LOCUS       NM_001009548            2589 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 20 (Adam20),
            mRNA.
ACCESSION   NM_001009548 XM_357873
VERSION     NM_001009548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2589)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2589)
  AUTHORS   Nandadasa,S., Kraft,C.M., Wang,L.W., O'Donnell,A., Patel,R.,
            Gee,H.Y., Grobe,K., Cox,T.C., Hildebrandt,F. and Apte,S.S.
  TITLE     Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical
            role in ciliary vesicle growth during ciliogenesis
  JOURNAL   Nat Commun 10 (1), 953 (2019)
   PUBMED   30814516
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2589)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2589)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133113.1.
            
            On Nov 15, 2007 this sequence version replaced NM_001009548.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133113.1, AK015933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2548              AK133113.1         2-2549
            2549-2589           AK133113.1         2551-2591
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..2589
                     /gene="Adam20"
                     /gene_synonym="4930529F22Rik; Adam38"
                     /note="a disintegrin and metallopeptidase domain 20"
                     /db_xref="GeneID:384806"
                     /db_xref="MGI:MGI:2152342"
     exon            1..81
                     /gene="Adam20"
                     /gene_synonym="4930529F22Rik; Adam38"
                     /inference="alignment:Splign:2.1.0"
     exon            82..2589
                     /gene="Adam20"
                     /gene_synonym="4930529F22Rik; Adam38"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2423
                     /gene="Adam20"
                     /gene_synonym="4930529F22Rik; Adam38"
                     /codon_start=1
                     /product="testase-8"
                     /protein_id="NP_001009548.1"
                     /db_xref="CCDS:CCDS40325.1"
                     /db_xref="GeneID:384806"
                     /db_xref="MGI:MGI:2152342"
                     /translation="MQTTQRASSFAAAEDNIAMDKAVVYTRIPHLYVWLEILNILSSR
                     PLTGYAQHTSLPEVVIPLRVTGNRPMWAMGWLTYSLHFGGQKHFIHIKAKKFLVSRLF
                     SVFTYTKQGALHKDQPYVQNDCYYHGHMDGDPESMVAITTCYGGFQGILQINGTVYEI
                     KPKNLSSTFEHLVHKMDSEETELLPMRCALTEEIAKQMKRQQNENPTLMQNHYEEWWT
                     HRSFLDLALVVDCERIRYHNNNKSHVLVEVFLIISLINKIYFALDIEVVLIGLELWNE
                     GNLVPVDRMQILLEEFCVWKTLSLNIRIPNDIAHLFVNHSFGKFLGLAYVGTVCLPSH
                     NCGVDRLLGPNLFQFAHIIAHEIGHNLGMEHDSSSCTCGGINYCLMSSTYSFNPEFSN
                     CSYSNFWTTYATTNCLRKEKMSIGNLQIQFCGNGVVDDGEQCDCGDRHMCERDQCCNS
                     RCALNDGAACAFGLCCLYCQIMPAGTVCREEVNECDLPEWCNGHSHKCPNDVYLLDGS
                     PCRDGGYCYEKRCNNRDEQCKQIFGKEARSADHSCYRELNTQGDRFGNCGMIRDAYLR
                     CHDSDILCGRVQCENVTRIPFLRDHSTVHWTHLNGVTCWGTDYHFGMTIPDIGIVKDG
                     TDCGPEHVCINKKCVSKPIWLEQCSSKTCTMKGVCNNLHHCHCNRGWDPPHCLESGFG
                     GSVDSGPPPGEEESQQHMDLVLITPILSIVSLVFLLPWLLNRYIRTSSKFEEPTVSTS
                     KEEEESHVASNESEAQQVET"
     regulatory      2561..2566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam20"
                     /gene_synonym="4930529F22Rik; Adam38"
                     /note="hexamer: AATAAA"
     polyA_site      2587
                     /gene="Adam20"
                     /gene_synonym="4930529F22Rik; Adam38"
                     /note="major polyA site"
ORIGIN      
        1 acaagaaaaa tctaccctgc agatgtgaca tgaagcagct atcattagac aaggtcctgg
       61 acattctcac ttcacttgct atcctgctac tctaatgcat caactcagtc agaagacaga
      121 ccattaaaag ccagcactgc atgcagacaa cacaaagggc atcctccttt gctgccgcag
      181 aggacaacat agctatggat aaggctgtgg tatacacaag gatacctcat ctgtacgtct
      241 ggctagagat attgaatatt ctttcatcac ggcccttgac tgggtatgct cagcacacca
      301 gcctcccaga agtagtgata cccttacggg tcacaggcaa cagaccaatg tgggctatgg
      361 gatggctgac ctatagcctg cattttgggg gccagaaaca ttttattcac ataaaggcca
      421 agaagttctt ggtttctaga ctcttctctg tattcaccta cactaagcaa ggtgctctgc
      481 acaaggacca gccttatgtc cagaatgatt gctactacca tggccatatg gatggagacc
      541 cagagtctat ggttgctatt accacctgtt atggaggctt tcaaggaata ttacagataa
      601 atggcacagt ctatgaaatc aaacccaaga acctttcttc cacatttgaa catttggttc
      661 acaagatgga cagtgaggag acagaattac tccccatgag atgtgcattg acagaagaga
      721 tagcaaagca aatgaaacgt cagcagaatg agaaccccac tctgatgcaa aaccactatg
      781 aggaatggtg gacccacagg agttttcttg acctggcatt ggttgttgac tgtgagcgaa
      841 ttcgttatca taacaataac aaatcacacg tgttagtgga agtattcttg attatcagtt
      901 taataaataa gatttatttt gcactggata ttgaggtagt tttaattgga cttgagttgt
      961 ggaatgaagg aaatcttgtg cccgtggata gaatgcaaat tcttctagag gaattttgtg
     1021 tttggaagac tctcagcctt aatattcgaa ttccaaatga cattgcacat ctttttgtga
     1081 atcattcatt tggtaaattc cttggtttag cctatgttgg tactgtctgt ctgccatctc
     1141 ataattgtgg agttgatcgt ctgttaggtc ctaatctttt tcaatttgca catattatag
     1201 cacatgagat tggtcataat ctgggtatgg agcatgatag cagctcatgt acatgtggag
     1261 gaataaatta ttgcttaatg tcttcaacgt acagtttcaa ccccgagttc agtaactgta
     1321 gttattctaa cttctggaca acatatgcta ctaccaattg tttgcgcaag gaaaagatgt
     1381 caataggcaa cctacaaatc cagttctgtg ggaatggagt tgttgacgat ggagaacagt
     1441 gtgattgtgg agacaggcat atgtgtgaaa gagatcaatg ttgtaactcc aggtgtgccc
     1501 ttaatgatgg cgctgcctgt gcttttgggc tttgctgctt atattgccag atcatgccag
     1561 caggcacagt ttgccgagaa gaggtcaatg aatgtgatct tccagaatgg tgcaacggac
     1621 attcacataa gtgtcctaat gacgtttatt tgcttgatgg gagtccctgt agagatggtg
     1681 gctactgcta tgagaagaga tgtaataacc gagatgaaca atgtaagcaa atcttcggca
     1741 aagaagccag gagtgcagat cacagttgct acagagaact caacacccaa ggtgaccgtt
     1801 ttggcaactg tggtatgatc agagatgcat acttaagatg tcatgactca gacatcctct
     1861 gtggcagagt tcaatgtgag aacgtaacac gcattccatt tttgagggac cattccactg
     1921 tacactggac tcacctcaat ggtgtcacct gttgggggac tgactaccat tttgggatga
     1981 caatccctga cattggtatt gtgaaagatg gcacagactg tggtccagag catgtgtgta
     2041 ttaataagaa gtgtgttagt aagccaattt ggctagaaca gtgttcatcc aagacatgta
     2101 ctatgaaagg tgtgtgcaac aatttacatc actgccactg caaccggggg tgggacccac
     2161 cacattgcct ggaaagtggc tttggaggga gtgttgacag tggccctcca cctggagaag
     2221 aggaatccca gcaacatatg gacctggtac tgattactcc aattctttcc attgtttcct
     2281 tagtctttct gttaccttgg cttttgaata ggtatataag aacatcatca aagtttgagg
     2341 aacccactgt ttccacttcc aaggaggaag aagagagcca tgtggcaagt aatgagtcag
     2401 aagcgcaaca ggttgaaaca tgaaaagtaa tacattatac accttcatgc attaccacat
     2461 atcatcttgg catatgtagc attgcatgtt ttaaaattaa ctggcacaaa gttctagaga
     2521 tatttaatat ttcagcatga aaaaaaaacc ctcagcattc aataaaagta taggtcctgg
     2581 tatataacc
//
