LOCUS       NM_001024139            6033 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            15 (Adamts15), transcript variant 1, mRNA.
ACCESSION   NM_001024139 XM_134720
VERSION     NM_001024139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6033)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6033)
  AUTHORS   Boschann,F., Cogulu,M.O., Pehlivan,D., Balachandran,S.,
            Vallecillo-Garcia,P., Grochowski,C.M., Hansmeier,N.R., Coban
            Akdemir,Z.H., Prada-Medina,C.A., Aykut,A., Fischer-Zirnsak,B.,
            Badura,S., Durmaz,B., Ozkinay,F., Hagerling,R., Posey,J.E.,
            Stricker,S., Gillessen-Kaesbach,G., Spielmann,M., Horn,D.,
            Brockmann,K., Lupski,J.R., Kornak,U. and Schmidt,J.
  TITLE     Biallelic variants in ADAMTS15 cause a novel form of distal
            arthrogryposis
  JOURNAL   Genet Med 24 (10), 2187-2193 (2022)
   PUBMED   35962790
  REMARK    GeneRIF: Biallelic variants in ADAMTS15 cause a novel form of
            distal arthrogryposis.
            Erratum:[Genet Med. 2023 May;25(5):100799. doi:
            10.1016/j.gim.2023.100799.. PMID: 36853234]
REFERENCE   3  (bases 1 to 6033)
  AUTHORS   Agarwal,M., Sharma,A., Kumar,P., Kumar,A., Bharadwaj,A., Saini,M.,
            Kardon,G. and Mathew,S.J.
  TITLE     Myosin heavy chain-embryonic regulates skeletal muscle
            differentiation during mammalian development
  JOURNAL   Development 147 (7) (2020)
   PUBMED   32094117
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6033)
  AUTHORS   Sandireddy,R., Cibi,D.M., Gupta,P., Singh,A., Tee,N., Uemura,A.,
            Epstein,J.A. and Singh,M.K.
  TITLE     Semaphorin 3E/PlexinD1 signaling is required for cardiac
            ventricular compaction
  JOURNAL   JCI Insight 4 (16), 125908 (2019)
   PUBMED   31434798
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6033)
  AUTHORS   Cao,M., Ouyang,J., Guo,J., Lin,S. and Chen,S.
  TITLE     Metalloproteinase Adamts16 Is Required for Proper Closure of the
            Optic Fissure
  JOURNAL   Invest Ophthalmol Vis Sci 59 (3), 1167-1177 (2018)
   PUBMED   29625437
REFERENCE   6  (bases 1 to 6033)
  AUTHORS   Dancevic,C.M., Fraser,F.W., Smith,A.D., Stupka,N., Ward,A.C. and
            McCulloch,D.R.
  TITLE     Biosynthesis and expression of a disintegrin-like and
            metalloproteinase domain with thrombospondin-1 repeats-15: a novel
            versican-cleaving proteoglycanase
  JOURNAL   J Biol Chem 288 (52), 37267-37276 (2013)
   PUBMED   24220035
  REMARK    GeneRIF: these data suggest a role for ADAMTS15 in a wide range of
            biological processes that are potentially mediated through the
            processing of versican.
REFERENCE   7  (bases 1 to 6033)
  AUTHORS   Stupka,N., Kintakas,C., White,J.D., Fraser,F.W., Hanciu,M.,
            Aramaki-Hattori,N., Martin,S., Coles,C., Collier,F., Ward,A.C.,
            Apte,S.S. and McCulloch,D.R.
  TITLE     Versican processing by a disintegrin-like and metalloproteinase
            domain with thrombospondin-1 repeats proteinases-5 and -15
            facilitates myoblast fusion
  JOURNAL   J Biol Chem 288 (3), 1907-1917 (2013)
   PUBMED   23233679
REFERENCE   8  (bases 1 to 6033)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   9  (bases 1 to 6033)
  AUTHORS   McCulloch,D.R., Nelson,C.M., Dixon,L.J., Silver,D.L., Wylie,J.D.,
            Lindner,V., Sasaki,T., Cooley,M.A., Argraves,W.S. and Apte,S.S.
  TITLE     ADAMTS metalloproteases generate active versican fragments that
            regulate interdigital web regression
  JOURNAL   Dev Cell 17 (5), 687-698 (2009)
   PUBMED   19922873
REFERENCE   10 (bases 1 to 6033)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154722.2.
            
            On Aug 13, 2022 this sequence version replaced NM_001024139.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active versicanase enzyme. This gene is located adjacent to a
            related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq,
            Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094677.1, SRR10223970.11091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1277              AC154722.2         175841-177117       c
            1278-1410           AC154722.2         166241-166373       c
            1411-1578           AC154722.2         165670-165837       c
            1579-1862           AC154722.2         165158-165441       c
            1863-2040           AC154722.2         160621-160798       c
            2041-2222           AC154722.2         159320-159501       c
            2223-2398           AC154722.2         159041-159216       c
            2399-6033           AC154722.2         153715-157349       c
FEATURES             Location/Qualifiers
     source          1..6033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.45 cM"
     gene            1..6033
                     /gene="Adamts15"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 15"
                     /db_xref="GeneID:235130"
                     /db_xref="MGI:MGI:2449569"
     exon            1..1277
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..3173
                     /gene="Adamts15"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin and metalloproteinase with
                     thrombospondin motifs 15; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 15; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 15"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 15 isoform 1 preproprotein"
                     /protein_id="NP_001019310.1"
                     /db_xref="CCDS:CCDS22945.1"
                     /db_xref="GeneID:235130"
                     /db_xref="MGI:MGI:2449569"
                     /translation="MLLLGISILALAWRPAGSSEPEWEVVVPIRRDPDINGRHYYRRG
                     TEDSGDQGLIFQITAFQQDFYLHLTPDAQFLAPAFATEYLGVPLQRLTGSSLDLRRCF
                     YSGYVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNTSAPEAQRHSQGAHLLQRR
                     GAPVGPSGDPTSRCGVASGWNPAILRALDPYKPRRTGAGESHNRRRSGRAKRFVSIPR
                     YVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLGDRD
                     TGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMAD
                     VGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSP
                     TLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPITLPEDLPGTSYSLSQQCEL
                     AFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKFCLKGACVERH
                     NPNKYRVDGSWAKWEPYGSCSRTCGGGVQLARRQCSNPTPANGGKYCEGVRVKYRSCN
                     LEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANG
                     TGYFYVLAPKVVDGTLCTPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGDNKSC
                     KRVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGH
                     FVVSAVERDLVVKGSVLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSF
                     YLPKEPREDKSTRPKDPRGSPVLRNSVLSLSNQVEQPDNRPPARWVAGSWGPCSVSCG
                     SGLQKRAVDCRDSPGQQGASACDVDHRPLEKRACGEPCPTWELGNWSPCSKSCGRGFK
                     RRPLKCVGHGGRLLARDQCDLRRKPQELDFCVLRPC"
     exon            1278..1410
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1578
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1862
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2040
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2222
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2398
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..6033
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6007..6012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts15"
                     /note="hexamer: AATAAA"
     polyA_site      6033
                     /gene="Adamts15"
                     /note="major polyA site"
ORIGIN      
        1 gcaccgctag cggctgcggt tcgcgaagca gcccgccacc tcgcgtcact tctccacggc
       61 aaattttcgg ctgtgcactt gacagcgacc gtactaaagc tcccagagcg cgctttgctc
      121 agggaggaac aggtaggagg cgcgggctgc cctgtgcacg ctcgctgctc tgggaggagt
      181 ctcgcggact tggttggctg tcctttctgg gaactgccca ttgtcccggg cgttggtgtg
      241 tgggctacaa ggggacagtg cttgccgtgg gagccgggct aagtcccatc ccagagcgcg
      301 tctgtgcgcg gcccggcgcc atgcttctac tgggcatctc aatcctggct ctcgcctggc
      361 gacctgctgg cagctccgag ccagagtggg aggtggtcgt tccaatccga cgggacccgg
      421 acatcaatgg ccgccactac tacaggaggg gtacggagga ctccggggat cagggtctca
      481 tttttcagat cacagctttt cagcaggact tttatctaca cctgacgcca gatgcccagt
      541 tcctggctcc cgcctttgct actgagtatc taggtgtccc gctgcagagg ctcactggca
      601 gctctctaga cctgcgacgc tgcttctatt ccgggtatgt gaacgcggag ccagactcct
      661 ttgctgctgt gagcctatgc gggggtctcc gcggagcctt tggctaccga ggtgcggagt
      721 atgtcattag ccctctgccc aacaccagcg cgccagaggc gcagcgtcac agccagggcg
      781 cacaccttct ccagcgccgg ggtgctcctg tagggccttc cggagacccc acctctcgtt
      841 gcggggtggc ctcgggctgg aaccccgcca tcctgagggc tctggaccct tataagccac
      901 ggcggacggg cgcgggggag agccacaacc gccgcaggtc tgggcgcgcc aagcgcttcg
      961 tgtctatacc acggtacgtg gagacactgg tggtggcgga cgagtcaatg gtcaagtttc
     1021 acggcgcgga tttggaacat tatctactga cgctgctggc cacggcggcg cgactctacc
     1081 gccaccccag catcctcaac cctatcaaca tcgtggtggt caaggtgcta ctcttaggag
     1141 atcgtgacac tgggcccaag gtcacaggca acgcggccct gactctgcgc aacttctgtg
     1201 cctggcagaa aaagctgaac aaagtgagcg ataagcaccc tgagtactgg gacacagcca
     1261 tcctcttcac cagacaggac ctatgcgggg ctaccacctg tgacaccttg ggtatggctg
     1321 atgtgggcac catgtgtgac cccaagagaa gctgctctgt cattgaggac gatgggcttc
     1381 catcagcctt caccactgcc catgagctgg gccatgtgtt caacatgccc catgacaacg
     1441 tgaaggtgtg tgaggaggtg tttgggaagc tcagagccaa ccacatgatg tctccgaccc
     1501 tcatccagat tgaccgtgcc aacccctggt cagcctgcag cgctgccatt attactgact
     1561 tcctggatag tgggcatggt gactgcctcc tggaccagcc cagcaagccc atcaccctgc
     1621 ctgaggacct gccgggcaca agctacagtt tgagccagca gtgcgagctg gcctttgggg
     1681 tgggctctaa gccctgccca tatatgcagt actgtacaaa gctgtggtgc actggcaagg
     1741 ccaaggggca gatggtgtgc cagactcgcc acttcccctg ggcagatggc accagctgtg
     1801 gggaaggcaa gttctgcctc aagggagcct gcgtggagag acacaaccca aacaagtacc
     1861 gggtggacgg ctcttgggcc aagtgggagc cctacggttc ctgctcccgc acctgcggtg
     1921 ggggcgtgca gctggcccgg aggcagtgca gcaaccctac ccctgccaac ggtggaaaat
     1981 actgcgaggg agtaagagtg aaataccgat cttgcaactt ggagccctgc cccagctcag
     2041 cctctggcaa gagcttccgg gaagagcaat gtgaagcttt caatggctac aaccacagca
     2101 ccaaccggct cactttagct gtggcatggg tacccaagta ctcaggcgtg tcaccacgtg
     2161 acaagtgtaa gctcatctgc cgagccaatg ggactggcta cttctatgta ctagcaccta
     2221 aggtggtgga tggtacgctg tgtactcctg actccacctc ggtctgtgtc caaggcaagt
     2281 gcatcaaggc tggctgcgac gggaatctgg gctccaagaa gaaatttgac aaatgtggtg
     2341 tgtgtggtgg agacaataag agctgtaaga gggtgacagg actcttcacc aagcctatgc
     2401 acggctacaa ttttgtagtg gccatccctg ccggcgcctc cagcattgat atccgtcagc
     2461 gtggttacaa ggggctcatt ggagatgaca actacctggc tttgaagaac agccaaggca
     2521 aatacctgct caatgggcac tttgtggtat ccgctgtaga gcgggacctg gtggtaaaag
     2581 gcagtgtgct acgctatagt ggcactggca ctgcagtgga gagcctgcag gcttctcgac
     2641 ccatcctgga gccactcacc gtggaggtcc tgtcggtggg gaagatgaca ccgccccgtg
     2701 tgcgttattc tttctacctg cccaaagaac ctcgggagga caagtccact cgccccaagg
     2761 accctcgagg ttcccccgtg ttgcgcaaca gtgttctcag cctttccaac caagtagagc
     2821 agccagataa cagacctcct gcgcgctggg tggcaggcag ctggggacct tgctcagtga
     2881 gctgtggcag tggcctacag aagcgagcag tggactgccg ggactcccca gggcagcaag
     2941 gagcctctgc ttgtgatgta gaccatcggc cattggagaa gcgagcctgt ggggaaccct
     3001 gcccaacttg ggagctcggc aactggtcgc cctgttctaa aagctgtggc cgtggattta
     3061 agaggcgtcc gctcaagtgt gtgggccacg gaggcaggct gctggctcgg gaccagtgtg
     3121 acttacgccg caagccccag gaattagact tctgcgtctt gagaccctgc tgaggggtac
     3181 ttggtgtctc actcctttat tctccacccg ctgttgtgct ggtgccgtgg tcagctggag
     3241 cagaggacag cggccagtgg tctgtgtcac agtgtcactc acatccagaa caaggaccat
     3301 gggtctgggt tagaggttcc ttcctccttg gactgggcag ggggaagtta actaatgcac
     3361 agtctacctc atgccctgct tctcgggcca gttgtgggga gacgcttcaa cagaagggtg
     3421 ctgggcagaa ggtgctgaag gccagcttcc aaggaacctg gaagttggat gcctccagtg
     3481 tagaacttca gggaccttgg cccccataat ggaggtcaca ggctgctgga agagccatgg
     3541 cctgcagctt ggcaccctca ggtgatcctg ggagctctga gctgtccctg aacaaggcag
     3601 gggtctggtg gtgcctctgc cttctttctt tttgactgat gtggatctaa gagtaaaact
     3661 gttcaggggt tactagaagc caaagggaca atgagattgg gttcatttgg gtgcaacttc
     3721 cctgtttgct catcttccat cttggtcctc cttgaaagac cagcattttg caacctggat
     3781 ggttaaggca ttagaccagc tggggaagcc ttgatgtggc ccctgatgct tcgaaggcag
     3841 ccagagaaac tacagggacc acttgttgat caagagagag caaatatgac gaacagatgc
     3901 ttgccacgtc aaaggggaga tgatttggtg gctgaagcag agaacacaaa agctctagag
     3961 ggttctgctc tcagtagggt taggatgagt aggtatggag ctgtggggtc tggcctggaa
     4021 gaatgtcatc ctgggatagc gaaaaggagt tctgacactt tggtcatcta gaaaggaaca
     4081 tgtaagagag gctgatgatg aagatcatgc actgccctag ggaccttcca aagtgaccat
     4141 agccctgtac ccactgaggg gaagtggttg tgcctgggag ggtgaggtgc tgagaaccca
     4201 catgctggca agtcagcctt ctactctggc agctcctgct gtctcctgtg ggcatgctac
     4261 attatgtctc ccggccttca gttctctggt aggtaaacgg gcttcattgt ttgctacctc
     4321 agatcatgct ctctaggaca gaagtaacct ggtgctctca cccgtctcag caggatgtgc
     4381 tcagccacgg aaataagtct gtgcgtggct ttcctgatcc catagcctgg ctatcagctg
     4441 gggctctaaa tacaaagaca gagtcgggta gggtatcttc ttcctcaggt tccttgggat
     4501 catgttttag aaacacttaa gaatcagtac cctgaccttg ggacactgga gacccatctg
     4561 tcattcttgt agacatggca gtcaaaaaga aatccaggtg tttcttatag cagggtaatt
     4621 cttgaagact tggaagctcc aatgtatata ggacatctcc aaagactcgg cagtacatcc
     4681 aggacctcag cggaggacta gatggagaca agaccaaaac ccttgtcttc actgtggagg
     4741 aggggggtct ttgtcagtcc ttttacatgt tccctagtag tcagaatcca cagaccagct
     4801 tagcccctag agcagtggtt ctcagcctcc taatgctgca acctataata tggttcctca
     4861 tgttgtggtg acccccaacc ataaaagtat tttcattgct acttcataac taatttttct
     4921 accgttgtga atcatactgt aaatttctat gttttccaat ggtcttaagc aacccctatg
     4981 aaagggtaga ttgacctcca aaggtaccgc tacccacagg ctgagaacga ctactctaga
     5041 ctgttattct aaccctggtc tgtctctggg ctgtagacct agaacagaac tcctacagtg
     5101 ggtgaagggc atgcgaccct ctgagactag gatgccatca ctggcgaagg acatcgtact
     5161 tcggatttat agcgacaaaa tgagtacgtc agagttgtag tgacaaaagg tccccagggc
     5221 ctgaggctga aggggagcct tgcttgctga tgagaacatg gtgccctgtg cttggggcat
     5281 tctgtccctg tgaagagagg cactgctggg ctgagtggaa agggtcgagg tacaggcagg
     5341 tgggcagtga ggtgctctca ctaaggtgac tggcctctaa cagcattgct gtcagctgtt
     5401 ttacaagtca tttcaaggag ggatggccac tcttgttcct gactcatgcc aggtatccac
     5461 actctttttc ctgtcacaat agtttttatt tttgttttaa aatttcttct tttgaaaaga
     5521 actatgacga agacaacttg ggaagtttgt cttgcttttg aacattttct gtcaacccgt
     5581 gctgagcaga ggtgaggtgg aggcacaggt ttctaatgat ggaataaaaa gtcaaagtga
     5641 tgtctcacac ttatggagaa ggacgttctg ggggctccag gagtatcttc attgggttat
     5701 ggaccagtaa gactttgggt tagggatccc ctagtctctt ctgcctattg tgtgcactga
     5761 ttggagggtt tagaccaatc cctcctctta tggagctcat catgttaggg aggaggctgg
     5821 aaggagccca gcgtggaagt cggctcctgg agactctaga tactgttgct agagcctctt
     5881 cccctttggg cttgcttctt ttgcatttcg tgtactgcag aaggatgaga gggtctggcg
     5941 actggctgag tgtgtatact gtgtatacat gggagctggc tgctgaggtg acagcgacct
     6001 cctcctaata aagtaggata tatttaaaac ttg
//
