LOCUS       NM_001418085            9315 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 22 (Adam22),
            transcript variant 6, mRNA.
ACCESSION   NM_001418085 XM_036164738
VERSION     NM_001418085.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9315)
  AUTHORS   Xing,B., Lei,Z., Wang,Z., Wang,Q., Jiang,Q., Zhang,Z., Liu,X.,
            Qi,Y., Li,S., Guo,X., Liu,Y., Li,X., Shu,K., Zhang,H.,
            Bartsch,J.W., Nimsky,C., Huang,Y. and Lei,T.
  TITLE     A disintegrin and metalloproteinase 22 activates integrin beta1
            through its disintegrin domain to promote the progression of
            pituitary adenoma
  JOURNAL   Neuro Oncol 26 (1), 137-152 (2024)
   PUBMED   37555799
  REMARK    GeneRIF: A disintegrin and metalloproteinase 22 activates integrin
            beta1 through its disintegrin domain to promote the progression of
            pituitary adenoma.
REFERENCE   2  (bases 1 to 9315)
  AUTHORS   Yokoi,N., Fukata,Y., Okatsu,K., Yamagata,A., Liu,Y., Sanbo,M.,
            Miyazaki,Y., Goto,T., Abe,M., Kassai,H., Sakimura,K., Meijer,D.,
            Hirabayashi,M., Fukai,S. and Fukata,M.
  TITLE     14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure
            thresholds in mice
  JOURNAL   Cell Rep 37 (11), 110107 (2021)
   PUBMED   34910912
REFERENCE   3  (bases 1 to 9315)
  AUTHORS   Fukata,Y., Chen,X., Chiken,S., Hirano,Y., Yamagata,A., Inahashi,H.,
            Sanbo,M., Sano,H., Goto,T., Hirabayashi,M., Kornau,H.C., Pruss,H.,
            Nambu,A., Fukai,S., Nicoll,R.A. and Fukata,M.
  TITLE     LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for
            synaptic transmission and epilepsy prevention
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33397806
  REMARK    GeneRIF: LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment
            for synaptic transmission and epilepsy prevention.
REFERENCE   4  (bases 1 to 9315)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 9315)
  AUTHORS   Zhang,S.M., Jiang,L., Zhao,X., Liu,J.F., Liang,B., Liu,C., Liu,N.
            and Ma,C.S.
  TITLE     A disintegrin and metalloprotease 22 accelerates neointima
            formation by activating ERK signaling
  JOURNAL   Atherosclerosis 283, 92-99 (2019)
   PUBMED   30822685
REFERENCE   6  (bases 1 to 9315)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 9315)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   8  (bases 1 to 9315)
  AUTHORS   Fukata,Y., Adesnik,H., Iwanaga,T., Bredt,D.S., Nicoll,R.A. and
            Fukata,M.
  TITLE     Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate
            synaptic transmission
  JOURNAL   Science 313 (5794), 1792-1795 (2006)
   PUBMED   16990550
REFERENCE   9  (bases 1 to 9315)
  AUTHORS   Sagane,K., Hayakawa,K., Kai,J., Hirohashi,T., Takahashi,E.,
            Miyamoto,N., Ino,M., Oki,T., Yamazaki,K. and Nagasu,T.
  TITLE     Ataxia and peripheral nerve hypomyelination in ADAM22-deficient
            mice
  JOURNAL   BMC Neurosci 6, 33 (2005)
   PUBMED   15876356
  REMARK    GeneRIF: ADAM22 is closely involved in the correct functioning of
            the nervous system.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 9315)
  AUTHORS   Sagane,K., Yamazaki,K., Mizui,Y. and Tanaka,I.
  TITLE     Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
  JOURNAL   Gene 236 (1), 79-86 (1999)
   PUBMED   10433968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC152165.2, AC156022.2 and
            AC140364.4.
            
            On Mar 15, 2023 this sequence version replaced XM_036164738.1.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature, functional protein.
            The protein encoded by this gene is believed to lack
            metalloproteinase activity due to the lack of a critical catalytic
            motif. Mice lacking the encoded protein exhibit severe ataxia,
            hypomyelination and premature death. Alternative splicing results
            in multiple transcript variants encoding different isoforms, some
            of which may undergo similar processing. [provided by RefSeq, May
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2338588.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AC152165.2         176236-176494
            260-420             AC152165.2         177009-177169
            421-497             AC156022.2         28131-28207
            498-564             AC156022.2         125511-125577
            565-647             AC140364.4         203913-203995       c
            648-711             AC140364.4         197322-197385       c
            712-781             AC140364.4         195413-195482       c
            782-852             AC140364.4         188965-189035       c
            853-927             AC140364.4         185794-185868       c
            928-999             AC140364.4         183041-183112       c
            1000-1166           AC140364.4         182139-182305       c
            1167-1251           AC140364.4         180807-180891       c
            1252-1342           AC140364.4         179628-179718       c
            1343-1394           AC140364.4         178305-178356       c
            1395-1494           AC140364.4         173392-173491       c
            1495-1566           AC140364.4         171399-171470       c
            1567-1659           AC140364.4         171098-171190       c
            1660-1740           AC140364.4         168985-169065       c
            1741-1791           AC140364.4         167071-167121       c
            1792-1855           AC140364.4         166795-166858       c
            1856-1961           AC140364.4         163913-164018       c
            1962-2081           AC140364.4         157634-157753       c
            2082-2250           AC140364.4         154175-154343       c
            2251-2365           AC140364.4         153131-153245       c
            2366-2456           AC140364.4         148481-148571       c
            2457-2474           AC140364.4         143588-143605       c
            2475-2582           AC140364.4         131659-131766       c
            2583-2683           AC140364.4         129317-129417       c
            2684-2750           AC140364.4         128926-128992       c
            2751-2837           AC140364.4         124568-124654       c
            2838-2961           AC140364.4         118732-118855       c
            2962-9315           AC140364.4         108939-115292       c
FEATURES             Location/Qualifiers
     source          1..9315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.39 cM"
     gene            1..9315
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /note="a disintegrin and metallopeptidase domain 22"
                     /db_xref="GeneID:11496"
                     /db_xref="MGI:MGI:1340046"
     exon            1..259
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2982
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 6; disintegrin and metalloproteinase
                     domain-containing protein 22; a disintegrin and
                     metalloprotease domain (ADAM) 22"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 22 isoform 6 precursor"
                     /protein_id="NP_001405014.1"
                     /db_xref="GeneID:11496"
                     /db_xref="MGI:MGI:1340046"
                     /translation="MQAAAAASFWLLCVLGTCPLARCGRAGVASLKGLERGKENRFLE
                     RQSIIPLRLIYRLGGEDETQHNQLDTRVRGDPGGPQLTHVDKASFRVDAFGTSFVLDV
                     LLNHELLSSGYVERQIEHGGKVVENKGGEHCYYQGQIRGNPVSFVALSTCHGLHGMFY
                     DGNHTYLIEPEENEKSQESSHCHSVYKSRQFEFPLDDLPSEFQRVNITPPQFILKPRL
                     KRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYK
                     DQLKTRIVLVAMETWAADNKFAISENPLITLREFMKYRRDFIKEKADAVHLFSGSQFE
                     SSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNVGIISDKRKLASGECKC
                     EDTWSGCIMGDTGYYLPKKFTQCNVEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFI
                     ETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDC
                     DIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRY
                     CYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLV
                     VQQGRTLNCSGAHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCSSSKA
                     GTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGII
                     AGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDFPPGGSTNSASSS
                     KKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNMGGNKKKIRGKRFRPRSNST
                     EYLNPWFKRDYNVAKWVEDVNKNTEGPYFRTLSPAKSPSSSTGSIASSRKYPYPMPPL
                     PDEGKTAGRQSARLWETSI"
     exon            260..420
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..497
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..564
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..647
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..711
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..781
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..852
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..927
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..999
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1166
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1251
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1342
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1394
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1494
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1566
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1659
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1740
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1791
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1855
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1961
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2081
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2250
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2365
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2456
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2474
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2582
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2683
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2750
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2837
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2961
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..9315
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /note="hexamer: AATAAA"
     polyA_site      3322
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
ORIGIN      
        1 gccacttagc tacaggctgg cgcccgaagc ggcgctcgct cgctgccccc gccaccgaag
       61 cgctcgccag gcacaatgca gcactgaggc cacggaggct gcggtagcgg ctcgagctgg
      121 gaaggggcgg ttgggaggcc gagccccagg cccgggcaag agcagctgag cgccgccacc
      181 atgcaggcag cggcggccgc gtccttctgg ctgctctgcg tcttggggac ctgccccctg
      241 gcgcgctgcg gtcgggcagg agtcgcctca ctgaaaggac tggagagggg gaaagaaaac
      301 cgcttcctgg agcgccagag catcatacca ctgcgcctca tctatcgctt gggcggcgag
      361 gatgaaactc agcacaacca gctcgacacg cgggtgcggg gcgaccctgg cggaccgcag
      421 ctgacgcatg tggacaaggc aagcttccgg gtggacgcct ttggaacctc tttcgttctc
      481 gacgtcctgc tgaaccacga gttgctgtcg tcaggttatg tagagagaca gattgaacat
      541 ggaggcaagg tcgtggagaa caaaggagga gaacactgtt attaccaggg ccagattcga
      601 ggaaaccctg tctcatttgt tgccctatca acatgccatg gactccatgg gatgttctat
      661 gatggaaacc acacatatct cattgagcca gaagaaaatg agaagtctca agagtcgtct
      721 cattgtcact ccgtgtacaa atccagacag tttgaatttc ccttggatga ccttccgtct
      781 gaatttcaac gcgtaaacat tactccccct cagtttattt tgaagccaag actaaagagg
      841 agaaaaagac agcttcttcg atttcctcgg aatgtagagg aggaaaccaa atacatcgaa
      901 ctgatgattg tgaatgatca tctcatgttt aaaaagcacc ggctttctgt tgtatatact
      961 aatacctatg cgaagtctgt ggtgaacatg gcagatgtga tctataaaga ccaactgaaa
     1021 actaggattg tattggttgc catggaaacc tgggctgctg acaacaagtt tgccatatct
     1081 gaaaacccac tgattaccct tcgtgagttc atgaaataca ggagggattt tatcaaggag
     1141 aaggctgatg cagttcatct tttctcgggc agtcaatttg agagtagccg gagcggggca
     1201 gcttatattg gtgggatttg ctcgctgctg agaggaggag gcgtgaatga atttggaaaa
     1261 acggatttaa tggcagttac cctcgctcag tcactagccc acaatgtcgg tataatctct
     1321 gacaaaagaa aactagcaag tggtgagtgt aaatgtgagg acacctggtc cgggtgcata
     1381 atgggagaca ccggctacta tctcccgaaa aagttcactc agtgcaatgt cgaggaatat
     1441 catgacttcc tgaatagtgg tggaggtgcc tgcctgttca acaagccttc caagcttctt
     1501 gatcctcctg agtgtggaaa cggcttcatt gaaaccggag aggagtgtga ttgtggcacc
     1561 cctgcagaat gtgcccttga aggggcagag tgttgtaaga aatgcacctt gacccaggat
     1621 tctcaatgca gtgatggcct ttgttgtaaa aagtgcaagt ttcagcctct ggggaccgtg
     1681 tgccgagagg cagtgaacga ctgtgacatt cgtgaaatat gttcaggaaa ttcgagccag
     1741 tgtgccccca atgtgcataa aatggatgga tattcgtgtg atggtactca gggaatttgc
     1801 tttggaggaa gatgtaaaac cagagataga caatgcaaat acatctgggg gcaaaaggta
     1861 acagcatctg acaggtactg ctatgagaaa ctgaacattg aggggacgga gaagggtaac
     1921 tgtgggaaag acaaggacac gtggacacag tgcaacaaac gggatgtact ttgtggttac
     1981 ctcctgtgca caaacattgg caacatccca aggctcgggg agcttgatgg tgagatcaca
     2041 tccacattag ttgtgcagca aggaagaaca ttaaactgca gtggcgcgca tgttaaactt
     2101 gaagaagatg tggatcttgg ctatgtggaa gatgggacgc cctgtggccc tcagatgatg
     2161 tgcttggaac acaggtgtct tcctgtggct tccttcaact tcagtacttg ctccagcagt
     2221 aaagcaggca ccgtgtgctc aggaaatgga gtttgcagca atgagctcaa gtgtgtgtgc
     2281 aacaggcact ggacaggggc tgactgcggc acccactttc ctcacaatga tgatgcaaag
     2341 actggcatca ccctgtctgg caatggtgtt gctggcacta atatcataat aggaataatt
     2401 gccggcacca ttttagtgct ggccctcatc ttaggaataa ctgcctgggg ttataaaaac
     2461 taccgagaac agagacagtt accccaggga gattatgtaa aaaagcctgg cgatggcgac
     2521 tctttttata gcgactttcc tcccggaggc agcacaaact cagcatctag ttctaagaag
     2581 aggtcaaatg gactctctca ttcttggagt gaaaggattc cagacacaaa acatatttca
     2641 gacatctgtg aaaatgggag acctcgcagt aactcctggc aaggtaacat gggaggcaac
     2701 aaaaagaaaa tcagagggaa aagatttaga cctcgatcta actcaactga gtatttaaac
     2761 ccatggttca aaagagacta taatgtagct aagtgggtag aagatgtgaa taaaaacact
     2821 gaaggaccat actttaggac cctgtcacct gccaagtctc cttcttcatc aactgggtct
     2881 attgcctcca gcagaaaata cccgtaccct atgcctccgc ttccagacga ggggaagaca
     2941 gcgggccgac agagcgccag gctatgggag acatccattt aagaacaact gtttacatgt
     3001 gacacatcga aactgtttac ttctactttt atagaaaccc aaccacccgc aaccactgca
     3061 aatctatctg ctctctggac gatttcaaga ccctctgaga taccagagga gaggaagcca
     3121 tgggtcatac ctggacacca tacttttttt tttttttttt tttttttttt tggtcattgg
     3181 cttaagtttt aaccaaatgg taaaaagaat tactggaatg tcacactaca acatggaatc
     3241 atttatgatc tggtattggt atgttaatgg ataatctgca tgacagaaat atgtagaata
     3301 tcaataaaat taactcccat gacccaagtt tagcaggttt tcctgaggga cagaagtgga
     3361 ttcagaacgg agcattctga aacacatcct cattgcaaac agtaacgcca tatgcatgac
     3421 gcttctgttt attgttttcc atatataagg aaacaacatc tcataataga aactagcatg
     3481 cagaggctaa ggcatatagg attcttctgc aggactgtaa ggctttgaga ggccaatatc
     3541 ccatacgcta tctttaaaca tgtattttta ttttattttt tacttttcat atttatatta
     3601 gcatccaagg acaactgtac atatgtaaac atttttaaaa tttaaaaagt aactgttcca
     3661 cataagtgta tttttgccaa atgcctacag tcagtcacag ttctgtcacc gtcctccatc
     3721 ctgcgtcttc agcgtacaag tggacgagat tgtaaataga gtggtcagtg ctgtaaacgt
     3781 atctctccat aactggtgtt tgtctgaaac atgtgatttc cgtttaaagt gtgtccagtc
     3841 tggaagaggt tttattgagt aagagaacaa aatgctcaaa cgtctagcct ctgcttctca
     3901 ccgaaggagg agtccagatg tgcggcagcc gtggagcttc agggtaccct ggagctcaca
     3961 ggctctctgg gagtctgcca gcctatccac tccacagcta agacacatga cgcctgtcac
     4021 agtagctgtt ctcagtacca gggcatatca attaatctta accgggggcc atggagtccc
     4081 ctcctctcta gaaagtgtct tctatgattg gccagatgca ctaaagacat ggaccccaga
     4141 gcgcagagct ccctcttgac caatgcctga gccttgtctg atctgaagtt tgggttcctg
     4201 gacagaatcc tttcagccat tctcatctgt ggaagaaata atgactcggt tcaactcggt
     4261 tcaatttgaa cacgtttcat caccaggatg tgagtcccag taggtcattc tgtctggctt
     4321 tgaaccagat ggtggatgga agcctgagca agacatgaaa gattaaataa agcccatggc
     4381 tacacaggtg cagtaactgc aagaggaacc ataagcctgc aagggaaaga gccttgggtg
     4441 ttgagccaac ctttgatcca cttttttttt tttttaaaga atgttctatg tgaaatcttg
     4501 tcatttaaaa agaaacatta atagctgttt caatgcaatg ttgtcatgca aagagaaagc
     4561 ccctctagtg agatctgaag ttggtaggct caatcatgtg gtccactgtg aaccacactt
     4621 gtgatttccc ccttctcctt gctgttttat gtgaggaatg cagtcatcag acaagaactc
     4681 agaaatggac tctaagtttg acttctttga gaggcatcca gggacacagt ttgttgcatc
     4741 tctgtgtagt tgtcttagat acccaaattg aagaggcaga ctagaaggca aaggtatgct
     4801 cagctcatgt cttttgcaat ggtccactct tctaaaacgc tctgaaggtg ttagaaaaca
     4861 aatttaatca ggcaaaatta tacagtgaaa aacatttttc ctgacaggca aggatatagt
     4921 ttgctgatga ctcaataaag cagtctcaga caaaggcata gatgagtgtt gaacaatatc
     4981 tccacatagc ttaaggtatg gcagacaggt gacagatgaa agagatgtag caaacgaagt
     5041 gacttttgaa caagaacact ttagatgtgc actgaatgtt tcttggtatt gagtatataa
     5101 aggctaatgt aatataaggt ttattttgac tacggaagag agagtttata gtttgactga
     5161 gaggtgcctc ctgtaaatat gctttgtagt tatagttagt tacctaagcc ctaacgtgaa
     5221 agaattcaca aaaggttagc tagtaaactc attatctgtc tacctactga tctttcctta
     5281 ccttctcaat tatttttacc tggggttatt attgagaatt aaaatcatta tcgcgtgcct
     5341 tttgggagaa tcagttgctc tggcttgtaa tcatcttcag atgaaatgag aggaaaaggt
     5401 tttgcttaac ttgcaaagtg attttagaaa tataatagct ttaatgttct agtctgggtc
     5461 tctatctctc atgtttaagc attcttagaa ttgtttttgg aattaacaga ctttagtctt
     5521 gatggataac ttcaagaagt atgtatcatt ccactgaact ctgtatgact tcattcactg
     5581 aggtacacag aagagactcg tggaatcaaa cccaagcaca gtgattattt cattcttaaa
     5641 tgtctatttt gaagaggaac tttgcagctc catgtggttt gaatcatgca actagtattc
     5701 atacttccca gtgtgctgtg ggatcattgc tacaaagagg agggcagcga tgtgtttgtt
     5761 cattggatgc tatttctcgt tctcataatc ttggcatcga tagggcttca gatacccaga
     5821 tgcctgagat gtcccattat gcagatcatt tctgttccaa tgaaaacaga cattcaagtc
     5881 tttccactac attagcaggg gaggcctgca gtaacagagg atcctaaaga atgaactggc
     5941 cggactcact cttcccagct actttcctta gatgggaagt cctcctccag agtcagcaag
     6001 atagaaaatg actccagtcg cacaaagtct gcagagagaa accagtgctg cttagatggt
     6061 gccacatgaa gattcttagt gctctgcagt ggctggctct gaagagcaaa agccagacac
     6121 ctcagtccct cccttagatg ctaactgatg agtaaccact ttggttactc aaggagagtc
     6181 actggggaca ggaaaacagg gcttaggatg ttgttgtagc aggtgagagg agtgctctat
     6241 ttcaggatgt ggtgtggttt cttctcctgg cttcacaagg cttttaaagt aatgtttgca
     6301 caggcgggtc caatgtagtc tttatgcatg agagattggt ggtagtctaa aagaagccac
     6361 tgtgaagata agattaaata ctccctgccc tccaggggtg tgcatggggg agtggggctg
     6421 ctatgctttc aaggacagat ccacatgctt ctcttctggg taccttgaat ctctgctgac
     6481 ttcatcctgc ctgttgccct aggctttctg cagctacttt acctgttgcc cttttcatgc
     6541 tttgtccccc ttttttgggg gggagggggg tacctttaat ccaggaaaag tgggatacct
     6601 ctgcctgcgt tttttctttc agagtcaagt ttgttcactt cactgtgtga gttttctatt
     6661 gccatagttc catcttaacc tttgatctgt acagtgcttt agagaagccc tgctctgaag
     6721 gcaagattac tttttagtct tacttaaatg taaaggaaag aaaggctgtt tggtagcttg
     6781 caccatataa agagaagggg acagagtttg gaactgatgg gagtaaggag aagcaagaca
     6841 cctagctgca cagccagggg tggtgcagct ggctgctgct actggctgcc gtgtttgggg
     6901 cattctctaa agatctcagc agcagcaagt tggcttgagc actgagacac ctggactcct
     6961 gttggcagca cattttctac tttttatgtt cctaattgtc tcttttgttt gttttcttct
     7021 atagctatca tctgcttccc tctcctcccc caaaaggcag tcaaattgaa tttttcattc
     7081 ttattccacg agctttatat gaccagctga catttctgtg gaagagggct tagttggggc
     7141 cttgaatact tagtttcctc tggtgggaga gttaagacta ctctggcttc agagacaggg
     7201 tcctttctct ggccactgga gagctgggga ctgggttcca gatcctcctt tatcgtattg
     7261 taaagaattg agctggcatt tgtgagaacc agctgaggcc acagcccatc tggctgtgtg
     7321 agagcagcat gctgtaaaag tggcttggcc gttcgctgtt ggcacctgct tatagcatat
     7381 gctctgcagg gcagacactt tcagctcaaa gacgtttcct accacacctg cagggacaga
     7441 acaaagttgc cccggacttg gagagcagaa ggtagtattt ccatcccagt tttattcatg
     7501 gttttgccag ttctcaacat ggagcaccta aagtcaggca gcagaaaatg aaaacttaca
     7561 agacgattgt tggttgtacc tctgcccttc aaattcatgg ccttatggga cagtatcatt
     7621 tctgttggat ttgatggctg catttagaac cttcctactt gcaaagttcc gtgttcagta
     7681 tctgtgcggc acttttcctc ttgatcagtg gcatccccta ttcggggcct tctttggttc
     7741 aaatgagaat taggaataca gagtggtaat gttagttttc atttccttct gacatgctgg
     7801 tttgattgtg caccatggaa agtcgctaag acatgggtct cagggtataa atctcaggaa
     7861 gtgaataagc aagcggcaca gagatttgag agatcctggg tcacttagtc ccagcctagg
     7921 agcacagtgg acatccacat aaaccatgta gcagagctca acacagtcac cggatatgct
     7981 ggagggacgg acctactgcc gccaagggca gacatgtgct ctgcggtttt tggaagtgtt
     8041 acctttggaa gcgttttact atcccatgtc ccttgcattg ttcccagacc tgcgtcactg
     8101 ggaggggctt cagaagtggc aggcatgtct atcacaggtc gcctgtggca tcaaatccaa
     8161 gcaaagtgtg ttttattgtt tcattttacc agaagtcata cagtaagaca aaggaatctt
     8221 gttaatatac acaaggccac ccgttcctgg gcttgtgacc taggcctccc tacatgtatg
     8281 aagaggcatg tatgcacatt ctgcactcaa cttccgccgt ttcgggacgt gatttgcttt
     8341 gatcgttggg ttttaaaata gtgcaaatat cccaaatctt taaataaagc ggtgctaagt
     8401 tttatcagat aacacaatac agaaagtgct gaaatgaatt cagacccctc ggagttcctc
     8461 gagggttcct gttaaattac acacgtgtat cactgcctga ttggaaaccc cacttttcct
     8521 ttctaatcca gcacaatatc aaactgtgat tctataactt gtctttttaa tagctacaaa
     8581 taacccaaca tctttttttt tttttatgga aaacttttct ttttagcact aactgcaaag
     8641 tgcttagcaa aaggttcctt ctggataaca gagcactgct attattatta ttgctatcat
     8701 tgttattcct ccttcttcaa cttgttggaa gacttgcccc tccaaacgag catttccaaa
     8761 agacagtttt cagaaacttc acatttcacc taatgaaagc tgtgcatatg ttagtctgtg
     8821 cattaggtct ctgctagtgt gtcccatgtc catagcctcc atggggtgat gcccatctgc
     8881 agatgttaga aaccacccca tggggacctg ggagtagcat cagtgtggtt cactttgggt
     8941 agctgggtac tcacgtgtat atacttagat ttgcatcatt caaacctcct ctctgctttt
     9001 ccgcacgcac ttctagctct tctgctattt taaaattcac tgggttttgg tgaacaccaa
     9061 cataaatgta agcgatgatt gctttcctga gcaggcgtga tttgttgtat ggctgtttaa
     9121 gttataaagt tgttctcata ttgtaggtga ataaaatctt gctgttttta aaggtcactg
     9181 taactcgaga ttaaaatttc tggcacaatt ttatgagtgt tcacttctga agctaataag
     9241 acaatagagt tttctatgtt actctcactg taacatcgat aaagtgactt tgaataaaag
     9301 atttctgtta ttttg
//
