LOCUS       NM_033615               3176 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 33 (Adam33),
            transcript variant 1, mRNA.
ACCESSION   NM_033615
VERSION     NM_033615.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3176)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3176)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 3176)
  AUTHORS   Haitchi,H.M., Bassett,D.J., Bucchieri,F., Gao,X., Powell,R.M.,
            Hanley,N.A., Wilson,D.I., Holgate,S.T. and Davies,D.E.
  TITLE     Induction of a disintegrin and metalloprotease 33 during embryonic
            lung development and the influence of IL-13 or maternal allergy
  JOURNAL   J Allergy Clin Immunol 124 (3), 590-597 (2009)
   PUBMED   19665773
  REMARK    GeneRIF: Adam33/Adam33 shows 2 significant increments in expression
            during lung morphogenesis, suggesting important developmental
            regulation.
REFERENCE   4  (bases 1 to 3176)
  AUTHORS   Chen,C., Huang,X. and Sheppard,D.
  TITLE     ADAM33 is not essential for growth and development and does not
            modulate allergic asthma in mice
  JOURNAL   Mol Cell Biol 26 (18), 6950-6956 (2006)
   PUBMED   16943435
  REMARK    GeneRIF: ADAM33 is not essential for growth or reproduction in the
            mouse and does not modulate baseline or allergen-induced airway
            responsiveness.
REFERENCE   5  (bases 1 to 3176)
  AUTHORS   Huang,J., Bridges,L.C. and White,J.M.
  TITLE     Selective modulation of integrin-mediated cell migration by
            distinct ADAM family members
  JOURNAL   Mol Biol Cell 16 (10), 4982-4991 (2005)
   PUBMED   16079176
REFERENCE   6  (bases 1 to 3176)
  AUTHORS   Umland,S.P., Wan,Y., Shah,H., Garlisi,C.G., Devito,K.E.,
            Braunschweiger,K., Gheyas,F. and Del Mastro,R.
  TITLE     Mouse ADAM33: two splice variants differ in protein maturation and
            localization
  JOURNAL   Am J Respir Cell Mol Biol 30 (4), 530-539 (2004)
   PUBMED   12972401
REFERENCE   7  (bases 1 to 3176)
  AUTHORS   Van Eerdewegh,P., Little,R.D., Dupuis,J., Del Mastro,R.G.,
            Falls,K., Simon,J., Torrey,D., Pandit,S., McKenny,J.,
            Braunschweiger,K., Walsh,A., Liu,Z., Hayward,B., Folz,C.,
            Manning,S.P., Bawa,A., Saracino,L., Thackston,M., Benchekroun,Y.,
            Capparell,N., Wang,M., Adair,R., Feng,Y., Dubois,J.,
            FitzGerald,M.G., Huang,H., Gibson,R., Allen,K.M., Pedan,A.,
            Danzig,M.R., Umland,S.P., Egan,R.W., Cuss,F.M., Rorke,S.,
            Clough,J.B., Holloway,J.W., Holgate,S.T. and Keith,T.P.
  TITLE     Association of the ADAM33 gene with asthma and bronchial
            hyperresponsiveness
  JOURNAL   Nature 418 (6896), 426-430 (2002)
   PUBMED   12110844
REFERENCE   8  (bases 1 to 3176)
  AUTHORS   Yoshinaka,T., Nishii,K., Yamada,K., Sawada,H., Nishiwaki,E.,
            Smith,K., Yoshino,K., Ishiguro,H. and Higashiyama,S.
  TITLE     Identification and characterization of novel mouse and human
            ADAM33s with potential metalloprotease activity
  JOURNAL   Gene 282 (1-2), 227-236 (2002)
   PUBMED   11814695
  REMARK    GeneRIF: The mouse and human predicted proteins consisted of 797
            and 813 amino acids, respectively, and they shared 70% homology of
            the entire amino acid sequence.
REFERENCE   9  (bases 1 to 3176)
  AUTHORS   Gunn,T.M., Azarani,A., Kim,P.H., Hyman,R.W., Davis,R.W. and
            Barsh,G.S.
  TITLE     Identification and preliminary characterization of mouse Adam33
  JOURNAL   BMC Genet 3, 2 (2002)
   PUBMED   11897009
  REMARK    GeneRIF: Identification and preliminary characterization of mouse
            Adam33.
REFERENCE   10 (bases 1 to 3176)
  AUTHORS   Gunn,T.M., Miller,K.A., He,L., Hyman,R.W., Davis,R.W., Azarani,A.,
            Schlossman,S.F., Duke-Cohan,J.S. and Barsh,G.S.
  TITLE     The mouse mahogany locus encodes a transmembrane form of human
            attractin
  JOURNAL   Nature 398 (6723), 152-156 (1999)
   PUBMED   10086356
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL833771.4, BC138139.1 and
            AW048228.1.
            
            On May 13, 2016 this sequence version replaced NM_033615.2.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. This gene is widely expressed, most highly
            in the adult brain, heart, kidney, lung and testis. The encoded
            preproprotein undergoes proteolytic processing to generate a
            mature, functional metalloprotease enzyme. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms, some of which may undergo similar processing. [provided
            by RefSeq, May 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB059632.1, AF472524.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AL833771.4         182443-182719       c
            278-2208            BC138139.1         1-1931
            2209-2286           AL833771.4         172128-172205       c
            2287-2783           BC138139.1         1932-2428
            2784-3176           AW048228.1         1-393               c
FEATURES             Location/Qualifiers
     source          1..3176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.26 cM"
     gene            1..3176
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /note="a disintegrin and metallopeptidase domain 33"
                     /db_xref="GeneID:110751"
                     /db_xref="MGI:MGI:1341813"
     exon            1..400
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2694
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin and metalloprotease domain 33;
                     disintegrin and metalloproteinase domain-containing
                     protein 33"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 33 isoform 1 preproprotein"
                     /protein_id="NP_291093.2"
                     /db_xref="CCDS:CCDS16753.1"
                     /db_xref="GeneID:110751"
                     /db_xref="MGI:MGI:1341813"
                     /translation="MGSRCGRPGGSPVLLLLPLLLPSCPLRSARMFPGNAHGELVTPH
                     WILEGRLWLKVTLEEPILKPDSVLVALEAEGQDLLLELEKKHKLLAPGYTETHYRPDG
                     HPVVLSPNHTDHCQYHGRVRGFRESWVVLSTCSGMSGLIVLSSKVSYYLQPRTPGDTK
                     DFPTHEIFRMEQLFTWRGVQRDKNSQYKAGMASLPHVPQSRVRREARRSPRYLELYIV
                     ADHTLFLLQHQNLNHTRQRLLEVANCVDQILRTLDIQLVLTGLEVWTEQDLSRITQDA
                     NETLWAFLQWRRGVWARRPHDSTQLLTGRTFQGTTVGLAPVEGICRAESSGGVSTDHS
                     ELPIGTAATMAHEIGHSLGLHHDPEGCCVQADAEQGGCVMEAATGHPFPRVFSACSRR
                     QLRTFFRKGGGPCLSNTSAPGLLVLPSRCGNGFLEAGEECDCGSGQKCPDPCCFAHNC
                     SLRAGAQCAHGDCCARCLLKSAGTPCRPAATDCDLPEFCTGTSPYCPADVYLLDGSPC
                     AEGRGYCLDGWCPTLEQQCQQLWGPGSKPAPEPCFQQMNSMGNSQGNCGQDHKGSFLP
                     CAQRDALCGKLLCQGGEPNPLVPHIVTMDSTILLEGREVVCRGAFVLPDSHLDQLDLG
                     LVEPGTGCGPRMVCQDRHCQNATSQELERCLTACHNGGVCNSNRNCHCAAGWAPPFCD
                     KPGLGGSVDSGPAQSANRDAFPLAMLLSFLLPLLPGAGLAWCYYQLPTFCHRRGLCCR
                     RDPLWNRDIPLGSVHPVEFGSIITGEPSPPPPWTSCQQRSHPPSLDLLSDPANSELT"
     exon            401..480
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            481..557
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            558..636
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            637..713
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            714..903
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            904..969
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1041
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1208
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1293
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1436
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1614
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1704
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1900
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2009
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2208
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2286
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2395
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2540
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2611
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..3160
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2846..2851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /note="hexamer: AATAAA"
     polyA_site      2873
                     /gene="Adam33"
                     /gene_synonym="Adaml"
     regulatory      3142..3147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /note="hexamer: AATAAA"
     polyA_site      3160
                     /gene="Adam33"
                     /gene_synonym="Adaml"
                     /note="major polyA site"
ORIGIN      
        1 ctgtggggat cacttagcta gtgcctctat tcagcaccag agaggttctc taagaacctt
       61 cccggacttt ccgccctcgc ctcccttggc cagcgtggat aggattgttg cagataacgc
      121 cagggagggt catcctggct cccgcagcgc ggactcctgt tttgcgggcc agggtagggc
      181 cacactcctg cgctcctgtg aggtggcgcg aggcccgctg agggcgggag gaggcggccc
      241 cctctagccg gggtggagcc aacagcacag caagagtgag agggaaaggc actcccagcc
      301 atgggctcga ggtgcgggag acccgggggg tctccggtgc tgctattgct gccgctgttg
      361 ctgccctcgt gtccgctgcg gagcgctcgg atgtttccag gaaatgccca tggagagcta
      421 gtcactcccc actggatcct ggagggcaga ctctggctca aggtcaccct ggaggagccg
      481 atcttgaagc ctgactcggt gctggtggct ttagaggctg aaggccagga tctcctgctt
      541 gaactggaga agaagcacaa gcttctggcc ccaggataca cagaaaccca ctacaggcca
      601 gatgggcatc cggtagtgct gtcccccaac cacacggatc attgccaata tcacgggcgt
      661 gtgaggggct tccgggaatc ctgggtggtt ctcagcacct gctctgggat gagtggcctt
      721 attgtgctca gcagcaaagt cagctattat ctgcaacctc ggactcctgg ggataccaaa
      781 gacttcccaa cccacgagat cttccggatg gagcagttgt tcacctggag aggggtccag
      841 agagacaaga actcccaata caaagcagga atggccagtc ttcctcatgt cccccagagc
      901 cgggtgaggc gagaggcgcg caggagtccc aggtacctgg aactgtacat agtggctgac
      961 cacaccctgt tcttgcttca gcatcagaac ttgaaccaca cgagacagcg cctcctggag
     1021 gttgccaatt gcgtggacca gattctcagg actctggata tacagttggt gttgaccggg
     1081 ctggaagtgt ggaccgagca ggatctcagt cgcatcactc aggacgcaaa cgaaacgctc
     1141 tgggctttcc tacagtggcg ccgcggggtg tgggccagga gaccacacga ctccacacaa
     1201 ctgctcacgg gccgcacctt ccagggtacc acggtgggcc tggcacctgt ggagggcata
     1261 tgccgcgcgg agagctccgg aggtgtgagc acagaccact cggaactccc catcggcaca
     1321 gcagccacca tggcccacga gataggccac agcctgggcc tccaccatga tcccgagggc
     1381 tgctgcgtgc aggccgatgc agagcaagga ggctgcgtca tggaggcagc cacagggcac
     1441 cctttcccgc gcgtcttcag cgcctgcagc cgccgccagc tgcgcacctt cttccgcaaa
     1501 gggggcggtc cttgcctctc caacacctcg gcgccggggc tcctggtgct gcccagccgc
     1561 tgcggaaacg gcttcttgga agcaggagaa gagtgcgact gcggttctgg ccagaagtgc
     1621 ccagacccct gctgctttgc ccacaattgc tccctgcgtg cgggggctca atgtgcccac
     1681 ggtgattgct gtgcgaggtg cctgttaaag tccgcgggca cgccttgtcg tcctgctgcg
     1741 actgactgcg atctccccga gttctgcacc ggcacctccc cgtattgccc cgcagatgtt
     1801 tacctactgg atggctcacc ctgcgctgag ggtcgcggct attgcctaga cggctggtgt
     1861 cccacgctgg agcagcagtg ccagcagcta tgggggcctg ggtccaagcc ggccccagag
     1921 ccatgtttcc agcagatgaa ctccatgggg aattcgcaag ggaactgtgg ccaggaccac
     1981 aagggtagct tcctgccttg tgctcagagg gacgctctgt gtgggaaact gctgtgccag
     2041 ggaggggagc cgaacccact agtgccgcac atagtgacta tggactccac aattctccta
     2101 gagggccgcg aagtggtttg ccgaggggcc tttgtgctcc cagatagtca cctggaccag
     2161 cttgacttgg gtctggtaga gccaggcacc ggctgtggac ctagaatggt gtgccaggac
     2221 aggcactgtc agaatgctac ctcccaggag ctggaacgtt gcttgactgc ctgccataac
     2281 ggtggggttt gcaatagcaa tcgtaactgt cactgtgctg ctggctgggc tccacccttc
     2341 tgtgacaagc ctggcttggg tggtagcgtg gatagtggcc ctgcacagtc tgcaaaccga
     2401 gatgccttcc ccttggccat gctcctcagc ttcctgctgc ctctgctccc tggggctggc
     2461 ctagcctggt gctactacca gctcccaaca ttctgtcatc gaaggggact gtgctgcagg
     2521 agggaccccc tatggaatag agacataccc ctgggcagtg tgcatccggt ggagtttggc
     2581 tccatcatca ctggagagcc ctcgccccct cccccatgga cctcttgcca acagcgttcg
     2641 caccctccat ctcttgactt gctctcagac cctgcgaact ctgagcttac ctaagaacta
     2701 ccctctgaag cagcctggtc tacagattga gttccagacc tgccctatcc ctatggtatg
     2761 gaagcaccct gaggacctcc tgttgcccag tcacctacct ctgtctcagt ttgttgtccc
     2821 ctcctcagat ttacaggctt gcatcaataa agaaatgaga catgggcctc agagaagctg
     2881 ttgtcataga gaccatgatg ctggaagccc taggggcagg gaagggagac actgtggttc
     2941 ttcttgggtc cttatagagg gaggacaaat gtgccctgcc atgtgacttg cagtcctcag
     3001 tttctcagac gcactcttat aattcctatg ggctgtatgc tgagctctta ctcagcatag
     3061 gaaccccaga gcccgatcat gttgtatccc gcctgccctg agagctgtgc tattctgaaa
     3121 tgttagaatg tatctaataa caataaatcc acaagttata aaaaaaaaaa aaaaaa
//
