LOCUS       NM_001329153            4254 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            10 (Adamts10), transcript variant 8, mRNA.
ACCESSION   NM_001329153 XM_017317425
VERSION     NM_001329153.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4254)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 4254)
  AUTHORS   Wu,H.J., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Optic neuropathy associated with TGFbeta dysregulation in mice with
            a glaucoma-causative mutation of ADAMTS10
  JOURNAL   Matrix Biol 113, 83-99 (2022)
   PUBMED   36216203
  REMARK    GeneRIF: Optic neuropathy associated with TGFbeta dysregulation in
            mice with a glaucoma-causative mutation of ADAMTS10.
REFERENCE   3  (bases 1 to 4254)
  AUTHORS   Mead,T.J., Martin,D.R., Wang,L.W., Cain,S.A., Gulec,C., Cahill,E.,
            Mauch,J., Reinhardt,D., Lo,C., Baldock,C. and Apte,S.S.
  TITLE     Proteolysis of fibrillin-2 microfibrils is essential for normal
            skeletal development
  JOURNAL   Elife 11, e71142 (2022)
   PUBMED   35503090
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4254)
  AUTHORS   Wu,H.J., Mortlock,D.P., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Altered Ocular Fibrillin Microfibril Composition in Mice With a
            Glaucoma-Causing Mutation of Adamts10
  JOURNAL   Invest Ophthalmol Vis Sci 62 (10), 26 (2021)
   PUBMED   34424262
  REMARK    GeneRIF: Altered Ocular Fibrillin Microfibril Composition in Mice
            With a Glaucoma-Causing Mutation of Adamts10.
REFERENCE   5  (bases 1 to 4254)
  AUTHORS   Matsuzaki,T., Kitayama,H., Omura,A., Nishimoto,E., Alexander,D.B.
            and Noda,M.
  TITLE     The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
  JOURNAL   Biol Open 7 (10) (2018)
   PUBMED   30287421
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4254)
  AUTHORS   Ramdas,V., McBride,M., Denby,L. and Baker,A.H.
  TITLE     Canonical transforming growth factor-beta signaling regulates
            disintegrin metalloprotease expression in experimental renal
            fibrosis via miR-29
  JOURNAL   Am J Pathol 183 (6), 1885-1896 (2013)
   PUBMED   24103556
  REMARK    GeneRIF: TGF-beta stimulation of renal cells results in a
            significant up-regulation of Adams 10, 17, 12, and 19
REFERENCE   7  (bases 1 to 4254)
  AUTHORS   Dun,M.D., Anderson,A.L., Bromfield,E.G., Asquith,K.L., Emmett,B.,
            McLaughlin,E.A., Aitken,R.J. and Nixon,B.
  TITLE     Investigation of the expression and functional significance of the
            novel mouse sperm protein, a disintegrin and metalloprotease with
            thrombospondin type 1 motifs number 10 (ADAMTS10)
  JOURNAL   Int J Androl 35 (4), 572-589 (2012)
   PUBMED   22458710
  REMARK    GeneRIF: these studies support the notion that sperm-oocyte
            interactions involve considerable functional redundancy and
            identify ADAMTS10 as a novel candidate in the mediation of these
            fundamentally important events.
REFERENCE   8  (bases 1 to 4254)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   9  (bases 1 to 4254)
  AUTHORS   Somerville,R.P., Jungers,K.A. and Apte,S.S.
  TITLE     Discovery and characterization of a novel, widely expressed
            metalloprotease, ADAMTS10, and its proteolytic activation
  JOURNAL   J Biol Chem 279 (49), 51208-51217 (2004)
   PUBMED   15355968
  REMARK    GeneRIF: ADAMTS10 is a functional metalloprotease as demonstrated
            by cleavage of alpha2-macroglobulin
REFERENCE   10 (bases 1 to 4254)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT030734.24 and AK042525.1.
            
            On Jul 2, 2016 this sequence version replaced XM_017317425.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate a
            functional, zinc-dependent metallopeptidase enzyme. [provided by
            RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.180549.1,
                                           SRR1660815.196253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               CT030734.24        189229-189352
            125-722             AK042525.1         2-599
            723-723             CT030734.24        195291-195291
            724-1830            AK042525.1         601-1707
            1831-1938           AK042525.1         1725-1832
            1939-2084           CT030734.24        208780-208925
            2085-2881           AK042525.1         1833-2629
            2882-2885           CT030734.24        214624-214627
            2886-3526           AK042525.1         2630-3270
            3527-3527           CT030734.24        216545-216545
            3528-4239           AK042525.1         3272-3983
            4240-4254           CT030734.24        218912-218926
FEATURES             Location/Qualifiers
     source          1..4254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..4254
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 10"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
     exon            1..174
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            175..361
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            362..708
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            709..865
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1083
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1172
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1318
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1362
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1705
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1830
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             1786..3666
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="isoform 4 is encoded by transcript variant 8; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 10; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 10;
                     zinc metalloendopeptidase; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 10"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 10 isoform 4"
                     /protein_id="NP_001316082.1"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
                     /translation="MMLMSSADSSMESNREVCSELWCLSKSNRCITNSIPAAEGTLCQ
                     THTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPRPT
                     IGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTWKTYRGGGVKA
                     CSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCR
                     VCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQES
                     LLLEGLPGTPQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASLIIMVLAQAELPALH
                     YRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSGHS
                     KLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSAC
                     PQPRPPVLEACQGPMCPPEWATLDWSECTPSCGPGLRHRVVLCKSADQRSTLPPGHCL
                     PAAKPPSTMRCNLRRCPPARWVTSEWGECSTQCGLGQQQRTVRCTSHTGQPSRECTEA
                     LRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ
                     GR"
     exon            1831..1938
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2084
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2148
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2251
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2385
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2509
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2590
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2754
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2881
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..3011
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3216
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3393
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3556
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..4254
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4220..4225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="hexamer: AATAAA"
     polyA_site      4242
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt tggtttttct ttttttttaa taaccctggc aggctgctca ggaagtgagt
       61 gccttcccgc gccccctccc ccggccacgc caccgggcgc ttgctccctc ccttcctgtg
      121 cgccgggcgg tgagtctgtg cgtctacagc ggaccgaagg ctccaggcac gcaggggacc
      181 agtgatgctg cccagactgt gaacagggga ggcagcactg taggggctgc cagcagccgg
      241 ggctggggag agacatgtgg acacgtagcc cctatggctt ctgcctgcca gatcctccgc
      301 tgggcccttg ccctggggct gggcctcaca ttcaaggtca cgcatgcctt cagatctcaa
      361 gatgagctcc tgtccagttt ggagagctat gagattgcct tcccaactcg agtggaccac
      421 aacggggcaa tgctggcctt ctctccacct gccttccgga ggcagcgtcg gggtgcaggg
      481 gctacaactg agtcccgcct attctacaag gtggccgcac ccagcactca cttcctgctg
      541 aacctgaccc gcagcccccg tctcctggca gggcacgtct cggtggaata ctggacacgg
      601 gaaggcctgg cttggcagag ggctgcccgg gcccactgcc tatacgctgg ccacctgcag
      661 ggccaggctg gtagctccca tgtggccgtc agcacctgtg ggggcctgca tggcctgatt
      721 gtggcagatg atgaagagta tctgattgaa cccctgcaag gtggacccaa aggtcaccgt
      781 ggcccagaag agagtggccc ccatgtagta tacaagcgtt cctctctgcg tcacccccat
      841 ctggacacag cctgtggagt gagagatgag aaaccgtgga agggtcgtcc atggtggtta
      901 cgtaccctga agccaccacc tgccaggccc ctggggaatg aatctgagcg aggccagctg
      961 ggcctgaaga gatcagtcag cagagagcgc tatgtggaga ccctggtggt agccgacaag
     1021 atgatggtgg cctaccatgg gcggagagat gtggagcagt atgtgttggc catcatgaac
     1081 attgtcaggt tgccaaactt ttccaggact cgagtctggg aaacatcgtc aacatcctgg
     1141 tcactcgcct catcctgctc acagaggacc agcccaccct ggagatcacc caccatgccg
     1201 ggaagtcact ggacagcttc tgtaagtggc agaaatccat cgtgagccac agtggccatg
     1261 gcaacgccat cccagagaat ggtgtggcaa accatgacac agctgtgctc atcacacgct
     1321 atgacatctg catctacaag aacaaaccct gcggcactct aggcctggcc cctgtgggtg
     1381 gaatgtgtga gcgtgagagg agctgcagta tcaatgaaga tatcggcctg gccacggctt
     1441 tcaccattgc ccatgagatc gggcacacgt gaggccaggg gacacaggat aggggaggat
     1501 ccgaggatct gggttgggtt cccttagttc ttagcagagc tgatactctt ctcctcagat
     1561 ttggcatgaa tcacgatggc gtgggaaacg gctgtggggc ccgtgggcag gacccagcga
     1621 agctcatggc tgcccacatt accatgaaga ctaatccatt cgtgtggtca tcgtgtagtc
     1681 gagactacat caccagcttt ctggactcgg gcctggggct ttgcttgaat aaccggcctc
     1741 ctagacagga cttcgtgtac ccaacggtgg ctcccggcca ggcctatgat gctgatgagc
     1801 agtgccgatt ccagcatgga gtcaaatcgc gaggtctgca gtgaactgtg gtgtctgagc
     1861 aagagcaatc ggtgcatcac caatagcatc ccagctgctg agggaacact gtgccaaaca
     1921 cacactatcg acaaagggtg gtgctacaaa cgagtctgtg tcccctttgg ctctcggcca
     1981 gagggtgtag acggggcctg gggcccttgg actccatggg gtgactgcag caggtcatgt
     2041 ggcggtggtg tgtcatcttc tagccgtcac tgcgacagtc ccaggccaac cattgggggc
     2101 aagtactgtc tgggcgagag acgaaggcac cggtcctgca acaccaatga ctgtccacct
     2161 ggctcccagg acttcagaga aatgcagtgc tctgaatttg acagtgtccc tttccgcgga
     2221 aaattctaca cgtggaagac ataccgagga gggggtgtga aggcctgttc gctgacttgc
     2281 ctagcagaag gcttcaactt ttatacggag cgagcagcag ctgtggtgga tggaacaccc
     2341 tgccgccctg acacggtgga catttgtgtc agcggcgagt gcaagcatgt aggctgtgac
     2401 agggtcctgg gttctgatct ccgagaggac aaatgccgtg tgtgtggggg tgatggcagt
     2461 gcctgtgaga ccattgaagg tgtctttagc ccagctttgc caggaactgg gtatgaggac
     2521 gtcgtctgga tccccaaagg ctcggtccac attttcatcc aagatctgaa cctgtccctg
     2581 agtcacctgg ccctaaaggg ggaccaagag tctctgctac tggaggggct acctgggacc
     2641 ccccaacctc accgccttcc cctggctgga accacatttc atctacggca ggggccggac
     2701 caggcacaga gcctggaagc cctgggaccc attaatgcat ctctcatcat catggtgctg
     2761 gcccaggcag agttgcctgc tctccactac cgcttcaatg cacccattgc ccgggatgca
     2821 ctgcctccct actcctggca ctatgccccc tggaccaaat gctcagccca gtgtgcaggc
     2881 ggcagccagg tccaagtagt ggagtgccga aatcagctgg acagctcagc agtggcccca
     2941 cactactgta gtggccacag taaattgccc aagaggcagc gtgcctgcaa cacagaacca
     3001 tgtccaccag attgggttgt aggaaactgg tcacgctgca gccgtagctg tgacgctggt
     3061 gtgcgtagcc gctcagtggt gtgccaacgc cgggtgtctg ctgcagagga aaaagcctta
     3121 gacgacagtg cctgtccaca gccacgccca cctgtgctgg aggcctgcca aggcccaatg
     3181 tgccctcctg agtgggcaac cctcgactgg tctgagtgta ccccaagctg tgggcctggt
     3241 ctccgccacc gagtggtcct ttgtaagagt gcagatcaac gatctactct gccccctggg
     3301 cactgccttc ctgcagccaa gccaccatct actatgcgat gtaacttgcg ccgctgccct
     3361 cctgcccgct gggtgaccag tgagtggggt gagtgttcca cacagtgtgg cctcggccag
     3421 cagcagcgca cagtgcgctg caccagccac accggccagc catctcgaga gtgcactgaa
     3481 gccttgcggc catccaccat gcagcagtgt gaggccaagt gtgacagtgt ggtgccgcct
     3541 ggagatggcc cagaagaatg caaggatgtg aacaaggtgg cttactgccc cctggtgctc
     3601 aaatttcagt tctgtagccg agcctacttc cgccagatgt gctgcaaaac ctgccaaggc
     3661 cgctagggta cctggaacca acctggagca caggctgagg caggggacat cccactggag
     3721 agggcatgag ggaaaggggg gcttgaattg aagggtgaga tgcagttgaa agttatttat
     3781 tgggtaaccc tacagggctc ctgactaagg ggtggagaag agctggctac ccagggaccc
     3841 tctgctgtat cttgcccagt tgatagtgaa gagagaggac tccttgttgc acacatattt
     3901 aagtccctag cacccctccc accctttgat cggaatatgt actgtgaaga gtgggggtgg
     3961 ggaggggtgt gctggtgccc tgccccctgc actgttctat ccctacactc tgagctgggg
     4021 ggatttatat ctgctatggg gggggtaggc ttgataccac ctccctgtag ccctccccca
     4081 gactgacgaa ggggaagatc caccccaacc tctgccctgc ctgccccagg ggggagttca
     4141 acatccaggc cgttccccat catggtgcta caagccctgc cctggggccc acacactcct
     4201 caccaagaag ccttacatta ataaagttct gtcttgtgta gatttctgct cctg
//
