LOCUS       NM_001329154            4056 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            10 (Adamts10), transcript variant 9, mRNA.
ACCESSION   NM_001329154 XM_017317427
VERSION     NM_001329154.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4056)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 4056)
  AUTHORS   Wu,H.J., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Optic neuropathy associated with TGFbeta dysregulation in mice with
            a glaucoma-causative mutation of ADAMTS10
  JOURNAL   Matrix Biol 113, 83-99 (2022)
   PUBMED   36216203
  REMARK    GeneRIF: Optic neuropathy associated with TGFbeta dysregulation in
            mice with a glaucoma-causative mutation of ADAMTS10.
REFERENCE   3  (bases 1 to 4056)
  AUTHORS   Mead,T.J., Martin,D.R., Wang,L.W., Cain,S.A., Gulec,C., Cahill,E.,
            Mauch,J., Reinhardt,D., Lo,C., Baldock,C. and Apte,S.S.
  TITLE     Proteolysis of fibrillin-2 microfibrils is essential for normal
            skeletal development
  JOURNAL   Elife 11, e71142 (2022)
   PUBMED   35503090
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4056)
  AUTHORS   Wu,H.J., Mortlock,D.P., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Altered Ocular Fibrillin Microfibril Composition in Mice With a
            Glaucoma-Causing Mutation of Adamts10
  JOURNAL   Invest Ophthalmol Vis Sci 62 (10), 26 (2021)
   PUBMED   34424262
  REMARK    GeneRIF: Altered Ocular Fibrillin Microfibril Composition in Mice
            With a Glaucoma-Causing Mutation of Adamts10.
REFERENCE   5  (bases 1 to 4056)
  AUTHORS   Matsuzaki,T., Kitayama,H., Omura,A., Nishimoto,E., Alexander,D.B.
            and Noda,M.
  TITLE     The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
  JOURNAL   Biol Open 7 (10) (2018)
   PUBMED   30287421
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4056)
  AUTHORS   Ramdas,V., McBride,M., Denby,L. and Baker,A.H.
  TITLE     Canonical transforming growth factor-beta signaling regulates
            disintegrin metalloprotease expression in experimental renal
            fibrosis via miR-29
  JOURNAL   Am J Pathol 183 (6), 1885-1896 (2013)
   PUBMED   24103556
  REMARK    GeneRIF: TGF-beta stimulation of renal cells results in a
            significant up-regulation of Adams 10, 17, 12, and 19
REFERENCE   7  (bases 1 to 4056)
  AUTHORS   Dun,M.D., Anderson,A.L., Bromfield,E.G., Asquith,K.L., Emmett,B.,
            McLaughlin,E.A., Aitken,R.J. and Nixon,B.
  TITLE     Investigation of the expression and functional significance of the
            novel mouse sperm protein, a disintegrin and metalloprotease with
            thrombospondin type 1 motifs number 10 (ADAMTS10)
  JOURNAL   Int J Androl 35 (4), 572-589 (2012)
   PUBMED   22458710
  REMARK    GeneRIF: these studies support the notion that sperm-oocyte
            interactions involve considerable functional redundancy and
            identify ADAMTS10 as a novel candidate in the mediation of these
            fundamentally important events.
REFERENCE   8  (bases 1 to 4056)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   9  (bases 1 to 4056)
  AUTHORS   Somerville,R.P., Jungers,K.A. and Apte,S.S.
  TITLE     Discovery and characterization of a novel, widely expressed
            metalloprotease, ADAMTS10, and its proteolytic activation
  JOURNAL   J Biol Chem 279 (49), 51208-51217 (2004)
   PUBMED   15355968
  REMARK    GeneRIF: ADAMTS10 is a functional metalloprotease as demonstrated
            by cleavage of alpha2-macroglobulin
REFERENCE   10 (bases 1 to 4056)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT030734.24 and AK042525.1.
            
            On Jul 2, 2016 this sequence version replaced XM_017317427.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate a
            functional, zinc-dependent metallopeptidase enzyme. [provided by
            RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.150456.1,
                                           SRR1660817.16688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               CT030734.24        189229-189352
            125-510             AK042525.1         2-387
            511-524             AK042525.1         586-599
            525-525             CT030734.24        195291-195291
            526-1632            AK042525.1         601-1707
            1633-1740           AK042525.1         1725-1832
            1741-1886           CT030734.24        208780-208925
            1887-2683           AK042525.1         1833-2629
            2684-2687           CT030734.24        214624-214627
            2688-3328           AK042525.1         2630-3270
            3329-3329           CT030734.24        216545-216545
            3330-4041           AK042525.1         3272-3983
            4042-4056           CT030734.24        218912-218926
FEATURES             Location/Qualifiers
     source          1..4056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..4056
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 10"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
     exon            1..174
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            175..361
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            362..510
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            511..667
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            668..885
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            886..974
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1120
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1164
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1507
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1632
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             1588..3468
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="isoform 4 is encoded by transcript variant 9; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 10; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 10;
                     zinc metalloendopeptidase; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 10"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 10 isoform 4"
                     /protein_id="NP_001316083.1"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
                     /translation="MMLMSSADSSMESNREVCSELWCLSKSNRCITNSIPAAEGTLCQ
                     THTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPRPT
                     IGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTWKTYRGGGVKA
                     CSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCR
                     VCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQES
                     LLLEGLPGTPQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASLIIMVLAQAELPALH
                     YRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSGHS
                     KLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSAC
                     PQPRPPVLEACQGPMCPPEWATLDWSECTPSCGPGLRHRVVLCKSADQRSTLPPGHCL
                     PAAKPPSTMRCNLRRCPPARWVTSEWGECSTQCGLGQQQRTVRCTSHTGQPSRECTEA
                     LRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ
                     GR"
     exon            1633..1740
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1886
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1950
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2053
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2187
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2311
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2392
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2556
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2683
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2813
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..3018
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3195
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3358
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..4056
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4022..4027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="hexamer: AATAAA"
     polyA_site      4044
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt tggtttttct ttttttttaa taaccctggc aggctgctca ggaagtgagt
       61 gccttcccgc gccccctccc ccggccacgc caccgggcgc ttgctccctc ccttcctgtg
      121 cgccgggcgg tgagtctgtg cgtctacagc ggaccgaagg ctccaggcac gcaggggacc
      181 agtgatgctg cccagactgt gaacagggga ggcagcactg taggggctgc cagcagccgg
      241 ggctggggag agacatgtgg acacgtagcc cctatggctt ctgcctgcca gatcctccgc
      301 tgggcccttg ccctggggct gggcctcaca ttcaaggtca cgcatgcctt cagatctcaa
      361 gatgagctcc tgtccagttt ggagagctat gagattgcct tcccaactcg agtggaccac
      421 aacggggcaa tgctggcctt ctctccacct gccttccgga ggcagcgtcg gggtgcaggg
      481 gctacaactg agtcccgcct attctacaag catggcctga ttgtggcaga tgatgaagag
      541 tatctgattg aacccctgca aggtggaccc aaaggtcacc gtggcccaga agagagtggc
      601 ccccatgtag tatacaagcg ttcctctctg cgtcaccccc atctggacac agcctgtgga
      661 gtgagagatg agaaaccgtg gaagggtcgt ccatggtggt tacgtaccct gaagccacca
      721 cctgccaggc ccctggggaa tgaatctgag cgaggccagc tgggcctgaa gagatcagtc
      781 agcagagagc gctatgtgga gaccctggtg gtagccgaca agatgatggt ggcctaccat
      841 gggcggagag atgtggagca gtatgtgttg gccatcatga acattgtcag gttgccaaac
      901 ttttccagga ctcgagtctg ggaaacatcg tcaacatcct ggtcactcgc ctcatcctgc
      961 tcacagagga ccagcccacc ctggagatca cccaccatgc cgggaagtca ctggacagct
     1021 tctgtaagtg gcagaaatcc atcgtgagcc acagtggcca tggcaacgcc atcccagaga
     1081 atggtgtggc aaaccatgac acagctgtgc tcatcacacg ctatgacatc tgcatctaca
     1141 agaacaaacc ctgcggcact ctaggcctgg cccctgtggg tggaatgtgt gagcgtgaga
     1201 ggagctgcag tatcaatgaa gatatcggcc tggccacggc tttcaccatt gcccatgaga
     1261 tcgggcacac gtgaggccag gggacacagg ataggggagg atccgaggat ctgggttggg
     1321 ttcccttagt tcttagcaga gctgatactc ttctcctcag atttggcatg aatcacgatg
     1381 gcgtgggaaa cggctgtggg gcccgtgggc aggacccagc gaagctcatg gctgcccaca
     1441 ttaccatgaa gactaatcca ttcgtgtggt catcgtgtag tcgagactac atcaccagct
     1501 ttctggactc gggcctgggg ctttgcttga ataaccggcc tcctagacag gacttcgtgt
     1561 acccaacggt ggctcccggc caggcctatg atgctgatga gcagtgccga ttccagcatg
     1621 gagtcaaatc gcgaggtctg cagtgaactg tggtgtctga gcaagagcaa tcggtgcatc
     1681 accaatagca tcccagctgc tgagggaaca ctgtgccaaa cacacactat cgacaaaggg
     1741 tggtgctaca aacgagtctg tgtccccttt ggctctcggc cagagggtgt agacggggcc
     1801 tggggccctt ggactccatg gggtgactgc agcaggtcat gtggcggtgg tgtgtcatct
     1861 tctagccgtc actgcgacag tcccaggcca accattgggg gcaagtactg tctgggcgag
     1921 agacgaaggc accggtcctg caacaccaat gactgtccac ctggctccca ggacttcaga
     1981 gaaatgcagt gctctgaatt tgacagtgtc cctttccgcg gaaaattcta cacgtggaag
     2041 acataccgag gagggggtgt gaaggcctgt tcgctgactt gcctagcaga aggcttcaac
     2101 ttttatacgg agcgagcagc agctgtggtg gatggaacac cctgccgccc tgacacggtg
     2161 gacatttgtg tcagcggcga gtgcaagcat gtaggctgtg acagggtcct gggttctgat
     2221 ctccgagagg acaaatgccg tgtgtgtggg ggtgatggca gtgcctgtga gaccattgaa
     2281 ggtgtcttta gcccagcttt gccaggaact gggtatgagg acgtcgtctg gatccccaaa
     2341 ggctcggtcc acattttcat ccaagatctg aacctgtccc tgagtcacct ggccctaaag
     2401 ggggaccaag agtctctgct actggagggg ctacctggga ccccccaacc tcaccgcctt
     2461 cccctggctg gaaccacatt tcatctacgg caggggccgg accaggcaca gagcctggaa
     2521 gccctgggac ccattaatgc atctctcatc atcatggtgc tggcccaggc agagttgcct
     2581 gctctccact accgcttcaa tgcacccatt gcccgggatg cactgcctcc ctactcctgg
     2641 cactatgccc cctggaccaa atgctcagcc cagtgtgcag gcggcagcca ggtccaagta
     2701 gtggagtgcc gaaatcagct ggacagctca gcagtggccc cacactactg tagtggccac
     2761 agtaaattgc ccaagaggca gcgtgcctgc aacacagaac catgtccacc agattgggtt
     2821 gtaggaaact ggtcacgctg cagccgtagc tgtgacgctg gtgtgcgtag ccgctcagtg
     2881 gtgtgccaac gccgggtgtc tgctgcagag gaaaaagcct tagacgacag tgcctgtcca
     2941 cagccacgcc cacctgtgct ggaggcctgc caaggcccaa tgtgccctcc tgagtgggca
     3001 accctcgact ggtctgagtg taccccaagc tgtgggcctg gtctccgcca ccgagtggtc
     3061 ctttgtaaga gtgcagatca acgatctact ctgccccctg ggcactgcct tcctgcagcc
     3121 aagccaccat ctactatgcg atgtaacttg cgccgctgcc ctcctgcccg ctgggtgacc
     3181 agtgagtggg gtgagtgttc cacacagtgt ggcctcggcc agcagcagcg cacagtgcgc
     3241 tgcaccagcc acaccggcca gccatctcga gagtgcactg aagccttgcg gccatccacc
     3301 atgcagcagt gtgaggccaa gtgtgacagt gtggtgccgc ctggagatgg cccagaagaa
     3361 tgcaaggatg tgaacaaggt ggcttactgc cccctggtgc tcaaatttca gttctgtagc
     3421 cgagcctact tccgccagat gtgctgcaaa acctgccaag gccgctaggg tacctggaac
     3481 caacctggag cacaggctga ggcaggggac atcccactgg agagggcatg agggaaaggg
     3541 gggcttgaat tgaagggtga gatgcagttg aaagttattt attgggtaac cctacagggc
     3601 tcctgactaa ggggtggaga agagctggct acccagggac cctctgctgt atcttgccca
     3661 gttgatagtg aagagagagg actccttgtt gcacacatat ttaagtccct agcacccctc
     3721 ccaccctttg atcggaatat gtactgtgaa gagtgggggt ggggaggggt gtgctggtgc
     3781 cctgccccct gcactgttct atccctacac tctgagctgg ggggatttat atctgctatg
     3841 gggggggtag gcttgatacc acctccctgt agccctcccc cagactgacg aaggggaaga
     3901 tccaccccaa cctctgccct gcctgcccca ggggggagtt caacatccag gccgttcccc
     3961 atcatggtgc tacaagccct gccctggggc ccacacactc ctcaccaaga agccttacat
     4021 taataaagtt ctgtcttgtg tagatttctg ctcctg
//
