LOCUS       NM_001081127            5169 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            14 (Adamts14), transcript variant 1, mRNA.
ACCESSION   NM_001081127 XM_137117
VERSION     NM_001081127.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5169)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 5169)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5169)
  AUTHORS   Carter,E.P., Yoneten,K.K., Gavara,N., Tyler,E.J., Gauthier,V.,
            Murray,E.R., Ten Dijke,P., Cameron,A.J., Pearce,O. and Grose,R.P.
  TITLE     Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast
            differentiation and function
  JOURNAL   J Pathol 262 (1), 90-104 (2024)
   PUBMED   37929635
  REMARK    GeneRIF: Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast
            differentiation and function.
REFERENCE   4  (bases 1 to 5169)
  AUTHORS   Kentistou,K.A., Luan,J., Wittemans,L.B.L., Hambly,C., Klaric,L.,
            Kutalik,Z., Speakman,J.R., Wareham,N.J., Kendall,T.J.,
            Langenberg,C., Wilson,J.F., Joshi,P.K. and Morton,N.M.
  TITLE     Large scale phenotype imputation and in vivo functional validation
            implicate ADAMTS14 as an adiposity gene
  JOURNAL   Nat Commun 14 (1), 307 (2023)
   PUBMED   36658113
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5169)
  AUTHORS   Dupont,L., Joannes,L., Morfoisse,F., Blacher,S., Monseur,C.,
            Deroanne,C.F., Noel,A. and Colige,A.C.
  TITLE     ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for
            pro-VEGFC activation and lymphatic homeostasis
  JOURNAL   JCI Insight 7 (8), e151509 (2022)
   PUBMED   35316211
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5169)
  AUTHORS   Rosell-Garcia,T., Paradela,A., Bravo,G., Dupont,L., Bekhouche,M.,
            Colige,A. and Rodriguez-Pascual,F.
  TITLE     Differential cleavage of lysyl oxidase by the metalloproteinases
            BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine
            sulfate domain
  JOURNAL   J Biol Chem 294 (29), 11087-11100 (2019)
   PUBMED   31152061
REFERENCE   7  (bases 1 to 5169)
  AUTHORS   Dupont,L., Ehx,G., Chantry,M., Monseur,C., Leduc,C., Janssen,L.,
            Cataldo,D., Thiry,M., Jerome,C., Thomassin,J.M., Nusgens,B.,
            Dubail,J., Baron,F. and Colige,A.
  TITLE     Spontaneous atopic dermatitis due to immune dysregulation in mice
            lacking Adamts2 and 14
  JOURNAL   Matrix Biol 70, 140-157 (2018)
   PUBMED   29649548
  REMARK    GeneRIF: Mice lacking Adamts2 and Adamts14 develop spontaneous
            atopic dermatitis due to immune dysregulation.
REFERENCE   8  (bases 1 to 5169)
  AUTHORS   Le Goff,C., Somerville,R.P., Kesteloot,F., Powell,K., Birk,D.E.,
            Colige,A.C. and Apte,S.S.
  TITLE     Regulation of procollagen amino-propeptide processing during mouse
            embryogenesis by specialization of homologous ADAMTS proteases:
            insights on collagen biosynthesis and dermatosparaxis
  JOURNAL   Development 133 (8), 1587-1596 (2006)
   PUBMED   16556917
REFERENCE   9  (bases 1 to 5169)
  AUTHORS   Colige,A., Vandenberghe,I., Thiry,M., Lambert,C.A., Van Beeumen,J.,
            Li,S.W., Prockop,D.J., Lapiere,C.M. and Nusgens,B.V.
  TITLE     Cloning and characterization of ADAMTS-14, a novel ADAMTS
            displaying high homology with ADAMTS-2 and ADAMTS-3
  JOURNAL   J Biol Chem 277 (8), 5756-5766 (2002)
   PUBMED   11741898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151895.4 and AC123530.4.
            
            On Jun 29, 2018 this sequence version replaced NM_001081127.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158014.1, AK145103.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AC151895.4         134048-134311       c
            265-665             AC151895.4         131749-132149       c
            666-822             AC151895.4         110496-110652       c
            823-1013            AC151895.4         106818-107008       c
            1014-1097           AC151895.4         91310-91393         c
            1098-1245           AC151895.4         90548-90695         c
            1246-1351           AC151895.4         87999-88104         c
            1352-1495           AC123530.4         163747-163890       c
            1496-1628           AC123530.4         162683-162815       c
            1629-1742           AC123530.4         161194-161307       c
            1743-1891           AC123530.4         160268-160416       c
            1892-2067           AC123530.4         156768-156943       c
            2068-2201           AC123530.4         151940-152073       c
            2202-2325           AC123530.4         151534-151657       c
            2326-2406           AC123530.4         149998-150078       c
            2407-2570           AC123530.4         145710-145873       c
            2571-2739           AC123530.4         143774-143942       c
            2740-2872           AC123530.4         143257-143389       c
            2873-3080           AC123530.4         141233-141440       c
            3081-3210           AC123530.4         139586-139715       c
            3211-3321           AC123530.4         138773-138883       c
            3322-5169           AC123530.4         135522-137369       c
FEATURES             Location/Qualifiers
     source          1..5169
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.16 cM"
     gene            1..5169
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 14"
                     /db_xref="GeneID:237360"
                     /db_xref="MGI:MGI:2179942"
     exon            1..264
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..3803
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 14; a disintegrin
                     and metalloproteinase with thrombospondin motifs 14; a
                     disintegrin-like and metallopeptidase (reprolysin type)
                     with thrombospondin type 1 motif, 14"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 14 precursor"
                     /protein_id="NP_001074596.1"
                     /db_xref="CCDS:CCDS35915.1"
                     /db_xref="GeneID:237360"
                     /db_xref="MGI:MGI:2179942"
                     /translation="MAWLRALLHCLLPWYCALCAAAGSQTPDLRLSGKLHDYVVTVPC
                     STDFQGRFLSHVVSAPAAPSPRSHLRVARSPLSLERETPRPGGPRQHFLYFNVTVFGK
                     LLHLRLQPNRRLVAPGAPVEWQEDFRELFRQPLQQECVYTGGVTGMPGAAVAISNCDG
                     LAGLIRTDNSDYFIEPLERGQQEKEAGGRTHVVYRREAVQREWKEPHGDLHNEAFGLG
                     DLPNVLDLVGDRLGDAERKRRHAKPGSYSIEVLLAVDDSVVRFHGREHTQNYVLTLMN
                     IVDEIYHDESLGAHVNIALVRLIMVGYRQSLSLIERGNPARSLEQVCRWAHSQQRQDP
                     SHTEHHDHVIFLTRQNFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVVAHETGHVLG
                     MEHDGQGNGCDDETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFER
                     TWPQPPELPGIDYSMDEQCRFDFGTGYHTCLAFRTFEPCKQLWCSHPDNPYFCKTKKG
                     PPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTNFGSCSRSCGGGVRSRSRSC
                     DNPPPAYGGRPCSGSMFEYQICNSEDCPGPYEDFRAQQCAKRNSYYTHQDAKHSWLPY
                     EPDSDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPFGCDKEVG
                     SMKTDDKCGVCGGDNSHCRTVKGTLGKGSKQAAALKQVQIPAGARHIQIELLEKAPHR
                     IAVKNQVTGSFIFNPKGKEASSRTFTALGLEWEHEAEDTKDSLRTNGPLPEAIAILVL
                     PPAEGKPRGSLAYKYVIHEDLLPLIGSNNVLLEETDTYEWALKSWSPCSKACGGGIQF
                     TKYGCRRRRDHHMVHRHLCDHKKRPKPIRRRCNQHSCPQPTWVTEEWGACSRSCGKLG
                     LQTRGVQCLLPLSNGTHKAMPAKACLGNRPEAKKPCLRVPCPAQWRTGAWSQCSATCG
                     EGIQQRQVVCRNTSSALGPCEGVKPDMVQICSLPACGGDLQNSTVKAEVQDPVTKTGY
                     REPQSRPLTPEDRISTMEPCVRDRSVFCRMEVLDRYCTIPGYHRLCCESCIKKTSGPN
                     ASLALPPTFSTPGSLLPAPKATLEDVKSTRGPTSLEDHRQSQPTQLPDVADRISPVTQ
                     YPVTPQMLSPKAFPGNSPATPRRPPQDWTQTAMPTSEGQGQSREEPGHGGTSLPATSP
                     VT"
     exon            265..665
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            666..822
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1013
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1097
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1245
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1351
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1495
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1628
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1742
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1891
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2067
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2201
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2325
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2406
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2570
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2739
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2872
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3080
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3210
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3321
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..5169
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5169
                     /gene="Adamts14"
                     /gene_synonym="Adamts-14; TS14"
                     /note="major polyA site"
ORIGIN      
        1 gccgagtccc tgcggctcgg gacagcgcgg gcggactgag ctaccgccgc tggagccaac
       61 agtgagggcg ccgtgctggg gggccgggaa cgggccagca ggaggcggag gctgccggct
      121 gctctgcgat ccggcagtcc cgggactctg actcctggag gtccccgtcc ccgcgcagcc
      181 acatggcttg gctccgagct ctgctccact gcctgctgcc ctggtactgc gcgctctgtg
      241 ccgccgccgg cagtcagacc ccagacctgc gcctctctgg gaaacttcac gactatgttg
      301 tgacggtgcc ttgcagcaca gatttccagg gacgcttctt gtcccatgtg gtgtctgccc
      361 ccgcagctcc ctcaccacgg agccacctcc gcgtggctcg cagccccctg agcctggaaa
      421 gagagacccc gaggcctggc ggtccgaggc agcatttcct ctactttaat gtgactgtct
      481 ttgggaagct gcttcacttg aggctgcagc cgaaccggag gttggtggcc ccaggggccc
      541 cggtggaatg gcaggaggac tttcgggaac tcttccgaca acccttgcag caggagtgtg
      601 tgtacactgg aggtgtcact ggaatgcccg gggcagctgt ggccatcagc aactgtgatg
      661 gattggccgg cctcatccgc acagacaact cagactactt catcgagccc ctggagcgag
      721 ggcagcagga gaaagaggct ggtgggagga cccatgtggt ataccgccgg gaagccgtcc
      781 agagggagtg gaaagagcct catggtgacc ttcacaacga agcctttggc cttggcgacc
      841 ttcccaacgt gctggatctg gtgggggacc ggctgggtga cgcagagcgg aagcggcgac
      901 acgccaagcc cggcagctac agcatcgagg ttctgctggc ggtggatgac tcggtggtcc
      961 gcttccacgg cagggagcat acgcagaact acgtgctgac gctcatgaat atcgtggatg
     1021 agatttacca tgacgaatcg ctgggagccc acgtgaacat cgcccttgtc cgcctgatca
     1081 tggtgggcta ccgacagtcc ctgagcctga ttgagcgagg gaacccagcg cgcagcctgg
     1141 agcaggtgtg tcgctgggca cactcccagc agcgccagga ccctagccac actgaacatc
     1201 acgaccacgt catcttcctc acgcgccaga acttcggccc ctcggggtat gcacctgtta
     1261 ctgggatgtg ccacccacta agaagctgtg ccctcaacca cgaggatggc ttctcctcag
     1321 cttttgtcgt ggctcatgag acaggccatg tgcttggcat ggagcatgac ggccagggca
     1381 atggctgcga tgatgagacc agtctgggca gcgtcatggc gcccctggtt caggccgcct
     1441 tccacaggtt ccactggtct cgctgcagca agctggagct cagccgctac ctcccatcct
     1501 acgattgcct ccttgatgac cccttcgagc gcacctggcc ccagccccca gaactgcccg
     1561 ggatcgacta ctccatggat gagcaatgcc ggttcgactt tggcactggg taccacacct
     1621 gcttagcttt caggaccttt gagccctgca agcagctatg gtgcagccac cctgacaacc
     1681 catacttctg caagaccaag aaggggccgc cgctggatgg gacagagtgt gcaccaggca
     1741 agtggtgctt caaaggccat tgtatctgga agtcaccaga gcaaacttat ggccaggatg
     1801 gaggctggag ttcctggacc aattttggct catgttctcg gtcgtgtgga ggaggggtgc
     1861 gatcccgaag ccggagctgc gacaaccctc ctccagccta tggaggccgc ccgtgctcag
     1921 ggtccatgtt tgagtaccag atctgcaaca gtgaggactg tcctgggccc tacgaggact
     1981 tccgagccca gcagtgtgcc aagcgaaact cctactatac ccaccaggat gccaagcaca
     2041 gctggctgcc ctatgagccc gacagtgatg cccagaagtg cgagctcatt tgccagtctg
     2101 ccgacactgg agatgtggta tttatgaacc aagtagtcca cgatgggaca cgctgcagct
     2161 atcgcgatcc ttacagcgtc tgtgcccgtg gcgagtgtgt gccctttggt tgcgacaagg
     2221 aggtgggatc catgaagacg gatgacaagt gcggtgtctg cggtggggac aattctcact
     2281 gtaggactgt gaaggggact ctgggaaagg gctccaagca ggcagcggct ctcaaacagg
     2341 tgcagatccc ggcgggtgcc aggcacattc agattgaatt gctggagaag gctccccacc
     2401 gaatcgcggt gaagaaccag gtgaccggaa gcttcatctt caaccccaag ggcaaggagg
     2461 cctctagcag gaccttcact gcgctgggcc tagagtggga gcacgaagcg gaggacacca
     2521 aggacagcct caggaccaat ggacccctgc ctgaagccat cgccatcctg gttcttcccc
     2581 cggctgaggg taaaccccga ggtagcctgg cctacaagta cgtcatccat gaggacctgc
     2641 tgcccctcat cgggagtaat aatgtgctcc tggaagagac agacacctac gaatgggctc
     2701 tcaagagctg gtctccctgc agcaaggcct gtggaggagg aatccagttc actaaatatg
     2761 gctgccggcg ccgcagggac caccacatgg tgcaccggca cctgtgtgac cataaaaaga
     2821 ggcccaagcc tatccgacgg cgttgcaacc agcactcgtg tccccagccc acgtgggtga
     2881 cagaagagtg gggtgcctgt agccgaagct gcgggaagct ggggctgcag acccggggag
     2941 tgcagtgcct gctgcctctc tccaatggca cccacaaagc catgccagcc aaggcctgcc
     3001 taggtaaccg gccagaggcc aagaagccat gcctccgtgt gccctgccca gcccagtggc
     3061 ggacaggagc ctggtcccag tgctctgcta cctgcggaga aggcatccag caaaggcagg
     3121 tggtatgcag gaacacttcc agtgccctcg ggccatgcga aggggtcaag ccggacatgg
     3181 tgcagatctg cagcctgcct gcctgtggag gagatctcca gaactctaca gtgaaggcgg
     3241 aggtccagga ccctgtgacc aaaacaggat accgggaacc ccaatccagg cccctgactc
     3301 ctgaggacag gatctcaaca atggagccct gtgtgcgaga cagatccgtc ttctgccgaa
     3361 tggaagtgtt ggaccgttac tgcaccatcc ccggctacca ccgtctatgc tgtgagtctt
     3421 gcataaagaa gacctcaggc cccaatgcca gcctggcctt accacccacc ttctccactc
     3481 ctgggagtct cttgccagca cccaaggcca ccctggagga tgtgaagtct acaagggggc
     3541 caaccagcct ggaagatcat cggcaaagcc agcccacaca gctaccagat gtggcggaca
     3601 ggatctcccc agtgactcag tatccggtca ccccccagat gctaagccct aaagcgtttc
     3661 cgggcaattc tcctgctacc ccacggaggc cacctcagga ctggacccaa acagctatgc
     3721 caacctctga gggtcaagga cagtccaggg aggaaccagg gcatggaggc accagccttc
     3781 ccgccacctc cccagtgaca tgagcccatc cctccagtct tttttacact ctgcctgtgg
     3841 tcccagggat cctggctcag aggactcaag cgcaggggac aggaggtagc acaggttccc
     3901 ttttaaatta tttgccctct tgttctgttt ggggctgtga cgctctttac tcccgtgaca
     3961 gggttggggg aggagaggga gatcagggac tgccctaacc agaaatacct cagctagcag
     4021 agtccgggct ccacttccca gagtttttat atgatttgtt cctctagtct cagtaatgcc
     4081 ccttcccata cccactgggc catacagggc tgaagcccat gcaggagcct gtcagagatt
     4141 cttgcttgtc catgacttct gactaccagg gaggcctgtc cagccataca cacacacaca
     4201 cacacacaca cacacacaca cacacacaca cacacacaca ccaaagacaa agcaggactc
     4261 aggaggtagg gctgcacaca ggcagacttg ggaagggtcc gggatggatg tagaggtgag
     4321 gcttcatggc tgcagggtcg ggcaggggag agttcttctc aggcctggct cttgtcagct
     4381 gatggctgct aatctcgggc agagatcagt tcacctttgc cggccatagt gtcactttcg
     4441 tggcccgatc tgtccctgta gatgtcactg ctggtgactc taggtaacag actgaccctc
     4501 caatgtcaca cccaagtcac cagaggagga ggcctggata cacagctttg acatccagga
     4561 gttaacaagc tggggcttgg tccctggtta gaccaggatc ggtgacttca gtcatcacgg
     4621 gggcttgcag gagacccagc ctgaaaggtg accaccggaa agatgtcacc tctaagactg
     4681 tccccctcag tcatcactct ctgctgaagt ctactcctcc tggagttgag ggcgggggct
     4741 cttcccttct ggcttaaact gggcccgaat gcgtgatgct cagaagacca gtcaggtggc
     4801 tagcgacttg agaatccact cagctggact gtgcagaggg ccctggcagg atgctagctg
     4861 ctgttgatcc caggttaggg tagggaagat gcgtagagca ccttccatgg tcctcagact
     4921 ctcaggaaat tgcctagacc ctcactcagt ttgagggcca agtggcagag gtgcttgtct
     4981 atccaccttc ctccgctgga ggaaggaaag cccctggcct gcaagctctg gagagctggg
     5041 atgctgggaa ctctgcatgc tcctcccact cctgtctcct gctctgcagg tgcctggagc
     5101 taccctgagt caagtcatgt gtggaccggc ctggagatgc tgatttttaa aacgttacct
     5161 atttattaa
//
