LOCUS       NM_009621               4902 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            1 (Adamts1), mRNA.
ACCESSION   NM_009621
VERSION     NM_009621.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4902)
  AUTHORS   Chen,T., Liu,S., Yang,Z., Feng,S., Fang,W., Lu,X. and Li,J.
  TITLE     Investigation roles of Adamts1 and Adamts5 in scleral fibroblasts
            under hypoxia and mice with form-deprived myopia
  JOURNAL   Exp Eye Res 247, 110026 (2024)
   PUBMED   39122105
  REMARK    GeneRIF: Investigation roles of Adamts1 and Adamts5 in scleral
            fibroblasts under hypoxia and mice with form-deprived myopia.
REFERENCE   2  (bases 1 to 4902)
  AUTHORS   Mead,T.J., Bhutada,S., Foulcer,S.J., Peruzzi,N., Nelson,C.M.,
            Seifert,D.E., Larkin,J., Tran-Lundmark,K., Filmus,J. and Apte,S.S.
  TITLE     Combined genetic-pharmacologic inactivation of tightly linked
            ADAMTS proteases in temporally specific windows uncovers distinct
            roles for versican proteolysis and glypican-6 in cardiac
            development
  JOURNAL   Matrix Biol 131, 1-16 (2024)
   PUBMED   38750698
  REMARK    GeneRIF: Combined genetic-pharmacologic inactivation of tightly
            linked ADAMTS proteases in temporally specific windows uncovers
            distinct roles for versican proteolysis and glypican-6 in cardiac
            development.
REFERENCE   3  (bases 1 to 4902)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   4  (bases 1 to 4902)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4902)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4902)
  AUTHORS   Kelwick,R., Desanlis,I., Wheeler,G.N. and Edwards,D.R.
  TITLE     The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin
            motifs) family
  JOURNAL   Genome Biol 16 (1), 113 (2015)
   PUBMED   26025392
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4902)
  AUTHORS   Kuno,K., Terashima,Y. and Matsushima,K.
  TITLE     ADAMTS-1 is an active metalloproteinase associated with the
            extracellular matrix
  JOURNAL   J Biol Chem 274 (26), 18821-18826 (1999)
   PUBMED   10373500
REFERENCE   8  (bases 1 to 4902)
  AUTHORS   Kuno,K. and Matsushima,K.
  TITLE     ADAMTS-1 protein anchors at the extracellular matrix through the
            thrombospondin type I motifs and its spacing region
  JOURNAL   J Biol Chem 273 (22), 13912-13917 (1998)
   PUBMED   9593739
REFERENCE   9  (bases 1 to 4902)
  AUTHORS   Kuno,K., Iizasa,H., Ohno,S. and Matsushima,K.
  TITLE     The exon/intron organization and chromosomal mapping of the mouse
            ADAMTS-1 gene encoding an ADAM family protein with TSP motifs
  JOURNAL   Genomics 46 (3), 466-471 (1997)
   PUBMED   9441751
REFERENCE   10 (bases 1 to 4902)
  AUTHORS   Kuno,K., Kanada,N., Nakashima,E., Fujiki,F., Ichimura,F. and
            Matsushima,K.
  TITLE     Molecular cloning of a gene encoding a new type of
            metalloproteinase-disintegrin family protein with thrombospondin
            motifs as an inflammation associated gene
  JOURNAL   J Biol Chem 272 (1), 556-562 (1997)
   PUBMED   8995297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK163622.1, AK161409.1,
            AC126936.4, CF738767.1 and BP764139.1.
            
            On Oct 6, 2015 this sequence version replaced NM_009621.4.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motif) family and
            preproprotein that is proteolytically processed to generate a
            mature protein product. This secreted protein product plays an
            important role in ovulation, likely through its cleavage of the
            extracellular matrix component versican. The encoded protein may
            enhance tumorigenesis in a mouse model of breast cancer. Homozygous
            knockout mice for this gene exhibit enhanced perinatal lethality,
            impaired growth and adipose tissue development, and impaired
            ovulation in females. [provided by RefSeq, Oct 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050834.1, AK156830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2935              AK163622.1         2-2936
            2936-3235           AK161409.1         2040-2339
            3236-3659           AC126936.4         111421-111844       c
            3660-4338           CF738767.1         1-679
            4339-4902           BP764139.1         28-591              c
FEATURES             Location/Qualifiers
     source          1..4902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 48.2 cM"
     gene            1..4902
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 1"
                     /db_xref="GeneID:11504"
                     /db_xref="MGI:MGI:109249"
     exon            1..1136
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1483
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1616
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1784
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..2071
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2258
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2434
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2610
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..4884
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4859..4864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /note="hexamer: AATAAA"
     polyA_site      4884
                     /gene="Adamts1"
                     /gene_synonym="ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1;
                     METH1"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgcta gaaagcagct ccgagctagg tgctatcgca aggccagagc gcacagcccg
       61 gcggagagag cagatccttg ctcagatcga gtcaaatcgg ggccaaggcg gaggacgaag
      121 agtccaggct cctattctgg acttgttccc cagctccggg ggcgcttcta ggtcctgcag
      181 cagccagcag tgcggagcca ccaactcggt gctggaatga aaaaattccc gcgcgccagt
      241 gcagaatctt tctaagtgac ccggagcttc gggtgctagc tctgcacgaa ctttcccatc
      301 aaagtgatcg tgaattttaa gcatcaggag caggccagcg aagctctacg cgtctaaacg
      361 tctatccaga ccaagagttc tctgcggtgc agggtgcggt gccatgcagc caaaagtccc
      421 tttggggtca cgcaagcaga agccctgctc cgacatgggg gacgtccagc gggcagcgag
      481 atctcggggc tctctgtccg cacacatgct gttgctgctc ctcgcttcca taacaatgct
      541 gctatgtgcg cggggcgcac acgggcgccc cacggaggaa gatgaggagc tggtcctgcc
      601 ctcgctggag cgcgccccgg gccacgattc caccaccaca cgccttcgtc tggacgcctt
      661 tggccagcag ctacatctga agttgcagcc ggacagcggt ttcttggcgc ctggcttcac
      721 cctgcagact gtggggcgca gtcccgggtc cgaggcacaa catctggacc ccaccgggga
      781 cctggctcac tgcttctact ctggcacggt gaacggtgat cccggctctg ccgcagccct
      841 cagcctctgt gaaggtgtgc gtggtgcctt ctacctacaa ggagaggagt tcttcattca
      901 gccagcgcct ggagtggcca ccgagcgcct ggcccctgcc gtgcccgagg aggagtcatc
      961 cgcacggccg cagttccaca tcctgaggcg aaggcggcgg ggcagtggcg gcgccaagtg
     1021 cggcgtcatg gacgacgaga ccctgccaac cagcgactcg cgacccgaga gccagaacac
     1081 ccggaaccag tggcctgtgc gggaccccac gcctcaggac gcgggaaagc catcaggacc
     1141 aggaagcata aggaagaagc gatttgtgtc cagcccccgt tatgtggaaa ccatgctcgt
     1201 agctgaccag tccatggccg acttccacgg cagcggtcta aagcattacc ttctaaccct
     1261 gttctcggtg gcagccaggt tttacaagca tcccagcatt aggaattcaa ttagcctggt
     1321 ggtggtgaag atcttggtca tatacgagga gcagaaggga ccagaagtta cctccaatgc
     1381 agctctcacc cttcggaatt tctgcagctg gcagaaacaa cacaacagcc ccagtgaccg
     1441 ggatccagag cactatgaca ctgcaattct gttcaccaga caggatttat gtggctccca
     1501 cacgtgtgac actctcggaa tggcagatgt tggaaccgta tgtgacccca gcaggagctg
     1561 ctcagtcata gaagatgatg gtttgcaagc cgccttcacc acagcccatg aattgggcca
     1621 tgtgtttaac atgccgcacg atgatgctaa gcactgtgcc agcttgaatg gtgtgagtgg
     1681 cgattctcat ctgatggcct cgatgctctc cagcttagac catagccagc cctggtcacc
     1741 ttgcagtgcc tacatggtca cgtccttcct agataatgga cacggggaat gtttgatgga
     1801 caagccccag aatccaatca agctcccttc tgatcttccc ggtaccttgt acgatgccaa
     1861 ccgccagtgt cagtttacat tcggagagga atccaagcac tgccctgatg cagccagcac
     1921 atgtactacc ctgtggtgca ctggcacctc cggtggctta ctggtgtgcc aaacaaaaca
     1981 cttcccttgg gcagatggca ccagctgtgg agaagggaag tggtgtgtca gtggcaagtg
     2041 cgtgaacaag acagacatga agcattttgc tactcctgtt catggaagct ggggaccatg
     2101 gggaccgtgg ggagactgct caagaacctg tggtggtgga gttcaataca caatgagaga
     2161 atgtgacaac ccagtcccaa agaacggagg gaagtactgt gaaggcaaac gagtccgcta
     2221 caggtcctgt aacatcgagg actgtccaga caataacgga aaaacgttca gagaggagca
     2281 gtgcgaggcg cacaatgagt tttccaaagc ttcctttggg aatgagccca ctgtagagtg
     2341 gacacccaag tacgccggcg tctcgccaaa ggacaggtgc aagctcacct gtgaagccaa
     2401 aggcattggc tactttttcg tcttacagcc caaggttgta gatggcactc cctgtagtcc
     2461 agactctacc tctgtctgtg tgcaagggca gtgtgtgaaa gctggctgtg atcgcatcat
     2521 agactccaaa aagaagtttg ataagtgtgg cgtttgtgga ggaaacggtt ccacatgcaa
     2581 gaagatgtca ggaatagtca ctagtacaag acctgggtat catgacattg tcacaattcc
     2641 tgctggagcc accaacattg aagtgaaaca tcggaatcaa agggggtcca gaaacaatgg
     2701 cagctttctg gctattagag ccgctgatgg tacctatatt ctgaatggaa acttcactct
     2761 gtccacacta gagcaagacc tcacctacaa aggtactgtc ttaaggtaca gtggttcctc
     2821 ggctgcgctg gaaagaatcc gcagctttag tccactcaaa gaacccttaa ccatccaggt
     2881 tcttatggta ggccatgctc tccgacccaa aattaaattc acctacttta tgaagaagaa
     2941 gacagagtca ttcaacgcca ttcccacatt ttctgagtgg gtgattgaag agtgggggga
     3001 gtgctccaag acatgcggct caggttggca gagaagagta gtgcagtgca gagacattaa
     3061 cggacaccct gcttccgaat gtgcaaagga agtgaagcca gccagtacca gaccttgtgc
     3121 agaccttcct tgcccacact ggcaggtggg ggattggtca ccatgttcca aaacttgcgg
     3181 gaagggttac aagaagagaa ccttgaaatg tgtgtcccac gatgggggcg tgttatcaaa
     3241 tgagagctgt gatcctttga agaagccaaa gcattacatt gacttttgca cactgacaca
     3301 gtgcagttaa gaggcgttag aggacaaggt agcgtgggga ggggctgata cactgagtgc
     3361 aagagtactg gagggatcca gtgagtcaaa ccagtaagca gtgaggtgtg gcaaggaggt
     3421 gtgtgtaggg gatacatagc aaaggaggta gatcaggaca ctaccctgcc agttacattc
     3481 tgataaggta gttaatgagg cacagtagca tctgaaagac catacagagc actaaggagc
     3541 cccaaagcac tattagtatc tcttttctta tatctatcgc ccaaataatt ttcagagtct
     3601 ggcagaagcc ctgttgcact gtactaacta gatacttctt atcacaaaga ttgggaaagg
     3661 caaagcagaa agatggtaag actgggtttc aaacaaggct tggtttcaat cactggaggc
     3721 aaggaggagg ggacaaacaa gatcattatt cgaagtcgct ggttgctgtg gttttacgga
     3781 aggttgatgc atcattccta tcaacagtga aaagttcagc ttgttcaacg tgacagaaag
     3841 gctcatctcc gtgaaagagc tcctgatttc ttcttacacc atctcagttc ttaactatag
     3901 ttcatgttga ggtagaaaca attcatctat ttataaaatg tacattggaa aaaaaaagtg
     3961 aagtttatga ggtacacata aaaactgaag gaaacaatga gcaacatgcc tcctgctttg
     4021 cttcctcctg aggtaaacct gcctggggat tgaggttgtt taagattatc catggctcac
     4081 aagaggcagt aaaataatac atgttgtgcc agagttagaa tggggtatag agatcagggt
     4141 cccatgagat ggggaacatg gtgatcactc atctcacatg ggaggctgct gcagggtagc
     4201 aggtccactc ctggcagctg gtccaacagt cgtatcctgg tgaatgtctg ttcagctctt
     4261 ctactgagag agaatatgac tgtttccata tgtatatgta tatagtaaaa tatgttacta
     4321 tgaattgcat gtactttata agtattggtg tgtctgttcc ttctaagaag gactatagtt
     4381 tataataaat gcctataata acatatttat ttttatacat ttatttctaa tgataaaacc
     4441 tttaagttat atcgcttttg taaaagtgca tataaaaata gagtatttat acaatatatg
     4501 ttaactagaa ataataaaag aacacttttg aatgtgtatg cctattttct ggagtgggat
     4561 taacttctgg gcaagaaatc tgatgagaca caaacattgg acttcaagac agttttaaaa
     4621 tttgggtaaa tgaactgtat ttcctgttta tagacgtact aataaaaaag aagttgatga
     4681 tgtctttagt ggtaagattg ttactaatgt ggttggcaaa ttgctgtaaa gagccagata
     4741 gtaagcattt atggcattgt aggctatctt tcctgccaca accatgtgac agtgagtgct
     4801 ttgtaggact gagagcagcc ataaatgaca tgtaaatgat aaactgtggc tgtgctttaa
     4861 taaaacttta tttacaaaaa caaaaaaaaa aaaaaaaaaa aa
//
