LOCUS       NM_007403               3117 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 8 (Adam8),
            transcript variant 1, mRNA.
ACCESSION   NM_007403
VERSION     NM_007403.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Rosendahl AH, Monnius M, Laitala A, Railo A, Miinalainen I,
            Heljasvaara R, Maki JM and Myllyharju J.
  TITLE     Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in
            FoxD1-lineage mesenchymal cells leads to congenital truncal
            alopecia
  JOURNAL   J Biol Chem 298 (4), 101787 (2022)
   PUBMED   35247391
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Yao L, Shao W, Chen Y, Wang S and Huang D.
  TITLE     Suppression of ADAM8 attenuates angiotensin II-induced cardiac
            fibrosis and endothelial-mesenchymal transition via inhibiting
            TGF-beta1/Smad2/Smad3 pathways
  JOURNAL   Exp Anim 71 (1), 90-99 (2022)
   PUBMED   34615811
  REMARK    GeneRIF: Suppression of ADAM8 attenuates angiotensin II-induced
            cardiac fibrosis and endothelial-mesenchymal transition via
            inhibiting TGF-beta1/Smad2/Smad3 pathways.
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U,
            Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin
            SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M,
            Valet C, Qiu L, Singer JP, Eltzschig HK, Bertrams W, Herold S,
            Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR and Bartsch JW.
  CONSRTM   CAPSys Study Group
  TITLE     ADAM8 signaling drives neutrophil migration and ARDS severity
  JOURNAL   JCI Insight 7 (3), e149870 (2022)
   PUBMED   35132956
  REMARK    GeneRIF: ADAM8 signaling drives neutrophil migration and ARDS
            severity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Awan T, Babendreyer A, Wozniak J, Alvi AM, Sterzer V, Cook L,
            Bartsch JW, Liedtke C, Yildiz D and Ludwig A.
  TITLE     Expression of the Metalloproteinase ADAM8 Is Upregulated in Liver
            Inflammation Models and Enhances Cytokine Release In Vitro
  JOURNAL   Mediators Inflamm 2021, 6665028 (2021)
   PUBMED   33814981
  REMARK    GeneRIF: Expression of the Metalloproteinase ADAM8 Is Upregulated
            in Liver Inflammation Models and Enhances Cytokine Release In
            Vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Ichijo R, Kabata M, Kidoya H, Muramatsu F, Ishibashi R, Abe K,
            Tsutsui K, Kubo H, Iizuka Y, Kitano S, Miyachi H, Kubota Y,
            Fujiwara H, Sada A, Yamamoto T and Toyoshima F.
  TITLE     Vasculature-driven stem cell population coordinates tissue scaling
            in dynamic organs
  JOURNAL   Sci Adv 7 (7) (2021)
   PUBMED   33568475
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Kataoka M, Yoshiyama K, Matsuura K, Hijiya N, Higuchi Y and
            Yamamoto S.
  TITLE     Structure of the murine CD156 gene, characterization of its
            promoter, and chromosomal location
  JOURNAL   J Biol Chem 272 (29), 18209-18215 (1997)
   PUBMED   9218457
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K and Yamamoto S.
  TITLE     CD156 (human ADAM8): expression, primary amino acid sequence, and
            gene location
  JOURNAL   Genomics 41 (1), 56-62 (1997)
   PUBMED   9126482
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Ballock RT, Heydemann A, Wakefield LM, Flanders KC, Roberts AB and
            Sporn MB.
  TITLE     Inhibition of the chondrocyte phenotype by retinoic acid involves
            upregulation of metalloprotease genes independent of TGF-beta
  JOURNAL   J Cell Physiol 159 (2), 340-346 (1994)
   PUBMED   8163572
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Ito M, Hioki K, Yokoyama M and Nomura T.
  TITLE     Preservation of an inbred mouse strain by the storage of frozen
            embryos: an estimate of the time of occurrence of a serum IgG1
            deficiency mutation found in MRL-lpr
  JOURNAL   Lab Anim Sci 42 (2), 211-213 (1992)
   PUBMED   1318459
REFERENCE   10 (bases 1 to 3117)
  AUTHORS   Yoshida S, Setoguchi M, Higuchi Y, Akizuki S and Yamamoto S.
  TITLE     Molecular cloning of cDNA encoding MS2 antigen, a novel cell
            surface antigen strongly expressed in murine monocytic lineage
  JOURNAL   Int Immunol 2 (6), 585-591 (1990)
   PUBMED   1982220
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107822.18, AK155912.1 and
            BE634944.1.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_007403.4.
            
            On Mar 18, 2015 this sequence version replaced NM_007403.2.
            
            Summary: This gene encodes a member of the Adam family of proteins
            that contain the disintegrin and metalloprotease domains. The
            encoded protein is localized to the cell surface, where it is
            involved in the remodeling of extracellular matrix and cell
            migration. Mice lacking the encoded protein display persistent
            inflammation upon treatment with allergens. Alternative splicing of
            this gene results in multiple variants. [provided by RefSeq, Mar
            2015].
            
            Transcript Variant: This variant (1) encodes the longer protein
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155912.1, X13335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC107822.18        197226-197279       c
            55-3116             AK155912.1         2-3063
            3117-3117           BE634944.1         1-1                 c
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 84.96 cM"
     gene            1..3117
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /note="a disintegrin and metallopeptidase domain 8"
                     /db_xref="GeneID:11501"
                     /db_xref="MGI:MGI:107825"
     exon            1..131
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2572
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cell surface antigen MS2; macrophage
                     cysteine-rich glycoprotein; disintegrin and
                     metalloproteinase domain-containing protein 8; a
                     disintegrin and metalloprotease domain 8"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 8 isoform 1 precursor"
                     /protein_id="NP_031429.1"
                     /db_xref="CCDS:CCDS21959.1"
                     /db_xref="GeneID:11501"
                     /db_xref="MGI:MGI:107825"
                     /translation="MLGLWLLSVLWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRAL
                     PSHWGQYPESLSYALGTSGHVFTLHLRKNRDLLGSSYTETYSAANGSEVTEQLQEQDH
                     CLYQGHVEGYEGSAASISTCAGLRGFFRVGSTVHLIEPLDADEEGQHAMYQAKHLQQK
                     AGTCGVKDTNLNDLGPRALEIYRAQPRNWLIPRETRYVELYVVADSQEFQKLGSREAV
                     RQRVLEVVNHVDKLYQELSFRVVLVGLEIWNKDKFYISRYANVTLENFLSWREQNLQG
                     QHPHDNVQLITGVDFIGSTVGLAKVSALCSRHSGAVNQDHSKNSIGVASTMAHELGHN
                     LGMSHDEDIPGCYCPEPREGGGCIMTESIGSKFPRIFSRCSKIDLESFVTKPQTGCLT
                     NVPDVNRFVGGPVCGNLFVEHGEQCDCGTPQDCQNPCCNATTCQLVKGAECASGTCCH
                     ECKVKPAGEVCRLSKDKCDLEEFCDGRKPTCPEDAFQQNGTPCPGGYCFDGSCPTLAQ
                     QCRDLWGPGARVAADSCYTFSIPPGCNGRMYSGRINRCGALYCEGGQKPLERSFCTFS
                     SNHGVCHALGTGSNIDTFELVLQGTKCEEGKVCMDGSCQDLRVYRSENCSAKCNNHGV
                     CNHKRECHCHKGWAPPNCVQRLADVSDEQAASTSLPVSVVVVLVILVAAMVIVAGIVI
                     YRKAPRQIQRRSVAPKPISGLSNPLFYTRDSSLPAKNRPPDPSETVSTNQPPRPIVKP
                     KRPPPAPPGAVSSSPLPVPVYAPKIPNQFRPDPPTKPLPELKPKQVKPTFAPPTPPVK
                     PGTGGTVPGATQGAGEPKVALKVPIQKR"
     exon            132..235
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            236..312
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..391
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..468
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..652
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..715
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..784
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..951
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1033
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1182
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1360
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1450
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1640
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1716
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1882
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1960
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2054
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2169
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2329
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2395
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2446
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2521
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..3117
                     /gene="Adam8"
                     /gene_synonym="ADAM 8; CD156; CD156a; E430039A18Rik; MS2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggaagg gcactcagaa agaagtacca ggccagtgat gaagagagta ctttgtggaa
       61 cctctagggt tagtgtgctc cagatcccat catgcttggc ctctggctgc tcagcgtctt
      121 atggacacca gcagtagccc ctggacctcc tttgccccat gtgaaacagt atgaagtggt
      181 ttggcctcgg cgcctagctg catcccgctc ccgcagagcc ctgccctccc actggggcca
      241 gtacccagag agtctgagct atgctcttgg gaccagcggg cacgttttca ccctgcacct
      301 tcgaaagaac agggacctgc tgggctcaag ctacacagag acctactcag ctgccaatgg
      361 ctctgaggtg acagagcaac tgcaggagca ggaccattgc ctctaccaag gccatgtgga
      421 agggtacgag ggctcagctg ccagtattag cacctgtgct ggcctcaggg gctttttccg
      481 agttgggtcc actgtccact tgattgagcc tctggatgct gatgaagagg ggcaacatgc
      541 gatgtatcag gcaaagcatc tgcaacagaa ggctgggacc tgtggggtca aagataccaa
      601 cctgaatgac ctagggcctc gggcattaga aatatacagg gctcagccac ggaactggct
      661 gatacccaga gaaacccgct atgtggagtt gtatgtggtt gcagacagcc aagagttcca
      721 gaagttgggg agcagagagg ccgtgcgcca gcgagtgctg gaggttgtaa accacgtgga
      781 caagctttat caggaactca gttttcgagt tgtcctggtg ggcctggaga tctggaacaa
      841 ggacaaattc tacatcagcc gctatgccaa cgtgacactg gagaacttct tgtcctggag
      901 ggaacagaac ttgcaagggc agcacccaca tgacaacgtg caacttatca cgggggttga
      961 tttcattggg agcactgttg gactggctaa ggtgtctgcc ctgtgttccc gtcactccgg
     1021 agctgtgaat caggaccact ccaagaactc cattggtgta gcctccacca tggcccatga
     1081 gctgggccac aacctgggca tgagccatga tgaggacatt ccaggatgct actgtcctga
     1141 accacgggag ggtggtggct gcatcatgac cgaaagcatc ggctccaagt tccccaggat
     1201 attcagcagg tgtagcaaga ttgacctaga gtcattcgtg acaaaacccc agacaggctg
     1261 cctgaccaat gttccagatg tcaaccggtt cgtgggtggc cctgtgtgtg gaaacctgtt
     1321 tgtggagcat ggagagcagt gtgactgtgg cacacctcag gactgtcaaa acccctgctg
     1381 caatgccacc acttgccagc tggtcaaggg ggcagagtgt gccagtggta cctgttgtca
     1441 tgaatgcaag gtgaagccag ctggagaggt gtgtcgtctc agtaaggaca aatgtgacct
     1501 ggaggagttc tgtgatggcc ggaagccaac atgtcccgaa gatgccttcc aacagaatgg
     1561 cactccctgc ccagggggct actgctttga tgggagctgt cccaccctgg cacagcagtg
     1621 ccgggatctg tgggggccag gtgctcgggt agcagccgac tcctgctata cctttagcat
     1681 ccctccgggc tgcaatggga ggatgtactc tggcaggatc aaccggtgtg gagcgctgta
     1741 ctgtgaggga ggccagaagc cccttgaacg ctccttctgc actttctcct ccaaccatgg
     1801 agtctgccat gctcttggca caggcagcaa cattgacacc tttgagctgg tattgcaggg
     1861 caccaagtgc gaggagggaa aggtttgcat ggatggaagc tgccaggacc tccgtgtata
     1921 cagatctgaa aactgctctg ctaaatgcaa caaccatggg gtatgcaacc acaagaggga
     1981 gtgccactgt cacaagggct gggcaccacc caactgtgta cagcggctgg cagatgtatc
     2041 agatgaacaa gcagcgtcta cgagcctccc agtcagtgtg gttgtggtct tggtgatcct
     2101 ggtggctgcg atggtcatcg tggcaggcat cgtcatctac cgaaaggctc cgagacaaat
     2161 ccagaggagg agtgtggcac ccaagcctat ctcggggctc tccaaccccc tattctacac
     2221 aagggacagc agcctgccag ctaagaacag gcctccagac ccttctgaga cagtttctac
     2281 caaccagccc ccaagaccca tagtgaaacc aaagaggcct ccccctgcac ctccaggtgc
     2341 tgtgtccagt tcaccactcc cagttcctgt ttatgcccca aagataccaa atcagtttag
     2401 acctgatcct cccaccaagc ccctcccaga gctgaaaccc aagcaggtca agccaacctt
     2461 tgcacccccg acaccaccag tcaagcccgg gactggaggg acggtgcctg gagcaactca
     2521 gggagctggt gagccaaagg ttgctctgaa ggtccccatc cagaagaggt gaccagctag
     2581 ggcaccccag ggccatcgtt tgtggacgtt tggagatacc actgctccta taaatgtgtt
     2641 ccttcagcaa caccacaacc accacccagg ctggacctgc acacgctgtt cctacctcag
     2701 gaataatctt tctgtggctc ttgctgtcca gatgccctca tgaaccagtg gcctctcact
     2761 ggccttggcc agcttagacc atacatctgc gtatgctagt tgctaggcag gggcggtgta
     2821 ccctgcagtg ggcgtgatca agtctgtctg tctctgggtg gacagaatgc caggagtccc
     2881 ctcccagcaa cttctgcact ggccctcaca cagtgacctc tctccaaggc acagttcctg
     2941 tatctacatc ccactcgtgt atgagactta ggaaaggaaa agacgtcgtt cttggggtgt
     3001 tgggacaaga agttgccgtc atctccggat tgaaacagat tagttgttga aattatgact
     3061 aaacactatt cactaataaa gattctattt tatcaataga ttatagatca cattcta
//
