LOCUS       NM_001329202            4164 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            10 (Adamts10), transcript variant 14, mRNA.
ACCESSION   NM_001329202 NR_037707
VERSION     NM_001329202.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 4164)
  AUTHORS   Wu,H.J., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Optic neuropathy associated with TGFbeta dysregulation in mice with
            a glaucoma-causative mutation of ADAMTS10
  JOURNAL   Matrix Biol 113, 83-99 (2022)
   PUBMED   36216203
  REMARK    GeneRIF: Optic neuropathy associated with TGFbeta dysregulation in
            mice with a glaucoma-causative mutation of ADAMTS10.
REFERENCE   3  (bases 1 to 4164)
  AUTHORS   Mead,T.J., Martin,D.R., Wang,L.W., Cain,S.A., Gulec,C., Cahill,E.,
            Mauch,J., Reinhardt,D., Lo,C., Baldock,C. and Apte,S.S.
  TITLE     Proteolysis of fibrillin-2 microfibrils is essential for normal
            skeletal development
  JOURNAL   Elife 11, e71142 (2022)
   PUBMED   35503090
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4164)
  AUTHORS   Wu,H.J., Mortlock,D.P., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Altered Ocular Fibrillin Microfibril Composition in Mice With a
            Glaucoma-Causing Mutation of Adamts10
  JOURNAL   Invest Ophthalmol Vis Sci 62 (10), 26 (2021)
   PUBMED   34424262
  REMARK    GeneRIF: Altered Ocular Fibrillin Microfibril Composition in Mice
            With a Glaucoma-Causing Mutation of Adamts10.
REFERENCE   5  (bases 1 to 4164)
  AUTHORS   Matsuzaki,T., Kitayama,H., Omura,A., Nishimoto,E., Alexander,D.B.
            and Noda,M.
  TITLE     The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
  JOURNAL   Biol Open 7 (10) (2018)
   PUBMED   30287421
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4164)
  AUTHORS   Ramdas,V., McBride,M., Denby,L. and Baker,A.H.
  TITLE     Canonical transforming growth factor-beta signaling regulates
            disintegrin metalloprotease expression in experimental renal
            fibrosis via miR-29
  JOURNAL   Am J Pathol 183 (6), 1885-1896 (2013)
   PUBMED   24103556
  REMARK    GeneRIF: TGF-beta stimulation of renal cells results in a
            significant up-regulation of Adams 10, 17, 12, and 19
REFERENCE   7  (bases 1 to 4164)
  AUTHORS   Dun,M.D., Anderson,A.L., Bromfield,E.G., Asquith,K.L., Emmett,B.,
            McLaughlin,E.A., Aitken,R.J. and Nixon,B.
  TITLE     Investigation of the expression and functional significance of the
            novel mouse sperm protein, a disintegrin and metalloprotease with
            thrombospondin type 1 motifs number 10 (ADAMTS10)
  JOURNAL   Int J Androl 35 (4), 572-589 (2012)
   PUBMED   22458710
  REMARK    GeneRIF: these studies support the notion that sperm-oocyte
            interactions involve considerable functional redundancy and
            identify ADAMTS10 as a novel candidate in the mediation of these
            fundamentally important events.
REFERENCE   8  (bases 1 to 4164)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   9  (bases 1 to 4164)
  AUTHORS   Somerville,R.P., Jungers,K.A. and Apte,S.S.
  TITLE     Discovery and characterization of a novel, widely expressed
            metalloprotease, ADAMTS10, and its proteolytic activation
  JOURNAL   J Biol Chem 279 (49), 51208-51217 (2004)
   PUBMED   15355968
  REMARK    GeneRIF: ADAMTS10 is a functional metalloprotease as demonstrated
            by cleavage of alpha2-macroglobulin
REFERENCE   10 (bases 1 to 4164)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT030734.24, BC056427.1 and
            AK169468.1.
            
            On Jul 7, 2016 this sequence version replaced NR_037707.2.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate a
            functional, zinc-dependent metallopeptidase enzyme. [provided by
            RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056427.1, SRR1660815.215800.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               CT030734.24        189229-189369
            142-4150            BC056427.1         1-4009
            4151-4164           AK169468.1         2409-2422
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..4164
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 10"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
     exon            1..174
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            175..361
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            362..708
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            709..865
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1083
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1172
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1318
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1362
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1468
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1615
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1740
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             1696..3576
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="isoform 4 is encoded by transcript variant 14; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 10; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 10;
                     zinc metalloendopeptidase; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 10"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 10 isoform 4"
                     /protein_id="NP_001316131.1"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
                     /translation="MMLMSSADSSMESNREVCSELWCLSKSNRCITNSIPAAEGTLCQ
                     THTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPRPT
                     IGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTWKTYRGGGVKA
                     CSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCR
                     VCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQES
                     LLLEGLPGTPQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASLIIMVLAQAELPALH
                     YRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSGHS
                     KLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSAC
                     PQPRPPVLEACQGPMCPPEWATLDWSECTPSCGPGLRHRVVLCKSADQRSTLPPGHCL
                     PAAKPPSTMRCNLRRCPPARWVTSEWGECSTQCGLGQQQRTVRCTSHTGQPSRECTEA
                     LRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ
                     GR"
     exon            1741..1848
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1994
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2058
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2161
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2295
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2419
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2500
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2664
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2791
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2921
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3126
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3303
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3466
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..4164
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4130..4135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="hexamer: AATAAA"
     polyA_site      4152
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt tggtttttct ttttttttaa taaccctggc aggctgctca ggaagtgagt
       61 gccttcccgc gccccctccc ccggccacgc caccgggcgc ttgctccctc ccttcctgtg
      121 cgccgggcgg tgagtctgtg cgtctacagc ggaccgaagg ctccaggcac gcaggggacc
      181 agtgatgctg cccagactgt gaacagggga ggcagcactg taggggctgc cagcagccgg
      241 ggctggggag agacatgtgg acacgtagcc cctatggctt ctgcctgcca gatcctccgc
      301 tgggcccttg ccctggggct gggcctcaca ttcaaggtca cgcatgcctt cagatctcaa
      361 gatgagctcc tgtccagttt ggagagctat gagattgcct tcccaactcg agtggaccac
      421 aacggggcaa tgctggcctt ctctccacct gccttccgga ggcagcgtcg gggtgcaggg
      481 gctacaactg agtcccgcct attctacaag gtggccgcac ccagcactca cttcctgctg
      541 aacctgaccc gcagcccccg tctcctggca gggcacgtct cggtggaata ctggacacgg
      601 gaaggcctgg cttggcagag ggctgcccgg gcccactgcc tatacgctgg ccacctgcag
      661 ggccaggctg gtagctccca tgtggccgtc agcacctgtg ggggcctgca tggcctgatt
      721 gtggcagatg atgaagagta tctgattgaa cccctgcaag gtggacccaa aggtcaccgt
      781 ggcccagaag agagtggccc ccatgtagta tacaagcgtt cctctctgcg tcacccccat
      841 ctggacacag cctgtggagt gagagatgag aaaccgtgga agggtcgtcc atggtggtta
      901 cgtaccctga agccaccacc tgccaggccc ctggggaatg aatctgagcg aggccagctg
      961 ggcctgaaga gatcagtcag cagagagcgc tatgtggaga ccctggtggt agccgacaag
     1021 atgatggtgg cctaccatgg gcggagagat gtggagcagt atgtgttggc catcatgaac
     1081 attgtcaggt tgccaaactt ttccaggact cgagtctggg aaacatcgtc aacatcctgg
     1141 tcactcgcct catcctgctc acagaggacc agcccaccct ggagatcacc caccatgccg
     1201 ggaagtcact ggacagcttc tgtaagtggc agaaatccat cgtgagccac agtggccatg
     1261 gcaacgccat cccagagaat ggtgtggcaa accatgacac agctgtgctc atcacacgct
     1321 atgacatctg catctacaag aacaaaccct gcggcactct aggcctggcc cctgtgggtg
     1381 gaatgtgtga gcgtgagagg agctgcagta tcaatgaaga tatcggcctg gccacggctt
     1441 tcaccattgc ccatgagatc gggcacacat ttggcatgaa tcacgatggc gtgggaaacg
     1501 gctgtggggc ccgtgggcag gacccagcga agctcatggc tgcccacatt accatgaaga
     1561 ctaatccatt cgtgtggtca tcgtgtagtc gagactacat caccagcttt ctggactcgg
     1621 gcctggggct ttgcttgaat aaccggcctc ctagacagga cttcgtgtac ccaacggtgg
     1681 ctcccggcca ggcctatgat gctgatgagc agtgccgatt ccagcatgga gtcaaatcgc
     1741 gaggtctgca gtgaactgtg gtgtctgagc aagagcaatc ggtgcatcac caatagcatc
     1801 ccagctgctg agggaacact gtgccaaaca cacactatcg acaaagggtg gtgctacaaa
     1861 cgagtctgtg tcccctttgg ctctcggcca gagggtgtag acggggcctg gggcccttgg
     1921 actccatggg gtgactgcag caggtcatgt ggcggtggtg tgtcatcttc tagccgtcac
     1981 tgcgacagtc ccaggccaac cattgggggc aagtactgtc tgggcgagag acgaaggcac
     2041 cggtcctgca acaccaatga ctgtccacct ggctcccagg acttcagaga aatgcagtgc
     2101 tctgaatttg acagtgtccc tttccgcgga aaattctaca cgtggaagac ataccgagga
     2161 gggggtgtga aggcctgttc gctgacttgc ctagcagaag gcttcaactt ttatacggag
     2221 cgagcagcag ctgtggtgga tggaacaccc tgccgccctg acacggtgga catttgtgtc
     2281 agcggcgagt gcaagcatgt aggctgtgac agggtcctgg gttctgatct ccgagaggac
     2341 aaatgccgtg tgtgtggggg tgatggcagt gcctgtgaga ccattgaagg tgtctttagc
     2401 ccagctttgc caggaactgg gtatgaggac gtcgtctgga tccccaaagg ctcggtccac
     2461 attttcatcc aagatctgaa cctgtccctg agtcacctgg ccctaaaggg ggaccaagag
     2521 tctctgctac tggaggggct acctgggacc ccccaacctc accgccttcc cctggctgga
     2581 accacatttc atctacggca ggggccggac caggcacaga gcctggaagc cctgggaccc
     2641 attaatgcat ctctcatcat catggtgctg gcccaggcag agttgcctgc tctccactac
     2701 cgcttcaatg cacccattgc ccgggatgca ctgcctccct actcctggca ctatgccccc
     2761 tggaccaaat gctcagccca gtgtgcaggc ggcagccagg tccaagtagt ggagtgccga
     2821 aatcagctgg acagctcagc agtggcccca cactactgta gtggccacag taaattgccc
     2881 aagaggcagc gtgcctgcaa cacagaacca tgtccaccag attgggttgt aggaaactgg
     2941 tcacgctgca gccgtagctg tgacgctggt gtgcgtagcc gctcagtggt gtgccaacgc
     3001 cgggtgtctg ctgcagagga aaaagcctta gacgacagtg cctgtccaca gccacgccca
     3061 cctgtgctgg aggcctgcca aggcccaatg tgccctcctg agtgggcaac cctcgactgg
     3121 tctgagtgta ccccaagctg tgggcctggt ctccgccacc gagtggtcct ttgtaagagt
     3181 gcagatcaac gatctactct gccccctggg cactgccttc ctgcagccaa gccaccatct
     3241 actatgcgat gtaacttgcg ccgctgccct cctgcccgct gggtgaccag tgagtggggt
     3301 gagtgttcca cacagtgtgg cctcggccag cagcagcgca cagtgcgctg caccagccac
     3361 accggccagc catctcgaga gtgcactgaa gccttgcggc catccaccat gcagcagtgt
     3421 gaggccaagt gtgacagtgt ggtgccgcct ggagatggcc cagaagaatg caaggatgtg
     3481 aacaaggtgg cttactgccc cctggtgctc aaatttcagt tctgtagccg agcctacttc
     3541 cgccagatgt gctgcaaaac ctgccaaggc cgctagggta cctggaacca acctggagca
     3601 caggctgagg caggggacat cccactggag agggcatgag ggaaaggggg gcttgaattg
     3661 aagggtgaga tgcagttgaa agttatttat tgggtaaccc tacagggctc ctgactaagg
     3721 ggtggagaag agctggctac ccagggaccc tctgctgtat cttgcccagt tgatagtgaa
     3781 gagagaggac tccttgttgc acacatattt aagtccctag cacccctccc accctttgat
     3841 cggaatatgt actgtgaaga gtgggggtgg ggaggggtgt gctggtgccc tgccccctgc
     3901 actgttctat ccctacactc tgagctgggg ggatttatat ctgctatggg gggggtaggc
     3961 ttgataccac ctccctgtag ccctccccca gactgacgaa ggggaagatc caccccaacc
     4021 tctgccctgc ctgccccagg ggggagttca acatccaggc cgttccccat catggtgcta
     4081 caagccctgc cctggggccc acacactcct caccaagaag ccttacatta ataaagttct
     4141 gtcttgtgta gatttctgct cctg
//
