LOCUS       NM_021475               2433 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus ADAM-like, decysin 1 (Adamdec1), mRNA.
ACCESSION   NM_021475
VERSION     NM_021475.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2433)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   2  (bases 1 to 2433)
  AUTHORS   Wang,X., Gao,F., Cheng,C. and Zhang,Y.
  TITLE     Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell
            injury and atherosclerosis progression
  JOURNAL   Funct Integr Genomics 24 (1), 1 (2023)
   PUBMED   38063920
  REMARK    GeneRIF: Knockdown of ADAMDEC1 ameliorates ox-LDL-induced
            endothelial cell injury and atherosclerosis progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2433)
  AUTHORS   Zhao,L., Song,W. and Chen,Y.G.
  TITLE     Mesenchymal-epithelial interaction regulates gastrointestinal tract
            development in mouse embryos
  JOURNAL   Cell Rep 40 (2), 111053 (2022)
   PUBMED   35830795
REFERENCE   4  (bases 1 to 2433)
  AUTHORS   Ha,S.E., Jorgensen,B.G., Wei,L., Jin,B., Kim,M.S., Poudrier,S.M.,
            Singh,R., Bartlett,A., Zogg,H., Kim,S., Baek,G., Kurahashi,M.,
            Lee,M.Y., Kim,Y.S., Choi,S.C., Sasse,K.C., Rubin,S.J.S.,
            Gottfried-Blackmore,A., Becker,L., Habtezion,A., Sanders,K.M. and
            Ro,S.
  TITLE     Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic
            Subepithelial PDGFRalpha+ Cells Is a New Marker for Inflammatory
            Bowel Disease
  JOURNAL   Int J Mol Sci 23 (9), 5007 (2022)
   PUBMED   35563399
  REMARK    GeneRIF: Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in
            Colonic Subepithelial PDGFRalpha(+) Cells Is a New Marker for
            Inflammatory Bowel Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2433)
  AUTHORS   Jasso,G.J., Jaiswal,A., Varma,M., Laszewski,T., Grauel,A., Omar,A.,
            Silva,N., Dranoff,G., Porter,J.A., Mansfield,K., Cremasco,V.,
            Regev,A., Xavier,R.J. and Graham,D.B.
  TITLE     Colon stroma mediates an inflammation-driven fibroblastic response
            controlling matrix remodeling and healing
  JOURNAL   PLoS Biol 20 (1), e3001532 (2022)
   PUBMED   35085231
  REMARK    GeneRIF: Colon stroma mediates an inflammation-driven fibroblastic
            response controlling matrix remodeling and healing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2433)
  AUTHORS   Rampon,C., Bouillot,S., Climescu-Haulica,A., Prandini,M.H.,
            Cand,F., Vandenbrouck,Y. and Huber,P.
  TITLE     Protocadherin 12 deficiency alters morphogenesis and
            transcriptional profile of the placenta
  JOURNAL   Physiol Genomics 34 (2), 193-204 (2008)
   PUBMED   18477666
REFERENCE   7  (bases 1 to 2433)
  AUTHORS   Kim,E., Rhee,S.D., Bae,Y., Okumoto,M., Yoon,J.B., Song,C.W. and
            Yoon,S.K.
  TITLE     Genomic organization of the region spanning D14Mit262 and D14Mit86
            on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the
            cataract-causing gene, lr2
  JOURNAL   Cytogenet Genome Res 116 (1-2), 12-17 (2007)
   PUBMED   17268172
REFERENCE   8  (bases 1 to 2433)
  AUTHORS   Baran,N., Kelly,P.A. and Binart,N.
  TITLE     Decysin, a new member of the metalloproteinase family, is regulated
            by prolactin and steroids during mouse pregnancy
  JOURNAL   Biol Reprod 68 (5), 1787-1792 (2003)
   PUBMED   12606478
REFERENCE   9  (bases 1 to 2433)
  AUTHORS   Bates,E.E., Fridman,W.H. and Mueller,C.G.
  TITLE     The ADAMDEC1 (decysin) gene structure: evolution by duplication in
            a metalloprotease gene cluster on chromosome 8p12
  JOURNAL   Immunogenetics 54 (2), 96-105 (2002)
   PUBMED   12037602
REFERENCE   10 (bases 1 to 2433)
  AUTHORS   Mueller,C.G., Cremer,I., Paulet,P.E., Niida,S., Maeda,N.,
            Lebeque,S., Fridman,W.H. and Sautes-Fridman,C.
  TITLE     Mannose receptor ligand-positive cells express the metalloprotease
            decysin in the B cell follicle
  JOURNAL   J Immunol 167 (9), 5052-5060 (2001)
   PUBMED   11673514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025563.11 and AC154706.2.
            
            On Feb 17, 2022 this sequence version replaced NM_021475.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046324.1, AK156586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               CT025563.11        122764-122891
            129-247             CT025563.11        124195-124313
            248-324             CT025563.11        125620-125696
            325-403             CT025563.11        126921-126999
            404-480             CT025563.11        127687-127763
            481-667             CT025563.11        131585-131771
            668-727             CT025563.11        131965-132024
            728-799             CT025563.11        133026-133097
            800-966             CT025563.11        133352-133518
            967-1048            CT025563.11        133877-133958
            1049-1179           AC154706.2         239-369
            1180-1354           AC154706.2         1555-1729
            1355-1437           AC154706.2         4840-4922
            1438-2433           AC154706.2         6065-7060
FEATURES             Location/Qualifiers
     source          1..2433
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 35.69 cM"
     gene            1..2433
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /note="ADAM-like, decysin 1"
                     /db_xref="GeneID:58860"
                     /db_xref="MGI:MGI:1917650"
     exon            1..128
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1444
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /note="decysin; disintegrin metalloprotease (decysin);
                     ADAM DEC1; ADAM-like protein decysin-1; a disintegrin and
                     metalloproteinase domain-like protein decysin-1"
                     /codon_start=1
                     /product="ADAM DEC1 precursor"
                     /protein_id="NP_067450.1"
                     /db_xref="CCDS:CCDS49532.1"
                     /db_xref="GeneID:58860"
                     /db_xref="MGI:MGI:1917650"
                     /translation="MLPGTSRLPTEASMSWVLLSVLWLIIQIQVIDATLTPELKPHEI
                     VRPKKLPISQKRGLENNQTERYGKEEKYAPEVQYQIILNGEEIVFHLKRTKHLLGPDY
                     TETSYSPRGEESTRHSQDVKPCYYEGHIQNARGSLARISTCDGLRGYFTHRDQRYQIK
                     PLQSTDEGEHAVLPYSWKGQDTVHDKDAEKQVVRKRSHLRTSRSLKNPNEDLLQGQKY
                     IGLFLVLDNAYYKLYNGNVTQMRTFLFKVLNLLNMIYKTINIQVSLVGMEIWSDQDKI
                     KVEPNLGATFTHFMRWHYSNLGKRIHNHAQLLSGASFRHGRVGMAAGNSFCTTSSVSV
                     IEAKKKNNVALVALMSHELGHALGMKDVPYYTKCPSGSCVMNQYLSSKFPKDFSTVSR
                     SHFQGFLSSRNARCLLLAPDPKNIIKPTCGNQVLDVGEECDCGSPEECTNLCCEPLTC
                     RLKSQPDCSEASNHITE"
     exon            129..247
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            248..324
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            325..403
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            404..480
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            481..667
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            668..727
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            728..799
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            800..966
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1048
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1179
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1354
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1437
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..2433
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2410..2415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /note="hexamer: AATAAA"
     polyA_site      2433
                     /gene="Adamdec1"
                     /gene_synonym="2210414L24Rik; Dcsn"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagat aaaactggcc actggagaga ccatagctgt atgctgcctg ggacttctcg
       61 gctacccaca gaagccagca tgtcttgggt cctgctttca gtcctgtggc ttatcattca
      121 aatccaagtg atagatgcaa cgttaacccc cgagttaaag cctcacgaaa tagttcgtcc
      181 taaaaaacta cccatttcac agaaaagagg gcttgagaac aaccagacag agagatatgg
      241 caaagaggaa aaatatgcac cagaagttca atatcagatc atactaaatg gagaagaaat
      301 tgtttttcac ctaaagagaa ccaagcatct tctggggcca gactacactg aaacatctta
      361 ctcacccaga ggagaagaga gcaccagaca ctctcaggat gtgaaaccct gctactatga
      421 aggccacatc caaaatgcaa ggggctctct ggccaggatc agtacctgtg atgggttgag
      481 agggtacttc acacatcgtg atcagagata tcaaataaag cctctacaaa gcacagatga
      541 gggagagcat gctgttctcc catacagctg gaagggacaa gacacagttc atgacaagga
      601 tgctgagaag caagttgtca ggaaacgaag ccatcttcga acttccaggt cactcaaaaa
      661 cccaaatgaa gacttacttc aaggacagaa gtacattggt ctctttttgg tgctggataa
      721 tgcctattat aagctgtata atgggaatgt gactcagatg agaacctttc tgttcaaggt
      781 gctgaatctg ctcaatatga tttataaaac cataaatatt caagtgtctt tggtgggcat
      841 ggagatctgg tctgaccagg acaagataaa ggtggagccc aaccttggtg ccacgttcac
      901 acacttcatg agatggcatt attctaacct ggggaaaagg atccataacc acgcccagct
      961 tctcagtgga gctagcttcc gccatggacg tgtgggaatg gcagctggga attccttttg
     1021 tactacatcg tctgtgtctg taattgaggc taaaaaaaag aataatgtgg ctcttgttgc
     1081 actgatgtca catgagttgg gccacgccct tggtatgaag gatgttccat attataccaa
     1141 gtgtccctct ggcagctgtg tgatgaatca gtacctgagt tcaaaattcc ccaaggattt
     1201 cagtaccgtc agccgttctc attttcaagg gtttctctca tctagaaatg caaggtgtct
     1261 gctgctggca cctgacccta aaaacataat aaaaccaaca tgtgggaacc aagtcctgga
     1321 tgtgggagaa gagtgtgact gtggctctcc tgaggaatgt accaatcttt gctgtgagcc
     1381 cctgacatgt aggctgaaat ctcaacctga ctgcagtgaa gcatccaacc acatcacaga
     1441 atgatccagt gtctaattca cagagaagct actttgccag gacagaagtc cagaccctgc
     1501 ctctgccagg aagcccgcct atcctgtgca cctatacaga caaacctatc tctgtgtgcc
     1561 atgttctctg tgaacccatg acttcaatca ctgaagaaga agaatgcccc aaaatacgac
     1621 ttgtacctgt catgaatatg taggcatttt ctcctcagta ctccataaat aatagagtat
     1681 aacagctatt tgtatagcgt ttttgtagat taagttttag aagtagtcta gagatgacaa
     1741 gatacttaga agaattttag tagttgtatg caaacatact ccaggtctag aaagactgtt
     1801 agtcctgaga tttgggaatc tgtgtaatca tggagccgaa tcctggtgaa caatgaagga
     1861 agatctttgc ttttctcttt cctttctact ttatgtgttt ctaccagtcc agtcaacagg
     1921 tcaatagaca tgctaaggtg atgctgtctg ttcattcagg tcttatctat agtgtgagtg
     1981 tgaggagcct gaaagtgtgg ttttagtttc actttttgga ggacaaaata gatgaacctt
     2041 tgcagaactt ctcaacgtac tccacagaat tgttgagtta atcccaaact gcaaagtgac
     2101 tagtaattta accctaaatc tctttgttcc tgaggcgtag gaatcaaagc ctgccacctg
     2161 ctgagggagg gagctggcag aaagaacaga gccccagccc cttcctgtct ctgggcagcc
     2221 agtttgtctt acatcctgta aacttcccgg attttctggc tcgtgggaat attggttaca
     2281 ttcaaacact tttcatttga gcaaatagag tttctcacac catcatgtat aagaattatt
     2341 tttgagaagt ctgtgtggct tatttcttag tggaaatgga aaagtaaggc ttcattcatt
     2401 ggtttttgta ataaactatg ctatcaataa aaa
//
