LOCUS       NM_010085               2494 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ADAM metallopeptidase domain 26A (Adam26a), mRNA.
ACCESSION   NM_010085 XM_990922
VERSION     NM_010085.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2494)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2494)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2494)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2494)
  AUTHORS   Grayson,P. and Civetta,A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol Biol 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2494)
  AUTHORS   Han,C., Choi,E., Park,I., Lee,B., Jin,S., Kim,D.H., Nishimura,H.
            and Cho,C.
  TITLE     Comprehensive analysis of reproductive ADAMs: relationship of ADAM4
            and ADAM6 with an ADAM complex required for fertilization in mice
  JOURNAL   Biol Reprod 80 (5), 1001-1008 (2009)
   PUBMED   19129510
REFERENCE   7  (bases 1 to 2494)
  AUTHORS   Zhu,G.Z., Lin,Y., Myles,D.G. and Primakoff,P.
  TITLE     Identification of four novel ADAMs with potential roles in
            spermatogenesis and fertilization
  JOURNAL   Gene 234 (2), 227-237 (1999)
   PUBMED   10395895
REFERENCE   8  (bases 1 to 2494)
  AUTHORS   Weskamp,G. and Blobel,C.P.
  TITLE     A family of cellular proteins related to snake venom disintegrins
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2748-2751 (1994)
   PUBMED   8146185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK029756.1 and AC131115.3.
            
            On May 12, 2016 this sequence version replaced NM_010085.2.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. This gene is expressed in a regulated
            fashion during the late stages of spermatogenesis. The encoded
            preproprotein undergoes proteolytic processing to generate a
            mature, functional metalloprotease enzyme. This gene is located
            adjacent to two other ADAM genes on chromosome 8. [provided by
            RefSeq, May 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167404.1, AK029756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2010              AK029756.1         2-2011
            2011-2011           AC131115.3         54937-54937         c
            2012-2489           AK029756.1         2013-2490
            2490-2494           AC131115.3         54454-54458         c
FEATURES             Location/Qualifiers
     source          1..2494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 24.02 cM"
     gene            1..2494
                     /gene="Adam26a"
                     /gene_synonym="Adam26; Dtgn4"
                     /note="ADAM metallopeptidase domain 26A"
                     /db_xref="GeneID:13525"
                     /db_xref="MGI:MGI:105985"
     exon            1..158
                     /gene="Adam26a"
                     /gene_synonym="Adam26; Dtgn4"
                     /inference="alignment:Splign:2.1.0"
     exon            159..2494
                     /gene="Adam26a"
                     /gene_synonym="Adam26; Dtgn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..2409
                     /gene="Adam26a"
                     /gene_synonym="Adam26; Dtgn4"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 26A; a disintegrin and metalloprotease domain 26;
                     disintegrin 4; testase 3; a disintegrin and
                     metallopeptidase domain 26A (testase 3)"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 26A preproprotein"
                     /protein_id="NP_034215.2"
                     /db_xref="CCDS:CCDS22269.1"
                     /db_xref="GeneID:13525"
                     /db_xref="MGI:MGI:105985"
                     /translation="MFLKFCLWTMFFFSAWSPIGHAKYSSLLEVVTPLRVTVTRGNNI
                     SPGWLSYSLNIGGQRHIITMKPKKNLISRNFLLFTYSDQGDLLEQHHFVQNDCYYHGY
                     VDEDLESPVIVNTCFGSLQGTLEINGTSYEIMPKSSTSTFEHLVYKMDSGDSESSPMR
                     CGLSEEETAQQTKLQESNAPTLLQIPYENWWTHHRFIEYFVVLDHKQYVHRNNNITTC
                     IQDMLQIVNGVNGYYLQIDTDVVLTTLEVWNEKNYINVELSIFKVLGDFCTWKQNMFG
                     NRIRHDIIHLLVRQGYGLYLGLAYLADVCTPYNCGVSSVLSDVMSDMAHIVAHEMGHN
                     FGMKHDGIGCTCGLKDCLMAPYKTNSPKFSNCSYEEMYSVVTKRSCLYDIPEALVTNL
                     TVCGNKVVEEGEQCDCGNSESCLQDPCCSSDCVLKPGAQCAFGLCCKNCQFLKAGTVC
                     RKEKNECDLPEWCNGTSAECPGDVYKADGIPCSGEGYCYKMECHQRDEQCRKIFGNGS
                     RSADEICYMEMNRQGDRFGNCGNDSSTYRTCQIADVLCGQIQCENVIQLPQRRNHETV
                     HYTHFSNITCWTMDYHFGITIDDIGAVSDGTAYAPDHICVDRKCVSKSVLVSNCSPQL
                     YHMQGICNNKQHCHCGVTWKPPDCQKRGHGGSIDSGPPPLPLSHSKWIVYILIVLDVC
                     IVIIIYLFSFYKLSK"
     regulatory      2463..2468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam26a"
                     /gene_synonym="Adam26; Dtgn4"
                     /note="hexamer: AATAAA"
     polyA_site      2494
                     /gene="Adam26a"
                     /gene_synonym="Adam26; Dtgn4"
                     /note="major polyA site"
ORIGIN      
        1 acatgagtct agaacttact ccatgagaga caagtgaagg acttatattc tcttgtgcat
       61 cctcaaacaa caacctttgt tcctgagata ggatgtaaaa atgttttatg agcaagacaa
      121 taacaattaa aagaacatgg gcatcactca acctgaggtc ctgcctctag tatgattcaa
      181 ccatgtcaga agacaccagt gctgcttgca accacacaaa gtgaggactg ggacaccaag
      241 gacttctcaa gctcctcctt ggctctcgaa taggatatag tgagtggggc taaggtcctg
      301 gtccataaaa ggaacatgtt ccttaagttc tgcctgtgga cgatgttctt cttctctgca
      361 tggtcaccaa ttggacatgc taagtacagt agccttctag aagtagtgac acccttgagg
      421 gtcactgtca ctagaggaaa taatatttca ccaggttggc tgtcctatag cctgaacatt
      481 ggggggcaga ggcacataat cactatgaaa cccaagaaaa acttgatatc cagaaacttc
      541 ttattattca cttatagtga ccaaggtgat ctccttgaac aacaccattt tgtgcagaat
      601 gactgctatt accatggcta tgtggatgaa gacctagagt ccccggtcat tgtcaacacc
      661 tgttttggaa gtttgcaagg cacactagag ataaatggca caagttatga aatcatgccc
      721 aagagctcaa cgtcaacatt tgaacatctg gtttacaaaa tggacagtgg ggattcagaa
      781 tcatctccca tgagatgtgg gttatcagaa gaggaaacag cacaacaaac gaagctacaa
      841 gaaagcaatg cccccacact tttacaaatt ccctatgaga attggtggac ccaccacagg
      901 tttattgaat attttgtagt actagaccat aaacaatatg ttcatagaaa taacaatatc
      961 acaacttgta ttcaagatat gttgcaaata gtcaatggag taaatggtta ttatcttcaa
     1021 atagatactg atgtggtttt aaccactctt gaagtatgga atgaaaaaaa ctatatcaat
     1081 gtagaactca gtatatttaa agtccttggt gatttctgta cttggaagca aaacatgttt
     1141 ggcaatcgca ttagacatga tatcatacac cttttagtca gacagggata tggtttatat
     1201 ttagggttag cttatttagc tgacgtttgt acaccttata attgtggagt tagcagtgtc
     1261 ctttctgatg taatgtcaga catggcacac attgtagcac acgagatggg gcataacttc
     1321 ggtatgaaac atgatggaat tggatgtact tgtgggttaa aagactgtct aatggcccca
     1381 tataaaacaa attctccaaa attcagcaac tgtagttatg aagaaatgta ttcagttgtt
     1441 accaaacgaa gttgcttata tgatattcca gaagcactag taacaaacct gaccgtgtgt
     1501 gggaataagg tggttgaaga aggagagcag tgtgattgtg ggaactctga atcctgttta
     1561 caagatcctt gctgtagcag cgactgtgtt ctcaaacctg gtgctcaatg tgcttttgga
     1621 ctttgttgca aaaattgcca gttccttaaa gcaggcactg tgtgtagaaa agagaaaaat
     1681 gagtgtgacc ttccagagtg gtgcaatgga acttcagctg agtgtccagg agatgtgtat
     1741 aaagcagacg gaatcccttg cagtggtgag ggctattgct ataaaatgga atgtcatcaa
     1801 cgtgatgagc agtgtcggaa gatttttggc aatggaagta gaagtgcaga tgaaatttgc
     1861 tacatggaaa tgaacagaca gggtgaccgc tttgggaact gtggcaatga tagctctaca
     1921 tatagaacat gccaaattgc tgatgtactc tgtgggcaaa ttcagtgtga gaatgtgata
     1981 caacttcccc aaaggagaaa ccatgaaaca gtgcattata ctcacttcag taatatcacc
     2041 tgctggacta tggactatca ttttgggatc accatagatg atattggagc tgtgagcgat
     2101 ggcacagctt atgctccaga ccatatatgt gttgacagaa agtgtgtcag caagtctgtt
     2161 ctggtaagta actgttcacc acagttatac catatgcaag gaatctgcaa taataaacaa
     2221 cactgccatt gtggtgtcac atggaaacca ccagactgtc aaaaacgtgg ccatggaggt
     2281 agtatagaca gtggaccacc tccattgcct ttatctcatt ccaaatggat tgtgtacatc
     2341 cttattgttt tagatgtgtg tattgttatc ataatttatt tattttcttt ttataagtta
     2401 agcaaataat tcctaaaaga aattgtgcca gattcagaat tgggtgaaaa acatcttacc
     2461 tgaataaaaa cagaatttca ggtctactga aaaa
//
