LOCUS       NM_007402               3469 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 7 (Adam7),
            mRNA.
ACCESSION   NM_007402
VERSION     NM_007402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3469)
  AUTHORS   Choi,H., Han,C., Jin,S., Kwon,J.T., Kim,J., Jeong,J., Kim,J.,
            Ham,S., Jeon,S., Yoo,Y.J. and Cho,C.
  TITLE     Reduced Fertility and Altered Epididymal and Sperm Integrity in
            Mice Lacking ADAM7
  JOURNAL   Biol Reprod 93 (3), 70 (2015)
   PUBMED   26246218
  REMARK    GeneRIF: ADAM7 is required for normal fertility and is important
            for the maintenance of epididymal integrity and for sperm
            morphology
REFERENCE   2  (bases 1 to 3469)
  AUTHORS   Grayson,P. and Civetta,A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol Biol 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3469)
  AUTHORS   Han,C., Park,I., Lee,B., Jin,S., Choi,H., Kwon,J.T., Kwon,Y.I.,
            Kim,D.H., Park,Z.Y. and Cho,C.
  TITLE     Identification of heat shock protein 5, calnexin and integral
            membrane protein 2B as Adam7-interacting membrane proteins in mouse
            sperm
  JOURNAL   J Cell Physiol 226 (5), 1186-1195 (2011)
   PUBMED   20945367
  REMARK    GeneRIF: Suggest that Adam7 functions in fertilization through the
            formation of a complex with heat shock protein 5, calnexin and
            Itm2b during capacitation in sperm.
REFERENCE   4  (bases 1 to 3469)
  AUTHORS   Oh,J.S., Han,C. and Cho,C.
  TITLE     ADAM7 is associated with epididymosomes and integrated into sperm
            plasma membrane
  JOURNAL   Mol Cells 28 (5), 441-446 (2009)
   PUBMED   19855936
  REMARK    GeneRIF: This study provides new information regarding the unique
            mode of secretion and interaction of ADAM7 during the
            epididymis-to-sperm transfer process.
REFERENCE   5  (bases 1 to 3469)
  AUTHORS   Kim,E., Rhee,S.D., Bae,Y., Okumoto,M., Yoon,J.B., Song,C.W. and
            Yoon,S.K.
  TITLE     Genomic organization of the region spanning D14Mit262 and D14Mit86
            on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the
            cataract-causing gene, lr2
  JOURNAL   Cytogenet Genome Res 116 (1-2), 12-17 (2007)
   PUBMED   17268172
REFERENCE   6  (bases 1 to 3469)
  AUTHORS   Oh,J., Woo,J.M., Choi,E., Kim,T., Cho,B.N., Park,Z.Y., Kim,Y.C.,
            Kim,D.H. and Cho,C.
  TITLE     Molecular, biochemical, and cellular characterization of epididymal
            ADAMs, ADAM7 and ADAM28
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1374-1383 (2005)
   PUBMED   15883027
REFERENCE   7  (bases 1 to 3469)
  AUTHORS   Yang,L.T., Nichols,J.T., Yao,C., Manilay,J.O., Robey,E.A. and
            Weinmaster,G.
  TITLE     Fringe glycosyltransferases differentially modulate Notch1
            proteolysis induced by Delta1 and Jagged1
  JOURNAL   Mol Biol Cell 16 (2), 927-942 (2005)
   PUBMED   15574878
REFERENCE   8  (bases 1 to 3469)
  AUTHORS   Lin,Y.C., Sun,G.H., Lee,Y.M., Guo,Y.W. and Liu,H.W.
  TITLE     Cloning and characterization of a complementary DNA encoding a
            human epididymis-associated disintegrin and metalloprotease 7
            protein
  JOURNAL   Biol Reprod 65 (3), 944-950 (2001)
   PUBMED   11514362
REFERENCE   9  (bases 1 to 3469)
  AUTHORS   Cornwall,G.A. and Hsia,N.
  TITLE     ADAM7, a member of the ADAM (a disintegrin and metalloprotease)
            gene family is specifically expressed in the mouse anterior
            pituitary and epididymis
  JOURNAL   Endocrinology 138 (10), 4262-4272 (1997)
   PUBMED   9322939
REFERENCE   10 (bases 1 to 3469)
  AUTHORS   Ballock,R.T., Heydemann,A., Wakefield,L.M., Flanders,K.C.,
            Roberts,A.B. and Sporn,M.B.
  TITLE     Inhibition of the chondrocyte phenotype by retinoic acid involves
            upregulation of metalloprotease genes independent of TGF-beta
  JOURNAL   J Cell Physiol 159 (2), 340-346 (1994)
   PUBMED   8163572
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK136692.1, AF013107.1 and
            AC154706.2.
            
            On Jul 14, 2006 this sequence version replaced NM_007402.1.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. This gene is specifically expressed in
            epididymis where the encoded protein is transferred to the sperm
            surface during epididymal transit. This gene is located adjacent to
            a related gene from the ADAM family of proteins on chromosome 14.
            [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136692.1, AF013107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               AK136692.1         1-530
            531-604             AF013107.1         517-590
            605-686             AK136692.1         606-687
            687-687             AC154706.2         48478-48478
            688-771             AF013107.1         674-757
            772-885             AK136692.1         771-884
            886-1202            AF013107.1         872-1188
            1203-1680           AK136692.1         1202-1679
            1681-1727           AF013107.1         1667-1713
            1728-3372           AK136692.1         1727-3371
            3373-3469           AF013107.1         3354-3450
FEATURES             Location/Qualifiers
     source          1..3469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 35.69 cM"
     gene            1..3469
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /note="a disintegrin and metallopeptidase domain 7"
                     /db_xref="GeneID:11500"
                     /db_xref="MGI:MGI:107247"
     exon            1..66
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2384
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /note="epididymal apical protein I; disintegrin and
                     metalloproteinase domain-containing protein 7; a
                     disintegrin and metalloprotease domain (ADAM) 7"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 7 preproprotein"
                     /protein_id="NP_031428.2"
                     /db_xref="CCDS:CCDS27234.1"
                     /db_xref="GeneID:11500"
                     /db_xref="MGI:MGI:107247"
                     /translation="MLTTGIFWMTVLISHIQERGIVGVEGQELVHPKKLPLLHKRDLE
                     RIHDSDIPEEYEEELLYEIKLGKKTLILHLLKAREFLSSNYSETYYNVKREVFTKHPQ
                     ILDHCFYQGSIIHEFDSAASISTCNGLRGFFRVNDQRYLIEPVKYSDDGEHLVYKYNV
                     KAPYATNHSCVGLNFTKKSALIDVENIEEHNAEDHHKEKFIELFVVADEYVYRRNNKP
                     QNKLRKRIWGMVNFVNMIYKTLNIHVTLAGFEIWSAGDKIEIVSNLESTLLHFSTWQE
                     TVLKKRKDFDHVILLSGKWLYTSMQGIAYPGGICQILRSCSVVKDLLPDVNIIGNRMA
                     HQLGHSLGMQHDGFPCTCPLGKCVMGDGSIPAIKFSKCSQTQYQQFLQDQKPACILNN
                     PFPEEFNDYPFCGNKKVDEGEECDCGPVQECTNPCCDAHKCVLKPGFTCVEGECCESC
                     QMKKEGAVCRLAKNECDISEVCTGYSPECPKDEFQANGFPCRNGEGYCFMGLCPTRNE
                     QCSELFIGGAEESHSLCYRMNKKGNRFGYCKNKGNTFVPCEEKDLKCGKIYCSGGRPS
                     SRLGEDKAYNLKNVKQNVTIKCRTMFLHHNSRDMGLVNSGTKCGDGMVCSNGECIEME
                     KAYNSTICSSPCDENDVDDNEPECQCEEGSIITEWGEALNLTSVSIMVIVLVMVIIGV
                     GLVILLIRYQKCIKMKQVQSSPREIRGVENKGYFPEEHQTRSEPILTDIHPLHTTAES
                     LERVPSSFSSPHYITLKSVSKDSRGIADPKQTDNVNLNLDTQSGCERLG"
     exon            67..170
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            171..247
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            248..326
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            327..403
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            404..593
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            594..647
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            648..719
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            720..889
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            890..974
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1102
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1277
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1367
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1563
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1666
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1853
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1934
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2013
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2119
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2219
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2282
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2339
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..3469
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3448..3453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /note="hexamer: AATAAA"
     polyA_site      3469
                     /gene="Adam7"
                     /gene_synonym="ADAM 7; EAP1; EAPI"
                     /note="major polyA site"
ORIGIN      
        1 gataaccctt cagaatgtta accacaggaa tattttggat gactgtcctt atttctcaca
       61 ttcaagaaag ggggattgtt ggagtagagg gtcaagaact ggttcatcct aaaaagcttc
      121 ccttgctaca caaacgggat cttgaacgca tccatgactc tgacataccg gaggaatatg
      181 aagaagaatt gttgtatgaa ataaaattgg gcaaaaaaac tttaatcctt caccttctga
      241 aagcaaggga attcctcagt tcaaattaca gtgaaacata ctacaacgta aagagagaag
      301 tgttcaccaa gcatccacag atcttggatc actgttttta ccaaggctcc atcattcatg
      361 aatttgattc tgctgctagt atcagcactt gcaatggtct gaggggtttc ttcagggtga
      421 atgaccagcg gtatctcatc gaaccagtaa aatactcaga tgatggagaa catttggtgt
      481 acaaatacaa tgtcaaggca ccctatgcta ccaatcactc ctgcgtgggg ctcaatttta
      541 ctaagaagtc tgctctgata gatgttgaga atatagaaga acataacgca gaagaccatc
      601 acaaagaaaa gttcattgaa ctgtttgttg ttgctgatga gtatgtgtac cgcaggaaca
      661 ataaacccca aaacaagcta agaaaacgaa tttgggggat ggtcaatttt gtcaacatga
      721 tttataaaac cttgaacatt catgtgactt tagctggttt tgaaatatgg tcagctgggg
      781 acaagataga aatagtgtcc aatctagaaa gtaccttatt gcatttttca acttggcaag
      841 aaacagttct caaaaaaagg aaggattttg atcatgtgat tttattgagt gggaagtggc
      901 tctacacatc tatgcaagga attgcttacc caggagggat atgccagatc cttcgttcat
      961 gcagtgttgt taaggatctt ctaccagatg taaatataat tgggaacaga atggcacatc
     1021 agctgggaca cagcctgggg atgcagcatg atggctttcc atgcacctgt cctttgggga
     1081 aatgtgtgat gggcgatgga agcatccctg caataaaatt cagcaaatgc agccaaaccc
     1141 aataccagca atttctgcag gatcagaaac cagcatgcat actcaacaac ccctttcccg
     1201 aagaattcaa tgattatcct ttctgtggga acaagaaggt ggatgaggga gaagagtgtg
     1261 actgtgggcc agttcaggag tgcaccaatc cctgctgtga cgcacacaaa tgtgtcctga
     1321 agccaggatt cacttgtgtg gaaggagagt gctgtgaatc atgtcagatg aagaaagaag
     1381 gggccgtatg cagactagcg aaaaatgaat gcgatatttc tgaagtgtgt actggctact
     1441 cccctgagtg ccctaaagac gagttccaag ccaacgggtt tccttgcagg aatggagaag
     1501 gctactgctt tatggggctg tgtcccaccc ggaatgagca gtgctcagag ttattcattg
     1561 gcggagcaga agagagtcac agcctttgct acaggatgaa taaaaaagga aacagatttg
     1621 gatactgcaa aaataagggc aacacatttg ttccctgtga agagaaagat ctcaaatgtg
     1681 ggaagatata ctgctcggga ggccggccct catcccgcct tggagaagat aaagcctata
     1741 atcttaagaa tgtgaagcag aacgtgacca tcaaatgcag aaccatgttt ttacaccaca
     1801 attctagaga catgggcctg gttaattctg gaacaaaatg tggagatgga atggtttgca
     1861 gcaatggtga atgtatagaa atggagaagg cctacaactc aaccatctgc tcctctccgt
     1921 gcgatgaaaa cgatgtggat gacaacgaac ctgagtgcca gtgtgaggaa ggatcaataa
     1981 ttacggagtg gggagaagcc ttaaacctta ccagtgtctc catcatggtc attgtgcttg
     2041 tcatggttat tattggtgtt ggacttgtca tattactaat ccgttaccag aaatgcatta
     2101 agatgaagca agttcaaagc tctcctcgag aaatacgggg ggtagaaaat aagggatact
     2161 ttcctgaaga acaccagacg aggagtgagc caatcttgac cgatatccat cccctacata
     2221 ccactgcaga gtccctggaa agagttcctt ccagcttttc aagtcctcac tatatcacac
     2281 tgaaatctgt cagcaaggac tcaagaggaa ttgcagaccc taagcaaact gataatgtga
     2341 atttgaacct ggatacccaa agtggctgtg aaagactggg ctaatcctcc gtgcagatca
     2401 ccaccacatt gatgtccgct aacacgttac ggttgttttc caaatattcc ttacctgaat
     2461 ttatgtacaa gagaaatagt ttcttcctat taacactaag tcataaaacc cacaatctat
     2521 agcacagaca taagctccag aaaaattgaa tataaaatgt ccaattggct ttaatttaat
     2581 gtccaaatag aaagtctctc tgctgtagta atttcctaca caatattaat cttgttacgt
     2641 ttataataat caaagcttag acagtgatca tgtagagcct cacaaataag gctagtagtt
     2701 ggctactttg ttaggatcat tttaaaagca cttactttta ggtcaggtat ggaggaccag
     2761 ccctgtgatt cctggaggct gaggcagtag gatcacacag gttcagggtc tctgtggact
     2821 gcagagagag accatgtcaa gactggacac cttggtgaga actctttagc aaaagcataa
     2881 aaattttaaa atgtgccagg gacattaggg aattgctggt agtagagcag aaagggagac
     2941 acactgggtg caaccctgag aattaaaaaa caaaagcaaa aacaaaaaca aaaaaaccca
     3001 gaaagatcaa aacagatgac agtgtgccta cttagatttg caaactacat cactaaagtc
     3061 tgctttcaat gaaattgtct cctatggaag tgacaggatg ggtactaccc agggtgtaga
     3121 agctcctaca agctctgggt tcctaggtct atctaccttt ctagaggtat aagtagccaa
     3181 gaaggtgaca ggaattttat aaagttcact ccacctcctt gtgcacatga gaggtctctg
     3241 agccctcggg aaacacagat cagggtgtgc ttggtgttca ctgtctttac tgcagatcac
     3301 tgcaggcttg tggttgtgtt gccttttgag gggatctttc cttatacaga tgtctgtggg
     3361 tgggagcact ttctctcaca gtctctgctt tcttaatggg agctgttaag ccttttgaat
     3421 ctatagatga tttttccccc atcctgaaat aaagatctca aacgctaaa
//
