LOCUS       NM_001001322            4580 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            13 (Adamts13), transcript variant 1, mRNA.
ACCESSION   NM_001001322 XM_205053
VERSION     NM_001001322.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Kwak,H., Choi,G., Kim,S., Park,J.M., Kwon,Y., Lee,Y., Lee,C.,
            Yang,S., Cataland,S., Kim,S., Bang,S.M., Yoon,J.H., Lee,W. and
            Nam,H.J.
  TITLE     GC1126A, a novel ADAMTS13 mutein, evades autoantibodies in
            immune-mediated thrombotic thrombocytopenic purpura
  JOURNAL   Sci Rep 15 (1), 1613 (2025)
   PUBMED   39794345
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Jiang,H., Hu,J., He,P., Wu,Y., Li,F. and Chen,Q.
  TITLE     ADAMTS13 deficiency exacerbates neuroinflammation by targeting
            matrix metalloproteinase-9 in ischemic brain injury
  JOURNAL   Neuroreport 35 (7), 447-456 (2024)
   PUBMED   38597325
  REMARK    GeneRIF: ADAMTS13 deficiency exacerbates neuroinflammation by
            targeting matrix metalloproteinase-9 in ischemic brain injury.
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Zhou,W., Bouhassira,E.E. and Tsai,H.M.
  TITLE     An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13
            variant proteins that are less effective in cleaving von Willebrand
            factor multimers
  JOURNAL   Blood 110 (3), 886-893 (2007)
   PUBMED   17426255
  REMARK    GeneRIF: the plasma ADAMTS13 activity levels of mouse strains
            segregated into a high and a low group. Low ADAMTS13 activity was
            detected in mice containing 2 alleles of intracisternal A-type
            particle (IAP) retrotransposon sequence
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Banno,F., Kokame,K., Okuda,T., Honda,S., Miyata,S., Kato,H.,
            Tomiyama,Y. and Miyata,T.
  TITLE     Complete deficiency in ADAMTS13 is prothrombotic, but it alone is
            not sufficient to cause thrombotic thrombocytopenic purpura
  JOURNAL   Blood 107 (8), 3161-3166 (2006)
   PUBMED   16368888
REFERENCE   7  (bases 1 to 4580)
  AUTHORS   Motto,D.G., Chauhan,A.K., Zhu,G., Homeister,J., Lamb,C.B.,
            Desch,K.C., Zhang,W., Tsai,H.M., Wagner,D.D. and Ginsburg,D.
  TITLE     Shigatoxin triggers thrombotic thrombocytopenic purpura in
            genetically susceptible ADAMTS13-deficient mice
  JOURNAL   J Clin Invest 115 (10), 2752-2761 (2005)
   PUBMED   16200209
REFERENCE   8  (bases 1 to 4580)
  AUTHORS   Zhou,W., Inada,M., Lee,T.P., Benten,D., Lyubsky,S.,
            Bouhassira,E.E., Gupta,S. and Tsai,H.M.
  TITLE     ADAMTS13 is expressed in hepatic stellate cells
  JOURNAL   Lab Invest 85 (6), 780-788 (2005)
   PUBMED   15806136
  REMARK    GeneRIF: Identification of the liver cell-type expressing ADAMTS13
            will have is important for understanding pathophysiological
            mechanisms regulating ADAMTS13 expression.
REFERENCE   9  (bases 1 to 4580)
  AUTHORS   Bruno,K., Volkel,D., Plaimauer,B., Antoine,G., Pable,S.,
            Motto,D.G., Lemmerhirt,H.L., Dorner,F., Zimmermann,K. and
            Scheiflinger,F.
  TITLE     Cloning, expression and functional characterization of the
            full-length murine ADAMTS13
  JOURNAL   J Thromb Haemost 3 (5), 1064-1073 (2005)
   PUBMED   15869605
  REMARK    GeneRIF: characterization of the full-length murine ADAMTS13
REFERENCE   10 (bases 1 to 4580)
  AUTHORS   Banno,F., Kaminaka,K., Soejima,K., Kokame,K. and Miyata,T.
  TITLE     Identification of strain-specific variants of mouse Adamts13 gene
            encoding von Willebrand factor-cleaving protease
  JOURNAL   J Biol Chem 279 (29), 30896-30903 (2004)
   PUBMED   15136581
  REMARK    GeneRIF: analysis of strain-specific variants of mouse Adamts13
            gene encoding von Willebrand factor-cleaving protease
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB095445.1 and AB112362.1.
            
            On Sep 8, 2006 this sequence version replaced NM_001001322.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. In certain
            mouse strains (C57BL/6, for example) an intracisternal A-type
            particle (IAP) retrotransposon sequence is located in the intron 23
            that causes an alternate splicing event resulting in a shorter
            transcript variants encoding shorter isoforms. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active enzyme that cleaves von Willebrand factor (VWF) in
            circulating blood. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created using transcript and
            genomic sequence data from the mouse strain 129/Sv which is
            different from the reference genome strain (C57BL/6J), and may be
            expressed only by certain mouse strains as reported in the
            literature (PMID: 15136581 and 17426255).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB112362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AB095445.1         3018-3138
            122-4068            AB112362.1         1-3947
            4069-4069           AB095445.1         32128-32128
            4070-4402           AB112362.1         3949-4281
            4403-4580           AB095445.1         33000-33177
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.14 cM"
     gene            1..4580
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 13"
                     /db_xref="GeneID:279028"
                     /db_xref="MGI:MGI:2685556"
     exon            1..238
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..4402
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /EC_number="3.4.24.87"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 13; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 13; von Willebrand factor-cleaving protease;
                     vWF-cleaving protease; vWF-CP mRNA for von Willebrand
                     factor-cleaving; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 13"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 13 isoform 1 preproprotein"
                     /protein_id="NP_001001322.1"
                     /db_xref="CCDS:CCDS15820.1"
                     /db_xref="GeneID:279028"
                     /db_xref="MGI:MGI:2685556"
                     /translation="MSQLCLWLTCQPCYAVSVRGILTGAIFILGCWGLSDFQKSLLQD
                     LEPKDVSSYFGHHAAPFTGHPPSHLQRLRRRRTLEDILHLELLVAVGPDVSRAHQEDT
                     ERYVLTNLNIGSELLRNPSLGVQFQVHLVKLITLSDSESTPNITANITSSLMSVCEWS
                     QTINPHDDRDPSHADLILYITRFDLELPDGNQQVRGVTQLGGACSLSWSCLITEDTGF
                     DLGVTIAHEIGHSFGLDHDGAPGSGSTCKASGHVMAADGATPTGGTLEWSACSQRQLQ
                     HLLSTGQMHCFQDPPGLQSGLTRHQLMAQPGLYYSADDQCRVAFGSGAVACTFSREGL
                     DVCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKARCRSLAELAPVAAVHGHW
                     SSWGPHSPCSRSCGGGVITRRRWCNNPRPAFGGRACVGEDLQAKMCNTQACEKTQLEF
                     MSEQCAQTDRQPLQLSQGTASFYHWDAAVQYSQGDTLCRHMCWAVGESFIVSRGDRFL
                     DGTRCVPSGPQDDGTLSLCLLGSCRTFGCDGRMDSQKVWDACQVCGGDNSTCSSRNGS
                     FTAGRAREYVTFLIVTPNMTNAHIVNRRPLFTHLAVRIQGHYIVAGKTSISPNTTYPS
                     LLEDYRVEYRVTLTEDQLPHLEEIHIRGPVRDDIEIQVYRRYGGEYGDLTHPDITFSY
                     FQLKQQAAWVWTAKRGPCSVSCGAGLRWVTYSCQDQAQDKWVKNAQCQGSPQPPAWQE
                     PCVSAPCSPYWVAGDFSPCSVSCGGGLRERSLRCVETQDGFLKTLPPARCRAVAQQPA
                     AEVENCNSQPCPTRWEVSDPGPCMSSACEAGLDSRNVTCVSRAGDPEKPETAGPCRTD
                     EMSAMLEPCSRSLCSPGLGQVDNTMSLGEEAPSPVGSDKPGAQAEHVWTPLVGLCSIS
                     CGRGLKELYFLCMDSVLKMPVQEELCGLASKPPSRWEVCRARPCPARWETQVLAPCPV
                     TCGGGRVPLSVRCVQLDRGHPISVPHSKCSPVPKPGSFEDCSPEPCPARWKVLSLGPC
                     SASCGLGTATQMVACMQLDQGHDNEVNETFCKALVRPQASVPCLIADCAFRWHISAWT
                     ECSVSCGDGIQRRHDTCLGPQAQVPVPANFCQHLPKPMTVRGCWAGPCAGQETSSSLP
                     HKEATLPSQTQAAATVASLQWSQPRARTPTLFSASQSLGLQENLEEHGACGRQYLEPT
                     GTIHMRDQGRLDCVVAIGRPLGEVVTLQILESSLKCSAGEQLLLWGRFTWRKTCRKMP
                     GMTFSTKTNTVVVKQHRVLPGGGVLLRYWSQPAPGTFYKECDRQLFGPRGEIVSPSLS
                     PDGRKAGTCRVFISVAPQARIAIRALASDMGTASEGTNANYVSIRDIHSLRTTTFWGQ
                     QVLYWESEGSEAELEFSPGFLEAHASLQGEYWTISPRTSEQDDSLALS"
     exon            239..308
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            309..457
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            458..541
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            542..666
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            667..813
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            814..960
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1123
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1228
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1380
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1444
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1571
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1720
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1841
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1922
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2104
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2240
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2370
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2556
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2749
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2873
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3003
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3183
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3388
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3701
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3848
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..4025
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4210
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4580
                     /gene="Adamts13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; Gm710; vWF-CP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaagctcc caagagtaaa cactgcctga tgtcccgccc agccagcaag tgaacattgc
       61 acactaacca gaatcccagt cactagggct cctgtccggc catcaactgc cttttctaaa
      121 gatgagccag ctttgcctgt ggttgacgtg ccagccttgt tatgctgtca gtgtcagagg
      181 aatcctcact ggtgccatct tcattctggg ctgctggggg ctctctgact tccagaagag
      241 tcttcttcaa gatctggagc ccaaggatgt gtcttcttac tttggccacc atgctgctcc
      301 attcacaggc catcctccct ctcacctcca gagactgaga cggagaagga ctttggagga
      361 cattctgcac ctggaactcc tggtagctgt gggccccgat gtttcccggg ctcatcagga
      421 ggacacagaa cgctacgtgc tcactaatct caatatcggg tcagaactgt tgagaaaccc
      481 atccctggga gtccagttcc aggtgcacct ggtgaagcta atcaccctct ctgactcaga
      541 gagtactccg aatatcacgg ccaacatcac ctcatccttg atgagcgtct gcgagtggag
      601 ccagacgatc aacccccacg atgacaggga tccaagtcac gctgacctga ttctctatat
      661 caccaggttt gacctggagt tgcctgatgg caaccagcag gttcggggtg tcacccagct
      721 gggaggtgcc tgctcccttt cctggagttg ccttatcact gaggatactg gctttgacct
      781 gggggtcacc atcgcccatg agattgggca cagcttcggg ctggaccatg atggtgctcc
      841 aggtagtggc agcacctgca aggccagtgg ccacgtgatg gcggctgatg gcgcaacacc
      901 tactggaggg accctggagt ggtctgcctg cagccaaagg cagttgcagc acctactcag
      961 cacagggcaa atgcactgct tccaggaccc acctgggctg cagtcaggac ttacacggca
     1021 ccagctgatg gcacagcctg gcctctacta cagtgcagat gatcagtgcc gtgtggcttt
     1081 cggttctggg gctgtcgcct gcaccttctc cagggagggt ctggatgtat gccaggccct
     1141 gtcctgccac acagacccct tggaccaaag cagctgcagc cgcctccttg ttcctctcct
     1201 ggatgggaca gaatgtggtg tggagaagtg gtgctccaag gctcgctgtc gctccctagc
     1261 tgagctggct cctgtggctg cagtacatgg acactggtct agctggggcc cccatagtcc
     1321 ctgctcccga tcctgtggag gaggtgtgat taccaggagg cggtggtgca acaaccccag
     1381 gcctgcattt gggggacgtg catgtgtggg tgaagacctc caggctaaga tgtgcaacac
     1441 gcaggcttgt gagaagactc agctggagtt catgtccgag cagtgtgccc agacagacag
     1501 acaaccactg caactttccc aaggcactgc ctccttctac cactgggatg ctgctgtgca
     1561 gtatagtcaa ggagataccc tgtgcagaca catgtgctgg gctgttggag aaagcttcat
     1621 tgtcagccgt ggggacaggt tcctagatgg gacccgttgt gtgccaagtg gtcctcagga
     1681 tgatgggacc ctaagcctct gtttgttggg cagctgcagg acctttggct gtgatggcag
     1741 gatggactcc cagaaggttt gggatgcgtg ccaggtgtgt ggaggagaca acagcacctg
     1801 cagctcacgg aatggttctt tcacagctgg gagagccaga gaatatgtca cgttcctgat
     1861 tgttactccc aacatgacca acgcacacat tgtcaaccgc aggcctctct tcacacactt
     1921 ggcggtgagg atccagggcc actacattgt ggcagggaag actagcatct cacccaacac
     1981 cacctaccct tcccttctgg aggactaccg tgtggaatac agagtgactc tcactgagga
     2041 ccagctgccc cacttagagg agattcacat ccggggaccc gtccgggatg acattgagat
     2101 tcaggtgtac agacgatatg gaggagaata tggggatctt acacacccag acatcacctt
     2161 ttcctacttt caactgaagc agcaggcagc ctgggtatgg accgctaagc gtggaccctg
     2221 ctcagtgagc tgtggggcag ggctgcgctg ggtgacctac agctgccagg atcaagctca
     2281 agacaagtgg gtaaagaacg cccagtgcca agggagccca cagccacctg catggcaaga
     2341 gccttgtgtc tctgccccct gctccccata ttgggtagct ggggacttca gcccatgtag
     2401 cgtgtcttgt ggcgggggcc ttcgggagcg gtcactgcgc tgtgtagaga cccaagatgg
     2461 cttcttaaag acactgccac ctgcccggtg cagagcagta gcccagcagc cagcagcaga
     2521 agtggaaaac tgcaactccc agccctgtcc caccaggtgg gaggtgtcag accctggccc
     2581 ttgcatgtca tctgcctgtg aggcaggtct ggactcaagg aatgtgacat gtgtgtccag
     2641 ggcgggtgac ccggagaagc cagaaactgc aggcccctgc cgcaccgacg agatgtcagc
     2701 tatgctggag ccctgctcca ggagcctgtg ttctccaggc ttgggtcagg tggacaacac
     2761 catgtctctg ggagaggagg ctccatcccc ggtgggcagt gacaagccag gggctcaggc
     2821 tgagcatgtg tggacccctc tggtggggct gtgctccatc tcttgtggga gaggtctgaa
     2881 ggaactgtat ttcctgtgca tggattctgt cctcaaaatg cctgtccagg aagagctatg
     2941 cggcttggct agtaagcccc caagccggtg ggaggtctgc agggctcgcc cctgtcctgc
     3001 tcggtgggag actcaagtct tggcaccgtg cccggtgacc tgtggtgggg ggcgagtgcc
     3061 actgtctgtt cgttgtgtgc agctagaccg tggccacccg atatctgtac ctcactccaa
     3121 gtgctcgcca gtgcctaagc caggctcctt cgaggactgc agccctgagc cttgtcctgc
     3181 tagatggaaa gtcctgtccc ttggcccatg ctcagccagc tgtggccttg gcactgccac
     3241 acaaatggtg gcctgcatgc agcttgacca gggccatgac aatgaggtga atgaaacttt
     3301 ctgtaaggct ctagtgcggc ctcaggccag tgtcccctgc ctcattgctg actgcgcatt
     3361 ccggtggcac atcagcgcct ggacagagtg ctctgtctcc tgtggggacg gtattcagcg
     3421 ccggcatgac acctgccttg gaccccaggc ccaagtgcct gtgccagcca atttctgcca
     3481 gcacctgccc aagccaatga ccgtgagagg ctgctgggct ggaccctgtg cagggcagga
     3541 gacctccagc tcactgcctc acaaggaagc tactcttccc agtcagaccc aggctgctgc
     3601 tactgttgct tctctgcagt ggtcccagcc ccgagcccgg acccccaccc ttttctcagc
     3661 ctcccagtct ctggggctcc aggaaaacct ggaagagcat ggtgcctgtg gaaggcagta
     3721 cctggagccc acaggaacca ttcacatgcg agatcaagga cggctagact gtgtggtggc
     3781 cattgggaga cctctaggtg aagtggtgac cctacaaatc cttgagagct ccctcaagtg
     3841 tagtgcaggg gagcaactgc tgctctgggg taggttcaca tggaggaaga catgcaggaa
     3901 gatgcctggc atgactttca gcaccaaaac caacacagtg gtggtgaagc agcatcgtgt
     3961 gctgccaggg ggtggagtgc tgctacggta ctggagtcaa cctgccccgg ggaccttcta
     4021 caaagaatgt gacaggcagc tctttggacc tcggggtgaa attgtgagtc cctcactgag
     4081 cccagacggg aggaaggcag ggacctgcag ggtcttcatc agtgtggctc cacaggcccg
     4141 cattgccatc cgcgccctgg ccagtgatat gggcactgct tctgagggga ccaatgccaa
     4201 ctatgtctcg atcagggaca tccacagtct gaggaccaca acattttggg ggcagcaggt
     4261 gctctactgg gagtccgaag gcagcgaggc tgaactggag tttagccctg gcttcctgga
     4321 ggcacatgcc agtctccagg gcgagtattg gaccatctca cctaggacat cggaacagga
     4381 cgacagcctg gctctgtcct aggtttctct ccaacagccg gggagtatgc aactttagcc
     4441 tctttagaag ttctaatgcc tgctagcctt agggaacctc ttttagtgac cttttccagg
     4501 tgcagaaggg ctgggactgg gaggtggaga tcagaaaaac agtcccagcc cccagtggtt
     4561 aataaaggat acaggatacc
//
