LOCUS       NP_899222                768 aa            linear   ROD 31-MAY-2024
DEFINITION  disintegrin and metalloproteinase domain-containing protein 28
            isoform 2 precursor [Mus musculus].
ACCESSION   NP_899222
VERSION     NP_899222.1
DBSOURCE    REFSEQ: accession NM_183366.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 768)
  AUTHORS   Bendavid,G., Hubeau,C., Perin,F., Gillard,A., Nokin,M.J.,
            Carnet,O., Gerard,C., Noel,A., Lefebvre,P., Rocks,N. and Cataldo,D.
  TITLE     Role for the metalloproteinase ADAM28 in the control of airway
            inflammation, remodelling and responsiveness in asthma
  JOURNAL   Front Immunol 13, 1067779 (2023)
   PUBMED   36685493
  REMARK    GeneRIF: Role for the metalloproteinase ADAM28 in the control of
            airway inflammation, remodelling and responsiveness in asthma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 768)
  AUTHORS   Kiyozumi,D., Noda,T., Yamaguchi,R., Tobita,T., Matsumura,T.,
            Shimada,K., Kodani,M., Kohda,T., Fujihara,Y., Ozawa,M., Yu,Z.,
            Miklossy,G., Bohren,K.M., Horie,M., Okabe,M., Matzuk,M.M. and
            Ikawa,M.
  TITLE     NELL2-mediated lumicrine signaling through OVCH2 is required for
            male fertility
  JOURNAL   Science 368 (6495), 1132-1135 (2020)
   PUBMED   32499443
REFERENCE   3  (residues 1 to 768)
  AUTHORS   Gerard,C., Hubeau,C., Carnet,O., Bellefroid,M., Sounni,N.E.,
            Blacher,S., Bendavid,G., Moser,M., Fassler,R., Noel,A., Cataldo,D.
            and Rocks,N.
  TITLE     Microenvironment-derived ADAM28 prevents cancer dissemination
  JOURNAL   Oncotarget 9 (98), 37185-37199 (2018)
   PUBMED   30647853
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 768)
  AUTHORS   Zhang,Y., Zhu,G., Xiao,H., Liu,X., Han,G., Chen,G., Hou,C.,
            Shen,B., Li,Y., Ma,N. and Wang,R.
  TITLE     CD19 regulates ADAM28-mediated Notch2 cleavage to control the
            differentiation of marginal zone precursors to MZ B cells
  JOURNAL   J Cell Mol Med 21 (12), 3658-3669 (2017)
   PUBMED   28707394
  REMARK    GeneRIF: The results suggest that CD19 controls the differentiation
            of marginal zone precursors to marginal zone B cells by regulating
            ADAM28-mediated Notch2 cleavage.
REFERENCE   5  (residues 1 to 768)
  AUTHORS   Abe,H., Mochizuki,S., Ohara,K., Ueno,M., Ochiai,H., Kitagawa,Y.,
            Hino,O., Sato,H. and Okada,Y.
  TITLE     Src plays a key role in ADAM28 expression in v-src-transformed
            epithelial cells and human carcinoma cells
  JOURNAL   Am J Pathol 183 (5), 1667-1678 (2013)
   PUBMED   24007880
REFERENCE   6  (residues 1 to 768)
  AUTHORS   Nuttall,R.K., Sampieri,C.L., Pennington,C.J., Gill,S.E.,
            Schultz,G.A. and Edwards,D.R.
  TITLE     Expression analysis of the entire MMP and TIMP gene families during
            mouse tissue development
  JOURNAL   FEBS Lett 563 (1-3), 129-134 (2004)
   PUBMED   15063736
REFERENCE   7  (residues 1 to 768)
  AUTHORS   Bridges,L.C., Tani,P.H., Hanson,K.R., Roberts,C.M., Judkins,M.B.
            and Bowditch,R.D.
  TITLE     The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the
            integrin alpha4beta1
  JOURNAL   J Biol Chem 277 (5), 3784-3792 (2002)
   PUBMED   11724793
  REMARK    GeneRIF: The authors report that recombinant human MDC-L (ADAM 28)
            protein with the disintegrin domain binds to the alpha(4)beta(1)
            integrin, and this binding may regulate the interaction between
            lymphocytes and leukocytes expressing alpha(4)beta(1).
REFERENCE   8  (residues 1 to 768)
  AUTHORS   Haidl,I.D., Huber,G. and Eichmann,K.
  TITLE     An ADAM family member with expression in thymic epithelial cells
            and related tissues
  JOURNAL   Gene 283 (1-2), 163-170 (2002)
   PUBMED   11867223
REFERENCE   9  (residues 1 to 768)
  AUTHORS   Howard,L., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Cloning and characterization of ADAM28: evidence for autocatalytic
            pro-domain removal and for cell surface localization of mature
            ADAM28
  JOURNAL   Biochem J 348 Pt 1 (Pt 1), 21-27 (2000)
   PUBMED   10794709
REFERENCE   10 (residues 1 to 768)
  AUTHORS   Weskamp,G. and Blobel,C.P.
  TITLE     A family of cellular proteins related to snake venom disintegrins
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2748-2751 (1994)
   PUBMED   8146185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT025563.11, BB629805.1 and
            AK136715.1.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            typically membrane-anchored, although a form of this protein may be
            secreted. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that is
            proteolytically processed to generate a mature protein product.
            This protein may bind to integrins and regulate lymphocyte
            migration by enhancing cell adhesion. [provided by RefSeq, Aug
            2015].
            
            Transcript Variant: This variant (2) contains an alternate 3' exon,
            and thus differs in the 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (2) has a shorter C-terminus,
            compared to isoform 1. It is not known whether this isoform (2) is
            proteolytically processed in the same manner as isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF163291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 35.69 cM"
     Protein         1..768
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 28 isoform 2 precursor"
                     /note="a disintegrin and metalloproteinase domain 28;
                     disintegrin and metalloproteinase domain-containing
                     protein 28; thymic epithelial cell-ADAM; disintegrin 1; a
                     disintegrin and metalloprotease domain 28;
                     metalloproteinase-disintegrin domain containing protein
                     TECADAM; ADAM 28"
                     /calculated_mol_wt=83650
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2202
     Region          31..155
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Site            91
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Region          169..176
                     /region_name="Cysteine switch. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Region          206..400
                     /region_name="ZnMc_adamalysin_II_like"
                     /note="Zinc-dependent metalloprotease; adamalysin_II_like
                     subfamily. Adamalysin II is a snake venom zinc
                     endopeptidase. This subfamily contains other snake venom
                     metalloproteinases, as well as membrane-anchored
                     metalloproteases belonging to the ADAM family; cd04269"
                     /db_xref="CDD:239797"
     Site            272
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Site            277
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Site            order(342..343,346,352)
                     /site_type="active"
                     /db_xref="CDD:239797"
     Region          419..491
                     /region_name="Disintegrin"
                     /note="pfam00200"
                     /db_xref="CDD:459709"
     Region          496..623
                     /region_name="ACR"
                     /note="ADAM Cysteine-Rich Domain; smart00608"
                     /db_xref="CDD:214743"
     Site            531
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Site            551
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Site            605
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Site            631
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Site            669..689
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN6.3)"
     Region          699..759
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN6.3)"
     CDS             1..768
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /coded_by="NM_183366.3:153..2459"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS88698.1"
                     /db_xref="GeneID:13522"
                     /db_xref="MGI:MGI:105988"
ORIGIN      
        1 mqqwsllvvs fllspvpvsa ikelpkakky evvypirlhp lrkretqepe pketfetelr
       61 ykmtvngkva vlylkknnkl lapdysetyy nssgnkvtts pqimdscyyq ghivnekvsa
      121 asistcqglr gyisqgdeky fieplssenl deqahalfkd dsnedqeksn cgvddalwlq
      181 glhqdvalpa trliklndgm vqepkkyiey yvvldngefk kynknlaeir kivlemanyi
      241 nmlynkldah valvgveiwt dgdkikitpd anttlenfsk wrgndllkrk hhdiaqliss
      301 tdfsgstvgl afmssmcspy hsvgivqdhs nyhlrvagtm ahemghnlgm ihdylsckcp
      361 sevcvmeqsl rfhmptdfss csrvnykqfl eeklshclfn splpsdiist pvcgnqllem
      421 nedcdcgtpk ectnkccdar tckikagfqc algeccekcq lkkpgvvcra akdecdlpev
      481 cdgksshcpg drfrvngspc qnghgyclkg kcptlqqqcm dmwgpgtkva ntscykqneg
      541 gtkygychve ngthmpckak damcgklfce ggsgdlpwkg ltisfltckl fdpedtsqgv
      601 dmvangtkcg tnkvcinaec vdmektyksa ncsskckgha vcdhelqcqc kegwappdce
      661 nsatvfhfsi vvgvlfplav ifvvvaiviq rqsarrkqrr vqrlpstkda klhnqkcrpq
      721 kvkdvqpqem sqmkklhvsd lpseepeppp dvlitkpnfp pppipvsl
//
