LOCUS       NM_001310439            9213 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 22 (Adam22),
            transcript variant 4, mRNA.
ACCESSION   NM_001310439 XM_006503539
VERSION     NM_001310439.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9213)
  AUTHORS   Xing,B., Lei,Z., Wang,Z., Wang,Q., Jiang,Q., Zhang,Z., Liu,X.,
            Qi,Y., Li,S., Guo,X., Liu,Y., Li,X., Shu,K., Zhang,H.,
            Bartsch,J.W., Nimsky,C., Huang,Y. and Lei,T.
  TITLE     A disintegrin and metalloproteinase 22 activates integrin beta1
            through its disintegrin domain to promote the progression of
            pituitary adenoma
  JOURNAL   Neuro Oncol 26 (1), 137-152 (2024)
   PUBMED   37555799
  REMARK    GeneRIF: A disintegrin and metalloproteinase 22 activates integrin
            beta1 through its disintegrin domain to promote the progression of
            pituitary adenoma.
REFERENCE   2  (bases 1 to 9213)
  AUTHORS   Yokoi,N., Fukata,Y., Okatsu,K., Yamagata,A., Liu,Y., Sanbo,M.,
            Miyazaki,Y., Goto,T., Abe,M., Kassai,H., Sakimura,K., Meijer,D.,
            Hirabayashi,M., Fukai,S. and Fukata,M.
  TITLE     14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure
            thresholds in mice
  JOURNAL   Cell Rep 37 (11), 110107 (2021)
   PUBMED   34910912
REFERENCE   3  (bases 1 to 9213)
  AUTHORS   Fukata,Y., Chen,X., Chiken,S., Hirano,Y., Yamagata,A., Inahashi,H.,
            Sanbo,M., Sano,H., Goto,T., Hirabayashi,M., Kornau,H.C., Pruss,H.,
            Nambu,A., Fukai,S., Nicoll,R.A. and Fukata,M.
  TITLE     LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for
            synaptic transmission and epilepsy prevention
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33397806
  REMARK    GeneRIF: LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment
            for synaptic transmission and epilepsy prevention.
REFERENCE   4  (bases 1 to 9213)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 9213)
  AUTHORS   Zhang,S.M., Jiang,L., Zhao,X., Liu,J.F., Liang,B., Liu,C., Liu,N.
            and Ma,C.S.
  TITLE     A disintegrin and metalloprotease 22 accelerates neointima
            formation by activating ERK signaling
  JOURNAL   Atherosclerosis 283, 92-99 (2019)
   PUBMED   30822685
REFERENCE   6  (bases 1 to 9213)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 9213)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   8  (bases 1 to 9213)
  AUTHORS   Fukata,Y., Adesnik,H., Iwanaga,T., Bredt,D.S., Nicoll,R.A. and
            Fukata,M.
  TITLE     Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate
            synaptic transmission
  JOURNAL   Science 313 (5794), 1792-1795 (2006)
   PUBMED   16990550
REFERENCE   9  (bases 1 to 9213)
  AUTHORS   Sagane,K., Hayakawa,K., Kai,J., Hirohashi,T., Takahashi,E.,
            Miyamoto,N., Ino,M., Oki,T., Yamazaki,K. and Nagasu,T.
  TITLE     Ataxia and peripheral nerve hypomyelination in ADAM22-deficient
            mice
  JOURNAL   BMC Neurosci 6, 33 (2005)
   PUBMED   15876356
  REMARK    GeneRIF: ADAM22 is closely involved in the correct functioning of
            the nervous system.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 9213)
  AUTHORS   Sagane,K., Yamazaki,K., Mizui,Y. and Tanaka,I.
  TITLE     Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
  JOURNAL   Gene 236 (1), 79-86 (1999)
   PUBMED   10433968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC152165.2, AC156022.2 and
            AC140364.4.
            
            On Mar 15, 2023 this sequence version replaced NM_001310439.1.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature, functional protein.
            The protein encoded by this gene is believed to lack
            metalloproteinase activity due to the lack of a critical catalytic
            motif. Mice lacking the encoded protein exhibit severe ataxia,
            hypomyelination and premature death. Alternative splicing results
            in multiple transcript variants encoding different isoforms, some
            of which may undergo similar processing. [provided by RefSeq, May
            2016].
            
            Transcript Variant: This variant (4, also known as G07) contains
            multiple differences in the 3' coding region and differs in the 3'
            UTR compared variant 1. The encoded isoform (c) has a distinct
            C-terminus and is longer than isoform a. This isoform (4) may
            undergo protein processing similar to isoform 5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AC152165.2         176236-176494
            260-420             AC152165.2         177009-177169
            421-497             AC156022.2         28131-28207
            498-564             AC156022.2         125511-125577
            565-647             AC140364.4         203913-203995       c
            648-711             AC140364.4         197322-197385       c
            712-781             AC140364.4         195413-195482       c
            782-852             AC140364.4         188965-189035       c
            853-927             AC140364.4         185794-185868       c
            928-999             AC140364.4         183041-183112       c
            1000-1166           AC140364.4         182139-182305       c
            1167-1251           AC140364.4         180807-180891       c
            1252-1342           AC140364.4         179628-179718       c
            1343-1394           AC140364.4         178305-178356       c
            1395-1494           AC140364.4         173392-173491       c
            1495-1566           AC140364.4         171399-171470       c
            1567-1659           AC140364.4         171098-171190       c
            1660-1740           AC140364.4         168985-169065       c
            1741-1791           AC140364.4         167071-167121       c
            1792-1855           AC140364.4         166795-166858       c
            1856-1961           AC140364.4         163913-164018       c
            1962-2081           AC140364.4         157634-157753       c
            2082-2250           AC140364.4         154175-154343       c
            2251-2365           AC140364.4         153131-153245       c
            2366-2456           AC140364.4         148481-148571       c
            2457-2557           AC140364.4         129317-129417       c
            2558-2624           AC140364.4         128926-128992       c
            2625-2735           AC140364.4         126728-126838       c
            2736-2859           AC140364.4         118732-118855       c
            2860-9213           AC140364.4         108939-115292       c
FEATURES             Location/Qualifiers
     source          1..9213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.39 cM"
     gene            1..9213
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /note="a disintegrin and metallopeptidase domain 22"
                     /db_xref="GeneID:11496"
                     /db_xref="MGI:MGI:1340046"
     exon            1..259
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2880
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; disintegrin and metalloproteinase
                     domain-containing protein 22; a disintegrin and
                     metalloprotease domain (ADAM) 22"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 22 isoform 4 precursor"
                     /protein_id="NP_001297368.1"
                     /db_xref="CCDS:CCDS80205.1"
                     /db_xref="GeneID:11496"
                     /db_xref="MGI:MGI:1340046"
                     /translation="MQAAAAASFWLLCVLGTCPLARCGRAGVASLKGLERGKENRFLE
                     RQSIIPLRLIYRLGGEDETQHNQLDTRVRGDPGGPQLTHVDKASFRVDAFGTSFVLDV
                     LLNHELLSSGYVERQIEHGGKVVENKGGEHCYYQGQIRGNPVSFVALSTCHGLHGMFY
                     DGNHTYLIEPEENEKSQESSHCHSVYKSRQFEFPLDDLPSEFQRVNITPPQFILKPRL
                     KRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYK
                     DQLKTRIVLVAMETWAADNKFAISENPLITLREFMKYRRDFIKEKADAVHLFSGSQFE
                     SSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNVGIISDKRKLASGECKC
                     EDTWSGCIMGDTGYYLPKKFTQCNVEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFI
                     ETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDC
                     DIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRY
                     CYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLV
                     VQQGRTLNCSGAHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCSSSKA
                     GTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGII
                     AGTILVLALILGITAWGYKSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNMGGN
                     KKKIRGKRFRPRSNSTEREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHRTLSP
                     AKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI"
     exon            260..420
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..497
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..564
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..647
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..711
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..781
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..852
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..927
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..999
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1166
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1251
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1342
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1394
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1494
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1566
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1659
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1740
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1791
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1855
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1961
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2081
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2250
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2365
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2456
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2557
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2624
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2735
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2859
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..9213
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3201..3206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /note="hexamer: AATAAA"
     polyA_site      3220
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
ORIGIN      
        1 gccacttagc tacaggctgg cgcccgaagc ggcgctcgct cgctgccccc gccaccgaag
       61 cgctcgccag gcacaatgca gcactgaggc cacggaggct gcggtagcgg ctcgagctgg
      121 gaaggggcgg ttgggaggcc gagccccagg cccgggcaag agcagctgag cgccgccacc
      181 atgcaggcag cggcggccgc gtccttctgg ctgctctgcg tcttggggac ctgccccctg
      241 gcgcgctgcg gtcgggcagg agtcgcctca ctgaaaggac tggagagggg gaaagaaaac
      301 cgcttcctgg agcgccagag catcatacca ctgcgcctca tctatcgctt gggcggcgag
      361 gatgaaactc agcacaacca gctcgacacg cgggtgcggg gcgaccctgg cggaccgcag
      421 ctgacgcatg tggacaaggc aagcttccgg gtggacgcct ttggaacctc tttcgttctc
      481 gacgtcctgc tgaaccacga gttgctgtcg tcaggttatg tagagagaca gattgaacat
      541 ggaggcaagg tcgtggagaa caaaggagga gaacactgtt attaccaggg ccagattcga
      601 ggaaaccctg tctcatttgt tgccctatca acatgccatg gactccatgg gatgttctat
      661 gatggaaacc acacatatct cattgagcca gaagaaaatg agaagtctca agagtcgtct
      721 cattgtcact ccgtgtacaa atccagacag tttgaatttc ccttggatga ccttccgtct
      781 gaatttcaac gcgtaaacat tactccccct cagtttattt tgaagccaag actaaagagg
      841 agaaaaagac agcttcttcg atttcctcgg aatgtagagg aggaaaccaa atacatcgaa
      901 ctgatgattg tgaatgatca tctcatgttt aaaaagcacc ggctttctgt tgtatatact
      961 aatacctatg cgaagtctgt ggtgaacatg gcagatgtga tctataaaga ccaactgaaa
     1021 actaggattg tattggttgc catggaaacc tgggctgctg acaacaagtt tgccatatct
     1081 gaaaacccac tgattaccct tcgtgagttc atgaaataca ggagggattt tatcaaggag
     1141 aaggctgatg cagttcatct tttctcgggc agtcaatttg agagtagccg gagcggggca
     1201 gcttatattg gtgggatttg ctcgctgctg agaggaggag gcgtgaatga atttggaaaa
     1261 acggatttaa tggcagttac cctcgctcag tcactagccc acaatgtcgg tataatctct
     1321 gacaaaagaa aactagcaag tggtgagtgt aaatgtgagg acacctggtc cgggtgcata
     1381 atgggagaca ccggctacta tctcccgaaa aagttcactc agtgcaatgt cgaggaatat
     1441 catgacttcc tgaatagtgg tggaggtgcc tgcctgttca acaagccttc caagcttctt
     1501 gatcctcctg agtgtggaaa cggcttcatt gaaaccggag aggagtgtga ttgtggcacc
     1561 cctgcagaat gtgcccttga aggggcagag tgttgtaaga aatgcacctt gacccaggat
     1621 tctcaatgca gtgatggcct ttgttgtaaa aagtgcaagt ttcagcctct ggggaccgtg
     1681 tgccgagagg cagtgaacga ctgtgacatt cgtgaaatat gttcaggaaa ttcgagccag
     1741 tgtgccccca atgtgcataa aatggatgga tattcgtgtg atggtactca gggaatttgc
     1801 tttggaggaa gatgtaaaac cagagataga caatgcaaat acatctgggg gcaaaaggta
     1861 acagcatctg acaggtactg ctatgagaaa ctgaacattg aggggacgga gaagggtaac
     1921 tgtgggaaag acaaggacac gtggacacag tgcaacaaac gggatgtact ttgtggttac
     1981 ctcctgtgca caaacattgg caacatccca aggctcgggg agcttgatgg tgagatcaca
     2041 tccacattag ttgtgcagca aggaagaaca ttaaactgca gtggcgcgca tgttaaactt
     2101 gaagaagatg tggatcttgg ctatgtggaa gatgggacgc cctgtggccc tcagatgatg
     2161 tgcttggaac acaggtgtct tcctgtggct tccttcaact tcagtacttg ctccagcagt
     2221 aaagcaggca ccgtgtgctc aggaaatgga gtttgcagca atgagctcaa gtgtgtgtgc
     2281 aacaggcact ggacaggggc tgactgcggc acccactttc ctcacaatga tgatgcaaag
     2341 actggcatca ccctgtctgg caatggtgtt gctggcacta atatcataat aggaataatt
     2401 gccggcacca ttttagtgct ggccctcatc ttaggaataa ctgcctgggg ttataagtca
     2461 aatggactct ctcattcttg gagtgaaagg attccagaca caaaacatat ttcagacatc
     2521 tgtgaaaatg ggagacctcg cagtaactcc tggcaaggta acatgggagg caacaaaaag
     2581 aaaatcagag ggaaaagatt tagacctcga tctaactcaa ctgagaggga gccccaagca
     2641 cccgagcctg ggcactccct cgcccagaca atcccatccc aaggcataag cccagggggc
     2701 tctgacagcc cccagacagg gagtctggat cacaggaccc tgtcacctgc caagtctcct
     2761 tcttcatcaa ctgggtctat tgcctccagc agaaaatacc cgtaccctat gcctccgctt
     2821 ccagacgagg ggaagacagc gggccgacag agcgccaggc tatgggagac atccatttaa
     2881 gaacaactgt ttacatgtga cacatcgaaa ctgtttactt ctacttttat agaaacccaa
     2941 ccacccgcaa ccactgcaaa tctatctgct ctctggacga tttcaagacc ctctgagata
     3001 ccagaggaga ggaagccatg ggtcatacct ggacaccata cttttttttt tttttttttt
     3061 tttttttttg gtcattggct taagttttaa ccaaatggta aaaagaatta ctggaatgtc
     3121 acactacaac atggaatcat ttatgatctg gtattggtat gttaatggat aatctgcatg
     3181 acagaaatat gtagaatatc aataaaatta actcccatga cccaagttta gcaggttttc
     3241 ctgagggaca gaagtggatt cagaacggag cattctgaaa cacatcctca ttgcaaacag
     3301 taacgccata tgcatgacgc ttctgtttat tgttttccat atataaggaa acaacatctc
     3361 ataatagaaa ctagcatgca gaggctaagg catataggat tcttctgcag gactgtaagg
     3421 ctttgagagg ccaatatccc atacgctatc tttaaacatg tatttttatt ttatttttta
     3481 cttttcatat ttatattagc atccaaggac aactgtacat atgtaaacat ttttaaaatt
     3541 taaaaagtaa ctgttccaca taagtgtatt tttgccaaat gcctacagtc agtcacagtt
     3601 ctgtcaccgt cctccatcct gcgtcttcag cgtacaagtg gacgagattg taaatagagt
     3661 ggtcagtgct gtaaacgtat ctctccataa ctggtgtttg tctgaaacat gtgatttccg
     3721 tttaaagtgt gtccagtctg gaagaggttt tattgagtaa gagaacaaaa tgctcaaacg
     3781 tctagcctct gcttctcacc gaaggaggag tccagatgtg cggcagccgt ggagcttcag
     3841 ggtaccctgg agctcacagg ctctctggga gtctgccagc ctatccactc cacagctaag
     3901 acacatgacg cctgtcacag tagctgttct cagtaccagg gcatatcaat taatcttaac
     3961 cgggggccat ggagtcccct cctctctaga aagtgtcttc tatgattggc cagatgcact
     4021 aaagacatgg accccagagc gcagagctcc ctcttgacca atgcctgagc cttgtctgat
     4081 ctgaagtttg ggttcctgga cagaatcctt tcagccattc tcatctgtgg aagaaataat
     4141 gactcggttc aactcggttc aatttgaaca cgtttcatca ccaggatgtg agtcccagta
     4201 ggtcattctg tctggctttg aaccagatgg tggatggaag cctgagcaag acatgaaaga
     4261 ttaaataaag cccatggcta cacaggtgca gtaactgcaa gaggaaccat aagcctgcaa
     4321 gggaaagagc cttgggtgtt gagccaacct ttgatccact tttttttttt tttaaagaat
     4381 gttctatgtg aaatcttgtc atttaaaaag aaacattaat agctgtttca atgcaatgtt
     4441 gtcatgcaaa gagaaagccc ctctagtgag atctgaagtt ggtaggctca atcatgtggt
     4501 ccactgtgaa ccacacttgt gatttccccc ttctccttgc tgttttatgt gaggaatgca
     4561 gtcatcagac aagaactcag aaatggactc taagtttgac ttctttgaga ggcatccagg
     4621 gacacagttt gttgcatctc tgtgtagttg tcttagatac ccaaattgaa gaggcagact
     4681 agaaggcaaa ggtatgctca gctcatgtct tttgcaatgg tccactcttc taaaacgctc
     4741 tgaaggtgtt agaaaacaaa tttaatcagg caaaattata cagtgaaaaa catttttcct
     4801 gacaggcaag gatatagttt gctgatgact caataaagca gtctcagaca aaggcataga
     4861 tgagtgttga acaatatctc cacatagctt aaggtatggc agacaggtga cagatgaaag
     4921 agatgtagca aacgaagtga cttttgaaca agaacacttt agatgtgcac tgaatgtttc
     4981 ttggtattga gtatataaag gctaatgtaa tataaggttt attttgacta cggaagagag
     5041 agtttatagt ttgactgaga ggtgcctcct gtaaatatgc tttgtagtta tagttagtta
     5101 cctaagccct aacgtgaaag aattcacaaa aggttagcta gtaaactcat tatctgtcta
     5161 cctactgatc tttccttacc ttctcaatta tttttacctg gggttattat tgagaattaa
     5221 aatcattatc gcgtgccttt tgggagaatc agttgctctg gcttgtaatc atcttcagat
     5281 gaaatgagag gaaaaggttt tgcttaactt gcaaagtgat tttagaaata taatagcttt
     5341 aatgttctag tctgggtctc tatctctcat gtttaagcat tcttagaatt gtttttggaa
     5401 ttaacagact ttagtcttga tggataactt caagaagtat gtatcattcc actgaactct
     5461 gtatgacttc attcactgag gtacacagaa gagactcgtg gaatcaaacc caagcacagt
     5521 gattatttca ttcttaaatg tctattttga agaggaactt tgcagctcca tgtggtttga
     5581 atcatgcaac tagtattcat acttcccagt gtgctgtggg atcattgcta caaagaggag
     5641 ggcagcgatg tgtttgttca ttggatgcta tttctcgttc tcataatctt ggcatcgata
     5701 gggcttcaga tacccagatg cctgagatgt cccattatgc agatcatttc tgttccaatg
     5761 aaaacagaca ttcaagtctt tccactacat tagcagggga ggcctgcagt aacagaggat
     5821 cctaaagaat gaactggccg gactcactct tcccagctac tttccttaga tgggaagtcc
     5881 tcctccagag tcagcaagat agaaaatgac tccagtcgca caaagtctgc agagagaaac
     5941 cagtgctgct tagatggtgc cacatgaaga ttcttagtgc tctgcagtgg ctggctctga
     6001 agagcaaaag ccagacacct cagtccctcc cttagatgct aactgatgag taaccacttt
     6061 ggttactcaa ggagagtcac tggggacagg aaaacagggc ttaggatgtt gttgtagcag
     6121 gtgagaggag tgctctattt caggatgtgg tgtggtttct tctcctggct tcacaaggct
     6181 tttaaagtaa tgtttgcaca ggcgggtcca atgtagtctt tatgcatgag agattggtgg
     6241 tagtctaaaa gaagccactg tgaagataag attaaatact ccctgccctc caggggtgtg
     6301 catgggggag tggggctgct atgctttcaa ggacagatcc acatgcttct cttctgggta
     6361 ccttgaatct ctgctgactt catcctgcct gttgccctag gctttctgca gctactttac
     6421 ctgttgccct tttcatgctt tgtccccctt ttttgggggg gaggggggta cctttaatcc
     6481 aggaaaagtg ggatacctct gcctgcgttt tttctttcag agtcaagttt gttcacttca
     6541 ctgtgtgagt tttctattgc catagttcca tcttaacctt tgatctgtac agtgctttag
     6601 agaagccctg ctctgaaggc aagattactt tttagtctta cttaaatgta aaggaaagaa
     6661 aggctgtttg gtagcttgca ccatataaag agaaggggac agagtttgga actgatggga
     6721 gtaaggagaa gcaagacacc tagctgcaca gccaggggtg gtgcagctgg ctgctgctac
     6781 tggctgccgt gtttggggca ttctctaaag atctcagcag cagcaagttg gcttgagcac
     6841 tgagacacct ggactcctgt tggcagcaca ttttctactt tttatgttcc taattgtctc
     6901 ttttgtttgt tttcttctat agctatcatc tgcttccctc tcctccccca aaaggcagtc
     6961 aaattgaatt tttcattctt attccacgag ctttatatga ccagctgaca tttctgtgga
     7021 agagggctta gttggggcct tgaatactta gtttcctctg gtgggagagt taagactact
     7081 ctggcttcag agacagggtc ctttctctgg ccactggaga gctggggact gggttccaga
     7141 tcctccttta tcgtattgta aagaattgag ctggcatttg tgagaaccag ctgaggccac
     7201 agcccatctg gctgtgtgag agcagcatgc tgtaaaagtg gcttggccgt tcgctgttgg
     7261 cacctgctta tagcatatgc tctgcagggc agacactttc agctcaaaga cgtttcctac
     7321 cacacctgca gggacagaac aaagttgccc cggacttgga gagcagaagg tagtatttcc
     7381 atcccagttt tattcatggt tttgccagtt ctcaacatgg agcacctaaa gtcaggcagc
     7441 agaaaatgaa aacttacaag acgattgttg gttgtacctc tgcccttcaa attcatggcc
     7501 ttatgggaca gtatcatttc tgttggattt gatggctgca tttagaacct tcctacttgc
     7561 aaagttccgt gttcagtatc tgtgcggcac ttttcctctt gatcagtggc atcccctatt
     7621 cggggccttc tttggttcaa atgagaatta ggaatacaga gtggtaatgt tagttttcat
     7681 ttccttctga catgctggtt tgattgtgca ccatggaaag tcgctaagac atgggtctca
     7741 gggtataaat ctcaggaagt gaataagcaa gcggcacaga gatttgagag atcctgggtc
     7801 acttagtccc agcctaggag cacagtggac atccacataa accatgtagc agagctcaac
     7861 acagtcaccg gatatgctgg agggacggac ctactgccgc caagggcaga catgtgctct
     7921 gcggtttttg gaagtgttac ctttggaagc gttttactat cccatgtccc ttgcattgtt
     7981 cccagacctg cgtcactggg aggggcttca gaagtggcag gcatgtctat cacaggtcgc
     8041 ctgtggcatc aaatccaagc aaagtgtgtt ttattgtttc attttaccag aagtcataca
     8101 gtaagacaaa ggaatcttgt taatatacac aaggccaccc gttcctgggc ttgtgaccta
     8161 ggcctcccta catgtatgaa gaggcatgta tgcacattct gcactcaact tccgccgttt
     8221 cgggacgtga tttgctttga tcgttgggtt ttaaaatagt gcaaatatcc caaatcttta
     8281 aataaagcgg tgctaagttt tatcagataa cacaatacag aaagtgctga aatgaattca
     8341 gacccctcgg agttcctcga gggttcctgt taaattacac acgtgtatca ctgcctgatt
     8401 ggaaacccca cttttccttt ctaatccagc acaatatcaa actgtgattc tataacttgt
     8461 ctttttaata gctacaaata acccaacatc tttttttttt tttatggaaa acttttcttt
     8521 ttagcactaa ctgcaaagtg cttagcaaaa ggttccttct ggataacaga gcactgctat
     8581 tattattatt gctatcattg ttattcctcc ttcttcaact tgttggaaga cttgcccctc
     8641 caaacgagca tttccaaaag acagttttca gaaacttcac atttcaccta atgaaagctg
     8701 tgcatatgtt agtctgtgca ttaggtctct gctagtgtgt cccatgtcca tagcctccat
     8761 ggggtgatgc ccatctgcag atgttagaaa ccaccccatg gggacctggg agtagcatca
     8821 gtgtggttca ctttgggtag ctgggtactc acgtgtatat acttagattt gcatcattca
     8881 aacctcctct ctgcttttcc gcacgcactt ctagctcttc tgctatttta aaattcactg
     8941 ggttttggtg aacaccaaca taaatgtaag cgatgattgc tttcctgagc aggcgtgatt
     9001 tgttgtatgg ctgtttaagt tataaagttg ttctcatatt gtaggtgaat aaaatcttgc
     9061 tgtttttaaa ggtcactgta actcgagatt aaaatttctg gcacaatttt atgagtgttc
     9121 acttctgaag ctaataagac aatagagttt tctatgttac tctcactgta acatcgataa
     9181 agtgactttg aataaaagat ttctgttatt ttg
//
