LOCUS       NM_174885               2507 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 6A (Adam6a),
            mRNA.
ACCESSION   NM_174885
VERSION     NM_174885.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Grayson P and Civetta A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol Biol 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Marcello MR, Jia W, Leary JA, Moore KL and Evans JP.
  TITLE     Lack of tyrosylprotein sulfotransferase-2 activity results in
            altered sperm-egg interactions and loss of ADAM3 and ADAM6 in
            epididymal sperm
  JOURNAL   J Biol Chem 286 (15), 13060-13070 (2011)
   PUBMED   21339297
  REMARK    GeneRIF: Lack of tyrosylprotein sulfotransferase-2 activity results
            in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in
            epididymal sperm.
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Han C, Choi E, Park I, Lee B, Jin S, Kim DH, Nishimura H and Cho C.
  TITLE     Comprehensive analysis of reproductive ADAMs: relationship of ADAM4
            and ADAM6 with an ADAM complex required for fertilization in mice
  JOURNAL   Biol Reprod 80 (5), 1001-1008 (2009)
   PUBMED   19129510
  REMARK    GeneRIF: The levels of ADAM4 and ADAM6 are dramatically reduced in
            Adam2 and Adam3 knockout sperm defective in various fertilization
            processes.
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Choi I, Oh J, Cho BN, Ahnn J, Jung YK, Han Kim D and Cho C.
  TITLE     Characterization and comparative genomic analysis of intronless
            Adams with testicular gene expression
  JOURNAL   Genomics 83 (4), 636-646 (2004)
   PUBMED   15028286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073553.5.
            
            On Dec 21, 2006 this sequence version replaced NM_174885.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY158689.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2507              AC073553.5         16509-19015         c
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 62.12 cM"
     gene            1..2507
                     /gene="Adam6a"
                     /gene_synonym="Adam6; tMDCIV"
                     /note="a disintegrin and metallopeptidase domain 6A"
                     /db_xref="GeneID:238406"
                     /db_xref="MGI:MGI:2676316"
     exon            1..2507
                     /gene="Adam6a"
                     /gene_synonym="Adam6; tMDCIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2366
                     /gene="Adam6a"
                     /gene_synonym="Adam6; tMDCIV"
                     /note="disintegrin and metalloproteinase domain 6; a
                     disintegrin and metallopeptidase domain 6"
                     /codon_start=1
                     /product="a disintegrin and metalloprotease domain 6"
                     /protein_id="NP_777479.2"
                     /db_xref="CCDS:CCDS26208.1"
                     /db_xref="GeneID:238406"
                     /db_xref="MGI:MGI:2676316"
                     /translation="MLSLTWGMRLVERPVVPRVLLLLFALWLLLLVPVWCSQGHPTWR
                     YISSEVVIPRKEIYHTKGLQAQRLLSYSLRFRGQRHIIHLRRKTLIWPRHLLLTTQDD
                     QGALQMEYPFFPVDCYYIGYLEGILQSMVTVDTCYGGLSGVIKLDNLTYEIKPLNDSQ
                     SFEHLVSQIVSESDDTGPMNAWKHWSHNTGSPSSRLEYADGAPRLSSKNYATHPAAIK
                     GHFQATHSVYSASGGDKLSSTVEYLFKVISLMDTYLTNLHMRYYVFLMTVYTEADPFS
                     QDFRVPGGQAHTFYERVFYAHFRPDAGAIINKNSPGDDAVNPAERSICSPSALICLGQ
                     HGRNPLFLSIIITNRVGRSLGLKHDEGYCICQRRNTCIMFKNPQLTDAFSNCSLAEIS
                     NILNTPDLMPCLFYDRHVYYNTSLTYKFCGNFKVDNNEQCDCGSQKACYSDPCCGNDC
                     RLTPGSICDKELCCANCTYSPSGTLCRPIQNICDLPEYCSGSKFICPDDTYLQDGTPC
                     SEEGYCYKGNCTDRNIQCMEIFGVSAKNANIKCYDINKQRFRFGHCTRAEESLTFNAC
                     ADQDKLCGRLQCTNVTNLPFLQEHVSFHQSVISGVTCFGLDEHRGTETADAGLVRHGT
                     PCSRGKFCDRGACNGSLSRLGYDCTPEKCNFRGVCNNRRNCHCHFGWSPPKCKEEGHS
                     GSIDSGSPPVQRRIIKQNLEPVVYLRILFGRIYFLFVALLFGIATRVGVTKIFRFEDL
                     QAALRSWQEQAKDK"
ORIGIN      
        1 ggtaaccact taggttggga gcctgaggag gtttttagtc ctctgtcagt attttctaga
       61 ccaggcagtg gccacagcag agggagttag ctccacccag gatgttatct ctgacctggg
      121 gcatgaggct agtggaaaga cctgtggtcc ccagggtcct cctcttgcta tttgcactct
      181 ggctgctcct cctggttcca gtctggtgtt ctcaaggcca tcccacttgg cgttacatct
      241 catcggaggt ggttattcct cggaaggaga tctaccatac caaaggactt caagcacaaa
      301 gactgctctc gtatagcttg cgttttcggg gccagagaca tatcatccac ctgcggagaa
      361 agacactcat ttggcccaga cacttgttgc tgacaactca agatgaccaa ggagccttac
      421 agatggagta cccctttttt cctgtagatt gttactatat tggctacctg gaggggatcc
      481 tgcaatccat ggtcactgtg gatacttgtt atgggggcct gtcaggggtc ataaagttgg
      541 ataaccttac ctatgaaatc aaacccctca atgattcaca gagctttgaa caccttgttt
      601 ctcagatagt atctgagtct gatgacacag ggcctatgaa tgcatggaag cactggagcc
      661 ataatacagg ttctccctcc tccagattgg aatatgcaga tggagctccc agactatcta
      721 gtaagaatta cgctacacat ccagctgcta taaaaggcca ctttcaagca acccattctg
      781 tatatagtgc ttctggaggt gacaaacttt catctactgt tgagtatttg tttaaagtca
      841 ttagtttaat ggacacctat ctgaccaatc ttcatatgcg gtactatgtc tttctcatga
      901 ctgtgtatac cgaggctgat ccattttcac aagattttcg agttccagga gggcaggctc
      961 atactttcta tgagagagta ttttatgctc attttaggcc tgatgcagga gctataatta
     1021 acaagaattc gccaggagat gatgctgtta atccagctga gaggagtata tgttctccct
     1081 cagccctaat ttgtcttggt caacatggtc gaaatccttt atttttatct attataataa
     1141 ccaatcgtgt tggaaggagt ttaggcctaa aacatgatga ggggtactgt atctgccaga
     1201 gaaggaacac ctgcatcatg ttcaaaaatc ctcaattaac agatgctttc agcaattgtt
     1261 cccttgcaga gataagcaac atacttaata ctcctgatct gatgccatgt cttttctatg
     1321 accgtcatgt ttattataat acatcattga cttataagtt ttgtggaaac ttcaaagtag
     1381 ataacaatga gcagtgtgac tgtggctccc aaaaggcatg ttattcagat ccctgctgtg
     1441 gaaatgattg caggttaaca cctggtagca tttgtgataa agaattatgc tgtgcaaatt
     1501 gcacttacag tccttctggg acactctgca gacctatcca gaacatatgt gatcttccag
     1561 agtactgtag tggctctaag ttcatttgcc cagatgacac ttatctgcaa gatgggacac
     1621 catgctcaga agagggttac tgctataaag gtaactgcac tgatcgcaac atacaatgca
     1681 tggaaatctt tggtgtaagt gctaagaatg ctaatattaa gtgctatgac atcaacaaac
     1741 aacggtttcg atttgggcat tgtactagag cagaagaaag cctcacattc aatgcttgtg
     1801 ctgatcagga caagctgtgt ggaaggttgc agtgtaccaa tgtcaccaat cttccatttt
     1861 tgcaagaaca tgtttcattc catcaatcgg ttatctctgg ggttacctgc tttgggcttg
     1921 atgaacatcg tgggacagaa acagcagatg ctggattggt gagacatggt accccgtgtt
     1981 caaggggtaa gttctgtgat cgaggagctt gcaatggaag tttatctcgt ttgggttatg
     2041 actgcacccc agaaaaatgc aatttcagag gagtgtgtaa caatcgtcgg aattgccatt
     2101 gccattttgg ttggagccct ccaaagtgca aagaagaggg acacagtggg agcatagaca
     2161 gtgggtcccc tccggttcaa aggcgcataa taaaacagaa cctagagcca gtagtgtatt
     2221 taagaatact ctttggtcgt atttacttcc tctttgttgc actgctcttt ggcattgcca
     2281 ctcgtgtagg agttactaag atatttaggt ttgaagactt gcaagctgct ttacgttctt
     2341 ggcaagaaca agcaaaggac aagtaaaatg agttagcccc ctgtctcctc taagataaag
     2401 agaatggaaa aaaaatctga atgtcattag gggacaaggt agaactccag tccacagttc
     2461 tggatggcct ttgtttatat catgggacat aagacgtgtt ggactcg
//
