LOCUS       NM_001048175            4054 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 28 (Adam28),
            transcript variant 4, mRNA.
ACCESSION   NM_001048175
VERSION     NM_001048175.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4054)
  AUTHORS   Bendavid,G., Hubeau,C., Perin,F., Gillard,A., Nokin,M.J.,
            Carnet,O., Gerard,C., Noel,A., Lefebvre,P., Rocks,N. and Cataldo,D.
  TITLE     Role for the metalloproteinase ADAM28 in the control of airway
            inflammation, remodelling and responsiveness in asthma
  JOURNAL   Front Immunol 13, 1067779 (2023)
   PUBMED   36685493
  REMARK    GeneRIF: Role for the metalloproteinase ADAM28 in the control of
            airway inflammation, remodelling and responsiveness in asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4054)
  AUTHORS   Kiyozumi,D., Noda,T., Yamaguchi,R., Tobita,T., Matsumura,T.,
            Shimada,K., Kodani,M., Kohda,T., Fujihara,Y., Ozawa,M., Yu,Z.,
            Miklossy,G., Bohren,K.M., Horie,M., Okabe,M., Matzuk,M.M. and
            Ikawa,M.
  TITLE     NELL2-mediated lumicrine signaling through OVCH2 is required for
            male fertility
  JOURNAL   Science 368 (6495), 1132-1135 (2020)
   PUBMED   32499443
REFERENCE   3  (bases 1 to 4054)
  AUTHORS   Gerard,C., Hubeau,C., Carnet,O., Bellefroid,M., Sounni,N.E.,
            Blacher,S., Bendavid,G., Moser,M., Fassler,R., Noel,A., Cataldo,D.
            and Rocks,N.
  TITLE     Microenvironment-derived ADAM28 prevents cancer dissemination
  JOURNAL   Oncotarget 9 (98), 37185-37199 (2018)
   PUBMED   30647853
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4054)
  AUTHORS   Zhang,Y., Zhu,G., Xiao,H., Liu,X., Han,G., Chen,G., Hou,C.,
            Shen,B., Li,Y., Ma,N. and Wang,R.
  TITLE     CD19 regulates ADAM28-mediated Notch2 cleavage to control the
            differentiation of marginal zone precursors to MZ B cells
  JOURNAL   J Cell Mol Med 21 (12), 3658-3669 (2017)
   PUBMED   28707394
  REMARK    GeneRIF: The results suggest that CD19 controls the differentiation
            of marginal zone precursors to marginal zone B cells by regulating
            ADAM28-mediated Notch2 cleavage.
REFERENCE   5  (bases 1 to 4054)
  AUTHORS   Abe,H., Mochizuki,S., Ohara,K., Ueno,M., Ochiai,H., Kitagawa,Y.,
            Hino,O., Sato,H. and Okada,Y.
  TITLE     Src plays a key role in ADAM28 expression in v-src-transformed
            epithelial cells and human carcinoma cells
  JOURNAL   Am J Pathol 183 (5), 1667-1678 (2013)
   PUBMED   24007880
REFERENCE   6  (bases 1 to 4054)
  AUTHORS   Nuttall,R.K., Sampieri,C.L., Pennington,C.J., Gill,S.E.,
            Schultz,G.A. and Edwards,D.R.
  TITLE     Expression analysis of the entire MMP and TIMP gene families during
            mouse tissue development
  JOURNAL   FEBS Lett 563 (1-3), 129-134 (2004)
   PUBMED   15063736
REFERENCE   7  (bases 1 to 4054)
  AUTHORS   Bridges,L.C., Tani,P.H., Hanson,K.R., Roberts,C.M., Judkins,M.B.
            and Bowditch,R.D.
  TITLE     The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the
            integrin alpha4beta1
  JOURNAL   J Biol Chem 277 (5), 3784-3792 (2002)
   PUBMED   11724793
  REMARK    GeneRIF: The authors report that recombinant human MDC-L (ADAM 28)
            protein with the disintegrin domain binds to the alpha(4)beta(1)
            integrin, and this binding may regulate the interaction between
            lymphocytes and leukocytes expressing alpha(4)beta(1).
REFERENCE   8  (bases 1 to 4054)
  AUTHORS   Haidl,I.D., Huber,G. and Eichmann,K.
  TITLE     An ADAM family member with expression in thymic epithelial cells
            and related tissues
  JOURNAL   Gene 283 (1-2), 163-170 (2002)
   PUBMED   11867223
REFERENCE   9  (bases 1 to 4054)
  AUTHORS   Howard,L., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Cloning and characterization of ADAM28: evidence for autocatalytic
            pro-domain removal and for cell surface localization of mature
            ADAM28
  JOURNAL   Biochem J 348 Pt 1 (Pt 1), 21-27 (2000)
   PUBMED   10794709
REFERENCE   10 (bases 1 to 4054)
  AUTHORS   Weskamp,G. and Blobel,C.P.
  TITLE     A family of cellular proteins related to snake venom disintegrins
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2748-2751 (1994)
   PUBMED   8146185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT025563.11, BB629805.1,
            AK136715.1 and AK078982.1.
            
            On Mar 30, 2013 this sequence version replaced NM_001048175.1.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            typically membrane-anchored, although a form of this protein may be
            secreted. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that is
            proteolytically processed to generate a mature protein product.
            This protein may bind to integrins and regulate lymphocyte
            migration by enhancing cell adhesion. [provided by RefSeq, Aug
            2015].
            
            Transcript Variant: This variant (4) includes an alternate terminal
            3' exon and its transcription extends past a splice site that is
            used in variant 1, resulting in a novel 3' coding region and 3' UTR
            compared to variant 1. The encoded isoform (4) has a distinct and
            shorter C-terminus, compared to isoform 1. It is not known whether
            this isoform (4) is proteolytically processed in the same manner as
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF163290.1, AF153350.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                CT025563.11        49008-49067
            61-513              BB629805.1         1-453
            514-541             CT025563.11        60566-60593
            542-734             CT025563.11        62642-62834
            735-806             CT025563.11        65633-65704
            807-878             CT025563.11        66717-66788
            879-1048            CT025563.11        67350-67519
            1049-1096           CT025563.11        69955-70002
            1097-2161           AK136715.1         1-1065
            2162-2260           CT025563.11        93854-93952
            2261-2339           CT025563.11        94914-94992
            2340-2408           CT025563.11        95675-95743
            2409-2455           CT025563.11        96887-96933
            2456-3015           CT025563.11        98254-98813
            3016-4054           AK078982.1         1-1039
FEATURES             Location/Qualifiers
     source          1..4054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 35.69 cM"
     gene            1..4054
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /note="a disintegrin and metallopeptidase domain 28"
                     /db_xref="GeneID:13522"
                     /db_xref="MGI:MGI:105988"
     exon            1..204
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..2477
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; a disintegrin and metalloproteinase domain 28;
                     disintegrin and metalloproteinase domain-containing
                     protein 28; thymic epithelial cell-ADAM; disintegrin 1; a
                     disintegrin and metalloprotease domain 28;
                     metalloproteinase-disintegrin domain containing protein
                     TECADAM; ADAM 28"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 28 isoform 4 precursor"
                     /protein_id="NP_001041640.1"
                     /db_xref="CCDS:CCDS36964.1"
                     /db_xref="GeneID:13522"
                     /db_xref="MGI:MGI:105988"
                     /translation="MQQWSLLVVSFLLSPVPVSAIKELPKAKKYEVVYPIRLHPLRKR
                     ETQEPEPKETFETELRYKMTVNGKVAVLYLKKNNKLLAPDYSETYYNSSGNKVTTSPQ
                     IMDSCYYQGHIVNEKVSAASISTCQGLRGYISQGDEKYFIEPLSSENLDEQAHALFKD
                     DSNEDQEKSNCGVDDALWLQGLHQDVALPATRLIKLNDGMVQEPKKYIEYYVVLDNGE
                     FKKYNKNLAEIRKIVLEMANYINMLYNKLDAHVALVGVEIWTDGDKIKITPDANTTLE
                     NFSKWRGNDLLKRKHHDIAQLISSTDFSGSTVGLAFMSSMCSPYHSVGIVQDHSNYHL
                     RVAGTMAHEMGHNLGMIHDYLSCKCPSEVCVMEQSLRFHMPTDFSSCSRVNYKQFLEE
                     KLSHCLFNSPLPSDIISTPVCGNQLLEMNEDCDCGTPKECTNKCCDARTCKIKAGFQC
                     ALGECCEKCQLKKPGVVCRAAKDECDLPEVCDGKSSHCPGDRFRVNGSPCQNGHGYCL
                     KGKCPTLQQQCMDMWGPGTKVANTSCYKQNEGGTKYGYCHVENGTHMPCKAKDAMCGK
                     LFCEGGSGDLPWKGLTISFLTCKLFDPEDTSQGVDMVANGTKCGTNKVCINAECVDME
                     KTYKSANCSSKCKGHAVCDHELQCQCKEGWAPPDCENSATVFHFSIVVGVLFPLAVIF
                     VVVAIVIQRQSARRKQRRVQRLPSTKDAKLHNQKCRPQKVKDVQPQEMSQMKKLHVSD
                     LPSEEPEPPPDVLITKPNFPPPPIPVSLDPNAKV"
     exon            205..308
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            309..385
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            386..464
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            465..541
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            542..734
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            735..806
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            807..878
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1048
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1133
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1264
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1442
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1532
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1728
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1831
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1991
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2072
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2151
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2260
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2339
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2408
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2455
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..4054
                     /gene="Adam28"
                     /gene_synonym="C130072N01Rik; D430033C21Rik; Dtgn1;
                     eMDCII; MDC-L; MDCL; TECADAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccccag ttgtgcaaca ccttcggtaa acacttgctg aagcgtacac aatgaagcag
       61 ggagtttctt tctgtctccc ttaagaggag gttggagcag aagcaacctc acaggtgtga
      121 ctggaggcag ccactgctcc tgggatcgca gaatgcagca atggagtctt ctggtagtct
      181 ctttccttct ttctccagtt ccagtaagtg caataaaaga actccctaaa gccaagaaat
      241 atgaagtggt ttatcccata agacttcatc cattgcgtaa aagagagacc caagagccag
      301 agccaaagga aacatttgaa actgagctaa ggtacaaaat gacagtaaat ggaaaggttg
      361 ctgtgctgta tctgaagaag aacaacaagc tccttgcgcc tgactactcg gaaacatact
      421 ataattccag tggaaacaag gtcaccacaa gcccgcaaat catggatagc tgttactacc
      481 aaggacacat cgtaaatgag aaagtttctg cagccagcat cagcacctgt caaggactac
      541 ggggttacat cagtcaagga gatgaaaagt attttatcga acctttgagc tcggagaact
      601 tggatgaaca ggcacatgca ctcttcaagg acgactccaa tgaagaccag gagaagagca
      661 actgtggtgt ggatgatgcg ctatggctcc aagggctgca tcaggacgtg gccctccctg
      721 ccaccaggtt gattaagttg aatgatggga tggttcaaga acctaagaaa tacatagaat
      781 attatgtggt cctggataat ggtgagttta agaaatacaa taaaaatctt gctgaaatac
      841 gaaagatagt gcttgagatg gccaattaca tcaacatgct ttacaataag cttgatgccc
      901 acgtggcctt agttggagtg gaaatctgga ccgatgggga taaaataaag ataacaccag
      961 atgccaacac caccctggaa aacttctcta agtggagggg aaatgatctg ctaaaacgaa
     1021 agcatcatga tattgcccag ctaatctcat caacagactt ttctggatca acagtgggtc
     1081 tagccttcat gtcgtcgatg tgttcacctt accattctgt tggcattgtt caggaccaca
     1141 gtaactacca tcttcgagtc gcaggaacaa tggctcatga aatgggtcac aatcttggca
     1201 tgattcatga ctacttgagc tgcaagtgtc catctgaagt ctgtgtaatg gagcagtcac
     1261 taaggttcca tatgcctaca gacttcagct cctgcagtcg tgtcaattac aaacagtttc
     1321 ttgaagaaaa attatcgcat tgcctcttta atagcccatt gccatcagat atcatatcca
     1381 ccccagtctg tgggaaccag ttgttggaaa tgaatgagga ctgtgactgt ggcacaccca
     1441 aggagtgtac taacaaatgc tgtgatgcaa ggacctgtaa aattaaagca ggtttccagt
     1501 gtgccctggg ggaatgctgt gagaaatgcc aacttaaaaa acctggggtt gtgtgcagag
     1561 cagcaaaaga tgagtgtgat ctgcctgaag tgtgtgatgg taaatccagc cactgcccag
     1621 gtgacagatt cagagtcaat ggctcccctt gccaaaatgg gcatggttac tgcttgaagg
     1681 gcaaatgtcc caccctgcag cagcagtgca tggacatgtg gggtccagga accaaggttg
     1741 caaatacatc atgttacaag cagaatgaag gtgggacaaa gtacggatac tgtcatgtgg
     1801 agaatggcac acacatgccc tgcaaagcaa aagatgccat gtgtgggaaa ttgttctgtg
     1861 aaggcggatc aggtgatttg ccctggaaag gacttaccat atctttcctg acatgtaaat
     1921 tatttgatcc tgaagacaca agtcaaggag tagacatggt ggccaatgga accaagtgtg
     1981 gaactaacaa ggtgtgcatt aatgctgagt gtgtggacat ggagaagact tacaagtcag
     2041 ccaactgctc ctcaaagtgc aaggggcacg cagtgtgtga ccatgagctt cagtgtcagt
     2101 gcaaggaagg atgggcccct cctgactgcg agaattcagc cacagtcttc cacttctcca
     2161 tcgtggttgg cgtgcttttc cccctagcag tcatatttgt ggtggttgct atagtgatcc
     2221 agcgccaaag tgccagaagg aagcagagga gagttcagag gctaccatcc accaaggatg
     2281 ccaagctaca caatcagaag tgtagacccc aaaaggtgaa ggatgttcaa ccccaggaga
     2341 tgagtcagat gaaaaagctc catgtgtctg atctgccctc tgaagagccg gagcctccac
     2401 ctgatgtcct aatcacaaag ccaaatttcc caccaccacc aattcctgtt tccttggacc
     2461 caaatgcaaa agtctgaaac aacagttaat cagatggtca gagtggaagc ctcgaaattt
     2521 tggatggaaa aagagatgtg cttagttctt tattactagc gctcttaacc ctcaggggtt
     2581 agcatgttct ggtttgtgct gtattttgag gagattaaaa gaaagataca cttttgaaaa
     2641 tctctgtgct aatttaaatg atttcctttc catattccta aggacatggc taaaggaatg
     2701 tataaactgt aaaactctag ttgatttccc cctttatttt tactatgatc ttgactgact
     2761 gctcaaatat attgaagccc ttaatgtcct catttggagg ggattgatgt gccctctaat
     2821 gaaaataaaa cagagcctgg cagtggtggt gcacgccttt aatcccagca cttgggaggc
     2881 agaggcaggc ggatttctga gttcgaggcc agcctagtct acagagtgag ttccaggaca
     2941 gccagggcta cacagagaaa ccctgtctca aaaaaaacaa aaacaaaaca aaataaaaca
     3001 aaacaaaaca aaaacaaaag aaaagaggaa aaaaaaagaa aaagaaaaag aaaaaaacgg
     3061 aacagaacag agaggacaaa acaaaatcat aaaccactga ggtgggggag ttaagtagca
     3121 gcgtcttgat tcttttaatt tgtcaacttg gaacatgcag tttgtttaaa aaaaatatgt
     3181 aagcacccta ttctatgtcc ttgcttccct ttcttctgaa atttttattc actttgttat
     3241 tttgggagtg ttctacaatc cagtaaaata tgtttattag aaaatgtagt atgccaacaa
     3301 atgagcttct ttttctaaat agagattgtt tctttagaga aatgagcata aaccagaagt
     3361 tacaaactgg agacctgttg gctgggtttg gatggcagat gtgttttatt tggtctaagt
     3421 taaagatgtt gacctcacag agtttatctt ttaaactgtt tttggtttca tagaaataaa
     3481 ttttaagttg tgagatcttg cataagcatc taaattcctg gattaaaaga aaaaaaaatc
     3541 agagagcctg tcaacagcat aaccacattg tctttaacat cttcagcttc attgacatat
     3601 ggtagaacca acatggttga atcggtacca aatactgact ggcttgcttt aagaactcta
     3661 atttactcta gctgtccagc tttagaatga tgggcaccac tccgtacatg ttatgctaac
     3721 acactcataa caatcatgag tttgttttgc catagatttg taagtagatg ggtacctccc
     3781 cattgtggcc tcgtggatga gggaggaagc attttgggaa atttctgagg agtatttctc
     3841 cattcatctt ttcttctggt tgttgacatc tggtattgct gcagctgtgc tgtgatctgg
     3901 agacaagaat gatgtgaaca agatagagca gggagataaa caaactccaa gtgcactttc
     3961 taagatgtta tgaactggta gatgaacaat tgttgaacta ggtccacgtt ttgctgggac
     4021 ttcttgtaca atcaataaat tttccttgtt gtcc
//
