LOCUS       NM_001007221            2722 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 22 (Adam22),
            transcript variant 2, mRNA.
ACCESSION   NM_001007221
VERSION     NM_001007221.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2722)
  AUTHORS   Xing,B., Lei,Z., Wang,Z., Wang,Q., Jiang,Q., Zhang,Z., Liu,X.,
            Qi,Y., Li,S., Guo,X., Liu,Y., Li,X., Shu,K., Zhang,H.,
            Bartsch,J.W., Nimsky,C., Huang,Y. and Lei,T.
  TITLE     A disintegrin and metalloproteinase 22 activates integrin beta1
            through its disintegrin domain to promote the progression of
            pituitary adenoma
  JOURNAL   Neuro Oncol 26 (1), 137-152 (2024)
   PUBMED   37555799
  REMARK    GeneRIF: A disintegrin and metalloproteinase 22 activates integrin
            beta1 through its disintegrin domain to promote the progression of
            pituitary adenoma.
REFERENCE   2  (bases 1 to 2722)
  AUTHORS   Yokoi,N., Fukata,Y., Okatsu,K., Yamagata,A., Liu,Y., Sanbo,M.,
            Miyazaki,Y., Goto,T., Abe,M., Kassai,H., Sakimura,K., Meijer,D.,
            Hirabayashi,M., Fukai,S. and Fukata,M.
  TITLE     14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure
            thresholds in mice
  JOURNAL   Cell Rep 37 (11), 110107 (2021)
   PUBMED   34910912
REFERENCE   3  (bases 1 to 2722)
  AUTHORS   Fukata,Y., Chen,X., Chiken,S., Hirano,Y., Yamagata,A., Inahashi,H.,
            Sanbo,M., Sano,H., Goto,T., Hirabayashi,M., Kornau,H.C., Pruss,H.,
            Nambu,A., Fukai,S., Nicoll,R.A. and Fukata,M.
  TITLE     LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for
            synaptic transmission and epilepsy prevention
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33397806
  REMARK    GeneRIF: LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment
            for synaptic transmission and epilepsy prevention.
REFERENCE   4  (bases 1 to 2722)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 2722)
  AUTHORS   Zhang,S.M., Jiang,L., Zhao,X., Liu,J.F., Liang,B., Liu,C., Liu,N.
            and Ma,C.S.
  TITLE     A disintegrin and metalloprotease 22 accelerates neointima
            formation by activating ERK signaling
  JOURNAL   Atherosclerosis 283, 92-99 (2019)
   PUBMED   30822685
REFERENCE   6  (bases 1 to 2722)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 2722)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   8  (bases 1 to 2722)
  AUTHORS   Fukata,Y., Adesnik,H., Iwanaga,T., Bredt,D.S., Nicoll,R.A. and
            Fukata,M.
  TITLE     Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate
            synaptic transmission
  JOURNAL   Science 313 (5794), 1792-1795 (2006)
   PUBMED   16990550
REFERENCE   9  (bases 1 to 2722)
  AUTHORS   Sagane,K., Hayakawa,K., Kai,J., Hirohashi,T., Takahashi,E.,
            Miyamoto,N., Ino,M., Oki,T., Yamazaki,K. and Nagasu,T.
  TITLE     Ataxia and peripheral nerve hypomyelination in ADAM22-deficient
            mice
  JOURNAL   BMC Neurosci 6, 33 (2005)
   PUBMED   15876356
  REMARK    GeneRIF: ADAM22 is closely involved in the correct functioning of
            the nervous system.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2722)
  AUTHORS   Sagane,K., Yamazaki,K., Mizui,Y. and Tanaka,I.
  TITLE     Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
  JOURNAL   Gene 236 (1), 79-86 (1999)
   PUBMED   10433968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC152165.2, AC156022.2 and
            AC140364.4.
            
            On Mar 15, 2023 this sequence version replaced NM_001007221.3.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature, functional protein.
            The protein encoded by this gene is believed to lack
            metalloproteinase activity due to the lack of a critical catalytic
            motif. Mice lacking the encoded protein exhibit severe ataxia,
            hypomyelination and premature death. Alternative splicing results
            in multiple transcript variants encoding different isoforms, some
            of which may undergo similar processing. [provided by RefSeq, May
            2016].
            
            Transcript Variant: This variant (2, also known as beta or A05)
            lacks an alternate in-frame exon in the 3' coding region, compared
            to variant 1. The encoded isoform (b) is shorter than isoform a.
            This isoform (b) may undergo protein processing similar to isoform
            5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AC152165.2         176236-176494
            260-420             AC152165.2         177009-177169
            421-497             AC156022.2         28131-28207
            498-564             AC156022.2         125511-125577
            565-647             AC140364.4         203913-203995       c
            648-711             AC140364.4         197322-197385       c
            712-781             AC140364.4         195413-195482       c
            782-852             AC140364.4         188965-189035       c
            853-927             AC140364.4         185794-185868       c
            928-999             AC140364.4         183041-183112       c
            1000-1166           AC140364.4         182139-182305       c
            1167-1251           AC140364.4         180807-180891       c
            1252-1342           AC140364.4         179628-179718       c
            1343-1394           AC140364.4         178305-178356       c
            1395-1494           AC140364.4         173392-173491       c
            1495-1566           AC140364.4         171399-171470       c
            1567-1659           AC140364.4         171098-171190       c
            1660-1740           AC140364.4         168985-169065       c
            1741-1791           AC140364.4         167071-167121       c
            1792-1855           AC140364.4         166795-166858       c
            1856-1961           AC140364.4         163913-164018       c
            1962-2081           AC140364.4         157634-157753       c
            2082-2250           AC140364.4         154175-154343       c
            2251-2365           AC140364.4         153131-153245       c
            2366-2456           AC140364.4         148481-148571       c
            2457-2474           AC140364.4         143588-143605       c
            2475-2575           AC140364.4         129317-129417       c
            2576-2722           AC140364.4         128846-128992       c
FEATURES             Location/Qualifiers
     source          1..2722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.39 cM"
     gene            1..2722
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /note="a disintegrin and metallopeptidase domain 22"
                     /db_xref="GeneID:11496"
                     /db_xref="MGI:MGI:1340046"
     exon            1..259
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2646
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; disintegrin and metalloproteinase
                     domain-containing protein 22; a disintegrin and
                     metalloprotease domain (ADAM) 22"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 22 isoform b precursor"
                     /protein_id="NP_001007222.1"
                     /db_xref="GeneID:11496"
                     /db_xref="MGI:MGI:1340046"
                     /translation="MQAAAAASFWLLCVLGTCPLARCGRAGVASLKGLERGKENRFLE
                     RQSIIPLRLIYRLGGEDETQHNQLDTRVRGDPGGPQLTHVDKASFRVDAFGTSFVLDV
                     LLNHELLSSGYVERQIEHGGKVVENKGGEHCYYQGQIRGNPVSFVALSTCHGLHGMFY
                     DGNHTYLIEPEENEKSQESSHCHSVYKSRQFEFPLDDLPSEFQRVNITPPQFILKPRL
                     KRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYK
                     DQLKTRIVLVAMETWAADNKFAISENPLITLREFMKYRRDFIKEKADAVHLFSGSQFE
                     SSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNVGIISDKRKLASGECKC
                     EDTWSGCIMGDTGYYLPKKFTQCNVEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFI
                     ETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDC
                     DIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRY
                     CYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLV
                     VQQGRTLNCSGAHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCSSSKA
                     GTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGII
                     AGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQ
                     GNMGGNKKKIRGKRFRPRSNSTE"
     exon            260..420
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..497
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..564
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..647
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..711
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..781
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..852
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..927
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..999
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1166
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1251
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1342
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1394
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1494
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1566
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1659
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1740
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1791
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1855
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1961
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2081
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2250
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2365
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2456
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2474
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2575
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2722
                     /gene="Adam22"
                     /gene_synonym="2900022I03Rik; MDC2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccacttagc tacaggctgg cgcccgaagc ggcgctcgct cgctgccccc gccaccgaag
       61 cgctcgccag gcacaatgca gcactgaggc cacggaggct gcggtagcgg ctcgagctgg
      121 gaaggggcgg ttgggaggcc gagccccagg cccgggcaag agcagctgag cgccgccacc
      181 atgcaggcag cggcggccgc gtccttctgg ctgctctgcg tcttggggac ctgccccctg
      241 gcgcgctgcg gtcgggcagg agtcgcctca ctgaaaggac tggagagggg gaaagaaaac
      301 cgcttcctgg agcgccagag catcatacca ctgcgcctca tctatcgctt gggcggcgag
      361 gatgaaactc agcacaacca gctcgacacg cgggtgcggg gcgaccctgg cggaccgcag
      421 ctgacgcatg tggacaaggc aagcttccgg gtggacgcct ttggaacctc tttcgttctc
      481 gacgtcctgc tgaaccacga gttgctgtcg tcaggttatg tagagagaca gattgaacat
      541 ggaggcaagg tcgtggagaa caaaggagga gaacactgtt attaccaggg ccagattcga
      601 ggaaaccctg tctcatttgt tgccctatca acatgccatg gactccatgg gatgttctat
      661 gatggaaacc acacatatct cattgagcca gaagaaaatg agaagtctca agagtcgtct
      721 cattgtcact ccgtgtacaa atccagacag tttgaatttc ccttggatga ccttccgtct
      781 gaatttcaac gcgtaaacat tactccccct cagtttattt tgaagccaag actaaagagg
      841 agaaaaagac agcttcttcg atttcctcgg aatgtagagg aggaaaccaa atacatcgaa
      901 ctgatgattg tgaatgatca tctcatgttt aaaaagcacc ggctttctgt tgtatatact
      961 aatacctatg cgaagtctgt ggtgaacatg gcagatgtga tctataaaga ccaactgaaa
     1021 actaggattg tattggttgc catggaaacc tgggctgctg acaacaagtt tgccatatct
     1081 gaaaacccac tgattaccct tcgtgagttc atgaaataca ggagggattt tatcaaggag
     1141 aaggctgatg cagttcatct tttctcgggc agtcaatttg agagtagccg gagcggggca
     1201 gcttatattg gtgggatttg ctcgctgctg agaggaggag gcgtgaatga atttggaaaa
     1261 acggatttaa tggcagttac cctcgctcag tcactagccc acaatgtcgg tataatctct
     1321 gacaaaagaa aactagcaag tggtgagtgt aaatgtgagg acacctggtc cgggtgcata
     1381 atgggagaca ccggctacta tctcccgaaa aagttcactc agtgcaatgt cgaggaatat
     1441 catgacttcc tgaatagtgg tggaggtgcc tgcctgttca acaagccttc caagcttctt
     1501 gatcctcctg agtgtggaaa cggcttcatt gaaaccggag aggagtgtga ttgtggcacc
     1561 cctgcagaat gtgcccttga aggggcagag tgttgtaaga aatgcacctt gacccaggat
     1621 tctcaatgca gtgatggcct ttgttgtaaa aagtgcaagt ttcagcctct ggggaccgtg
     1681 tgccgagagg cagtgaacga ctgtgacatt cgtgaaatat gttcaggaaa ttcgagccag
     1741 tgtgccccca atgtgcataa aatggatgga tattcgtgtg atggtactca gggaatttgc
     1801 tttggaggaa gatgtaaaac cagagataga caatgcaaat acatctgggg gcaaaaggta
     1861 acagcatctg acaggtactg ctatgagaaa ctgaacattg aggggacgga gaagggtaac
     1921 tgtgggaaag acaaggacac gtggacacag tgcaacaaac gggatgtact ttgtggttac
     1981 ctcctgtgca caaacattgg caacatccca aggctcgggg agcttgatgg tgagatcaca
     2041 tccacattag ttgtgcagca aggaagaaca ttaaactgca gtggcgcgca tgttaaactt
     2101 gaagaagatg tggatcttgg ctatgtggaa gatgggacgc cctgtggccc tcagatgatg
     2161 tgcttggaac acaggtgtct tcctgtggct tccttcaact tcagtacttg ctccagcagt
     2221 aaagcaggca ccgtgtgctc aggaaatgga gtttgcagca atgagctcaa gtgtgtgtgc
     2281 aacaggcact ggacaggggc tgactgcggc acccactttc ctcacaatga tgatgcaaag
     2341 actggcatca ccctgtctgg caatggtgtt gctggcacta atatcataat aggaataatt
     2401 gccggcacca ttttagtgct ggccctcatc ttaggaataa ctgcctgggg ttataaaaac
     2461 taccgagaac agaggtcaaa tggactctct cattcttgga gtgaaaggat tccagacaca
     2521 aaacatattt cagacatctg tgaaaatggg agacctcgca gtaactcctg gcaaggtaac
     2581 atgggaggca acaaaaagaa aatcagaggg aaaagattta gacctcgatc taactcaact
     2641 gagtaagttg tacctttaat gggaaaggtt ctgtgtattt agtgttaaat aatcagagag
     2701 tcaaagaatc ccttccatgc ct
//
