LOCUS       NM_020330               2920 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 21 (Adam21),
            mRNA.
ACCESSION   NM_020330
VERSION     NM_020330.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Chen,Y., Liu,C., Shang,Y., Wang,L., Li,W. and Li,G.
  TITLE     Adam21 is dispensable for reproductive processes in mice
  JOURNAL   PeerJ 9, e12210 (2021)
   PUBMED   34631320
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Yi,C., Woo,J.M., Han,C., Oh,J.S., Park,I., Lee,B., Jin,S., Choi,H.,
            Kwon,J.T., Cho,B.N., Kim,D.H. and Cho,C.
  TITLE     Expression analysis of the Adam21 gene in mouse testis
  JOURNAL   Gene Expr Patterns 10 (2-3), 152-158 (2010)
   PUBMED   20117247
  REMARK    GeneRIF: Adam21 gene produces two types of transcripts with
            different cellular localization in the mouse testis, and the
            production of these alternate transcripts is due to utilization of
            cell-type-specific promoters.
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Vincent,A.J., Lau,P.W. and Roskams,A.J.
  TITLE     SPARC is expressed by macroglia and microglia in the developing and
            mature nervous system
  JOURNAL   Dev Dyn 237 (5), 1449-1462 (2008)
   PUBMED   18366138
REFERENCE   4  (bases 1 to 2920)
  AUTHORS   Masinde,G.L., Li,R., Nguyen,B., Yu,H., Srivastava,A.K.,
            Edderkaoui,B., Wergedal,J.E., Baylink,D.J. and Mohan,S.
  TITLE     New quantitative trait loci that regulate wound healing in an
            intercross progeny from DBA/1J and 129 x 1/SvJ inbred strains of
            mice
  JOURNAL   Funct Integr Genomics 6 (2), 157-163 (2006)
   PUBMED   16208538
REFERENCE   5  (bases 1 to 2920)
  AUTHORS   Yang,P., Baker,K.A. and Hagg,T.
  TITLE     A disintegrin and metalloprotease 21 (ADAM21) is associated with
            neurogenesis and axonal growth in developing and adult rodent CNS
  JOURNAL   J Comp Neurol 490 (2), 163-179 (2005)
   PUBMED   16052496
REFERENCE   6  (bases 1 to 2920)
  AUTHORS   Liu,L. and Smith,J.W.
  TITLE     Identification of ADAM 31: a protein expressed in Leydig cells and
            specialized epithelia
  JOURNAL   Endocrinology 141 (6), 2033-2042 (2000)
   PUBMED   10830287
REFERENCE   7  (bases 1 to 2920)
  AUTHORS   Seldin,M.F., Hirohata,S. and Apte,S.S.
  TITLE     Chromosomal mapping of Adam9, Adam15 and Adam21
  JOURNAL   Matrix Biol 19 (2), 185-187 (2000)
   PUBMED   10842103
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK014827.2 and AV268091.1.
            
            On May 13, 2016 this sequence version replaced NM_020330.4.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature, functional
            metalloprotease enzyme. The encoded protein functions in the
            regulation of spermatogenesis in the testes and neurogenesis in the
            central nervous system. [provided by RefSeq, May 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014827.2, BY714350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2911              AK014827.2         2-2912
            2912-2920           AV268091.1         260-268
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 37.79 cM"
     gene            1..2920
                     /gene="Adam21"
                     /gene_synonym="Adam31"
                     /note="a disintegrin and metallopeptidase domain 21"
                     /db_xref="GeneID:56622"
                     /db_xref="MGI:MGI:1861229"
     exon            1..383
                     /gene="Adam21"
                     /gene_synonym="Adam31"
                     /inference="alignment:Splign:2.1.0"
     exon            384..2920
                     /gene="Adam21"
                     /gene_synonym="Adam31"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..2698
                     /gene="Adam21"
                     /gene_synonym="Adam31"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 21; disintegrin and metalloproteinase
                     domain-containing protein 31; a disintegrin and
                     metalloprotease domain (ADAM) 21"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 21 preproprotein"
                     /protein_id="NP_065063.1"
                     /db_xref="CCDS:CCDS26022.1"
                     /db_xref="GeneID:56622"
                     /db_xref="MGI:MGI:1861229"
                     /translation="MECFIMLGADARTLMRVTLLLLWLKALPSLIDLSQTGSTQYLSS
                     PEVVIPLKVTSRARGAKNSEWLSYSLVFGGRRHVVHMRVKKLLVSTHIPVLTYTEEHT
                     PLSDYPFVPSDCYYHGYVEGALESLVAFSACNGGLQGVLQMNGFSYEIEPIKHSSTFE
                     HLVYTLNNNKTQFPPMLCSLTEKRLLYQPFGVEEAKKSAMKQNYGKLWPHMWFLELAV
                     VVDYGFFTNAQQNLSKVRGDVVLVVNMVDSMYKPLDTYVTLVGIEIWNRGNVLPMENI
                     HQVLEDFSHWKQISLSQVHHDAAHIFIRSSLISVLGIAYIAGICRPPLDCGVENFQGD
                     AWSLFANTVAHELGHTFGMKHDEESCSCGKSGCVMSTFRVPAERFTNCSYSDFMKTTL
                     NQGTCLYNHPRPGAGFLVKRCGNGMVESEEECDCGSVQECEQDPCCFLNCTLRPAAAC
                     SFGLCCKDCKFMLLGELCRPKINECDLPEWCNGTSHQCPEDGYVQDGVPCGAGAYCYQ
                     KQCNNHDQQCREIFGKGARSASHNCYKEINLQGNRFGHCGTDGTVFLKCRMSDVFCGK
                     VHCENVEDIHHPQAPYVLQNIYANGITCWSTGHCLGMGVPDVGEVKDGTTCGVGKICL
                     HKKCVSLSVLSNACLPETCNRKGVCNNKHHCHCDYGWSPPFCLHRGYGGSIDSGPTSQ
                     KRRVIITVLSITVPVLSILICLLIAGLYRIYCKIPSGPKETKASSPG"
ORIGIN      
        1 agaagaagag agtctagagt tgggtgctct ctatgatttt gacttttaaa ataattttat
       61 gggtttgttg ttgttgttgt tgttgaactg tagatccaac ccagagcatt gggcttgcta
      121 ggcaaatact ttgccactga gctaaatctc tagagttggc tatttatata gaagtgaaag
      181 atctttgttg ctaagcaact aaatctagaa tttagctgtg aagtagacaa agggggtaag
      241 agaggggctt gatttcttcg ttcggtatag ctacaactgt aaacttctgt ttactgataa
      301 ggatcgtgcc aaccatctga caaaaggggc cagacaacaa ctgttttctg ctgatatgtc
      361 actcatccag tttaactctc cgtcactgca actctgatgc tcaggctctg ccaggacaca
      421 atctcgacat ggcagcacta ttccctggcc tgctccaggg gaagagccag gacagaagtg
      481 tctcataccc tgtctttatc agctctggat ggagtgcttc ataatgttag gtgcagatgc
      541 tagaacactc atgagagtca ctcttttgct gctctggctt aaggcacttc catcccttat
      601 tgacctctca cagactgggt ccactcaata cctcagttct ccagaagtag ttatccctct
      661 gaaggtgacc agcagggcca ggggtgcaaa gaattcagag tggctctcct atagccttgt
      721 atttggtggc cgtagacatg ttgtccatat gcgagtcaag aagctgttgg tttctactca
      781 catccctgta ctcacctaca cagaggaaca cacccccctc agcgattacc cctttgtccc
      841 tagtgactgt tactatcatg gttatgtaga gggagccctt gagtctttag ttgctttcag
      901 tgcctgcaat ggggggttgc agggagtgtt acaaatgaat ggcttctctt atgaaattga
      961 acctatcaag cactctagca cattcgagca cctagtctat acattaaata ataacaagac
     1021 acaatttcca cctatgctat gtagtttaac ggagaagaga ctactgtacc aaccctttgg
     1081 agttgaagag gctaagaagt cagctatgaa gcaaaattat ggaaaactgt ggccccacat
     1141 gtggtttctg gagctggctg tagtggtaga ctatggtttc ttcactaacg ctcaacaaaa
     1201 cttgtcaaag gtacgaggag atgtggttct tgttgttaac atggtagatt ccatgtacaa
     1261 gccgctggat acttatgtga ctttggttgg catcgagatt tggaatcgag gaaatgttct
     1321 cccaatggaa aacatacatc aggtcttaga agatttttct cattggaaac aaatcagtct
     1381 ttctcaggta catcatgatg cagcccatat cttcattaga agctcactta taagtgtact
     1441 tggtatagcc tacattgcag gaatatgtcg tcctcctctt gattgtggag ttgaaaattt
     1501 ccaaggggac gcctggtctc tttttgccaa cacggtggcc catgagttag gccatacttt
     1561 tggtatgaag catgatgagg aatcctgctc ttgtgggaaa agtggttgtg tcatgagtac
     1621 tttcagagtg ccagcagaga gattcaccaa ttgcagctat agtgatttta tgaagaccac
     1681 tttaaaccaa ggaacttgtc tgtacaatca tccaagacca ggggcaggtt tcctggtgaa
     1741 gcgctgtggg aatggtatgg ttgaaagtga agaagagtgt gactgtggat ctgtacagga
     1801 atgtgagcaa gatccctgtt gttttcttaa ctgtacgctg agacctgcag ctgcttgtag
     1861 ttttgggctc tgttgcaaag actgcaaatt catgctcttg ggggaactct gtagaccaaa
     1921 gatcaatgaa tgtgaccttc cagaatggtg caatggaaca tctcaccagt gcccagaaga
     1981 tggatatgta caggatgggg tcccctgtgg tgccggtgcc tactgctatc aaaagcagtg
     2041 taataaccat gaccaacagt gcagggagat ttttggcaaa ggtgcaagaa gcgcatctca
     2101 taattgctat aaagaaatca acttacaagg aaacaggttt ggccattgtg gcacagatgg
     2161 cacagtattc ctaaaatgca gaatgtcaga tgtgttttgt gggaaagtcc actgtgaaaa
     2221 tgtagaagac attcaccatc cccaggctcc ttatgttttg cagaacattt atgccaatgg
     2281 tatcacctgc tggagtactg gccattgttt ggggatgggt gtgcctgatg ttggtgaagt
     2341 gaaagatggc accacctgtg gagtaggaaa gatctgccta cacaagaagt gtgtcagtct
     2401 gtctgtcctt tcaaatgctt gccttcctga gacttgtaat aggaaggggg tctgtaataa
     2461 caagcatcac tgtcactgtg actatgggtg gtccccgcct ttctgcctgc acagaggtta
     2521 tggaggtagt attgacagtg gtccaacatc tcaaaaaaga agagtcatta tcactgtcct
     2581 gtcaataact gtgcctgttt tatccatcct aatttgtctg ctcatagctg ggctttatag
     2641 aatatattgt aaaatacctt ctggtcccaa agagactaag gcctcttcac caggttagga
     2701 agacatatag cttaatagcc gcctatgcac taagtttggc aacaacaata ttactgtatg
     2761 tatgaatctg ggcatatttc tgagagttta caggaagatg aaagtatctc cctcttcatc
     2821 tgtatcagaa atattgtcac caggcacagg taattcttaa tgtgttcttg gctgttattt
     2881 attctcttaa gcagcaaata aagtgtaatt gagaaatgat
//
