LOCUS       NM_001270996            4057 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus ADAM metallopeptidase domain 9 (Adam9), transcript
            variant 1, mRNA.
ACCESSION   NM_001270996
VERSION     NM_001270996.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4057)
  AUTHORS   Bazzone,L.E., Zhu,J., King,M., Liu,G., Guo,Z., MacKay,C.R.,
            Kyawe,P.P., Qaisar,N., Rojas-Quintero,J., Owen,C.A., Brass,A.L.,
            McDougall,W., Baer,C.E., Cashman,T., Trivedi,C.M., Gack,M.U.,
            Finberg,R.W. and Kurt-Jones,E.A.
  TITLE     ADAM9 promotes type I interferon-mediated innate immunity during
            encephalomyocarditis virus infection
  JOURNAL   Nat Commun 15 (1), 4153 (2024)
   PUBMED   38755212
  REMARK    GeneRIF: ADAM9 promotes type I interferon-mediated innate immunity
            during encephalomyocarditis virus infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4057)
  AUTHORS   Umeda,M., Yoshida,N., Hisada,R., Burbano,C., Orite,S.Y.K., Kono,M.,
            Kyttaris,V.C., Krishfield,S., Owen,C.A. and Tsokos,G.C.
  TITLE     ADAM9 enhances Th17 cell differentiation and autoimmunity by
            activating TGF-beta1
  JOURNAL   Proc Natl Acad Sci U S A 118 (18) (2021)
   PUBMED   33911034
  REMARK    GeneRIF: ADAM9 enhances Th17 cell differentiation and autoimmunity
            by activating TGF-beta1.
REFERENCE   3  (bases 1 to 4057)
  AUTHORS   Wang,W., Wu,C., Ren,L., Bao,Y., Han,Y., Li,C. and Li,Y.
  TITLE     MiR-30e-5p is sponged by Kcnq1ot1 and represses Angiotensin
            II-induced hypertrophic phenotypes in cardiomyocytes by targeting
            ADAM9
  JOURNAL   Exp Cell Res 394 (2), 112140 (2020)
   PUBMED   32535037
  REMARK    GeneRIF: MiR-30e-5p is sponged by Kcnq1ot1 and represses
            Angiotensin II-induced hypertrophic phenotypes in cardiomyocytes by
            targeting ADAM9.
REFERENCE   4  (bases 1 to 4057)
  AUTHORS   Abety,A.N., Pach,E., Giebeler,N., Fromme,J.E., Aramadhaka,L.R.,
            Mauch,C., Fox,J.W. and Zigrino,P.
  TITLE     Loss of ADAM9 Leads to Modifications of the Extracellular Matrix
            Modulating Tumor Growth
  JOURNAL   Biomolecules 10 (9), 1290 (2020)
   PUBMED   32906814
  REMARK    GeneRIF: Loss of ADAM9 Leads to Modifications of the Extracellular
            Matrix Modulating Tumor Growth.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4057)
  AUTHORS   Westmark,C.J., Maloney,B., Alisch,R.S., Sokol,D.K. and Lahiri,D.K.
  TITLE     FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs:
            Secondary Analysis of an N6-Methyladenosine Dataset
  JOURNAL   Sci Rep 10 (1), 10781 (2020)
   PUBMED   32612155
  REMARK    GeneRIF: FMRP Regulates the Nuclear Export of Adam9 and Psen1
            mRNAs: Secondary Analysis of an N(6)-Methyladenosine Dataset.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4057)
  AUTHORS   Roghani,M., Becherer,J.D., Moss,M.L., Atherton,R.E.,
            Erdjument-Bromage,H., Arribas,J., Blackburn,R.K., Weskamp,G.,
            Tempst,P. and Blobel,C.P.
  TITLE     Metalloprotease-disintegrin MDC9: intracellular maturation and
            catalytic activity
  JOURNAL   J Biol Chem 274 (6), 3531-3540 (1999)
   PUBMED   9920899
REFERENCE   7  (bases 1 to 4057)
  AUTHORS   Izumi,Y., Hirata,M., Hasuwa,H., Iwamoto,R., Umata,T., Miyado,K.,
            Tamai,Y., Kurisaki,T., Sehara-Fujisawa,A., Ohno,S. and Mekada,E.
  TITLE     A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and
            PKCdelta are involved in TPA-induced ectodomain shedding of
            membrane-anchored heparin-binding EGF-like growth factor
  JOURNAL   EMBO J 17 (24), 7260-7272 (1998)
   PUBMED   9857183
REFERENCE   8  (bases 1 to 4057)
  AUTHORS   Weskamp,G., Kratzschmar,J., Reid,M.S. and Blobel,C.P.
  TITLE     MDC9, a widely expressed cellular disintegrin containing
            cytoplasmic SH3 ligand domains
  JOURNAL   J Cell Biol 132 (4), 717-726 (1996)
   PUBMED   8647900
REFERENCE   9  (bases 1 to 4057)
  AUTHORS   Yagami-Hiromasa,T., Sato,T., Kurisaki,T., Kamijo,K., Nabeshima,Y.
            and Fujisawa-Sehara,A.
  TITLE     A metalloprotease-disintegrin participating in myoblast fusion
  JOURNAL   Nature 377 (6550), 652-656 (1995)
   PUBMED   7566181
REFERENCE   10 (bases 1 to 4057)
  AUTHORS   Weskamp,G. and Blobel,C.P.
  TITLE     A family of cellular proteins related to snake venom disintegrins
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2748-2751 (1994)
   PUBMED   8146185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156553.17, BC052710.1, AK155672.1 and BF466217.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052710.1, AK161778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC156553.17        115613-115740
            129-2919            BC052710.1         1-2791
            2920-4014           AK155672.1         2760-3854
            4015-4057           BF466217.1         1-43                c
FEATURES             Location/Qualifiers
     source          1..4057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 13.7 cM"
     gene            1..4057
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /note="ADAM metallopeptidase domain 9"
                     /db_xref="GeneID:11502"
                     /db_xref="MGI:MGI:105376"
     exon            1..238
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2733
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; disintegrin and metalloproteinase
                     domain-containing protein 9;
                     metalloprotease/disintegrin/cysteine-rich protein 9; a
                     disintegrin and metallopeptidase domain 9 (meltrin gamma);
                     myeloma cell metalloproteinase; a disintegrin and
                     metalloproteinase domain 9 (meltrin gamma)"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 9 isoform 1 precursor"
                     /protein_id="NP_001257925.1"
                     /db_xref="CCDS:CCDS85516.1"
                     /db_xref="GeneID:11502"
                     /db_xref="MGI:MGI:105376"
                     /translation="MGPRALSPLASLRLRWLLACGLLGPVLEAGRPDLEQTVHLSSYE
                     IITPWRLTRERREALGPSSQQISYVIQAQGKQHIIHLERNTDLLPNDFVVYTYDKEGS
                     LLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLENASFGIEPLHNSSHFEH
                     IFYPMDGIHQEPLRCGVSNRDTEKEGTQGDEEEHPSVTQLLRRRRAVLPQTRYVELFI
                     VVDKERYDMMGRNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGG
                     AGDVLGNFVQWREKFLITRWRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFG
                     QITVETFASIVAHELGHNLGMNHDDGRECFCGAKSCIMNSGASGSRNFSSCSAEDFEK
                     LTLNKGGSCLLNIPKPDEAYSAPSCGNKLVDPGEECDCGTAKECEVDPCCEGSTCKLK
                     SFAECAYGDCCKDCQFLPGGSMCRGKTSECDVPEYCNGSSQFCPPDVFIQNGYPCQNS
                     KAYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGFSGSEYKKCATG
                     NALCGKLQCENVQDMPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCD
                     AGKICRNFQCVNASVLNYDCDIQGKCHGHGVCNSNKNCHCEDGWAPPHCDTKGYGGSV
                     DSGPTYNAKSTALRDGLLVFFFLIVPLVAAAIFLFIKRDELRKTFRKKRSQMSDGRNQ
                     ANVSRQPGDPSISRPPGGPNVSRPPGGPGVSRPPGGPGVSRPPGGPGVSRPPGGPGVS
                     RPPGGPGVSRPPPGHGNRFPVPTYAAKQPAQFPSRPPPPQPKISSQGNLIPARPAPAP
                     PLYSSLT"
     exon            239..336
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            337..395
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            396..474
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            475..551
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            552..747
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            748..813
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            814..885
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1055
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1137
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1271
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1443
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1536
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1732
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1838
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2022
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2103
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2209
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2342
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2571
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2639
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..4039
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4000..4005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /note="hexamer: AATAAA"
     regulatory      4019..4024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /note="hexamer: AATAAA"
     polyA_site      4025
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /note="major polyA site"
     polyA_site      4039
                     /gene="Adam9"
                     /gene_synonym="MDC9; mKIAA0021; Mltng"
                     /note="major polyA site"
ORIGIN      
        1 gggttgctgc gtcagtgccg cgcgcgtgct cgccgagggc gagcgccccg ccagcccggg
       61 ggcccccgcg gggttgcaag gatgaccgaa ggggcggagg cggcggccgc gcgttgagcg
      121 gaacctgccg aagccctcgc tatggggccg cgcgcgctct cgccccttgc ctctctgcga
      181 ctaaggtggc tgctggcgtg tggcttgctg ggcccagtcc tcgaggccgg gcgaccagac
      241 ttggaacaga ctgtccatct ttcttcttat gaaattatta ctccttggag attaactaga
      301 gaaagaaggg aagctctggg gcccagttca cagcagatct cttacgtcat ccaggcccaa
      361 ggaaaacagc atattattca cttggaaaga aacacagacc ttttacctaa tgattttgta
      421 gtttacacct acgacaagga aggctcccta ctctctgacc atcccaacgt acagagccat
      481 tgtcactatc gaggctatgt ggagggagtg cagaattccg cggttgctgt gagcgcctgc
      541 tttggactca gaggcttgct gcatttggag aatgccagtt ttggaattga acctctgcac
      601 aacagctcac actttgagca catattttac cccatggatg gcatccacca ggagcctctg
      661 agatgtggag tctctaacag ggacacagag aaggaaggca cacaggggga tgaggaggag
      721 catccgagtg tcactcagct gctgcgcaga agaagagctg ttctaccaca gacccgctat
      781 gtggagctgt tcattgttgt agacaaggaa aggtacgaca tgatgggacg gaaccagact
      841 gctgtgagag aagagatgat tcgcttagca aactacctgg atagcatgta catcatgtta
      901 aacattcgaa ttgtgctggt tggactagaa atttggacag acagaaatcc tatcaatata
      961 attggaggag ctggagatgt gctgggcaac tttgttcagt ggcgggaaaa gttccttata
     1021 actcgttgga gacacgacag tgcacagttg gttttgaaga aaggctttgg tggaactgca
     1081 ggaatggcgt ttgtaggaac agtatgttca aggagccacg caggtgggat caatgtgttt
     1141 gggcaaatca ctgtggagac atttgcatcc attgttgctc atgaattggg gcataacctt
     1201 ggaatgaatc atgatgatgg gagagagtgt ttctgtggag caaagagctg tatcatgaat
     1261 tcaggagcat ccgggtccag aaactttagc agttgcagtg cggaggactt tgagaagtta
     1321 acgttgaata agggaggaag ctgcctgctt aacatcccga agcccgacga agcctacagc
     1381 gcgccctcct gtggtaataa gctggtggac cctggagagg agtgtgactg cggcacagcg
     1441 aaggagtgtg aggtggaccc atgctgtgaa ggaagcactt gtaagctcaa gtcatttgct
     1501 gagtgtgcat atggcgactg ttgtaaagat tgccagttcc ttccaggagg ctccatgtgc
     1561 agagggaaga ccagtgagtg tgatgttcct gagtactgca acggttcctc tcagttctgc
     1621 ccgccagatg tcttcattca gaatggatat ccttgccaga acagcaaagc ctactgctac
     1681 aatggcatgt gccaatatta tgacgcgcag tgtcaggtca tctttggttc aaaggctaag
     1741 gctgccccaa gagattgctt cattgaagtc aattctaaag gtgacagatt tggcaactgt
     1801 ggtttctccg gcagtgagta caagaagtgt gccactggga acgcgctgtg tggaaagctt
     1861 caatgcgaga atgtacagga catgccggtg tttggaatag taccagctat cattcagaca
     1921 cccagtcgag gcaccaaatg ctggggtgtg gatttccagc ttggttccga cgttccagac
     1981 ccagggatgg tgaatgaagg caccaaatgt gatgctggca agatttgcag gaattttcag
     2041 tgtgtaaatg cttctgtcct gaattatgac tgtgacattc agggaaaatg tcatggccat
     2101 ggggtgtgta acagcaataa gaattgtcac tgtgaagacg gctgggctcc cccacactgt
     2161 gacaccaaag gatatggagg aagcgtggac agcgggccga cgtataatgc aaagagcaca
     2221 gcactgaggg acgggcttct ggtcttcttc ttcctaatcg tcccccttgt tgcggctgcc
     2281 attttcctct ttatcaagag agatgaacta cggaaaacct tcaggaagaa gagatcacaa
     2341 atgtcagatg gcagaaatca agcaaacgtc tctagacagc caggagatcc tagtatctcc
     2401 agaccaccag ggggcccaaa tgtctccaga ccaccagggg gcccaggtgt ctccagacca
     2461 ccagggggcc caggtgtctc cagaccacca gggggcccag gtgtctccag accaccaggg
     2521 ggcccaggtg tctccagacc gccagggggc ccaggtgtct ccagaccgcc acctgggcat
     2581 ggaaacagat tcccagtacc aacctacgcc gccaagcagc ctgcgcagtt cccgtcaagg
     2641 ccacctccac cacaaccgaa aatatcttct cagggaaact tgattccggc tcggcccgct
     2701 cctgcacctc ctttatatag ctccctcacc tgatagtaga atattagaat cttatttttt
     2761 aaatgtcttc agggaactga gcaaatgttt gttgtttttt tttttcctga tgttttcttg
     2821 aaaagccttt ctcttccaac catgaatgaa cacaaaccac cacaaaacaa gctttattaa
     2881 cacaggagcc tagtggggat tgcgaaacac aggaatgtgc aggcgctccg gggggtgtaa
     2941 agtgaacgtt tccatcgtta gaatgttttc tctggccatt tgtggattta atgcacttga
     3001 cgtggattaa gttattctga gcatgttact gtaatgattc tcaaattaac tgtattagtg
     3061 taagctttgt cactatgcgc taaacgtaat cctgactttt tgaccccagt taccattaat
     3121 agtttctggt tgaccatttg aacatgtatt aacttaggaa gactaattgc caataacgtc
     3181 tgcattttca tcttgcatgg attaacagcc atttatatgg acttatgtct cttaatgcac
     3241 aaagaagcag atatctcgaa ggagcttaca caagaaccac aattactaga tcatgatata
     3301 cttggaaagt gtgaaatatg gtgtgtactc agttattggc ttccattttt tatgatcttt
     3361 caactataac aattatgata gaaatcgatt taacacaatc agttatgggc ttccattttc
     3421 aaatatcttt tcaactgtaa tgactatgac aggaactgat tcaactctca attttcttta
     3481 tgcatcatgg taaagcattg cagcagtgtt gttttgtttg aagtgcacac tctatggtac
     3541 gaggtgttta gtatacccaa gcagataggt gtcgatcgaa caggagcagg gagaatactt
     3601 ccaacagttg aggtgttacc aaaccacttg agaattcatg agcactttaa ctctaaactc
     3661 tgaatttcaa agcttgatgt gaagtcctct agaatgttta catttactaa ggtgtgctgg
     3721 gtcctgtctc ttttgactaa tattttcgta aacattaggc tggagaaagg aaggaagcag
     3781 tggtttcctt agataactac agaattatac tggtctctgg gattactctc tcagctgtat
     3841 taaaatgaat ttgtactttg aaaggaatga tattgacact aaaattttaa acatttaaat
     3901 tttttcataa tctttcataa agaagtttaa taataggtat attaactgaa tttcattagt
     3961 tttttaaaat aatattgttt gtgtatatat acatattaaa ataaaaacat ttacaacaaa
     4021 taaaatactt gaaattctta aaaaaaaaaa aaaaaaa
//
