LOCUS       NM_007401               2810 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 5 (Adam5),
            transcript variant 3, mRNA.
ACCESSION   NM_007401 XM_983122
VERSION     NM_007401.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Li,W., Guo,X.J., Teng,F., Hou,X.J., Lv,Z., Zhou,S.Y., Bi,Y.,
            Wan,H.F., Feng,C.J., Yuan,Y., Zhao,X.Y., Wang,L., Sha,J.H. and
            Zhou,Q.
  TITLE     Tex101 is essential for male fertility by affecting sperm migration
            into the oviduct in mice
  JOURNAL   J Mol Cell Biol 5 (5), 345-347 (2013)
   PUBMED   23969891
REFERENCE   3  (bases 1 to 2810)
  AUTHORS   Grayson,P. and Civetta,A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol Biol 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2810)
  AUTHORS   Chan,W.Y., Wu,S.M., Ruszczyk,L., Law,E., Lee,T.L., Baxendale,V.,
            Lap-Yin Pang,A. and Rennert,O.M.
  TITLE     The complexity of antisense transcription revealed by the study of
            developing male germ cells
  JOURNAL   Genomics 87 (6), 681-692 (2006)
   PUBMED   16458478
REFERENCE   5  (bases 1 to 2810)
  AUTHORS   Kim,T., Oh,J., Woo,J.M., Choi,E., Im,S.H., Yoo,Y.J., Kim,D.H.,
            Nishimura,H. and Cho,C.
  TITLE     Expression and relationship of male reproductive ADAMs in mouse
  JOURNAL   Biol Reprod 74 (4), 744-750 (2006)
   PUBMED   16407499
REFERENCE   6  (bases 1 to 2810)
  AUTHORS   Gwynn,B., Ciciotte,S.L., Hunter,S.J., Washburn,L.L., Smith,R.S.,
            Andersen,S.G., Swank,R.T., Dell'Angelica,E.C., Bonifacino,J.S.,
            Eicher,E.M. and Peters,L.L.
  TITLE     Defects in the cappuccino (cno) gene on mouse chromosome 5 and
            human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent
            mechanism
  JOURNAL   Blood 96 (13), 4227-4235 (2000)
   PUBMED   11110696
REFERENCE   7  (bases 1 to 2810)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   8  (bases 1 to 2810)
  AUTHORS   Wolfsberg,T.G., Straight,P.D., Gerena,R.L., Huovila,A.P.,
            Primakoff,P., Myles,D.G. and White,J.M.
  TITLE     ADAM, a widely distributed and developmentally regulated gene
            family encoding membrane proteins with a disintegrin and
            metalloprotease domain
  JOURNAL   Dev Biol 169 (1), 378-383 (1995)
   PUBMED   7750654
REFERENCE   9  (bases 1 to 2810)
  AUTHORS   Ballock,R.T., Heydemann,A., Wakefield,L.M., Flanders,K.C.,
            Roberts,A.B. and Sporn,M.B.
  TITLE     Inhibition of the chondrocyte phenotype by retinoic acid involves
            upregulation of metalloprotease genes independent of TGF-beta
  JOURNAL   J Cell Physiol 159 (2), 340-346 (1994)
   PUBMED   8163572
REFERENCE   10 (bases 1 to 2810)
  AUTHORS   Weskamp,G. and Blobel,C.P.
  TITLE     A family of cellular proteins related to snake venom disintegrins
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2748-2751 (1994)
   PUBMED   8146185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK161262.1 and BC094237.1.
            
            On Jan 10, 2013 this sequence version replaced NM_007401.2.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature, functional protein.
            This gene is located in a cluster of related ADAM genes on
            chromosome 8. Alternative splicing results in multiple transcript
            variants encoding different isoforms, some of which may undergo
            similar processing. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (3) contains an alternate 3'
            terminal exon, compared to variant 1. The encoded isoform (3) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161262.1, AK161417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2791              AK161262.1         1-2791
            2792-2810           BC094237.1         2272-2290
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 13.26 cM"
     gene            1..2810
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /note="a disintegrin and metallopeptidase domain 5"
                     /db_xref="GeneID:11499"
                     /db_xref="MGI:MGI:104730"
     exon            1..430
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..2631
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /note="isoform 3 preproprotein is encoded by transcript
                     variant 3; disintegrin and metalloproteinase
                     domain-containing protein 5; transmembrane
                     metalloproteinase-like, disintegrin-like, and
                     cysteine-rich protein II; a disintegrin and
                     metalloprotease domain (ADAM) 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5 isoform 3 preproprotein"
                     /protein_id="NP_031427.2"
                     /db_xref="CCDS:CCDS52525.1"
                     /db_xref="GeneID:11499"
                     /db_xref="MGI:MGI:104730"
                     /translation="MFLLLLLFLHLKGLQAGQNPQKTTLQTTVPEKISSPDVETDAED
                     HMAYLITINETPHFIHLKKQSFITPTAVVYTYDRNDVQHSQPLSALENCNYNGYVAGF
                     PNSIVTLTVCTGLRGIIQFENVSYAIEPVETLSGFVHVIYENTNKHAVIPDLGKNQSY
                     SWFDESDYQFRSNMKKSGFTVLRQRFIMMDIIVDKKLFDYMGSDTEVVLQKVIQIIGF
                     VNTMLSKLKLTVLINSIEIWSKENRIRLSKAVDDLLVQFSIWKHEYRSQHVAYLLAFE
                     EHPASTGALYPGNLCKLEYNAAVALYPKGLSLESFSVIVLQLLSIGMGLTYDTENCHC
                     TGEVCLMTPKAIYSGGVKDFSTCTLDDFKYLSTRQDLRCLQDLPLERKPARRPRRICG
                     NGILEMNEQCDCGTLKNCTHRKCCDPMSCRLKNKATCGSGECCSQDCTVKMNDVVCRK
                     SVDECDFVEYCNGKDPYCVPNTYARNGQYCESGEAFCFEGRCQTADKQCMSMLGKYVR
                     GASFACYEEFNSRGDRFGNCIHNFCAFRNSLCGKLICTWPFKKLVLKANLSVAYAQIR
                     DDLCVAMYKGGRIPKTTKTTYSNPADRDETFVNDGTICGPDMFCLRASCTETRFHMDS
                     SKCDSTRDCNDHGVCNNLQHCHCDIGYNPPFCEEHKGQFGSVDDGHKYHVEDGKSYKQ
                     QSHSNLKKNQLQLILYISLPLLVMISAVVIKQSKLSRVCDRERSESDSSTTEDSGSNT
                     NVTSSGGSTSH"
     exon            431..510
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            511..566
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            567..645
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            646..722
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            723..900
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            901..966
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1038
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1196
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1278
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1412
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1599
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1695
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1891
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1982
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2199
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2286
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2401
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2564
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2618
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2792
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2764..2769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /note="hexamer: AATAAA"
     polyA_site      2784
                     /gene="Adam5"
                     /gene_synonym="tMDC II; tMDCII"
                     /note="major polyA site"
ORIGIN      
        1 aattctgggg acagtacgcc gaagtatcct ggaagatgcg tggctgccgt cagtaacctg
       61 aatattttcg gatatctttt cctcagtgat gtgtaaattt tttttaaaag acatgataaa
      121 tgatacaaag aaaatcctta ccagctcttc ctagcctgaa gagtaaacct gcaggcatcc
      181 accttccttt ttacagttag caggatggtt ggtacctgaa tctatgcatc tatctcgttc
      241 tccagccctt tctgctctgg tttccctagc gacaaccctg caggttcagg gcccagagct
      301 tccgttactg gacacaacgc ccgccccgcc cagcctgttg ctccgcagca aagctccaag
      361 accaccaagg gagccatgtt cctccttctt ttgctctttt tgcatcttaa agggctgcag
      421 gcaggccaga atcctcagaa aaccaccctg cagacaactg ttcctgaaaa gatctcatca
      481 ccggatgtgg aaacagatgc agaagaccat atggcttatc ttattacaat aaatgaaacc
      541 ccccatttca tccatcttaa aaaacaatca tttataactc caactgcagt tgtttatact
      601 tacgacagaa atgatgttca acattctcaa cctttgtcag ctctggaaaa ttgcaattac
      661 aatggatatg ttgcaggttt cccaaactct atcgtgaccc tcaccgtttg cacaggactc
      721 aggggaatca tacagtttga aaatgtctcc tatgcaatcg agcccgtgga aaccctgtca
      781 ggatttgtgc acgtgatcta tgagaacaca aacaaacatg ctgtgattcc tgacctggga
      841 aagaatcagt catacagttg gtttgacgaa tcagattatc aattccggag taacatgaag
      901 aaatctggat ttaccgtgtt acgccaacga ttcattatga tggatatcat cgtggataaa
      961 aagctgtttg attacatggg ttctgacact gaagttgtgc tacagaaagt cattcagatc
     1021 atcggtttcg ttaacactat gctctccaag ttaaaactga ctgtcttaat aaattccatt
     1081 gaaatctggt cgaaggaaaa cagaattcgt ttatcaaagg cagttgatga cttattggtt
     1141 cagttctcaa tttggaaaca tgagtataga tcacaacatg ttgcatactt actggcattt
     1201 gaggagcacc ctgcttccac gggggctcta tatccaggga atctgtgcaa actggagtac
     1261 aatgctgctg ttgccctgta tccaaaaggt ttatcgttag aatcgtttag tgtcattgtc
     1321 ctgcagctgc tgagcattgg tatgggctta acttacgaca ctgagaactg ccactgtaca
     1381 ggagaagttt gcctaatgac gcccaaagca atatattctg ggggtgtgaa ggacttcagt
     1441 acttgtaccc tggatgactt taaatacctg tcaacaagac aagaccttag atgtctccag
     1501 gacttgcctt tggaaagaaa gccagctcgc aggccaagga gaatctgtgg caatgggata
     1561 ctggagatga acgagcaatg tgactgtggc actttgaaga actgtacaca tagaaaatgc
     1621 tgtgacccta tgtcatgtcg attgaaaaac aaggccacgt gtggttctgg ggagtgctgt
     1681 agtcaagatt gcacggtaaa aatgaatgat gtggtctgta gaaagtcggt agatgaatgt
     1741 gactttgtgg agtactgtaa cggaaaagat ccctattgtg tccctaacac atatgcacgc
     1801 aatgggcagt attgtgaatc aggtgaagcc ttctgttttg aaggacgatg tcagactgct
     1861 gacaagcaat gtatgagcat gcttgggaaa tacgtgagag gggcttcctt tgcgtgctat
     1921 gaagagttca attccagagg cgatagattt ggcaactgta ttcataattt ttgtgctttc
     1981 agaaattctc tctgtgggaa actaatctgt acgtggccat tcaagaagct ggtgctaaaa
     2041 gccaatttat ctgtggccta tgcgcaaatc cgggatgact tgtgtgtagc tatgtataaa
     2101 ggtgggagga tacctaagac aacaaagacg acatattcca atccagcgga cagagatgag
     2161 acatttgtaa acgacggcac catctgtggc cctgatatgt tttgtttgag agcatcatgc
     2221 acagaaacta gatttcacat ggattcttcc aagtgtgatt caactagaga ttgcaacgac
     2281 catggggttt gcaacaattt acagcattgc cactgtgata taggatataa ccctcctttt
     2341 tgtgaggaac ataagggaca gtttggaagc gttgatgatg gacataaata tcatgttgaa
     2401 gatggtaaaa gctataagca gcaaagtcat agtaatctta aaaaaaatca gcttcagctc
     2461 attctctaca tatctctgcc cttacttgtg atgatttcag ctgtagttat aaagcaaagc
     2521 aaactgagtc gtgtatgtga cagagaaaga agtgaaagcg acagctctac aacagaagat
     2581 agcgggagta acaccaatgt gaccagcagt ggaggaagca cctcccacta atcaagtatt
     2641 gctaccccaa aagaagataa tctggattaa ccatgagaaa ctgacattct gagcaagaag
     2701 atggaaaaca ccaaaccaaa acaacccaac ccacagcttc tctcccactc taaaccatga
     2761 actaataaat cagctatgac tgaacaaatg caaaaaaaaa aaaaaaaaaa
//
