LOCUS       NM_009619               2745 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ADAM metallopeptidase domain 3 (Adam3), transcript
            variant 1, mRNA.
ACCESSION   NM_009619
VERSION     NM_009619.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2745)
  AUTHORS   Noda,T., Shinohara,H., Kobayashi,S., Taira,A., Oura,S., Tahara,D.,
            Tokuyasu,M., Araki,K. and Ikawa,M.
  TITLE     Multiple genes in the Pate5-13 genomic region contribute to ADAM3
            processingdagger
  JOURNAL   Biol Reprod 110 (4), 750-760 (2024)
   PUBMED   38217862
  REMARK    GeneRIF: Multiple genes in the Pate5-13 genomic region contribute
            to ADAM3 processingdagger.
REFERENCE   2  (bases 1 to 2745)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2745)
  AUTHORS   Kiyozumi,D., Shimada,K., Chalick,M., Emori,C., Kodani,M., Oura,S.,
            Noda,T., Endo,T., Matzuk,M.M., Wreschner,D.H. and Ikawa,M.
  TITLE     A small secreted protein NICOL regulates lumicrine-mediated sperm
            maturation and male fertility
  JOURNAL   Nat Commun 14 (1), 2354 (2023)
   PUBMED   37095084
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2745)
  AUTHORS   Xiong,W., Shen,C., Li,C., Zhang,X., Ge,H., Tang,L., Shen,Y., Lu,S.,
            Zhang,H., Han,M., Zhang,A., Wang,J., Wu,Y., Fei,J. and Wang,Z.
  TITLE     Dissecting the PRSS37 interactome and potential mechanisms leading
            to ADAM3 loss in PRSS37-null sperm
  JOURNAL   J Cell Sci 134 (10) (2021)
   PUBMED   34028541
  REMARK    GeneRIF: Dissecting the PRSS37 interactome and potential mechanisms
            leading to ADAM3 loss in PRSS37-null sperm.
REFERENCE   5  (bases 1 to 2745)
  AUTHORS   Larasati,T., Noda,T., Fujihara,Y., Shimada,K., Tobita,T., Yu,Z.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     Tmprss12 is required for sperm motility and uterotubal junction
            migration in micedagger
  JOURNAL   Biol Reprod 103 (2), 254-263 (2020)
   PUBMED   32529245
REFERENCE   6  (bases 1 to 2745)
  AUTHORS   Shamsadin,R., Adham,I.M., Nayernia,K., Heinlein,U.A.,
            Oberwinkler,H. and Engel,W.
  TITLE     Male mice deficient for germ-cell cyritestin are infertile
  JOURNAL   Biol Reprod 61 (6), 1445-1451 (1999)
   PUBMED   10569988
REFERENCE   7  (bases 1 to 2745)
  AUTHORS   Yuan,R., Primakoff,P. and Myles,D.G.
  TITLE     A role for the disintegrin domain of cyritestin, a sperm surface
            protein belonging to the ADAM family, in mouse sperm-egg plasma
            membrane adhesion and fusion
  JOURNAL   J Cell Biol 137 (1), 105-112 (1997)
   PUBMED   9105040
REFERENCE   8  (bases 1 to 2745)
  AUTHORS   Wolfsberg,T.G. and White,J.M.
  TITLE     ADAMs in fertilization and development
  JOURNAL   Dev Biol 180 (2), 389-401 (1996)
   PUBMED   8954712
  REMARK    Review article
REFERENCE   9  (bases 1 to 2745)
  AUTHORS   Linder,B., Bammer,S. and Heinlein,U.A.
  TITLE     Delayed translation and posttranslational processing of cyritestin,
            an integral transmembrane protein of the mouse acrosome
  JOURNAL   Exp Cell Res 221 (1), 66-72 (1995)
   PUBMED   7589257
REFERENCE   10 (bases 1 to 2745)
  AUTHORS   Lemaire,L., Johnson,K.R., Bammer,S., Petry,P., Ruddle,F.H. and
            Heinlein,U.A.
  TITLE     Chromosomal assignment of three novel mouse genes expressed in
            testicular cells
  JOURNAL   Genomics 21 (2), 409-414 (1994)
   PUBMED   8088835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ047279.1, X64227.1, AC138355.17 and BC049609.1.
            
            On May 7, 2016 this sequence version replaced NM_009619.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X64227.1, SRR5189685.134708.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CJ047279.1         2-29
            29-253              X64227.1           12-236
            254-254             AC138355.17        19353-19353
            255-1562            X64227.1           238-1545
            1563-1563           AC138355.17        47664-47664
            1564-1724           X64227.1           1547-1707
            1725-2734           BC049609.1         199-1208
            2735-2745           X64227.1           2719-2729
FEATURES             Location/Qualifiers
     source          1..2745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 13.09 cM"
     gene            1..2745
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /note="ADAM metallopeptidase domain 3"
                     /db_xref="GeneID:11497"
                     /db_xref="MGI:MGI:102518"
     exon            1..154
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2565
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; a disintegrin and metallopeptidase domain 3
                     (cyritestin)"
                     /codon_start=1
                     /product="A disintegrin and metallopeptidase domain 3
                     isoform 1 precursor"
                     /protein_id="NP_033749.2"
                     /db_xref="CCDS:CCDS22196.1"
                     /db_xref="GeneID:11497"
                     /db_xref="MGI:MGI:102518"
                     /translation="MLPLFLVLSYLGQVIAAGKDVETPLLQITVPEKIDTNIQDAKEA
                     ETQVTYVVRIEGKAYTLQLEKQSFLHPLFGTYLRDKLGTLQPYFSLVKTHCFYQGHAA
                     EIPVSTVTLSTCSGLRGLLQLENITYGIEPLESSATFEHILYEIKNNKIDYSPLKENF
                     ANSEQESQSYRILVKPEKGSNSTLTKRILRIKIIMDKAMFDHMGSEVGVATQKVVHIF
                     GLINTMFSQLKMTVMLNSLEIWSEQDKIETNGDADEVLQRFLLWKSKEISQKAQDITY
                     LLLYKDHPDYVGATYHGMACNPNFTAGIALHPKTLAVEGFAIVLSQLLGINLGLAYDD
                     VYNCFCPGSTCIMNPSAIRSQGIKVFSSCSVDEFKQLASQPELDCLRNTSETEFVVQP
                     QGGSYCGNHLLEVPEQCDCGPPETCTHKKCCNPKDCTLIDAAQCGTGPCCDKRTCTIA
                     ERGRLCRKSKDQCDFPEFCNGETEGCAPDTKAADLEPCNNETAYCFGGVCRDPDRQCT
                     DLFGKYAKGPNYVCAQEVNLQNDKFGNCHGRCNYSAIFCGKAVCYWNFAEVIQTEKYD
                     VQYTYLGGQVCVSAHLRSQTGTRDDTYVHDGTVCGSGQVCFRGDCLRVHVLRGTRECE
                     ADDKCQGHGICNNLNNCQCESGFAPPECDMTPSSPGGSMDDGFWLPFDKSTPLIFKRH
                     GLKYKKVLLISFYILLPFLVVLAFMAVKRMIGKRLAKQNISKALEHKEEAFNRGSMNP
                     GVVSGGNTDQNLMTVPGSFNSYAYHGNTDQNFMTVPGSFNSYSYHGNTDQNFMTVPGS
                     FNSYSYQDVPYYRSIPEDGNDSQQ"
     exon            155..237
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            238..293
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            294..372
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            373..449
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            450..627
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            628..693
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            694..765
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            766..932
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1014
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1151
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1341
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1440
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1636
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1724
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1908
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1995
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2110
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2303
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2528
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2576
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2736
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2712..2717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /note="hexamer: AATAAA"
     polyA_site      2736
                     /gene="Adam3"
                     /gene_synonym="Cyrn1; Taz83; tMDC"
                     /note="major polyA site"
ORIGIN      
        1 ctgtctctcc tgctcccgaa gagctcaggc gcaggggcca cgagctgctg ccgttgcatc
       61 aactgacacc accgtggcaa agtcagcagc cacaccatgc tgcccttatt cctagtcctc
      121 tcatacctag gccaagtgat cgctgcaggc aaagacgtag aaacaccact tctgcagatc
      181 acagtaccag agaaaatcga caccaacatc caggatgcca aggaggcaga gacacaagtc
      241 acttacgtgg tcagaattga gggcaaagca tacacactcc aacttgaaaa acagtcattt
      301 ttacacccac tttttggaac atatttgcgt gacaagttgg gaacattgca accatacttt
      361 tctttagtaa agactcactg cttttatcaa ggacatgctg ccgagatccc agtatcaaca
      421 gtgacactca gcacttgctc aggtctcagg ggtttgttgc agttagagaa catcacttat
      481 ggaattgagc ccttggagtc ttcagctaca tttgaacaca tactttatga aattaagaat
      541 aacaaaattg actattctcc tttaaaagaa aacttcgcaa attctgagca agaaagtcag
      601 tcctaccgaa tccttgtcaa accagagaaa ggttcgaact cgacactaac aaagagaatt
      661 ctgaggataa agatcatcat ggataaagcc atgtttgacc atatgggctc tgaggtggga
      721 gttgcaactc agaaagttgt tcacatcttt ggtctcatta atactatgtt ttcccagctg
      781 aagatgacag tgatgttaaa ctctctggag atctggtcag aacaagacaa gatagaaacc
      841 aatggggatg ctgatgaggt cctgcaaagg ttcctgctgt ggaaaagcaa ggaaatatct
      901 caaaaggccc aggatataac ctacttactc ctgtataagg atcatcctga ttatgtggga
      961 gcgacatatc atgggatggc ctgcaaccca aattttaccg caggaattgc tctgcatcca
     1021 aagacgttag ctgtggaggg ctttgccatt gttctctcac agttgctggg aattaacctg
     1081 gggttggcat acgatgacgt ctacaattgt ttctgtccag gaagcacatg cataatgaat
     1141 ccttcggcaa tacgttccca aggcataaag gtttttagca gttgtagtgt ggatgaattc
     1201 aaacagctgg cttcacaacc tgaactggac tgccttcgga atacatcgga gacagaattt
     1261 gttgtccagc cccaaggtgg atcgtattgt ggtaaccatc tcctggaggt cccagagcaa
     1321 tgtgactgtg gcccaccaga gacctgtact cataaaaaat gctgtaaccc taaagactgt
     1381 actctgattg atgctgcgca gtgtggtaca gggccatgct gtgataaaag aacatgtacg
     1441 atagccgaaa gaggacgcct atgcagaaaa agtaaggacc agtgtgattt cccagagttc
     1501 tgcaatggag aaactgaagg ctgtgcccct gatacaaaag ctgcagacct ggaaccttgc
     1561 aacaacgaga ctgcctattg ctttggtggg gtttgccgag acccagatag gcagtgtaca
     1621 gatttatttg ggaaatatgc taagggtcct aattatgtgt gtgcacaaga agtgaatctg
     1681 caaaatgaca aatttggaaa ctgtcatggg cgatgtaatt atagtgctat attttgtgga
     1741 aaagcagttt gctactggaa ctttgcagaa gtcatacaaa cagagaaata tgatgttcag
     1801 tatacttact tgggaggcca ggtgtgtgtg tccgctcatt taagatcaca gactgggact
     1861 agagatgaca catatgtcca tgatggcact gtttgtggta gtggccaggt ttgcttccga
     1921 ggagattgct tacgtgtgca tgtcctaagg ggaaccaggg agtgtgaggc cgatgacaaa
     1981 tgccaaggac acgggatttg caacaatcta aacaactgtc agtgtgaatc tggttttgct
     2041 cctccagagt gtgacatgac accttcatct ccaggaggaa gcatggatga cggattttgg
     2101 ctgcccttcg ataaaagcac acctttgatt ttcaagcggc atggccttaa gtacaaaaaa
     2161 gtgcttttga tcagtttcta tatcctcctg cctttccttg ttgtgctagc cttcatggct
     2221 gttaagcgga tgattggtaa gcggcttgct aagcagaata tctcaaaggc attggagcac
     2281 aaagaggaag cattcaacag agggtccatg aacccaggcg tggtctccgg tggcaacaca
     2341 gaccagaacc tcatgacagt cccaggtagc ttcaacagct acgcatatca tggcaacaca
     2401 gaccagaact tcatgacggt cccaggtagc ttcaacagct actcatatca tggcaacaca
     2461 gaccagaact tcatgacggt cccaggtagc ttcaacagct actcatatca ggatgttcct
     2521 tactaccgat caataccaga agacggtaac gacagccagc agtaatagag tcaaagcaat
     2581 tatgcaacat caaagccaca acagaagaag accacaacca agaagctcac tgttctgtgg
     2641 tctgatacaa gagcaagaac tagcccatct ctttctctgt ggcttactgt ttttggttat
     2701 acatgcctcc aaataaagtc tatggctgac agtgtaaaaa aaaaa
//
