LOCUS       NM_172619               4176 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            10 (Adamts10), transcript variant 1, mRNA.
ACCESSION   NM_172619 XM_888563
VERSION     NM_172619.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4176)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 4176)
  AUTHORS   Wu,H.J., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Optic neuropathy associated with TGFbeta dysregulation in mice with
            a glaucoma-causative mutation of ADAMTS10
  JOURNAL   Matrix Biol 113, 83-99 (2022)
   PUBMED   36216203
  REMARK    GeneRIF: Optic neuropathy associated with TGFbeta dysregulation in
            mice with a glaucoma-causative mutation of ADAMTS10.
REFERENCE   3  (bases 1 to 4176)
  AUTHORS   Mead,T.J., Martin,D.R., Wang,L.W., Cain,S.A., Gulec,C., Cahill,E.,
            Mauch,J., Reinhardt,D., Lo,C., Baldock,C. and Apte,S.S.
  TITLE     Proteolysis of fibrillin-2 microfibrils is essential for normal
            skeletal development
  JOURNAL   Elife 11, e71142 (2022)
   PUBMED   35503090
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4176)
  AUTHORS   Wu,H.J., Mortlock,D.P., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Altered Ocular Fibrillin Microfibril Composition in Mice With a
            Glaucoma-Causing Mutation of Adamts10
  JOURNAL   Invest Ophthalmol Vis Sci 62 (10), 26 (2021)
   PUBMED   34424262
  REMARK    GeneRIF: Altered Ocular Fibrillin Microfibril Composition in Mice
            With a Glaucoma-Causing Mutation of Adamts10.
REFERENCE   5  (bases 1 to 4176)
  AUTHORS   Matsuzaki,T., Kitayama,H., Omura,A., Nishimoto,E., Alexander,D.B.
            and Noda,M.
  TITLE     The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
  JOURNAL   Biol Open 7 (10) (2018)
   PUBMED   30287421
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4176)
  AUTHORS   Ramdas,V., McBride,M., Denby,L. and Baker,A.H.
  TITLE     Canonical transforming growth factor-beta signaling regulates
            disintegrin metalloprotease expression in experimental renal
            fibrosis via miR-29
  JOURNAL   Am J Pathol 183 (6), 1885-1896 (2013)
   PUBMED   24103556
  REMARK    GeneRIF: TGF-beta stimulation of renal cells results in a
            significant up-regulation of Adams 10, 17, 12, and 19
REFERENCE   7  (bases 1 to 4176)
  AUTHORS   Dun,M.D., Anderson,A.L., Bromfield,E.G., Asquith,K.L., Emmett,B.,
            McLaughlin,E.A., Aitken,R.J. and Nixon,B.
  TITLE     Investigation of the expression and functional significance of the
            novel mouse sperm protein, a disintegrin and metalloprotease with
            thrombospondin type 1 motifs number 10 (ADAMTS10)
  JOURNAL   Int J Androl 35 (4), 572-589 (2012)
   PUBMED   22458710
  REMARK    GeneRIF: these studies support the notion that sperm-oocyte
            interactions involve considerable functional redundancy and
            identify ADAMTS10 as a novel candidate in the mediation of these
            fundamentally important events.
REFERENCE   8  (bases 1 to 4176)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   9  (bases 1 to 4176)
  AUTHORS   Somerville,R.P., Jungers,K.A. and Apte,S.S.
  TITLE     Discovery and characterization of a novel, widely expressed
            metalloprotease, ADAMTS10, and its proteolytic activation
  JOURNAL   J Biol Chem 279 (49), 51208-51217 (2004)
   PUBMED   15355968
  REMARK    GeneRIF: ADAMTS10 is a functional metalloprotease as demonstrated
            by cleavage of alpha2-macroglobulin
REFERENCE   10 (bases 1 to 4176)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT030734.24, AK076334.1,
            BQ571453.1 and AK169468.1.
            
            On Jul 2, 2016 this sequence version replaced NM_172619.3.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate a
            functional, zinc-dependent metallopeptidase enzyme. [provided by
            RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation lacks publicly available
            full-length transcript support in mouse. However, it is supported
            by the full-length human transcript AF163762.1, by partial mouse
            EST alignments including BB840099.1, and by the full-length
            sequence described for this mouse protein in PMID:15355968. Other
            mouse full-length transcript variants are available for this gene,
            including BC082773.1, AK042525.1 and BC056427.1, but it should be
            noted that all of these include an alternative splice acceptor site
            in exon 6, which results in a premature termination codon that
            likely leads to nonsense-mediated mRNA decay (NMD). The exon
            combination represented in this CCDS is therefore more likely to be
            protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.840887.1,
                                           SRR11927936.3070498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               CT030734.24        189229-189367
            140-1016            AK076334.1         3-879
            1017-1083           AK076334.1         881-947
            1084-1458           AK076334.1         953-1327
            1459-1883           BQ571453.1         284-708
            1884-3232           AK076334.1         1826-3174
            3233-4176           AK169468.1         1479-2422
FEATURES             Location/Qualifiers
     source          1..4176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..4176
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 10"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
     exon            1..174
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            175..361
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..3588
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin and metalloproteinase with
                     thrombospondin motifs 10; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 10; zinc metalloendopeptidase; a disintegrin-like
                     and metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 10"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 10 isoform 1 preproprotein"
                     /protein_id="NP_766207.2"
                     /db_xref="CCDS:CCDS37566.1"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
                     /translation="MASACQILRWALALGLGLTFKVTHAFRSQDELLSSLESYEIAFP
                     TRVDHNGAMLAFSPPAFRRQRRGAGATTESRLFYKVAAPSTHFLLNLTRSPRLLAGHV
                     SVEYWTREGLAWQRAARAHCLYAGHLQGQAGSSHVAVSTCGGLHGLIVADDEEYLIEP
                     LQGGPKGHRGPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPAR
                     PLGNESERGQLGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQ
                     DSSLGNIVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVSHSGHGNAIPEN
                     GVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSINEDIGLATAFTIAH
                     EIGHTFGMNHDGVGNGCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLG
                     LCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRC
                     ITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGG
                     VSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGK
                     FYTWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGC
                     DRVLGSDLREDKCRVCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLN
                     LSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASL
                     IIMVLAQAELPALHYRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQL
                     DSSAVAPHYCSGHSKLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRR
                     VSAAEEKALDDSACPQPRPPVLEACQGPMCPPEWATLDWSECTPSCGPGLRHRVVLCK
                     SADQRSTLPPGHCLPAAKPPSTMRCNLRRCPPARWVTSEWGECSTQCGLGQQQRTVRC
                     TSHTGQPSRECTEALRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFC
                     SRAYFRQMCCKTCQGR"
     exon            362..708
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            709..865
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1083
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1167
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1313
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1357
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1463
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1610
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1752
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1860
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2006
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2070
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2173
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2307
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2431
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2512
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2676
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2803
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2933
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3138
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3315
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3478
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..4176
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4142..4147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="hexamer: AATAAA"
     polyA_site      4164
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt tggtttttct ttttttttaa taaccctggc aggctgctca ggaagtgagt
       61 gccttcccgc gccccctccc ccggccacgc caccgggcgc ttgctccctc ccttcctgtg
      121 cgccgggcgg tgagtctgtg cgtctacagc ggaccgaagg ctccaggcac gcaggggacc
      181 agtgatgctg cccagactgt gaacagggga ggcagcactg taggggctgc cagcagccgg
      241 ggctggggag agacatgtgg acacgtagcc cctatggctt ctgcctgcca gatcctccgc
      301 tgggcccttg ccctggggct gggcctcaca ttcaaggtca cgcatgcctt cagatctcaa
      361 gatgagctcc tgtccagttt ggagagctat gagattgcct tcccaactcg agtggaccac
      421 aacggggcaa tgctggcctt ctctccacct gccttccgga ggcagcgtcg gggtgcaggg
      481 gctacaactg agtcccgcct attctacaag gtggccgcac ccagcactca cttcctgctg
      541 aacctgaccc gcagcccccg tctcctggca gggcacgtct cggtggaata ctggacacgg
      601 gaaggcctgg cttggcagag ggctgcccgg gcccactgcc tatacgctgg ccacctgcag
      661 ggccaggctg gtagctccca tgtggccgtc agcacctgtg ggggcctgca tggcctgatt
      721 gtggcagatg atgaagagta tctgattgaa cccctgcaag gtggacccaa aggtcaccgt
      781 ggcccagaag agagtggccc ccatgtagta tacaagcgtt cctctctgcg tcacccccat
      841 ctggacacag cctgtggagt gagagatgag aaaccgtgga agggtcgtcc atggtggtta
      901 cgtaccctga agccaccacc tgccaggccc ctggggaatg aatctgagcg aggccagctg
      961 ggcctgaaga gatcagtcag cagagagcgc tatgtggaga ccctggtggt agccgacaag
     1021 atgatggtgg cctaccatgg gcggagagat gtggagcagt atgtgttggc catcatgaac
     1081 attgttgcca aacttttcca ggactcgagt ctgggaaaca tcgtcaacat cctggtcact
     1141 cgcctcatcc tgctcacaga ggaccagccc accctggaga tcacccacca tgccgggaag
     1201 tcactggaca gcttctgtaa gtggcagaaa tccatcgtga gccacagtgg ccatggcaac
     1261 gccatcccag agaatggtgt ggcaaaccat gacacagctg tgctcatcac acgctatgac
     1321 atctgcatct acaagaacaa accctgcggc actctaggcc tggcccctgt gggtggaatg
     1381 tgtgagcgtg agaggagctg cagtatcaat gaagatatcg gcctggccac ggctttcacc
     1441 attgcccatg agatcgggca cacatttggc atgaatcacg atggcgtggg aaacggctgt
     1501 ggggcccgtg ggcaggaccc agcgaagctc atggctgccc acattaccat gaagactaat
     1561 ccattcgtgt ggtcatcgtg tagtcgagac tacatcacca gctttctgga ctcgggcctg
     1621 gggctttgct tgaataaccg gcctcctaga caggacttcg tgtacccaac ggtggctccc
     1681 ggccaggcct atgatgctga tgagcagtgc cgattccagc atggagtcaa atcgcgtcag
     1741 tgtaaatacg gggaggtctg cagtgaactg tggtgtctga gcaagagcaa tcggtgcatc
     1801 accaatagca tcccagctgc tgagggaaca ctgtgccaaa cacacactat cgacaaaggg
     1861 tggtgctaca aacgagtctg tgtccccttt ggctctcggc cagagggtgt agacggggcc
     1921 tggggccctt ggactccatg gggtgactgc agcaggtcat gtggcggtgg tgtgtcatct
     1981 tctagccgtc actgcgacag tcccaggcca accattgggg gcaagtactg tctgggcgag
     2041 agacgaaggc accggtcctg caacaccaat gactgtccac ctggctccca ggacttcaga
     2101 gaaatgcagt gctctgaatt tgacagtgtc cctttccgcg gaaaattcta cacgtggaag
     2161 acataccgag gagggggtgt gaaggcctgt tcgctgactt gcctagcaga aggcttcaac
     2221 ttttatacgg agcgagcagc agctgtggtg gatggaacac cctgccgccc tgacacggtg
     2281 gacatttgtg tcagcggcga gtgcaagcat gtaggctgtg acagggtcct gggttctgat
     2341 ctccgagagg acaaatgccg tgtgtgtggg ggtgatggca gtgcctgtga gaccattgaa
     2401 ggtgtcttta gcccagcttt gccaggaact gggtatgagg acgtcgtctg gatccccaaa
     2461 ggctcggtcc acattttcat ccaagatctg aacctgtccc tgagtcacct ggccctaaag
     2521 ggggaccaag agtctctgct actggagggg ctacctggga ccccccaacc tcaccgcctt
     2581 cccctggctg gaaccacatt tcatctacgg caggggccgg accaggcaca gagcctggaa
     2641 gccctgggac ccattaatgc atctctcatc atcatggtgc tggcccaggc agagttgcct
     2701 gctctccact accgcttcaa tgcacccatt gcccgggatg cactgcctcc ctactcctgg
     2761 cactatgccc cctggaccaa atgctcagcc cagtgtgcag gcggcagcca ggtccaagta
     2821 gtggagtgcc gaaatcagct ggacagctca gcagtggccc cacactactg tagtggccac
     2881 agtaaattgc ccaagaggca gcgtgcctgc aacacagaac catgtccacc agattgggtt
     2941 gtaggaaact ggtcacgctg cagccgtagc tgtgacgctg gtgtgcgtag ccgctcagtg
     3001 gtgtgccaac gccgggtgtc tgctgcagag gaaaaagcct tagacgacag tgcctgtcca
     3061 cagccacgcc cacctgtgct ggaggcctgc caaggcccaa tgtgccctcc tgagtgggca
     3121 accctcgact ggtctgagtg taccccaagc tgtgggcctg gtctccgcca ccgagtggtc
     3181 ctttgtaaga gtgcagatca acgatctact ctgccccctg ggcactgcct tcctgcagcc
     3241 aagccaccat ctactatgcg atgtaacttg cgccgctgcc ctcctgcccg ctgggtgacc
     3301 agtgagtggg gtgagtgttc cacacagtgt ggcctcggcc agcagcagcg cacagtgcgc
     3361 tgcaccagcc acaccggcca gccatctcga gagtgcactg aagccttgcg gccatccacc
     3421 atgcagcagt gtgaggccaa gtgtgacagt gtggtgccgc ctggagatgg cccagaagaa
     3481 tgcaaggatg tgaacaaggt ggcttactgc cccctggtgc tcaaatttca gttctgtagc
     3541 cgagcctact tccgccagat gtgctgcaaa acctgccaag gccgctaggg tacctggaac
     3601 caacctggag cacaggctga ggcaggggac atcccactgg agagggcatg agggaaaggg
     3661 gggcttgaat tgaagggtga gatgcagttg aaagttattt attgggtaac cctacagggc
     3721 tcctgactaa ggggtggaga agagctggct acccagggac cctctgctgt atcttgccca
     3781 gttgatagtg aagagagagg actccttgtt gcacacatat ttaagtccct agcacccctc
     3841 ccaccctttg atcggaatat gtactgtgaa gagtgggggt ggggaggggt gtgctggtgc
     3901 cctgccccct gcactgttct atccctacac tctgagctgg ggggatttat atctgctatg
     3961 gggggggtag gcttgatacc acctccctgt agccctcccc cagactgacg aaggggaaga
     4021 tccaccccaa cctctgccct gcctgcccca ggggggagtt caacatccag gccgttcccc
     4081 atcatggtgc tacaagccct gccctggggc ccacacactc ctcaccaaga agccttacat
     4141 taataaagtt ctgtcttgtg tagatttctg ctcctg
//
