juriloff DM, Harris MJ and Dewell SL.
  TITLE     A digenic cause of cleft lip in A-strain mice and definition of
            candidate genes for the two loci
  JOURNAL   Birth Defects Res A Clin Mol Teratol 70 (8), 509-518 (2004)
   PUBMED   15329828
REFERENCE   9  (bases 1 to 4987)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4987)
  AUTHORS   Holmberg M, Leonardsson G and Ny T.
  TITLE     The species-specific differences in the cAMP regulation of the
            tissue-type plasminogen activator gene between rat, mouse and human
            is caused by a one-nucleotide substitution in the cAMP-responsive
            element of the promoters
  JOURNAL   Eur J Biochem 231 (2), 466-474 (1995)
   PUBMED   7543410
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160108.2, AK173338.1 and
            CX216861.1.
            
            [WARNING] On Dec 12, 2023 this sequence was replaced by
            NM_172053.4.
            
            On Jul 13, 2016 this sequence version replaced NM_172053.2.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. This gene is
            co-expressed with the Wilms tumor protein, Wt1, in the developing
            glomeruli of embryonic kidneys. The encoded preproprotein undergoes
            proteolytic processing to generate an active enzyme. [provided by
            RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173338.1, SRR9219382.40027.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC160108.2         9978-10046
            70-4649             AK173338.1         5-4584
            4650-4987           CX216861.1         43-380
FEATURES             Location/Qualifiers
     source          1..4987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 35.97 cM"
     gene            1..4987
                     /gene="Adamts16"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 16"
                     /db_xref="GeneID:271127"
                     /db_xref="MGI:MGI:2429637"
     exon            1..322
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..3931
                     /gene="Adamts16"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 16; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 16 preproprotein; a disintegrin-like and
                     metallopetidase (reprolysin type) with thrombospondin type
                     1 motif, 16; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 16"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 16 preproprotein"
                     /protein_id="NP_742050.2"
                     /db_xref="CCDS:CCDS36723.1"
                     /db_xref="GeneID:271127"
                     /db_xref="MGI:MGI:2429637"
                     /translation="MESRGCAALWVLLLAQVSEQQTPACALGLAAAASGSPEDPQPPP
                     FSGSSWLETGEYDLVSAYEVDHRGDYVSHDIMHYQRRRRRRAVTQPGGDALHLRLKGP
                     RHDLHLDLKAASNLMAPGFMVQTLGKGGTKSVQMFPPEENCFYQGSLRSQGNSSVALS
                     TCQGLLGMIRTKDTDYFLKPLPPHLTSKLNRSAQGDSPSHVLYKRSTERQAPRENEVL
                     MITRKRDLARPHLHHDNFHLGPSQKQHFCGRRKKYMPQPPNDDLYILPDEYKPSSRHK
                     RSLLKSHRNEELNVETLVVVDRKMMQSHGHENITTYVLTILNMVSALFKDGTIGGNIN
                     IVIVGLILLEDEQPGLAISHHADHTLTSFCQWQSGLMGKDGTRHDHAILLTGLDICSW
                     KNEPCDTLGFAPISGMCSKYRSCTVNEDSGLGLAFTIAHESGHNFGMVHDGEGNMCKK
                     SEGNIMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGQ
                     LYDANTQCKWQFGEKAKLCMLDFRKDICKALWCHRIGRKCETKFMPAAEGTLCGQDMW
                     CRGGQCVKYGDEGPKPTHGHWSDWSPWSPCSRTCGGGISHRDRLCTNPRPSHGGKFCQ
                     GSTRTLKLCNSQRCPLDSVDFRAAQCAEYNSKRFRGWLYKWKPYTQLEDQDLCKLYCI
                     AEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGMCERVGCDNVLGSDATEDSCGVCKGNN
                     SDCVTHRGLYSKHHSTNQYYHMVTIPSGARSIHIYETNISTSYISVRNSLKRYYLNGH
                     WSVDWPGRYKFSGATFNYKRSYKEPENLTSPGPTNETLIVELLFQGRNPGVAWEFSLP
                     RSGAKKTPAAQPSYSWAIVRSECSVSCGGGKMNSKAGCYRDLKVPVNASFCNPKTRPV
                     TGLVPCKVSPCPSSWSVGNWSVCSRTCGGGTQSRPVRCTRRAHYRDESIPASLCPQPE
                     PPIHQACNSQSCPPAWSTGPWAECSRTCGKGWRKRTVACKSTNPSARAQLLHDTACTS
                     EPKPRTHEICLLKRCHKHKKLQWLVSAWSQCSVTCQGGTQQRVLRCAEKYISGKYREL
                     ASKKCLHLPKPDLELERACGLIPCPKHPPFDASGSPRGSWFASPWSQCTASCGGGVQR
                     RTVQCLLRGQPASDCFLHEKPETSSACNTHFCPIAEKRGTFCKDLFHWCYLVPQHGMC
                     GHRFYSKQCCNTCSKSNL"
     exon            323..425
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            426..757
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1019
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1219
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1303
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1463
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1569
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1707
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1861
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1957
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2106
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2279
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2410
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2534
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2779
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2918
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3045
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3247
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3442
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3667
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3815
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..4975
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccttctct accctcctcc ctgctgtccc ttggttgctg cgggtgcttt gccgcccccc
       61 gccaccactg ccactccacc tcccggtgcc gaacgaagct gcagtgataa ctctgatgtg
      121 catggtggaa tcgctgcctg gaaaccctgc gattttgccg ggtcggtcct ttgcacccta
      181 gcatactgct aacaccggga ctatccagtg acccagtcta gactgctgag ctgagtcctg
      241 tgagccctcg ggcaccgggg ccatggagtc ccgaggttgt gctgcgctct gggtgctgct
      301 gctggcgcag gtcagtgagc agcagacacc tgcgtgcgcc ctgggactcg cagctgcagc
      361 gtctgggagc ccggaagacc cgcagcctcc cccattctct gggtccagct ggctggaaac
      421 cggtgagtat gacctggtgt ctgcctatga agtagaccac aggggggatt atgtatccca
      481 tgacatcatg cactaccagc ggaggcgtcg gagaagagct gtgacccagc caggaggaga
      541 tgccctgcac ctaaggctta agggccctag gcatgacctc cacctcgacc tcaaagctgc
      601 cagcaacttg atggctcctg gattcatggt gcaaactctg gggaagggag gcaccaagtc
      661 tgtacagatg tttccaccag aagagaactg cttttaccaa ggatccttaa ggtcccaggg
      721 gaattcctca gtggcccttt ctacctgcca aggtttgtta ggcatgataa gaacaaaaga
      781 cactgattac ttcttgaagc cactgcctcc acacctaaca agcaaactga acagatctgc
      841 acagggcgac tccccctccc atgttctgta caagagatct acagagcgcc aggctcctag
      901 agaaaacgaa gtcctgatga tcaccaggaa gcgagatctg gcaagaccac acctgcacca
      961 tgacaacttc catcttggcc cctcacaaaa gcagcatttc tgtggaagac gcaagaaata
     1021 catgcctcag cctcccaacg atgacctcta catcttgcct gatgagtaca agcctagttc
     1081 ccgacacaag cgctcgctct tgaaatccca cagaaatgaa gagttaaatg tggagacact
     1141 ggtggtggtt gacagaaaga tgatgcaaag ccatggccat gaaaacatta cgacttatgt
     1201 cctcaccatt ctcaacatgg tgtctgcctt attcaaggat ggaacaattg ggggaaacat
     1261 caacattgtc attgtgggac tcattctgct ggaagatgaa cagccagggc tggcgattag
     1321 tcaccatgca gaccacacgt taaccagctt ctgccagtgg caatccggat tgatggggaa
     1381 agatggaact cgtcatgacc acgccatctt actgactggt ctggacatat gttcctggaa
     1441 gaatgagccc tgtgacacat tggggtttgc acccataagc gggatgtgca gtaagtaccg
     1501 cagctgcaca gtcaatgaag actcaggact tggactggcc ttcaccattg cccatgagtc
     1561 tggacacaac tttggcatgg tccatgatgg agaagggaat atgtgcaaga aatctgaggg
     1621 caacattatg tccccaacac tggcaggacg caatggtgtc ttctcctggt cttcctgcag
     1681 ccgtcagtac ctgcacaagt tcttaagcac cgcccaagcg atatgtcttg ctgatcagcc
     1741 aaagcctgtg aaagagtata agtaccccga gaagctgccg ggacagttat acgatgcaaa
     1801 tacccaatgc aagtggcagt ttggagagaa agccaagctc tgtatgctgg acttcagaaa
     1861 ggacatctgt aaggccttgt ggtgccatcg gattggaagg aaatgtgaga ccaagttcat
     1921 gccagcagca gagggtactc tgtgtgggca ggacatgtgg tgtcgtggag gacagtgtgt
     1981 caagtacggt gatgaaggcc caaagcccac ccatggccat tggtcagatt ggtccccctg
     2041 gtccccctgc tccaggacct gtgggggagg aatctctcac agagaccgtc tctgtaccaa
     2101 tcccagacca tctcatggag ggaagttttg ccagggctcc acacgcactc tgaagctttg
     2161 caacagtcag agatgccctc tggacagtgt ggatttccgt gctgcccagt gtgccgagta
     2221 taacagcaag cgctttcgag ggtggctcta caagtggaag ccttacaccc agttggaaga
     2281 tcaggactta tgcaaactct actgtatcgc agaaggattt gatttcttct tttctttgtc
     2341 aaataaagtg aaagatggga ctccatgctc ggaggatagc cgtaatgttt gtatagatgg
     2401 gatgtgtgag agggttggct gtgacaatgt ccttggatca gatgcaacag aggactcctg
     2461 tggggtctgc aaggggaata actcagactg tgtcacgcat agagggctct acagtaagca
     2521 ccattccacc aaccagtact accacatggt aaccattcct tctggagctc ggagcattca
     2581 catctacgaa acaaacatct ctacctccta tatttctgtg cgcaattctc tcaagagata
     2641 ttacctgaat ggacactgga gtgtggactg gcctgggcga tacaagtttt cgggtgccac
     2701 cttcaactac aaacggtcct acaaggagcc tgagaattta acctcccctg gaccaaccaa
     2761 tgaaactctg attgtggagc ttttgttcca aggcaggaac cctggtgtgg cctgggaatt
     2821 ttcattgcca aggtcagggg ctaagaagac tccagctgcc cagcccagct actcatgggc
     2881 catcgtacgc tctgagtgct ccgtctcctg tggagggggc aagatgaact caaaggcggg
     2941 atgctacaga gacctgaagg ttccggtgaa tgcatctttc tgcaacccca agacacgacc
     3001 tgtcacaggc cttgtgccct gtaaggtgtc accttgtcct tccagctggt ctgtgggaaa
     3061 ctggagcgtg tgcagccgga catgcggtgg gggcacccag agcaggcccg tgcggtgcac
     3121 acggagggca cactaccgtg acgagtccat cccagccagc ctgtgtccac agcccgagcc
     3181 ccccattcac caagcctgta actctcagag ctgcccacct gcttggagca ctgggccctg
     3241 ggcagagtgc tcaaggacct gtgggaaggg gtggaggaag aggacagtgg cctgcaaaag
     3301 caccaacccc tcagctcgag cccagctgtt gcacgacact gcctgcactt cagaacccaa
     3361 gcctcggacc cacgaaatct gcctgctcaa gcgctgccac aagcacaaga agctacagtg
     3421 gctggtatct gcctggtccc agtgctctgt gacatgccag ggggggacac aacagagagt
     3481 tctcaggtgt gctgagaagt acatctccgg aaagtatcga gagctggcct cgaagaaatg
     3541 cttgcatctg ccaaagcctg acctggagct ggaacgcgcc tgcggcctga ttccctgccc
     3601 caaacaccct ccgtttgatg cttcaggctc cccaagaggc agctggtttg cctcaccctg
     3661 gtctcagtgc acagccagct gtgggggtgg tgtgcagagg aggactgtac agtgcctgct
     3721 tcggggacag ccagcctcag attgcttcct gcatgagaaa cctgagacct cctcagcgtg
     3781 caacacccat ttctgcccca ttgcagagaa gagaggcacc ttctgcaaag acctcttcca
     3841 ctggtgctac ctggtacctc agcacggcat gtgtggccac aggttctaca gcaagcagtg
     3901 ttgcaatacc tgctccaaat ccaacctgtg agctgggacc agtcctggaa acaagaagat
     3961 gtccccatgg cagagagaga ggccagccct gagagctgca tggtgtgcac tgggatgcat
     4021 ccaaaaaaga caggagctgg aagaaggact gtgggtcttt tgacctagag tggatccatg
     4081 tgtttctgag tgtgggaaca cataactgca ccctgttggg tggggaagtg ggatcctgcg
     4141 ggctggtctc ctgcacgtgg aagggagagt ccgtgctata gtgcacagga agcagctttc
     4201 ccccatgttt tcgttcaatg gaatcaagtt ctaaagacag ccagatccaa gctagcaaat
     4261 gctgggtgca tttcttaaaa gaaaaagacc aagaaatcag gaaaatgttc acatatctgc
     4321 catccaagac accagccttc ctcctacttt ggagacccca ttttcactgt gaaaggttta
     4381 cgaaccttga taggcaggta tgggctaatt ctttcctgtc ccagtggctc ctggaacagg
     4441 tacctgcaag ttggatgggg gctatgatat agggctttgc atacttggaa aaacaacatt
     4501 cctgctaagg tgctttctgt acttctggtc tctgagctgg aggggcaact tcaacatttt
     4561 gtcttcttcc tcagcttttt atagtgagtt cctgtctcaa cccatttctc agtgttctgt
     4621 tttaaatgag ggattggaag cactggttac attaaaatct aggtgtccct ggaaagtgag
     4681 ggtcccctgt aatagaaatc agtcaagggg ccaatgtgct gttagtgtta aggtctagac
     4741 tgtgttttgt gtgttgagtg gtttttaaat acatcccata agtttgatta cttctgagct
     4801 gagagcaaag gtcaatagcc tataaaggaa agggcccacg gccacctcca acctctgctc
     4861 ccatctccct ctgcattggt gcttatttct ggtctcccca cttagggcct tcccagtagg
     4921 aacccagata tttatatttg ctgaagtttt ataataaatt ttatattgta tggtgaaaaa
     4981 aaaaaaa
//
