LOCUS       NM_001290465            3447 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            13 (Adamts13), transcript variant IAP-b, mRNA.
ACCESSION   NM_001290465 XM_006498102
VERSION     NM_001290465.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3447)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 3447)
  AUTHORS   Kwak,H., Choi,G., Kim,S., Park,J.M., Kwon,Y., Lee,Y., Lee,C.,
            Yang,S., Cataland,S., Kim,S., Bang,S.M., Yoon,J.H., Lee,W. and
            Nam,H.J.
  TITLE     GC1126A, a novel ADAMTS13 mutein, evades autoantibodies in
            immune-mediated thrombotic thrombocytopenic purpura
  JOURNAL   Sci Rep 15 (1), 1613 (2025)
   PUBMED   39794345
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3447)
  AUTHORS   Jiang,H., Hu,J., He,P., Wu,Y., Li,F. and Chen,Q.
  TITLE     ADAMTS13 deficiency exacerbates neuroinflammation by targeting
            matrix metalloproteinase-9 in ischemic brain injury
  JOURNAL   Neuroreport 35 (7), 447-456 (2024)
   PUBMED   38597325
  REMARK    GeneRIF: ADAMTS13 deficiency exacerbates neuroinflammation by
            targeting matrix metalloproteinase-9 in ischemic brain injury.
REFERENCE   4  (bases 1 to 3447)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3447)
  AUTHORS   Zhou,W., Bouhassira,E.E. and Tsai,H.M.
  TITLE     An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13
            variant proteins that are less effective in cleaving von Willebrand
            factor multimers
  JOURNAL   Blood 110 (3), 886-893 (2007)
   PUBMED   17426255
  REMARK    GeneRIF: the plasma ADAMTS13 activity levels of mouse strains
            segregated into a high and a low group. Low ADAMTS13 activity was
            detected in mice containing 2 alleles of intracisternal A-type
            particle (IAP) retrotransposon sequence
REFERENCE   6  (bases 1 to 3447)
  AUTHORS   Banno,F., Kokame,K., Okuda,T., Honda,S., Miyata,S., Kato,H.,
            Tomiyama,Y. and Miyata,T.
  TITLE     Complete deficiency in ADAMTS13 is prothrombotic, but it alone is
            not sufficient to cause thrombotic thrombocytopenic purpura
  JOURNAL   Blood 107 (8), 3161-3166 (2006)
   PUBMED   16368888
REFERENCE   7  (bases 1 to 3447)
  AUTHORS   Motto,D.G., Chauhan,A.K., Zhu,G., Homeister,J., Lamb,C.B.,
            Desch,K.C., Zhang,W., Tsai,H.M., Wagner,D.D. and Ginsburg,D.
  TITLE     Shigatoxin triggers thrombotic thrombocytopenic purpura in
            genetically susceptible ADAMTS13-deficient mice
  JOURNAL   J Clin Invest 115 (10), 2752-2761 (2005)
   PUBMED   16200209
REFERENCE   8  (bases 1 to 3447)
  AUTHORS   Zhou,W., Inada,M., Lee,T.P., Benten,D., Lyubsky,S.,
            Bouhassira,E.E., Gupta,S. and Tsai,H.M.
  TITLE     ADAMTS13 is expressed in hepatic stellate cells
  JOURNAL   Lab Invest 85 (6), 780-788 (2005)
   PUBMED   15806136
  REMARK    GeneRIF: Identification of the liver cell-type expressing ADAMTS13
            will have is important for understanding pathophysiological
            mechanisms regulating ADAMTS13 expression.
REFERENCE   9  (bases 1 to 3447)
  AUTHORS   Bruno,K., Volkel,D., Plaimauer,B., Antoine,G., Pable,S.,
            Motto,D.G., Lemmerhirt,H.L., Dorner,F., Zimmermann,K. and
            Scheiflinger,F.
  TITLE     Cloning, expression and functional characterization of the
            full-length murine ADAMTS13
  JOURNAL   J Thromb Haemost 3 (5), 1064-1073 (2005)
   PUBMED   15869605
  REMARK    GeneRIF: characterization of the full-length murine ADAMTS13
REFERENCE   10 (bases 1 to 3447)
  AUTHORS   Banno,F., Kaminaka,K., Soejima,K., Kokame,K. and Miyata,T.
  TITLE     Identification of strain-specific variants of mouse Adamts13 gene
            encoding von Willebrand factor-cleaving protease
  JOURNAL   J Biol Chem 279 (29), 30896-30903 (2004)
   PUBMED   15136581
  REMARK    GeneRIF: analysis of strain-specific variants of mouse Adamts13
            gene encoding von Willebrand factor-cleaving protease
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL773563.12, EU034706.1 and
            AL845266.2.
            
            On Mar 13, 2014 this sequence version replaced XM_006498102.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. In certain
            mouse strains (C57BL/6, for example) an intracisternal A-type
            particle (IAP) retrotransposon sequence is located in the intron 23
            that causes an alternate splicing event resulting in a shorter
            transcript variants encoding shorter isoforms. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active enzyme that cleaves von Willebrand factor (VWF) in
            circulating blood. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (IAP-b) uses an alternate in-frame
            splice site and lacks an alternate in-frame exon in the central
            coding region, and it also lacks seven 3' exons but instead
            contains an alternate 3' terminal exon and thus differs in the 3'
            coding region and 3' UTR, compared to variant 1. The encoded
            isoform (IAP-b) has a distinct C-terminus and is shorter than
            isoform 1. This isoform (IAP-b) may undergo proteolytic processing
            similar to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU034706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL773563.12        176947-177067
            122-1181            EU034706.1         1-1060
            1182-1182           AL845266.2         3948-3948
            1183-3447           EU034706.1         1062-3326
FEATURES             Location/Qualifiers
     source          1..3447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.14 cM"
     gene            1..3447
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 13"
                     /db_xref="GeneID:279028"
                     /db_xref="MGI:MGI:2685556"
     exon            1..238
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..3208
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /EC_number="3.4.24.87"
                     /note="isoform IAP-b precursor is encoded by transcript
                     variant IAP-b; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 13; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 13; von Willebrand factor-cleaving protease;
                     vWF-cleaving protease; vWF-CP mRNA for von Willebrand
                     factor-cleaving; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 13"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 13 isoform IAP-b precursor"
                     /protein_id="NP_001277394.1"
                     /db_xref="GeneID:279028"
                     /db_xref="MGI:MGI:2685556"
                     /translation="MSQLCLWLTCQPCYAVSVRGILTGAIFILGCWGLSDFQKSLLQD
                     LEPKDVSSYFGHHAAPFTGHPPSHLQRLRRRRTLEDILHLELLVAVGPDVSRAHQEDT
                     ERYVLTNLNIGSELLRNPSLGVQFQVHLVKLITLSDSESTPNITANITSSLMSVCEWS
                     QTINPHDDRDPSHADLILYITRFDLELPDGNQQVRGVTQLGGACSLSWSCLITEDTGF
                     DLGVTIAHEIGHSFGLDHDGAPGSGSTCKASGHVMAADGATPTGGTLEWSACSQRQLQ
                     HLLSTGQMHCFQDPPGLQSGLTRHQLMAQPGLYYSADDQCRVAFGSGAVACTFSREGL
                     DVCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKARCRSLAELAPVAAVHGHW
                     SSWGPHSPCSRSCGGGVITRRRWCNNPRPAFGGRACVGEDLQAKMCNTQACEKTQLEF
                     MSEQCAQTDRQPLQLSQGTASFYHWDAAVQYSQGDTLCRHMCWAVGESFIVSRGDRFL
                     DGTRCVPSGPQDDGTLSLCLLGSCRTFGCDGRMDSQKVWDACQVCGGDNSTCSSRNGS
                     FTAGRAREYVTFLIVTPNMTNAHIVNRRPLFTHLGEMPEDPSLYLATDFLVFEMPPPL
                     TPGAWWEKPNSPDPLRAATLTAKLIPGKVYRRYGGEYGDLTHPDITFSYFQLKQQAAW
                     VWTAKRGPCSVSCGAGLRWVTYSCQDQAQDKWVKNAQCQGSPQPPAWQEPCVSAPCSP
                     YWVAGDFSPCSVSCGGGLRERSLRCVETQDGFLKTLPPARCRAVAQQPAAEVENCNSQ
                     PCPTRWEVSDPGPCMSSACEAGLDSRNVTCVSRAGDPEKPETAGPCRTDEMSAMLEPC
                     SRSLCSPGLGQVDNTMSLGEEAPSPVGSDKPGAQAEHVWTPLVGLCSISCGRGLKELY
                     FLCMDSVLKMPVQEELCGLASKPPSRWEVCRARPCPARWETQVLAPCPVTCGGGRVPL
                     SVRCVQLDRGHPISVPHSKCSPVPKPGSFEDCSPEPCPARALVWEAAPTFAVTRWR"
     exon            239..308
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            309..457
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            458..541
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            542..666
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            667..813
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            814..960
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1123
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1228
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1380
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1444
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1571
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1720
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1841
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2077
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2213
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2343
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2529
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2722
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2846
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2976
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3156
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3447
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaagctcc caagagtaaa cactgcctga tgtcccgccc agccagcaag tgaacattgc
       61 acactaacca gaatcccagt cactagggct cctgtccggc catcaactgc cttttctaaa
      121 gatgagccag ctttgcctgt ggttgacgtg ccagccttgt tatgctgtca gtgtcagagg
      181 aatcctcact ggtgccatct tcattctggg ctgctggggg ctctctgact tccagaagag
      241 tcttcttcaa gatctggagc ccaaggatgt gtcttcttac tttggccacc atgctgctcc
      301 attcacaggc catcctccct ctcacctcca gagactgaga cggagaagga ctttggagga
      361 cattctgcac ctggaactcc tggtagctgt gggccccgat gtttcccggg ctcatcagga
      421 ggacacagaa cgctacgtgc tcactaatct caatatcggg tcagaactgt tgagaaaccc
      481 atccctggga gtccagttcc aggtgcacct ggtgaagcta atcaccctct ctgactcaga
      541 gagtactccg aatatcacgg ccaacatcac ctcatccttg atgagcgtct gcgagtggag
      601 ccagacgatc aacccccacg atgacaggga tccaagtcac gctgacctga ttctctatat
      661 caccaggttt gacctggagt tgcctgatgg caaccagcag gttcggggtg tcacccagct
      721 gggaggtgcc tgctcccttt cctggagttg ccttatcact gaggatactg gctttgacct
      781 gggggtcacc atcgcccatg agattgggca cagcttcggg ctggaccatg atggtgctcc
      841 aggtagtggc agcacctgca aggccagtgg ccacgtgatg gcggctgatg gcgcaacacc
      901 tactggaggg accctggagt ggtctgcctg cagccaaagg cagttgcagc acctactcag
      961 cacagggcaa atgcactgct tccaggaccc acctgggctg cagtcaggac ttacacggca
     1021 ccagctgatg gcacagcctg gcctctacta cagtgcagat gatcagtgcc gtgtggcttt
     1081 cggttctggg gctgtcgcct gcaccttctc cagggagggt ctggatgtat gccaggccct
     1141 gtcctgccac acagacccct tggaccaaag cagctgcagc cgcctccttg ttcctctcct
     1201 ggatgggaca gaatgtggtg tggagaagtg gtgctccaag gctcgctgtc gctccctagc
     1261 tgagctggct cctgtggctg cagtacatgg acactggtct agctggggcc cccatagtcc
     1321 ctgctcccga tcctgtggag gaggtgtgat taccaggagg cggtggtgca acaaccccag
     1381 gcctgcattt gggggacgtg catgtgtggg tgaagacctc caggctaaga tgtgcaacac
     1441 gcaggcttgt gagaagactc agctggagtt catgtccgag cagtgtgccc agacagacag
     1501 acaaccactg caactttccc aaggcactgc ctccttctac cactgggatg ctgctgtgca
     1561 gtatagtcaa ggagataccc tgtgcagaca catgtgctgg gctgttggag aaagcttcat
     1621 tgtcagccgt ggggacaggt tcctagatgg gacccgttgt gtgccaagtg gtcctcagga
     1681 tgatgggacc ctaagcctct gtttgttggg cagctgcagg acctttggct gtgatggcag
     1741 gatggactcc cagaaggttt gggatgcgtg ccaggtgtgt ggaggagaca acagcacctg
     1801 cagctcacgg aatggttctt tcacagctgg gagagccaga gaatatgtca cgttcctgat
     1861 tgttactccc aacatgacca acgcacacat tgtcaaccgc aggcctctct tcacacactt
     1921 gggtgagatg ccagaggatc cttccttgta cttagccact gatttcttag tcttcgagat
     1981 gcctccaccc ctaacacctg gtgcctggtg ggagaaaccc aactccccag acccccttag
     2041 agctgctaca ctcacagcta agcttatccc agggaaggtg tacagacgat atggaggaga
     2101 atatggggat cttacacacc cagacatcac cttttcctac tttcaactga agcagcaggc
     2161 agcctgggta tggaccgcta agcgtggacc ctgctcagtg agctgtgggg cagggctgcg
     2221 ctgggtgacc tacagctgcc aggatcaagc tcaagacaag tgggtaaaga acgcccagtg
     2281 ccaagggagc ccacagccac ctgcatggca agagccttgt gtctctgccc cctgctcccc
     2341 atattgggta gctggggact tcagcccatg tagcgtgtct tgtggcgggg gccttcggga
     2401 gcggtcactg cgctgtgtag agacccaaga tggcttctta aagacactgc cacctgcccg
     2461 gtgcagagca gtagcccagc agccagcagc agaagtggaa aactgcaact cccagccctg
     2521 tcccaccagg tgggaggtgt cagaccctgg cccttgcatg tcatctgcct gtgaggcagg
     2581 tctggactca aggaatgtga catgtgtgtc cagggcgggt gacccggaga agccagaaac
     2641 tgcaggcccc tgccgcaccg acgagatgtc agctatgctg gagccctgct ccaggagcct
     2701 gtgttctcca ggcttgggtc aggtggacaa caccatgtct ctgggagagg aggctccatc
     2761 cccggtgggc agtgacaagc caggggctca ggctgagcat gtgtggaccc ctctggtggg
     2821 gctgtgctcc atctcttgtg ggagaggtct gaaggaactg tatttcctgt gcatggattc
     2881 tgtcctcaaa atgcctgtcc aggaagagct atgcggcttg gctagtaagc ccccaagccg
     2941 gtgggaggtc tgcagggctc gcccctgtcc tgctcggtgg gagactcaag tcttggcacc
     3001 gtgcccggtg acctgtggtg gggggcgagt gccactgtct gttcgttgtg tgcagctaga
     3061 ccgtggccac ccgatatctg tacctcactc caagtgctcg ccagtgccta agccaggctc
     3121 cttcgaggac tgcagccctg agccttgtcc tgctagggca ctagtgtggg aagccgcccc
     3181 cacattcgcc gtcacaagat ggcgctgaca tcctgtgttc taagttggta aacaaataat
     3241 ctgcgcatga gccaagggta tttacgacta cttgtactct gtttttcccg tgaacgtcag
     3301 ctcggccatg ggctgcagcc aatcagggag tgatgcgtcc taggcaattg ttgttctctt
     3361 ttaaatagaa ggggtttcgt ttttctcttt ttcttgcttc ttacactctg gccccaaaaa
     3421 gatgtaagca ataaagcttt gccgtag
//
