LOCUS       NM_001329152            4255 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            10 (Adamts10), transcript variant 7, mRNA.
ACCESSION   NM_001329152 XM_017317419
VERSION     NM_001329152.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 4255)
  AUTHORS   Wu,H.J., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Optic neuropathy associated with TGFbeta dysregulation in mice with
            a glaucoma-causative mutation of ADAMTS10
  JOURNAL   Matrix Biol 113, 83-99 (2022)
   PUBMED   36216203
  REMARK    GeneRIF: Optic neuropathy associated with TGFbeta dysregulation in
            mice with a glaucoma-causative mutation of ADAMTS10.
REFERENCE   3  (bases 1 to 4255)
  AUTHORS   Mead,T.J., Martin,D.R., Wang,L.W., Cain,S.A., Gulec,C., Cahill,E.,
            Mauch,J., Reinhardt,D., Lo,C., Baldock,C. and Apte,S.S.
  TITLE     Proteolysis of fibrillin-2 microfibrils is essential for normal
            skeletal development
  JOURNAL   Elife 11, e71142 (2022)
   PUBMED   35503090
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4255)
  AUTHORS   Wu,H.J., Mortlock,D.P., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Altered Ocular Fibrillin Microfibril Composition in Mice With a
            Glaucoma-Causing Mutation of Adamts10
  JOURNAL   Invest Ophthalmol Vis Sci 62 (10), 26 (2021)
   PUBMED   34424262
  REMARK    GeneRIF: Altered Ocular Fibrillin Microfibril Composition in Mice
            With a Glaucoma-Causing Mutation of Adamts10.
REFERENCE   5  (bases 1 to 4255)
  AUTHORS   Matsuzaki,T., Kitayama,H., Omura,A., Nishimoto,E., Alexander,D.B.
            and Noda,M.
  TITLE     The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
  JOURNAL   Biol Open 7 (10) (2018)
   PUBMED   30287421
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4255)
  AUTHORS   Ramdas,V., McBride,M., Denby,L. and Baker,A.H.
  TITLE     Canonical transforming growth factor-beta signaling regulates
            disintegrin metalloprotease expression in experimental renal
            fibrosis via miR-29
  JOURNAL   Am J Pathol 183 (6), 1885-1896 (2013)
   PUBMED   24103556
  REMARK    GeneRIF: TGF-beta stimulation of renal cells results in a
            significant up-regulation of Adams 10, 17, 12, and 19
REFERENCE   7  (bases 1 to 4255)
  AUTHORS   Dun,M.D., Anderson,A.L., Bromfield,E.G., Asquith,K.L., Emmett,B.,
            McLaughlin,E.A., Aitken,R.J. and Nixon,B.
  TITLE     Investigation of the expression and functional significance of the
            novel mouse sperm protein, a disintegrin and metalloprotease with
            thrombospondin type 1 motifs number 10 (ADAMTS10)
  JOURNAL   Int J Androl 35 (4), 572-589 (2012)
   PUBMED   22458710
  REMARK    GeneRIF: these studies support the notion that sperm-oocyte
            interactions involve considerable functional redundancy and
            identify ADAMTS10 as a novel candidate in the mediation of these
            fundamentally important events.
REFERENCE   8  (bases 1 to 4255)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   9  (bases 1 to 4255)
  AUTHORS   Somerville,R.P., Jungers,K.A. and Apte,S.S.
  TITLE     Discovery and characterization of a novel, widely expressed
            metalloprotease, ADAMTS10, and its proteolytic activation
  JOURNAL   J Biol Chem 279 (49), 51208-51217 (2004)
   PUBMED   15355968
  REMARK    GeneRIF: ADAMTS10 is a functional metalloprotease as demonstrated
            by cleavage of alpha2-macroglobulin
REFERENCE   10 (bases 1 to 4255)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT030734.24 and AK042525.1.
            
            On Jul 2, 2016 this sequence version replaced XM_017317419.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate a
            functional, zinc-dependent metallopeptidase enzyme. [provided by
            RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.36961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               CT030734.24        189229-189352
            125-722             AK042525.1         2-599
            723-723             CT030734.24        195291-195291
            724-1083            AK042525.1         601-960
            1084-1831           AK042525.1         966-1713
            1832-1939           AK042525.1         1725-1832
            1940-2085           CT030734.24        208780-208925
            2086-2882           AK042525.1         1833-2629
            2883-2886           CT030734.24        214624-214627
            2887-3527           AK042525.1         2630-3270
            3528-3528           CT030734.24        216545-216545
            3529-4240           AK042525.1         3272-3983
            4241-4255           CT030734.24        218912-218926
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..4255
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 10"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
     exon            1..174
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            175..361
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            362..708
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            709..865
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1083
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1167
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1313
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1357
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1700
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1831
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             1781..3667
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="isoform 3 is encoded by transcript variant 7; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 10; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 10;
                     zinc metalloendopeptidase; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 10"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 10 isoform 3"
                     /protein_id="NP_001316081.1"
                     /db_xref="GeneID:224697"
                     /db_xref="MGI:MGI:2449112"
                     /translation="MMLMSSADSSMESNRVSEVCSELWCLSKSNRCITNSIPAAEGTL
                     CQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPR
                     PTIGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTWKTYRGGGV
                     KACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDK
                     CRVCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQ
                     ESLLLEGLPGTPQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASLIIMVLAQAELPA
                     LHYRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSG
                     HSKLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRRVSAAEEKALDDS
                     ACPQPRPPVLEACQGPMCPPEWATLDWSECTPSCGPGLRHRVVLCKSADQRSTLPPGH
                     CLPAAKPPSTMRCNLRRCPPARWVTSEWGECSTQCGLGQQQRTVRCTSHTGQPSRECT
                     EALRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKT
                     CQGR"
     exon            1832..1939
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2085
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2149
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2252
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2386
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2510
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2591
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2755
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2882
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3012
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3217
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3394
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3557
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..4255
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4221..4226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="hexamer: AATAAA"
     polyA_site      4243
                     /gene="Adamts10"
                     /gene_synonym="9430006O18; Adam-ts10; Adamts-10; Znmp"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt tggtttttct ttttttttaa taaccctggc aggctgctca ggaagtgagt
       61 gccttcccgc gccccctccc ccggccacgc caccgggcgc ttgctccctc ccttcctgtg
      121 cgccgggcgg tgagtctgtg cgtctacagc ggaccgaagg ctccaggcac gcaggggacc
      181 agtgatgctg cccagactgt gaacagggga ggcagcactg taggggctgc cagcagccgg
      241 ggctggggag agacatgtgg acacgtagcc cctatggctt ctgcctgcca gatcctccgc
      301 tgggcccttg ccctggggct gggcctcaca ttcaaggtca cgcatgcctt cagatctcaa
      361 gatgagctcc tgtccagttt ggagagctat gagattgcct tcccaactcg agtggaccac
      421 aacggggcaa tgctggcctt ctctccacct gccttccgga ggcagcgtcg gggtgcaggg
      481 gctacaactg agtcccgcct attctacaag gtggccgcac ccagcactca cttcctgctg
      541 aacctgaccc gcagcccccg tctcctggca gggcacgtct cggtggaata ctggacacgg
      601 gaaggcctgg cttggcagag ggctgcccgg gcccactgcc tatacgctgg ccacctgcag
      661 ggccaggctg gtagctccca tgtggccgtc agcacctgtg ggggcctgca tggcctgatt
      721 gtggcagatg atgaagagta tctgattgaa cccctgcaag gtggacccaa aggtcaccgt
      781 ggcccagaag agagtggccc ccatgtagta tacaagcgtt cctctctgcg tcacccccat
      841 ctggacacag cctgtggagt gagagatgag aaaccgtgga agggtcgtcc atggtggtta
      901 cgtaccctga agccaccacc tgccaggccc ctggggaatg aatctgagcg aggccagctg
      961 ggcctgaaga gatcagtcag cagagagcgc tatgtggaga ccctggtggt agccgacaag
     1021 atgatggtgg cctaccatgg gcggagagat gtggagcagt atgtgttggc catcatgaac
     1081 attgttgcca aacttttcca ggactcgagt ctgggaaaca tcgtcaacat cctggtcact
     1141 cgcctcatcc tgctcacaga ggaccagccc accctggaga tcacccacca tgccgggaag
     1201 tcactggaca gcttctgtaa gtggcagaaa tccatcgtga gccacagtgg ccatggcaac
     1261 gccatcccag agaatggtgt ggcaaaccat gacacagctg tgctcatcac acgctatgac
     1321 atctgcatct acaagaacaa accctgcggc actctaggcc tggcccctgt gggtggaatg
     1381 tgtgagcgtg agaggagctg cagtatcaat gaagatatcg gcctggccac ggctttcacc
     1441 attgcccatg agatcgggca cacgtgaggc caggggacac aggatagggg aggatccgag
     1501 gatctgggtt gggttccctt agttcttagc agagctgata ctcttctcct cagatttggc
     1561 atgaatcacg atggcgtggg aaacggctgt ggggcccgtg ggcaggaccc agcgaagctc
     1621 atggctgccc acattaccat gaagactaat ccattcgtgt ggtcatcgtg tagtcgagac
     1681 tacatcacca gctttctgga ctcgggcctg gggctttgct tgaataaccg gcctcctaga
     1741 caggacttcg tgtacccaac ggtggctccc ggccaggcct atgatgctga tgagcagtgc
     1801 cgattccagc atggagtcaa atcgcgtcag tgaggtctgc agtgaactgt ggtgtctgag
     1861 caagagcaat cggtgcatca ccaatagcat cccagctgct gagggaacac tgtgccaaac
     1921 acacactatc gacaaagggt ggtgctacaa acgagtctgt gtcccctttg gctctcggcc
     1981 agagggtgta gacggggcct ggggcccttg gactccatgg ggtgactgca gcaggtcatg
     2041 tggcggtggt gtgtcatctt ctagccgtca ctgcgacagt cccaggccaa ccattggggg
     2101 caagtactgt ctgggcgaga gacgaaggca ccggtcctgc aacaccaatg actgtccacc
     2161 tggctcccag gacttcagag aaatgcagtg ctctgaattt gacagtgtcc ctttccgcgg
     2221 aaaattctac acgtggaaga cataccgagg agggggtgtg aaggcctgtt cgctgacttg
     2281 cctagcagaa ggcttcaact tttatacgga gcgagcagca gctgtggtgg atggaacacc
     2341 ctgccgccct gacacggtgg acatttgtgt cagcggcgag tgcaagcatg taggctgtga
     2401 cagggtcctg ggttctgatc tccgagagga caaatgccgt gtgtgtgggg gtgatggcag
     2461 tgcctgtgag accattgaag gtgtctttag cccagctttg ccaggaactg ggtatgagga
     2521 cgtcgtctgg atccccaaag gctcggtcca cattttcatc caagatctga acctgtccct
     2581 gagtcacctg gccctaaagg gggaccaaga gtctctgcta ctggaggggc tacctgggac
     2641 cccccaacct caccgccttc ccctggctgg aaccacattt catctacggc aggggccgga
     2701 ccaggcacag agcctggaag ccctgggacc cattaatgca tctctcatca tcatggtgct
     2761 ggcccaggca gagttgcctg ctctccacta ccgcttcaat gcacccattg cccgggatgc
     2821 actgcctccc tactcctggc actatgcccc ctggaccaaa tgctcagccc agtgtgcagg
     2881 cggcagccag gtccaagtag tggagtgccg aaatcagctg gacagctcag cagtggcccc
     2941 acactactgt agtggccaca gtaaattgcc caagaggcag cgtgcctgca acacagaacc
     3001 atgtccacca gattgggttg taggaaactg gtcacgctgc agccgtagct gtgacgctgg
     3061 tgtgcgtagc cgctcagtgg tgtgccaacg ccgggtgtct gctgcagagg aaaaagcctt
     3121 agacgacagt gcctgtccac agccacgccc acctgtgctg gaggcctgcc aaggcccaat
     3181 gtgccctcct gagtgggcaa ccctcgactg gtctgagtgt accccaagct gtgggcctgg
     3241 tctccgccac cgagtggtcc tttgtaagag tgcagatcaa cgatctactc tgccccctgg
     3301 gcactgcctt cctgcagcca agccaccatc tactatgcga tgtaacttgc gccgctgccc
     3361 tcctgcccgc tgggtgacca gtgagtgggg tgagtgttcc acacagtgtg gcctcggcca
     3421 gcagcagcgc acagtgcgct gcaccagcca caccggccag ccatctcgag agtgcactga
     3481 agccttgcgg ccatccacca tgcagcagtg tgaggccaag tgtgacagtg tggtgccgcc
     3541 tggagatggc ccagaagaat gcaaggatgt gaacaaggtg gcttactgcc ccctggtgct
     3601 caaatttcag ttctgtagcc gagcctactt ccgccagatg tgctgcaaaa cctgccaagg
     3661 ccgctagggt acctggaacc aacctggagc acaggctgag gcaggggaca tcccactgga
     3721 gagggcatga gggaaagggg ggcttgaatt gaagggtgag atgcagttga aagttattta
     3781 ttgggtaacc ctacagggct cctgactaag gggtggagaa gagctggcta cccagggacc
     3841 ctctgctgta tcttgcccag ttgatagtga agagagagga ctccttgttg cacacatatt
     3901 taagtcccta gcacccctcc caccctttga tcggaatatg tactgtgaag agtgggggtg
     3961 gggaggggtg tgctggtgcc ctgccccctg cactgttcta tccctacact ctgagctggg
     4021 gggatttata tctgctatgg ggggggtagg cttgatacca cctccctgta gccctccccc
     4081 agactgacga aggggaagat ccaccccaac ctctgccctg cctgccccag gggggagttc
     4141 aacatccagg ccgttcccca tcatggtgct acaagccctg ccctggggcc cacacactcc
     4201 tcaccaagaa gccttacatt aataaagttc tgtcttgtgt agatttctgc tcctg
//
