LOCUS       NM_009618               2594 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 2 (Adam2),
            mRNA.
ACCESSION   NM_009618
VERSION     NM_009618.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2594)
  AUTHORS   Shi B, Xue J, Zhou J, Kasowitz SD, Zhang Y, Liang G, Guan Y, Shi Q,
            Liu M, Sha J, Huang X and Wang PJ.
  TITLE     MORC2B is essential for meiotic progression and fertility
  JOURNAL   PLoS Genet 14 (1), e1007175 (2018)
   PUBMED   29329290
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2594)
  AUTHORS   Choi H, Jin S, Kwon JT, Kim J, Jeong J, Kim J, Jeon S, Park ZY,
            Jung KJ, Park K and Cho C.
  TITLE     Characterization of Mammalian ADAM2 and Its Absence from Human
            Sperm
  JOURNAL   PLoS One 11 (6), e0158321 (2016)
   PUBMED   27341348
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2594)
  AUTHORS   Choi H, Han C, Jin S, Kwon JT, Kim J, Jeong J, Kim J, Ham S, Jeon
            S, Yoo YJ and Cho C.
  TITLE     Reduced Fertility and Altered Epididymal and Sperm Integrity in
            Mice Lacking ADAM7
  JOURNAL   Biol Reprod 93 (3), 70 (2015)
   PUBMED   26246218
REFERENCE   4  (bases 1 to 2594)
  AUTHORS   Grayson P and Civetta A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol Biol 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2594)
  AUTHORS   Vidaeus CM, von Kapp-Herr C, Golden WL, Eddy RL, Shows TB and Herr
            JC.
  TITLE     Human fertilin beta: identification, characterization, and
            chromosomal mapping of an ADAM gene family member
  JOURNAL   Mol Reprod Dev 46 (3), 363-369 (1997)
   PUBMED   9041139
REFERENCE   6  (bases 1 to 2594)
  AUTHORS   Hardy CM and Holland MK.
  TITLE     Cloning and expression of recombinant rabbit fertilin
  JOURNAL   Mol Reprod Dev 45 (2), 107-116 (1996)
   PUBMED   8914066
REFERENCE   7  (bases 1 to 2594)
  AUTHORS   Gupta SK, Alves K, Palladino LO, Mark GE and Hollis GF.
  TITLE     Molecular cloning of the human fertilin beta subunit
  JOURNAL   Biochem Biophys Res Commun 224 (2), 318-326 (1996)
   PUBMED   8702389
REFERENCE   8  (bases 1 to 2594)
  AUTHORS   Cho C, Primakoff P, White JM and Myles DG.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   9  (bases 1 to 2594)
  AUTHORS   Evans JP, Schultz RM and Kopf GS.
  TITLE     Mouse sperm-egg plasma membrane interactions: analysis of roles of
            egg integrins and the mouse sperm homologue of PH-30 (fertilin)
            beta
  JOURNAL   J Cell Sci 108 (Pt 10), 3267-3278 (1995)
   PUBMED   7593287
REFERENCE   10 (bases 1 to 2594)
  AUTHORS   Wolfsberg TG, Straight PD, Gerena RL, Huovila AP, Primakoff P,
            Myles DG and White JM.
  TITLE     ADAM, a widely distributed and developmentally regulated gene
            family encoding membrane proteins with a disintegrin and
            metalloprotease domain
  JOURNAL   Dev Biol 169 (1), 378-383 (1995)
   PUBMED   7750654
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY094547.1, AK016550.1 and
            AC126444.3.
            
            [WARNING] On Apr 13, 2023 this sequence was replaced by
            NM_009618.4.
            
            On May 6, 2016 this sequence version replaced NM_009618.2.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. This gene is predominantly expressed in the
            epididymis, where the encoded preproprotein undergoes proteolytic
            processing to generate a mature, functional protein. Male mice
            lacking the encoded protein are infertile and exhibit multiple
            defects in reproduction. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161266.1, AK016550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY094547.1         2-37
            37-2583             AK016550.1         1-2547
            2584-2594           AC126444.3         126756-126766       c
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.36 cM"
     gene            1..2594
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /note="a disintegrin and metallopeptidase domain 2"
                     /db_xref="GeneID:11495"
                     /db_xref="MGI:MGI:1340894"
     exon            1..120
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2255
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /note="a disintegrin and metalloprotease domain 2
                     (fertilin beta); disintegrin and metalloproteinase
                     domain-containing protein 2; fertilin subunit beta"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 2 preproprotein"
                     /protein_id="NP_033748.2"
                     /db_xref="CCDS:CCDS36959.1"
                     /db_xref="GeneID:11495"
                     /db_xref="MGI:MGI:1340894"
                     /translation="MWLILLLLSGLSELGGLSQSQTEGTREKLHVQVTVPEKIRSVTS
                     NGYETQVTYNLKIEGKTYTLDLMQKPFLPPNFRVYSYDNAGIMRSLEQKFQNICYFQG
                     YIEGYPNSMVIVSTCTGLRGFLQFGNVSYGIEPLESSSGFEHVIYQVEPEKGGALLYA
                     EKDIDLRDSQYKIRSIKPQRIVSHYLEIHIVVEKQMFEHIGADTAIVTQKIFQLIGLA
                     NAIFAPFNLTVILSSLEFWMDENKILTTGDANKLLYRFLKWKQSYLVLRPHDMAFLLV
                     YRNTTDYVGATYQGKMCDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGLAYDDVNK
                     CQCGVPVCVMNPEAPHSSGVRAFSNCSMEDFSKFITSQSSHCLQNQPRLQPSYKMAVC
                     GNGEVEEDEICDCGKKGCAEMPPPCCNPDTCKLSDGSECSSGICCNSCKLKRKGEVCR
                     LAQDECDVTEYCNGTSEVCEDFFVQNGHPCDNRKWICINGTCQSGEQQCQDLFGIDAG
                     FGSSECFWELNSKSDISGSCGISAGGYKECPPNDRMCGKIICKYQSENILKLRSATVI
                     YANISGHVCVSLEYPQGHNESQKMWVRDGTVCGSNKVCQNQKCVADTFLGYDCNLEKC
                     NHHGVCNNKKNCHCDPTYLPPDCKRMKDSYPGGSIDSGNKERAEPIPVRPYIASAYRS
                     KSPRWPFFLIIPFYVVILVLIGMLVKVYSQRMKWRMDDFSSEEQFESESESKD"
     exon            121..197
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            198..253
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            254..332
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            333..409
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            410..578
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            579..635
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            636..707
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            708..874
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            875..956
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1093
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1271
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1370
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1563
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1669
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1853
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1931
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2061
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2221
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2280
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2594
                     /gene="Adam2"
                     /gene_synonym="Ftnb; Ph30-beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggccaa ctgccattcc ccggggcggg gtccaggagg ccaggccatg tggctcatct
       61 tgcttctact gagtgggctg agtgaacttg gcggccttag ccagtcccaa acagaaggca
      121 ctcgtgagaa attacacgtg caagtcacag tgccagagaa aatccggtcc gtcacaagca
      181 atggctacga aacacaggtg acctacaatc tcaaaatcga agggaaaaca tacaccttgg
      241 acctaatgca aaaaccgttc ttgcctccca actttagagt atacagttat gacaacgcag
      301 gaatcatgag gtctcttgag cagaagtttc agaatatctg ctacttccaa ggatacattg
      361 aaggttatcc aaattctatg gtgattgtta gcacatgtac tggactcagg ggttttctcc
      421 aatttggaaa cgttagctat ggaattgaac ctctggaatc ttccagtggt tttgaacacg
      481 tgatctacca agtggaacct gagaaaggag gtgcattact ctacgccgag aaggatatcg
      541 atttaagaga ctcgcagtat aagatacgaa gtatcaagcc acagcggatc gtctctcact
      601 atttggaaat acatattgtc gttgaaaagc aaatgtttga gcatatcggg gctgatacag
      661 ccattgtcac tcaaaagatt ttccagttga ttggactggc aaatgctatc tttgccccct
      721 ttaatcttac agtaattctg tcttccctgg aattttggat ggatgaaaac aaaatcttga
      781 ccacaggcga tgctaacaag ttgctctaca ggttcctgaa gtggaaacag tcgtaccttg
      841 ttctgcgacc acatgatatg gcgtttttac tcgtctacag gaacactacc gattatgttg
      901 gcgctaccta tcaagggaag atgtgtgaca agaactatgc aggaggagtt gctttgcacc
      961 ccaaagccgt aactctggaa tcacttgcaa ttattttagt tcagctgctg agcctcagca
     1021 tggggctagc gtatgacgac gtgaacaagt gccagtgtgg cgtacctgtc tgcgtgatga
     1081 acccggaagc gcctcactcc agcggtgtcc gggccttcag taactgcagc atggaggact
     1141 tttccaagtt tatcacaagt caaagctccc actgtctgca gaaccagcca cggctacagc
     1201 catcttacaa gatggcggtc tgtgggaatg gagaggtgga agaagatgaa atttgcgact
     1261 gtggaaagaa gggctgtgca gaaatgcccc cgccatgctg taaccccgac acctgtaagc
     1321 tgtcagatgg ctccgagtgc tccagcggaa tatgctgcaa ctcgtgcaag ctgaagcgga
     1381 aaggggaggt ttgcaggctt gcccaagatg agtgtgatgt cacagagtac tgcaacggca
     1441 catccgaagt gtgtgaagac ttctttgttc aaaacggtca cccatgtgac aatcgcaagt
     1501 ggatctgtat taacggcacc tgtcagagtg gagaacagca gtgccaggat ctatttggca
     1561 tcgatgcagg ctttggttca agtgaatgtt tctgggagct gaattccaag agcgacatat
     1621 ctgggagctg tggaatctct gctgggggat acaaggaatg cccacctaat gaccggatgt
     1681 gtgggaaaat aatatgtaaa taccaaagtg aaaatatact aaaattgagg tctgccactg
     1741 ttatttatgc caatataagc gggcatgtct gcgtttccct ggaatatccc caaggtcata
     1801 atgagagcca gaagatgtgg gtgagagatg gaaccgtctg cgggtcaaat aaggtttgcc
     1861 agaatcaaaa atgtgtagca gacactttct tgggctatga ttgcaacctg gaaaaatgca
     1921 accaccatgg tgtatgtaat aacaagaaga actgccactg tgaccccaca tacttacctc
     1981 cagattgtaa aagaatgaaa gattcatatc ctggcgggag cattgatagt ggcaacaagg
     2041 aaagggctga acccatccct gtacggccct acattgcaag tgcttaccgc tccaagtctc
     2101 cacggtggcc atttttcttg atcatccctt tctacgttgt gatccttgtc ctgattggga
     2161 tgctggtaaa agtctattcc caaaggatga aatggagaat ggatgacttc tcaagcgaag
     2221 agcaatttga aagtgaaagt gaatccaaag actagtctgg acagattcca caatgtcaca
     2281 agtaattctc ttcagtggac agaaaaaaaa gtggaaaaga aaagcctatg cattatcttg
     2341 cctgaaagtc aagcctgcat atcgtggtct ccatcaggcc agaaatcata tctctccatt
     2401 acacatgtat gatacatatg tgtgtatatt attccataaa tgatttactt gtaagaaatg
     2461 aatgattatg aatttcatat tatactttga tattttaccc tatttctggt agtcggtagt
     2521 catcaattgt attttctagt aggtacatta tagaaaaggc tataagaaaa taaatgtggt
     2581 accatgactc aagt
//
