LOCUS       NM_011780               6271 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 23 (Adam23),
            mRNA.
ACCESSION   NM_011780 NM_177836 XM_289750
VERSION     NM_011780.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6271)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6271)
  AUTHORS   Miyazaki,Y., Otsuka,T., Yamagata,Y., Endo,T., Sanbo,M., Sano,H.,
            Kobayashi,K., Inahashi,H., Kornau,H.C., Schmitz,D., Pruss,H.,
            Meijer,D., Hirabayashi,M., Fukata,Y. and Fukata,M.
  TITLE     Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize
            juxtaparanodal Kv1 channel clustering for short-term synaptic
            plasticity
  JOURNAL   Cell Rep 43 (1), 113634 (2024)
   PUBMED   38194969
  REMARK    GeneRIF: Oligodendrocyte-derived LGI3 and its receptor ADAM23
            organize juxtaparanodal Kv1 channel clustering for short-term
            synaptic plasticity.
REFERENCE   3  (bases 1 to 6271)
  AUTHORS   Kozar-Gillan,N., Velichkova,A., Kanatouris,G., Eshed-Eisenbach,Y.,
            Steel,G., Jaegle,M., Aunin,E., Peles,E., Torsney,C. and Meijer,D.N.
  TITLE     LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons
            to regulate refractory period
  JOURNAL   J Cell Biol 222 (4) (2023)
   PUBMED   36828548
REFERENCE   4  (bases 1 to 6271)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6271)
  AUTHORS   Lancaster,E., Burnor,E., Zhang,J. and Lancaster,E.
  TITLE     ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents
  JOURNAL   Neurosci Lett 704, 159-163 (2019)
   PUBMED   30965109
  REMARK    GeneRIF: ADAM23 had a strong negative effect on the surface
            expression of Kv1.1 channels and on Kv1.1 current amplitude
REFERENCE   6  (bases 1 to 6271)
  AUTHORS   Fukata,Y., Adesnik,H., Iwanaga,T., Bredt,D.S., Nicoll,R.A. and
            Fukata,M.
  TITLE     Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate
            synaptic transmission
  JOURNAL   Science 313 (5794), 1792-1795 (2006)
   PUBMED   16990550
REFERENCE   7  (bases 1 to 6271)
  AUTHORS   Sun,Y.P., Deng,K.J., Wang,F., Zhang,J., Huang,X., Qiao,S. and
            Zhao,S.
  TITLE     Two novel isoforms of Adam23 expressed in the developmental process
            of mouse and human brains
  JOURNAL   Gene 325, 171-178 (2004)
   PUBMED   14697522
REFERENCE   8  (bases 1 to 6271)
  AUTHORS   Mitchell,K.J., Pinson,K.I., Kelly,O.G., Brennan,J., Zupicich,J.,
            Scherz,P., Leighton,P.A., Goodrich,L.V., Lu,X., Avery,B.J.,
            Tate,P., Dill,K., Pangilinan,E., Wakenight,P., Tessier-Lavigne,M.
            and Skarnes,W.C.
  TITLE     Functional analysis of secreted and transmembrane proteins critical
            to mouse development
  JOURNAL   Nat Genet 28 (3), 241-249 (2001)
   PUBMED   11431694
REFERENCE   9  (bases 1 to 6271)
  AUTHORS   Leighton,P.A., Mitchell,K.J., Goodrich,L.V., Lu,X., Pinson,K.,
            Scherz,P., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Defining brain wiring patterns and mechanisms through gene trapping
            in mice
  JOURNAL   Nature 410 (6825), 174-179 (2001)
   PUBMED   11242070
REFERENCE   10 (bases 1 to 6271)
  AUTHORS   Sagane,K., Yamazaki,K., Mizui,Y. and Tanaka,I.
  TITLE     Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
  JOURNAL   Gene 236 (1), 79-86 (1999)
   PUBMED   10433968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK046677.1, AB009673.1,
            AL645534.20 and AW046396.1.
            
            On Sep 19, 2015 this sequence version replaced NM_011780.2.
            
            Summary: This gene encodes a member of the disintegrin family of
            membrane-anchored proteins that play a role in diverse biological
            processes such as brain development, fertilization, tumor
            development and inflammation. The encoded protein undergoes
            proteolytic processing to generate a mature polypeptide comprised
            of an inactive metalloprotease and disintegrin domains. Transgenic
            disruption of this gene in mice results in postnatal neurological
            defects including tremor and ataxia resulting in death by 2 weeks
            of age. [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.54641.1, AB009673.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AK046677.1         2-242
            242-3124            AB009673.1         1-2883
            3125-5865           AL645534.20        45497-48237
            5866-6271           AW046396.1         1-406               c
FEATURES             Location/Qualifiers
     source          1..6271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.31 cM"
     gene            1..6271
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /note="a disintegrin and metallopeptidase domain 23"
                     /db_xref="GeneID:23792"
                     /db_xref="MGI:MGI:1345162"
     exon            1..522
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..2810
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /note="metalloproteinase-like, disintegrin-like, and
                     cysteine-rich protein 3; disintegrin and metalloproteinase
                     domain-containing protein 23; a disintegrin and
                     metalloprotease domain 23"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 23 preproprotein"
                     /protein_id="NP_035910.1"
                     /db_xref="CCDS:CCDS14999.1"
                     /db_xref="GeneID:23792"
                     /db_xref="MGI:MGI:1345162"
                     /translation="MKPPGSISRRPTLTGCSLPGASCGPGRCPAGPVPARAPPCRLLL
                     VLLLLPALATSSRPRARGAAAPSAPHWNETAEKTLGVLADEDNTLQQNSSSRNTSYSS
                     AVQKEITLPSRLVYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFI
                     LDLTLNNGLLSSDYVEIHYEDGKQMYSKGGEHCYYHGSIRGVKDSRVALSTCNGLHGM
                     FEDDTFVYMIEPLELTDDEKSTGRPHIIQKTLAGQYSKQMKNLSTDGSDQWPLLPELQ
                     WLRRRKRAVNPSRGVFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIY
                     KEQLNTRVVLVAVETWTEKDHIDITINPVQMLHDFSKYRQRIKQHADAVHLISRVTFH
                     YKRSSLSYFGGVCSRIRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCECI
                     ESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVE
                     AGEECDCGFHVECYGVCCKKCSLSNGAHCSDGPCCNNTSCLFQSRGYECRDAVNSCDI
                     TEYCTGDSGQCPPNLHKQDGYSCNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCY
                     EKLNTEGTEKGNCGKDGDRWIPCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYH
                     QGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSRGK
                     VCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNPNPPKDEGPKGPSATNLIIGSIAGA
                     ILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI"
     exon            523..743
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..820
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            821..884
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            885..967
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1031
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1104
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1178
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1244
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1316
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1480
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1565
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1656
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1705
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1805
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1877
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1967
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2048
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2099
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2163
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2269
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2389
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2558
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2670
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2761
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..6255
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /note="hexamer: ATTAAA"
     polyA_site      3066
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /note="major polyA site"
     regulatory      3609..3614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /note="hexamer: AACAAG"
     polyA_site      3628
                     /gene="Adam23"
                     /gene_synonym="MDC3"
     regulatory      6235..6240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /note="hexamer: ATTAAA"
     polyA_site      6255
                     /gene="Adam23"
                     /gene_synonym="MDC3"
ORIGIN      
        1 gcgcctcctc agcatcctta ggcccggcag caacccccgc agtcactggt gcggccgcgc
       61 ccgccactgg gagggtgcag ccactggagg aggctccaag ttggtggagc ggcggggacc
      121 cctctctgcg ggccgctccc ggaaaggcgg aaagagcaga ggacggcgcg ccgccgtccc
      181 cgagacccca gcccctgacc cctgcccgcg gccgcagcat gcgcgcccag ccggcgtgac
      241 cggctccgcc cgcagccgcc ccgcagccca gcccggctct ctcgcgggtc actcggaccg
      301 gcgcccggga gcgatgagcc atgaagccgc ccggcagcat ctcccggcgg ccgaccctga
      361 cgggttgcag ccttcccggc gcctcctgcg gccccggccg ctgccccgcc ggcccggtgc
      421 cggcccgcgc gccgccctgc cgcctgctcc tcgtccttct cctgctacct gcgctcgcca
      481 cctcatcccg gccccgtgcc cggggggccg ctgcgcccag cgctccgcac tggaatgaaa
      541 ctgcagaaaa aaccctggga gtcctggcag atgaagacaa cacattgcaa caaaatagca
      601 gcagcagaaa taccagctac agcagtgcag tgcaaaaaga aatcacactg ccttcaagac
      661 tggtgtatta catcaaccag gactcagaaa gcccctatca tgttcttgac acaaaggcca
      721 gacaccaaca gaaacacaat aaggctgtgc atctggccca ggcaagcttc cagatcgaag
      781 ctttcggctc caagttcatt cttgacctca cactgaacaa tggtttgcta tcttctgact
      841 acgtggagat ccactatgaa gacgggaagc agatgtactc taagggtgga gagcactgtt
      901 actaccacgg aagcatcaga ggcgtcaagg attccagggt ggctctatcg acctgcaatg
      961 gactccatgg catgtttgag gatgacacct ttgtgtatat gatagagccg ctggaactga
     1021 ctgatgatga gaaaagcaca ggccgaccac acataatcca gaaaaccttg gcaggacagt
     1081 attctaagca gatgaagaat ctcagcacag atggcagtga ccagtggcct ttgctacctg
     1141 aattacaatg gctgagaaga aggaaaagag cggtcaatcc atctcgtggt gtgtttgaag
     1201 aaatgaagta tttggagctt atgattgtta atgatcacaa gacgtataag aagcaccgct
     1261 cttctcacgc gcataccaac aacttcgcaa agtctgtggt caaccttgta gattctattt
     1321 acaaggaaca gctcaacacc agggttgtcc tggtggctgt cgagacctgg accgagaagg
     1381 atcacattga catcaccatc aaccccgtgc agatgctaca tgacttctcc aagtaccggc
     1441 agcgaatcaa acagcacgct gacgcggtcc acctcatctc gcgcgtgaca ttccattata
     1501 agagaagcag tctgagttac tttggaggcg tgtgttctcg aataagaggg gttggtgtga
     1561 atgagtatgg tcttccaatg gcggtggcac aagtattatc acagagcctg gctcaaaacc
     1621 ttggaatcca gtgggaacct tcgagcagga agccaaaatg tgaatgcata gagtcctggg
     1681 gcggctgcat catggaagaa acaggggtgt cccactctcg aaagttctca aagtgcagca
     1741 ttttggagta cagagacttt ttacagagag gtggcggagc atgtcttttc aataggccaa
     1801 ctaagctgtt tgagcccacg gaatgtggaa atggatatgt ggaggccggg gaggaatgcg
     1861 actgtggttt ccatgtggaa tgctatggag tttgctgtaa gaagtgttcg ctctccaatg
     1921 gggcccactg cagtgacggc ccctgctgta acaacacctc atgtcttttt cagtcacgag
     1981 ggtatgaatg tcgggatgcc gtaaacagct gtgatatcac cgagtactgc actggagact
     2041 ctggccagtg cccaccgaac ctccataaac aagatggcta tagctgcaat caaaatcagg
     2101 gtcgctgcta caatggcgag tgcaagacaa gggacaatca atgccagtac atctggggga
     2161 caaaggctgc ggggtcagac aagttctgct atgaaaagct gaacacggaa ggcaccgaga
     2221 agggcaattg tggaaaggat ggagaccggt ggatcccgtg cagcaagcat gatgtgttct
     2281 gtggatttct gctttgcacc aatcttaccc gagctccacg tatcggtcaa cttcaaggag
     2341 agatcatccc gacttccttc tatcatcaag gccgagtgat tgactgcagt ggtgctcatg
     2401 tagttttaga cgatgataca gacgtgggtt acgttgaaga tgggactccg tgtggcccct
     2461 ccatgatgtg cttagatcgg aagtgcctac agattcaagc cctgaatatg agcagctgcc
     2521 cacttgactc aaggggtaaa gtctgctccg gccacggggt gtgtagcaac gaagccacct
     2581 gcatctgtga tttcacttgg gcaggcacag actgcagcat ccgggatcca gttcggaacc
     2641 ccaacccccc taaggatgaa ggccctaagg gtcctagcgc caccaatctc ataataggct
     2701 ccatcgctgg tgccatcctg gtagcagcta ttgtccttgg gggcacaggc tggggattta
     2761 aaaacgtcaa gaagaggaga ttcgatccca ctcagcaagg ccccatctga atcgtctgca
     2821 ctggaggaat gccaccttgc actgttgggt tctgggaatg acatgttttc agccatgctg
     2881 ccggaactct taagtctgta aagaagaccc ttgggtggta atgactacag agcctcagat
     2941 ctgagaattg ggatggggta caagacaaag gtcccttttg gaaataactt caagtaaccc
     3001 cccccccatc acctgtcaat aacggggagg ggttaaagac catgtcatta aaaaaaacaa
     3061 caacaacttc agaatccttt tttttctttt taactaaagg agaagggagt agcaacaagt
     3121 gcaataaaag aacaaatagc aaatgaccct gccccccagc ctgctggcac ttaatatttt
     3181 ctaaatgatt tggcatgatt ttttttcctt ttactatcaa ggacaaactc cagtggcatg
     3241 aagatccaat tttggaaagg gtaaaaactg catggcatat ataacaacaa gctagcaagc
     3301 caaccttcag caaatcctac agtggaaatc ccgaggggaa gatgacagat gaccacacaa
     3361 acgctacctg ggtctggatt aatgcctttc catcctccac caccccccct ccacctctgc
     3421 cctggccaac cctttcccta cgtgcccctg gcccactcta aacacgccca tggcagcact
     3481 catctggact gtgttcttgt tgatccgctg tacccatcat ttctctcctg gaccaagcat
     3541 cctctggcaa tgggagctgg aacttgagca atgctattgt acagttcttt tctaagtgta
     3601 gatatggaaa caagatttca atatgccatt ttgcttgtct gtatggaaat gttttccgtg
     3661 cgaagattct gtctatactt gagtttgttg cttgctccac atcttatttt tctttctttt
     3721 ctgtcatttt ctttcctcct ttgtctctgt cctctctttt aacatgtcca ccaattgttg
     3781 agcttgctta acaagacaga agtagccaca gatgcaggga gtttgggcac aaatctagta
     3841 tgtttgaaac caaatattaa aagggggggg gggacacaga aaataaccca taacaagaac
     3901 acaaaagatt atgtaaatgt gagtgtatat gtactgatgg acctaacact tttgatgtca
     3961 tcataagcac atgtatatac tgtaggaaaa cagacccttc tcaaattaat cacaaaagtg
     4021 ccaagctcat tgttttagtt tctggtttcg acagctctct ttccctgtcg taaatgtgaa
     4081 aggaggagaa acttaaagcc ttaaataaaa aaattaataa ctttcaaatg ctggaagctt
     4141 ggaaaaagtt aagctttcca ttctgttcat attcaaatgt atttttttta tatgtataaa
     4201 tttcatttat acttcatcta actgcctcgg gaagtagcct gtgtgacaga gccccagtgt
     4261 ggcgaggcag cacagctggt catttctgct catttcaggt tgtcattctg aatggtgatt
     4321 ccaggaactc accctgctca gtgttttgct gagactctgg gttgcgatgg gattccactg
     4381 tgtatgaatc cacacccttc tttttcctcc aggtagctgg ggagatccca ggactgtctg
     4441 agtttccctc atcttccccc attccttctt taagtattgc caggagagct tccaatgcaa
     4501 tcctaaggga acaggctact gaggaaattc tctcaggttt gtttcggaca tgcaggtgta
     4561 cagtgaacac ccatcaagaa ctcagacccg ccagagagcc cctacttctc cactggccca
     4621 tttttaccaa gaagacatcc agataaacta tgcatttctt cccggcactg agttactttt
     4681 tacatttagc tctaaggccc tctccagcaa gactcatgtc ttaagtttta caacatattc
     4741 cttgactaga agggaggagg atttcctaaa aatagactgc atgaaactgg actttccctc
     4801 ctcccccaaa gatatcttta agtgttggct tttcaccctc acagagcaga aaccttgatt
     4861 gctatatact accccaaacc ataacaacat cttaaccttc ggatggcttt ctgagaaaca
     4921 ggtgctatgc aggtatgcag tctttcgctt gaatttgctg tttgtttata tagtaataac
     4981 agcgctatct ataaggctta ctggccttat tcctggttcc ataagacaca ggctgtaccc
     5041 ctttactgaa tggcatgggc tcagcttgga ggaaggtcag aggaaattca gataacttgg
     5101 tatctcttcc tgtcgttgca atgtttcggg gtccacttca ctatgagata ccaagcagct
     5161 gccaacctca ccatactcat ttcgttacaa tttctgaggc accgtggtga cttgatccga
     5221 catacgacca cgtcagttac aaaccagatc tttatggtta acttttgaac atttcacaaa
     5281 caacattgta aatgtgcgat gttatgtttt aaatcagacc acagtggtcc ccaaatatta
     5341 tgtacatatg acaaatgtca gtgtaacttt ttgttacact gacagtttca taggtaaaca
     5401 aacctacgct ccaatgttaa attatgcttg tgtatgtaaa atacacaagc attgggctat
     5461 gtgtgtacgg acatgagggt agtgcaatcg tactgtacga aatgggtcag aatcattttc
     5521 agtggtgtta ggttatgtag tttcagactc catgctgcat tttctcttgc acatgccatc
     5581 catttgctta ttttggagtg tgagtattcc ttcttattaa tttgaattca aagcacaagc
     5641 ctcccattgt tcaacattac ccaacaagag tgtccagtga tgaccgagtt atctcacctg
     5701 ctatactttt actgcaataa ttaatgacac ctggatgagg aggcgtgcgc tgacttcatt
     5761 gttcacccgg gatagtgcat gagcccactg aattagagct gcttctacca gcaaagtgag
     5821 cagtacacat aggtgcatgt ttgaaacatg aatcacatag agctatggag ttttgccaag
     5881 tgatgtgttt tctttttctt ttttcttttt ttttcttttt cttctttttt ttccttttct
     5941 tcttcttctt cttttttttt tttttttttt actatgcaaa gatgggaaat gcacaaactt
     6001 ccaagacatg tctgaagaac tttacaatac ttgaattttt tctttaatca tcccatcaca
     6061 tttatggtca ttgatgcttc cattgttatt tttcttttgt tcccttcaac ttcaatggtt
     6121 tgtaaatttt caatgcacaa cctgaacttt tgtttgaagt taacttccaa tcctattggc
     6181 tgcctgtgaa cggagattct gtcatcctta cacgcatctt ttagttgact gtgcattaaa
     6241 agttttatta atgtaaaaaa aaaaaaaaaa a
//
