LOCUS       NM_175501               8622 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            12 (Adamts12), mRNA.
ACCESSION   NM_175501
VERSION     NM_175501.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8622)
  AUTHORS   Hoeft,K., Koch,L., Ziegler,S., Zhang,L., Luetke,S., Tanzer,M.C.,
            Mohanta,D., Schumacher,D., Schreibing,F., Long,Q., Kim,H.,
            Klinkhammer,B.M., Schikarski,C., Maryam,S., Baens,M., Hermann,J.,
            Krieg,S., Peisker,F., De Laporte,L., Schaefer,G.J., Menzel,S.,
            Jankowski,J., Humphreys,B.D., Wahida,A., Schneider,R.K.,
            Versele,M., Boor,P., Mann,M., Sengle,G., Hayat,S. and Kramann,R.
  TITLE     ADAMTS12 promotes fibrosis by restructuring extracellular matrix to
            enable activation of injury-responsive fibroblasts
  JOURNAL   J Clin Invest 134 (18), e170246 (2024)
   PUBMED   39286973
  REMARK    GeneRIF: ADAMTS12 promotes fibrosis by restructuring extracellular
            matrix to enable activation of injury-responsive fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8622)
  AUTHORS   Mohamedi,Y., Fontanil,T., Vega,J.A., Cobo,T., Cal,S. and Obaya,A.J.
  TITLE     Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and
            ADAMTS-12
  JOURNAL   Int J Mol Sci 25 (4), 2024 (2024)
   PUBMED   38396702
  REMARK    GeneRIF: Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2
            and ADAMTS-12.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8622)
  AUTHORS   Dekky,B., Azar,F., Bonnier,D., Monseur,C., Kalebic,C., Arpigny,E.,
            Colige,A., Legagneux,V. and Theret,N.
  TITLE     ADAMTS12 is a stromal modulator in chronic liver disease
  JOURNAL   FASEB J 37 (11), e23237 (2023)
   PUBMED   37819632
  REMARK    GeneRIF: ADAMTS12 is a stromal modulator in chronic liver disease.
REFERENCE   5  (bases 1 to 8622)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8622)
  AUTHORS   Paulissen,G., El Hour,M., Rocks,N., Gueders,M.M., Bureau,F.,
            Foidart,J.M., Lopez-Otin,C., Noel,A. and Cataldo,D.D.
  TITLE     Control of allergen-induced inflammation and hyperresponsiveness by
            the metalloproteinase ADAMTS-12
  JOURNAL   J Immunol 189 (8), 4135-4143 (2012)
   PUBMED   22962682
  REMARK    GeneRIF: ADAMTS-12 plays protective roles acting against the
            development of asthma phenotype upon experimental allergen
            exposure, interfering with immunological processes leading to
            inflammation and airway hyperresponsiveness.
            Erratum:[J Immunol. 2021 Nov 1;207(9):2388-2389. doi:
            10.4049/jimmunol.2100809.. PMID: 34561231]
REFERENCE   7  (bases 1 to 8622)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   8  (bases 1 to 8622)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 8622)
  AUTHORS   El Hour,M., Moncada-Pazos,A., Blacher,S., Masset,A., Cal,S.,
            Berndt,S., Detilleux,J., Host,L., Obaya,A.J., Maillard,C.,
            Foidart,J.M., Ectors,F., Noel,A. and Lopez-Otin,C.
  TITLE     Higher sensitivity of Adamts12-deficient mice to tumor growth and
            angiogenesis
  JOURNAL   Oncogene 29 (20), 3025-3032 (2010)
   PUBMED   20208563
  REMARK    GeneRIF: Absence of Adamts-12 is associated with the increase in
            angiogenic response and tumor invasion into host tissue.
REFERENCE   10 (bases 1 to 8622)
  AUTHORS   Acar-Perk,B., Brautigam,K., Grunewald,R., Schmutzler,A., Schem,C.,
            Arnold,N.K., Jonat,W. and Weimer,J.
  TITLE     The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break
            in the ADAMTS12 gene
  JOURNAL   Comp Med 60 (2), 118-122 (2010)
   PUBMED   20412686
  REMARK    GeneRIF: Results define a break point in mouse chromosome 15qA1 to
            a 27-kb region containing ADAMTS12, and show that the break is
            likely between exons 2 and 3 of ADAMTS12.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB839765.1, AK135354.1,
            AJ537452.1, AK028459.1, AK028812.1, AC159963.7 and AI605170.1.
            
            On Jul 27, 2016 this sequence version replaced NM_175501.2.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active protease. Mice lacking the encoded protein exhibit increased
            angiogenic response and tumor invasion in different models of
            angiogenesis and, severe inflammation and delayed recovery when
            subjected to experimental conditions that induce colitis, endotoxic
            sepsis and pancreatitis. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ537452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BB839765.1         2-18
            18-258              AK135354.1         3-243
            259-3285            AJ537452.1         1-3027
            3286-6251           AK028459.1         1524-4489
            6252-6392           AK028812.1         1395-1535
            6393-6394           AC159963.7         147241-147242
            6395-7457           AK028812.1         1536-2598
            7458-7458           AC159963.7         148306-148306
            7459-8041           AK028812.1         2600-3182
            8042-8042           AC159963.7         148890-148890
            8043-8337           AK028812.1         3184-3478
            8338-8622           AI605170.1         1-285               c
FEATURES             Location/Qualifiers
     source          1..8622
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.43 cM"
     gene            1..8622
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 12"
                     /db_xref="GeneID:239337"
                     /db_xref="MGI:MGI:2146046"
     exon            1..385
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            386..753
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            754..904
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1101
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1185
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1310
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1460
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1604
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1749
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1842
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1988
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2158
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2292
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2413
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2658
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2797
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2924
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3135
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..4245
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4398
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4578
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4579..4722
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4882
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4883..8616
                     /gene="Adamts12"
                     /gene_synonym="ADAMTS-12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccatgct ctggcccgca ggaagaagaa gctgtcagct cattcactcc cctttcagga
       61 cagggagaga ataaaagctc tctggtccca tcggcttcaa aaagccacta gagcctcctg
      121 gtcagcttgc gggccgctcc cttcccatgc ttggaccatg ttctcgggcg tctttctgtg
      181 cggacacagg cgaggactgg atatctgcag ctgagagcta aaacttttaa aacttttctt
      241 ctccccaaca actgaaccat gccatgtgct cgggggagct ggctggccaa gctctcgatc
      301 gtggctcagc ttattaattt tggggctttt tgccacggga gacaaactca gccctggccg
      361 gttcgcttcc cagacccgag gcaagaacat tttatcaagt ccctgccaga ataccacata
      421 gtgagtccag tccaagtcga tgctggtggc catgttctgt cctatggcct gcatcaccct
      481 gtcactagca gcaggaagaa gagagctgca ggtggttctg gggaccagct gtactacaga
      541 atttcgcatg aagaaaaaga cctgtttttc aatctgacgg tcaactggga atttctttcc
      601 aacggctatg tcgtggagaa gagatatggg aacctttccc atgttaagat ggtggcttcc
      661 tcaggccagc cctgccatct caggggcaca gttctgcagc agggcaccac agtcgggatc
      721 gggacagcag ctctcagtgc ctgccaagga ctgactggat ttttccatct accacatgga
      781 gactttttca tcgagcctgt taaaaagcat ccactgaccg aggaagggtc ctaccctcat
      841 gtcgtataca ggagacagag catcagagct ccagagacaa aggagcccat ctgtggatta
      901 aaggacagtc ttgataactc tgtgaaacaa gagctacagc gggagaagtg ggagaggaaa
      961 accttgcgga gcagaagcct ctcccgacgt tccataagca aggagagatg ggtggagacc
     1021 ctcgtggtgg ccgacacgaa gacggtagag taccatggaa gcgagaacgt ggagtcgtac
     1081 atcctcacca tcatgaatat ggtcactggg ttgtttcata gcccaagcat tggcaatcta
     1141 gtccacattg ttgtggttcg gctcattcta cttgaagaag aggagcaagg attgaaaata
     1201 gttcatcatg cagagaagac actgtccagt ttctgcaagt ggcagaagag catcaatccc
     1261 aagagtgacc tcaaccctgt ccatcatgat gtggctgtcc ttatcaccag aaaggacatc
     1321 tgtgctggtg tcaatcgccc ttgtgagact ctggggctgt cccaattgtc aggaatgtgc
     1381 cagcctcaca ggagctgtaa catcaatgaa gactctggcc tccccctggc tttcaccatt
     1441 gcacatgaac ttggtcacag cttcggcatc cagcatgatg gaaaggaaaa tgactgtgag
     1501 cccgtgggca ggcacccata catcatgtcc caacagattc agtacgaccc aactccacta
     1561 acatggtcga aatgcagcaa ggagtacatc actcgcttct tggaccgagg cagggggttc
     1621 tgtcttgatg atatccccag caagaaaggc ttgaagtcca acgtcattgc tcctggagta
     1681 atttacgatg ttcatcacca gtgccagctc caatatggcc caaatgctac attctgccag
     1741 gaagtggaaa atgtttgcca gacactgtgg tgctcggtga aaggcttctg tcgctctaag
     1801 ctagatgctg ctgcagacgg gactcgttgc ggtgagaaga agtggtgtat ggctggaaag
     1861 tgtatcacag tggggaagaa accagagagc atccctggag gctggggacg ctggtcaccc
     1921 tggtcacact gttctagaac atgtggggca ggagctcaga gcgcagagag gctctgcaac
     1981 aacccagaac caaaatttgg agggaaatac tgcaccggag aaagaaaacg ctatcgctta
     2041 tgcaatgtcc acccctgccg ctcagacact ccaactttcc ggcagatgca gtgcagtgaa
     2101 tttgacacag tcccctacaa aaaccaattc taccgctggt tcccagtgtt taatgcagca
     2161 catccttgtg agctgtactg cagacccata gatgaacagt tttctgagag aatgctggaa
     2221 gctgtcattg atggcacccc atgcttcgaa ggtggcaaca gcagaaatgt ctgtattaat
     2281 ggcatatgta agagggttgg ctgtgactat gagattgatt ccaatgctac agaggatcgc
     2341 tgtggtgtgt gccttggaga tggctctgcc tgccagacgg tgaagaagct gtttagacag
     2401 aaggaaggat ctggttacgt tgacattgga cttattccca aaggtgcgag ggatataagg
     2461 gtgatggaaa tcaaggcagc tggcaatttc ctggccatta ggagtgaaga tccggaaaaa
     2521 tactacctca acggagggtt cattatccag tggaatggaa actataaact ggcagggacc
     2581 gttttccagt atgacaggaa aggagatctg gagaaactta tagctccagg ccccaccaac
     2641 gagtcagtgt ggctccagct acttttccag gtgactaacc ctggtatcaa gtatgagtac
     2701 acagtccgga aagatggcct tgacaatgac gtggagaagt tgctgtactt ctggcaattt
     2761 ggccgctgga cagaatgcag tgtaacgtgt ggaacaggta tccgccggca ggctgctcat
     2821 tgtgtcaaga agggccacgg tatagtgaaa acgaccttct gtaacccaga aacacagccc
     2881 agcgtgagac agaagaagtg ccatgaaaag gactgtccac ccaggtggtg ggcaggggag
     2941 tgggaagcgt gttcaacgac atgtgggccc tacggagaaa aaaagagaac ggtgctgtgc
     3001 atccagacca tgggctcgga tgaacaggct ctccctgcta cagactgcca gcacctgctg
     3061 aagcccaaag cactggtttc ctgcaacaga gatattctgt gtccatcaga ctggacagta
     3121 ggcaactgga gtgagtgctc tgtttcctgt ggtggtggag tgcggattcg cagtgtcaca
     3181 tgtgccaaga accttaatga gccttgtgac aagacccgga aacccaacag tcgagctctg
     3241 tgcggcctcc agcagtgccc atttagccgt agagttctga aacccaataa agatatagct
     3301 cccagtggga aaaatcaatc gacagcagaa catgacccct tcaagcccat cccagcacca
     3361 acatccaggc ccacgccact gtccacaccc acagtgcctg agtctatgag cacaagtact
     3421 cccacaatca acagccttgg ctccaccata gcatcccaag aagacgcaaa tgggatggga
     3481 tggcagaata attcaaccca agctgaagag ggctcccact tccctacttc ttctggaagc
     3541 acttcccagg tccccgtgac ttcctggtct ttgagtatcc aacctgatga tgagaatgtt
     3601 tccagctcag ctataggtcc tacttcagag ggtgactttt gggcaaccac aacaagtgat
     3661 tctggcttat catctagcga tgctatgact tggcaggtaa ctccatttta tagcaccatg
     3721 accacagatc cagaagtgga gatacatagt ggttcagggg aagacagtga ccagcctttg
     3781 aacaaggaca aaagcaactc tgtgatatgg aataagatcg gggtacctga acatgatgct
     3841 cccatggaga cggatgcaga actaccactt ggacctccac caacatctta tatgggggaa
     3901 gagccctcat ggcctccctt cagtacaaaa atggaaggct cattacctgc ctggtccttc
     3961 aaaaatgaga cacccaggga tgatgggatg atcgctgaaa aatcaaggaa gattccactc
     4021 cctcttgcag gagaccacca tccagcaacc tcagagaagt tagaaaacca tgacaaattg
     4081 gcattgccaa atactacaaa tccaacccaa ggctttgggc ctgtcctgac tgaagaagat
     4141 gcctccaatc tgattgccga ggggtttttg ctaaatgctt ctgattacaa gcatcttatg
     4201 aaggaccaca gccctgcata ctggattgtt ggaaactgga gtaaatgctc cactacctgt
     4261 gggctggggg cctactggag gagtgtggag tgcagctctg gggtggacgc tgactgcaca
     4321 accattcaga ggccagaccc tgctaagaag tgccacctcc gcccctgtgc tggctggcga
     4381 gtgggaaact ggagcaagtg ctcccgaaat tgcagtggag gcttcaagat tcgtgaggtt
     4441 cagtgcatgg acagcctgga ccaccaccgg agcctgaggc cgtttcactg tcaattccta
     4501 gctggcgctc ctcctccact gagtatgagc tgtaacctgg agccttgtgg agaatggcaa
     4561 gtggagccct ggagccagtg ttctaggtcc tgtggaggag gtgttcagga gagaggagtg
     4621 tcttgtcctg gaggcctctg tgactggaca aaaaggcctg caaccactgt gccctgcaac
     4681 agacaccttt gctgtcactg ggccactggg aactgggagc tgtgtaacac ttcctgtggt
     4741 ggtggctctc agaaaagaac cattcattgc atcccctcag aaaacagtac aactgaagat
     4801 caagaccagt gcctctgtga ccatcaagtc aaacccccag aattccaaac atgcaaccag
     4861 caagcctgca ggaagagtgc tgatttaact tgcttgaagg acagactttc aatcagcttc
     4921 tgccagacac tgaaatccat gaggaagtgc tctgtgccat cagtgcgagc ccagtgctgt
     4981 ctctcgtgtc cacaggcgcc cagcatccac acccagaggc aaagaaaaca gcagttgctc
     5041 caaaatcatg acatgctcta ggttcatggg cctccacagc ctgataccca agaacatggt
     5101 ccagacagtc acttcactaa tattttactt tacacattct aggttcaact ttgggtcata
     5161 acaaaacaaa atgcaatgtg tgtgtctagc cacaaaatgt tcctcacaga aagcttgggg
     5221 ctggctgctc cctgatagga agacaaagta tttgagagaa tgctgcagca gttgagatga
     5281 gttcctgggg aaagtgccag attaggcaaa tctgtgaaaa tatgtctttc gccctttaaa
     5341 gatacaagta cagaccagat tttatttttc caaactacct caagagtatc aagaaataga
     5401 gccacaatta cccaggaaat agataatctt tcaaatttgt cttcatgagt atatcctctt
     5461 tgggtgcttt gggtagccac tgtttagaag tcgtgtggca attttcagga acatctatcc
     5521 agtagtcaat aaggacagga aaatgttgct atctatgggg ctcagtcttc tctccatccc
     5581 tgtaggactt cacaactgga aacctagact ctagggacaa gccatggaga tttgagatta
     5641 aggagacacg agcaacagat gaagcctacg gggattagat tggcggtcaa gaagtcattt
     5701 ttcacttaat tacagtttct attaaaaatc ctaaaatcac gaagaaacag aaatcaactt
     5761 ctcacaagca taagaaagaa aatgagtggt tcttgttcct caaaccttcc tggctttgtc
     5821 agctggtcac agaacaaatg tgtgctcctg tctgccagac tttctcctgc cctgtcctta
     5881 ttggggtcat gacctcaggt cctgctgtca tccctgtgca ggaagattat acacaaaaac
     5941 tgctacaact agggctatag ctgattccat accctgtttc tctcccgaca gaaaaagtga
     6001 agttccaggt taaaccactt ttcaaaatca ggtaaattgt actaagtcta ggaatttagt
     6061 agaaatttat agtttagaag aaaaaagttc taaaaagtgg tcaggattac ctatttagtg
     6121 tatccattgg tgacttttaa aagtgttttg ccactagagg tatggagcta gggttgaatg
     6181 cacatttagc atagttgtgc aaggctgtaa ctttggtctc tagaaacatt catgcatacg
     6241 tatacacata cacagagaat caaaaacaga ggctaactta cattgtggaa agcaagcaag
     6301 tcaagagggt cccagacact gaaatggaag ttaacatgct tattttagac atacacacac
     6361 acacacacac acacacacac acacacacac acacgaacac atactgaagt cagaataggc
     6421 tgtgagcaca aaatcagagc aaatttccag gttagcctat agactgaacc tagagtgaaa
     6481 ggaagaacat ttagagagat gcaagccctg gggaaaggcc ccagaaccag ctcttgataa
     6541 gataggaggc aacgtatgcc ttcagtgata gatcacatag ctttaggctt atgcaccaat
     6601 atacatcatc ttcctacagt actccacagc tccctgtagt tatctatcca ttcagcagaa
     6661 tggtgctatt gaacttggtg ctaataccta gaaggtggca gagctagcag aaatgttaac
     6721 agtcatgtaa atgtgtgagt gtctacgaac ttccagatag acatatgttt tgtgtgatgg
     6781 tgttgctagc caatgtcagt cttacttgtt ctgagaccat gaacataaca ttatatagtt
     6841 tgtgctttta aactctttca agccactagc atgtattgtt ctgattaatt cctgtggaaa
     6901 taaaacactg gtatatggat ataattcaag gtataccaga aatcggagaa aatacacatt
     6961 tactgaagcc agggaattta tgtgtagtta ggcctacatt cttgtattct gtctttacat
     7021 aagaacattg ctggccaatg acaatctctg gtgaaatagc tattttagca ttattctgtt
     7081 agtggcataa atggagaaaa taagtagagg ggaacttgac tttctaataa ggaattttgc
     7141 aaagtctagt cgaataggct ttcagaagtg ttaattagta atccatgtga atttaactta
     7201 agctggtact gttctagagt aaagtacatg acactagagt cctgtgtatg accaggctta
     7261 tgaaactcag gaacaaactt ggatctttac taacctcaac aaacataagt aggccagatt
     7321 tcccaatgca aaaggtaaac catgtcattt gggacccatc atgagtctgt ggggagagtc
     7381 tggccaggtg cttcattcta gatcttcctc cagtttctga agtacaggaa ataggcctct
     7441 gatcatgtat tgtggacatc ctcttcctac catggtgaaa ctctcctatg gcatgtgtca
     7501 cttgtgcttg ctctcagagt catcagtcac tgctccgctg tgggctatca gtgtttccat
     7561 gggcatttaa tgcttgagat gctagaagaa ccgtgaatag caggatgacg ctgacagcaa
     7621 gagctagata gtgtcttcac agggtcagtt gtgaaggctt ggtttatttc acccatatcc
     7681 cccttcacgt taacaccttg aaggtatgag caagaagctc agcaagagac actggctata
     7741 cccttactat gagcctaaca ggtccaccaa gggccttgta cttaaataca tcattttggg
     7801 tttacattgc ttctcagagt gatagaatta gttctccaaa aagttatagg ctatttaatt
     7861 cttgaacatc aaaagagaac aatattccta gaaatgttat agtgaatact ttgtttaact
     7921 catgaatcat atcctgcaaa aaaggattgc tttactttgt gggaatagtc atagttcttc
     7981 ctaacaagag cacagacact tctcctggtc tcctgagaca gcatgtcttc actggcttcc
     8041 cagtgcaata ctttttgaga gtcagttttg aaccacctcc atcaaggatc tgaagcagtt
     8101 tgagggatta tattatttca gaccctaact tcccatctgg ttagctgttg ttctctagaa
     8161 gctacatgtt gctaacctag aaaagtgcaa agtcttagct ttctcctttc tcacttcaag
     8221 aagaagctct ggaacaacct atctggtgct caattcacag tgattcactt acacaggcca
     8281 catgtcttga gcttcttggt gctataacca atccaatatg tttgatgcta ctcctgttgc
     8341 taattcaagt attttctttt taattcaagt atttttattt taagttctgt cactaaagat
     8401 aatgtgatgg ggaaaaaatg tatttctccc taccattgcc ctccaaaata atggtgtgac
     8461 atccatggct aacgcattgt ctcccccatg tttctgcact gctgctttac cacctgattc
     8521 ccacactcct tatgtatcca gtgagtacct cagtattaaa accagattat aatcataggc
     8581 tgtcttcagg tggcatcaat aaatggccaa actcgtaaaa aa
//
