LOCUS       NM_011781               2632 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus ADAM metallopeptidase domain 25 (Adam25), mRNA.
ACCESSION   NM_011781
VERSION     NM_011781.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Zhu,G.Z., Lin,Y., Myles,D.G. and Primakoff,P.
  TITLE     Identification of four novel ADAMs with potential roles in
            spermatogenesis and fertilization
  JOURNAL   Gene 234 (2), 227-237 (1999)
   PUBMED   10395895
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121505.14, AK016581.1 and
            BB018763.1.
            
            On May 12, 2016 this sequence version replaced NM_011781.2.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. This gene is expressed in a regulated
            fashion during spermatogenesis. The encoded preproprotein undergoes
            proteolytic processing to generate a mature, functional
            metalloprotease enzyme. This gene is located adjacent to other ADAM
            genes on chromosome 8. [provided by RefSeq, May 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167403.1, AK016581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC121505.14        61382-61384
            4-2617              AK016581.1         2-2615
            2618-2632           BB018763.1         214-228
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..2632
                     /gene="Adam25"
                     /note="ADAM metallopeptidase domain 25"
                     /db_xref="GeneID:23793"
                     /db_xref="MGI:MGI:1345157"
     exon            1..84
                     /gene="Adam25"
                     /inference="alignment:Splign:2.1.0"
     exon            85..2632
                     /gene="Adam25"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2426
                     /gene="Adam25"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 25; a disintegrin and metalloprotease domain 25
                     (testase 2); a disintegrin and metallopeptidase domain 25
                     (testase 2)"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 25 preproprotein"
                     /protein_id="NP_035911.2"
                     /db_xref="CCDS:CCDS22256.1"
                     /db_xref="GeneID:23793"
                     /db_xref="MGI:MGI:1345157"
                     /translation="MQTRQRASSFAATEDNIAMDKAVVYTRIPHLYVWLEILNILSSW
                     PLTGYAQHTSLPEVVIPLRVTGNRPMWAMGWLTYSLHFGGQKHFIHIKAKKFLVSRLF
                     SVFTYTKQGALHKDQPYVQNDCYYHGHMDGDPESMVAITTCYGGFQGILQINGTVYEI
                     KPKNLSSTFEHLVQKMDSEETELLPMRCALTEEIARQMKLQQNENPTLMQSHYEGWWT
                     HKSFLDLALVVERERIRYHNNNTSRVLVEVFTIINIINNIYETLDVELVLLGVEMWNE
                     RNHVQVRSIEELLDEFCMWKARSLNFRIPNDIAHIFVNHEFGIYLGLAYIGSVCVPSH
                     NCGVDRLLGGNLFYFGRIIAHEMGHNLGMEHDSSSCTCGRKICLMAPADNGIPKFSNC
                     SYSYYWATYATAKCMRKEKKSKGILRGKLCGDGVVDDGEQCDCGSAKSCADDPCCKPS
                     CTLKDGAACAFGLCCLYCQIMPAGTVCRQEVNECDLPEWCNGHSHKCPNDVYLLDGSP
                     CRDGGYCYEKRCNNRDEQCKQIFGKEARSADHSCYRELNTQGDRFGNCGVIRDAYLRC
                     HDPDILCGRVQCENVAHIPFLRDHSTVHWTHLNGVTCWGTDYHFGMTIPDIGIVKDGT
                     DCGPEHVCINKKCVSKSIWRSQCSPKTCNMKGVCNNLHHCHCNLGWDPPHCLKSGLGG
                     SIDSGPPNYTENYTEKKHKKSIGLVILFWILFACFSVLFIVFLFFLRSYVELPMSEEP
                     KVPTPENKEDTNEVMNTETE"
     regulatory      2585..2590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam25"
                     /note="hexamer: AATAAA"
     polyA_site      2621
                     /gene="Adam25"
                     /note="major polyA site"
ORIGIN      
        1 gtcacaagaa aaatctaccc tgcagatgtg acattaagca actatcaata gacaaggtta
       61 tggacattat cacttcacct gctatcctgc tactctaatg catccactca gtcagaagac
      121 agaccattaa aagccagcac tgcatgcaga caagacaaag ggcatcctcc tttgctgcca
      181 cagaggacaa catagctatg gataaggctg tggtatacac aaggatacct catctgtacg
      241 tctggctaga gatattgaat attctttcat catggccctt gactgggtat gctcagcaca
      301 ccagcctccc agaagtagtg atacccttac gggtcacagg caacagacca atgtgggcta
      361 tgggatggct gacctatagc ctgcattttg ggggccagaa acattttatt cacataaagg
      421 ccaagaagtt cttggtttct agactcttct ctgtattcac ctacactaag caaggtgctc
      481 tgcacaagga ccagccttat gtccagaatg attgctacta ccatggccat atggatggag
      541 acccagagtc tatggttgct attaccacct gttatggagg ctttcaagga atattacaga
      601 taaatggcac agtctatgaa atcaaaccca agaacctttc ttccacattt gaacatttgg
      661 ttcagaagat ggacagtgag gagacagaat tactccccat gagatgtgca ctgacagaag
      721 agatagcaag gcaaatgaaa cttcagcaga atgagaaccc cactctgatg caaagccact
      781 atgaaggatg gtggacccac aagagttttc ttgacctggc attggttgtt gaacgtgagc
      841 gaattcgtta tcataacaat aacacatcac gtgtcttagt ggaagtattc accattatca
      901 atataataaa taatatttat gagacactgg atgttgagct agttttactt ggagttgaga
      961 tgtggaatga aagaaaccac gtgcaggtac gtagcataga agaactccta gatgaatttt
     1021 gtatgtggaa ggctcgcagc cttaattttc gaattccaaa tgacattgca catatttttg
     1081 tgaatcatga gtttggtatt taccttggtt tagcctatat tggaagtgtc tgtgtgccat
     1141 ctcataactg tggagttgat cgtctgttag gaggtaatct tttttatttt ggacgtatta
     1201 tagcacatga gatgggtcat aatctgggta tggagcatga tagcagctca tgtacatgtg
     1261 gaagaaagat ttgcttaatg gctccagcag acaatggtat cccgaagttc agtaactgta
     1321 gttattctta ctactgggct acatacgcta ctgccaagtg tatgcgcaag gaaaagaagt
     1381 caaaaggcat cctccgaggc aagctctgtg gggatggagt ggttgacgat ggagaacagt
     1441 gtgattgtgg atctgcaaaa agctgtgcag atgatccatg ctgtaagccc agctgcaccc
     1501 tcaaagatgg cgctgcctgt gcttttgggc tttgctgctt atattgccag atcatgccag
     1561 caggcacagt ttgccgacaa gaggtcaatg aatgtgatct tccagaatgg tgcaacggac
     1621 attcacataa gtgtcctaat gacgtttatt tgcttgatgg gagtccctgt agagatggtg
     1681 gctactgcta tgagaagaga tgtaataacc gagatgaaca gtgtaagcaa atcttcggca
     1741 aagaagccag gagtgcagat cacagttgct acagagaact caacacccaa ggtgaccgtt
     1801 ttggcaactg tggtgtgatc agagatgcat acttaagatg tcatgaccca gacatcctct
     1861 gtggcagagt tcaatgtgag aacgtagcac acattccatt tttgagggac cattccactg
     1921 tacactggac tcacctcaat ggtgtcacct gttgggggac tgactaccat tttgggatga
     1981 caatccctga cattggtatt gtgaaagatg gcacagactg tggtccagag catgtgtgta
     2041 ttaataagaa gtgtgtcagt aagtcaattt ggagaagtca gtgttcacct aagacatgca
     2101 acatgaaagg tgtgtgcaac aatttacacc actgccactg caaccttggg tgggacccac
     2161 cacattgcct gaaaagtggc cttggaggga gtattgacag tggccctccg aactatactg
     2221 aaaactatac tgaaaagaaa cacaagaaaa gtattgggct agtaattctt ttttggattc
     2281 tttttgcttg tttttccgta ttgttcattg tgttcctttt tttcttgagg agttacgtag
     2341 aactacctat gagtgaagaa cccaaagttc ccaccccaga aaacaaagaa gataccaatg
     2401 aagtaatgaa cactgaaaca gaataacaac aatttgtaat ttcaaatgtc attatcaaat
     2461 cttcctccat ttcccatgtt ctaccatgtg ttatcttggt atgtgaaaca ctgtatgttt
     2521 ctgaattcag tgacacaaag tcctagagat atttagtatt tcagcatgaa atacctcatc
     2581 attcaataaa gctatgatca tagtacgatc ataactcacg atcttcgctc tc
//
