LOCUS       NM_172125               3340 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 1b (Adam1b),
            mRNA.
ACCESSION   NM_172125 XM_916081
VERSION     NM_172125.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3340)
  AUTHORS   Grayson,P. and Civetta,A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol Biol 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3340)
  AUTHORS   Kim,E., Yamashita,M., Nakanishi,T., Park,K.E., Kimura,M.,
            Kashiwabara,S. and Baba,T.
  TITLE     Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg
            plasma membrane and effect fertilization
  JOURNAL   J Biol Chem 281 (9), 5634-5639 (2006)
   PUBMED   16407235
  REMARK    GeneRIF: These results suggest that mouse ADAM1b/ADAM2 fertilin may
            play a crucial role not in the sperm/egg fusion but in the
            appearance of these two ADAMs on the sperm surface.
REFERENCE   3  (bases 1 to 3340)
  AUTHORS   Nishimura,H., Kim,E., Nakanishi,T. and Baba,T.
  TITLE     Possible function of the ADAM1a/ADAM2 Fertilin complex in the
            appearance of ADAM3 on the sperm surface
  JOURNAL   J Biol Chem 279 (33), 34957-34962 (2004)
   PUBMED   15194697
REFERENCE   4  (bases 1 to 3340)
  AUTHORS   Kim,E., Nishimura,H. and Baba,T.
  TITLE     Differential localization of ADAM1a and ADAM1b in the endoplasmic
            reticulum of testicular germ cells and on the surface of epididymal
            sperm
  JOURNAL   Biochem Biophys Res Commun 304 (2), 313-319 (2003)
   PUBMED   12711316
  REMARK    GeneRIF: Localization of ADAM1b in the endoplasmic reticulum of
            testicular germ cells and on the surface of epididymal sperm.
REFERENCE   5  (bases 1 to 3340)
  AUTHORS   Nishimura,H., Kim,E., Fujimori,T., Kashiwabara,S., Kuroiwa,A.,
            Matsuda,Y. and Baba,T.
  TITLE     The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin alpha)
            gene, are localized on mouse chromosome 5
  JOURNAL   Gene 291 (1-2), 67-76 (2002)
   PUBMED   12095680
REFERENCE   6  (bases 1 to 3340)
  AUTHORS   Zhu,G.Z., Lin,Y., Myles,D.G. and Primakoff,P.
  TITLE     Identification of four novel ADAMs with potential roles in
            spermatogenesis and fertilization
  JOURNAL   Gene 234 (2), 227-237 (1999)
   PUBMED   10395895
REFERENCE   7  (bases 1 to 3340)
  AUTHORS   Evans,J.P., Schultz,R.M. and Kopf,G.S.
  TITLE     Roles of the disintegrin domains of mouse fertilins alpha and beta
            in fertilization
  JOURNAL   Biol Reprod 59 (1), 145-152 (1998)
   PUBMED   9675005
REFERENCE   8  (bases 1 to 3340)
  AUTHORS   Cho,C., Turner,L., Primakoff,P. and Myles,D.G.
  TITLE     Genomic organization of the mouse fertilin beta gene that encodes
            an ADAM family protein active in sperm-egg fusion
  JOURNAL   Dev Genet 20 (4), 320-328 (1997)
   PUBMED   9254906
REFERENCE   9  (bases 1 to 3340)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   10 (bases 1 to 3340)
  AUTHORS   Wolfsberg,T.G., Straight,P.D., Gerena,R.L., Huovila,A.P.,
            Primakoff,P., Myles,D.G. and White,J.M.
  TITLE     ADAM, a widely distributed and developmentally regulated gene
            family encoding membrane proteins with a disintegrin and
            metalloprotease domain
  JOURNAL   Dev Biol 169 (1), 378-383 (1995)
   PUBMED   7750654
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016558.1, AC129215.3, BC140979.1 and BB679367.1.
            
            On Jun 26, 2019 this sequence version replaced NM_172125.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK016558.1, BC140979.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AK016558.1         2-115
            115-115             AC129215.3         136468-136468       c
            116-2333            AK016558.1         117-2334
            2334-2962           BC140979.1         1971-2599
            2963-3173           AK016558.1         2963-3173
            3174-3335           BB679367.1         288-449
            3336-3340           AC129215.3         133243-133247       c
FEATURES             Location/Qualifiers
     source          1..3340
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.83 cM"
     gene            1..3340
                     /gene="Adam1b"
                     /gene_synonym="Adam1; Ftna"
                     /note="a disintegrin and metallopeptidase domain 1b"
                     /db_xref="GeneID:280667"
                     /db_xref="MGI:MGI:2429506"
     exon            1..3340
                     /gene="Adam1b"
                     /gene_synonym="Adam1; Ftna"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..2876
                     /gene="Adam1b"
                     /gene_synonym="Adam1; Ftna"
                     /note="PH-30 alpha; disintegrin and metalloproteinase
                     domain-containing protein 1b; fertilin subunit alpha-b;
                     fertilin alpha; a disintegrin and metalloproteinase domain
                     1b"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 1b precursor"
                     /protein_id="NP_742123.2"
                     /db_xref="CCDS:CCDS19636.1"
                     /db_xref="GeneID:280667"
                     /db_xref="MGI:MGI:2429506"
                     /translation="MERLKLGKIPEHWCIRLVAMLLLAIIFLPSTFCDIGSVYNSSYE
                     TVIPERLPGKGGKDPGGKVSYMLLMQGQKQLLHLEVKGHYPENNFPVYSYHNGILRQE
                     MPLLSQDCHYEGYMEGVPGSFVSVNICSGLRGVLIKEETSYGIEPMLSSKNFEHVLYT
                     MEHQPVVSCSVTPKDSPGDTSHPPRSRKPDDLLVLTDWWSHTKYVEMFVVVNHQRFQM
                     WGSNINETVQAVMDIIALANSFTRGINTEVVLVGLEIWTEGDPIEVPVDLQTTLRNFN
                     FWRQEKLVGRVRHDVAHLIVGHRPGENEGQAFLRGACSGEFAAAVEAFHHEDVLLFAA
                     LMAHELGHNLGIQHDHPTCTCGPKHFCLMGEKIGKDSGFSNCSSDHFLRFLHDHRGVC
                     LLDEPGRQSRMRRAANCGNGVVEDLEQCDCGSDCDKSQCCDENCKLKGNSVCSTELCC
                     FKCNFKKEGDVCRPADGPCDLEEYCNGTSAACPSDRKAQDGSKCHESFLCFNGQCMDP
                     TFQCSRIFGHGSRSASDYCYTSLNSRGDQFGNCGSSSQFPKKYTKCSDKNVMCGKLIC
                     TEVAFLPQIQPNNLLLQVPETEDWCWSVAVFDMRDSLHEEYVKDNTYCGKDKVCKNSI
                     CEDFTPFSFPCSPSKQCNKHGVCNDLGNCHCSFGFAPPDCKEEGTGGSVDSGPAVNLS
                     NDSSPGPNSTQSSTEELILNLKLIVLAVILVLMILLIIICIISAYTKSETASEAGPSE
                     LEELPEGEKEEQEEVLPEEAKGEEEELEYGKEEAEEQGAVEEEGAEEANEEAAAEKKD
                     EDEEEGEE"
     regulatory      3299..3304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam1b"
                     /gene_synonym="Adam1; Ftna"
                     /note="hexamer: AATAAA"
     polyA_site      3340
                     /gene="Adam1b"
                     /gene_synonym="Adam1; Ftna"
                     /note="major polyA site"
ORIGIN      
        1 gttccgtgtg tggctcctgc tgagtcaggt acagtcaagg tacagtccca cactgtagta
       61 gaggcacctc tctccatctt gtcaaaagga cttagagatg gcgtacagga gctgactttg
      121 aaagaagcaa ccaagaacag aaactgtctg aaaggtcaca gaggtcagag tcaccaggac
      181 aagacctagc cagaaagctg agctcacgga ggtggggagg aaccaacact taaaacacgc
      241 agcatcgatg tagggataat acccgggcct ccagatcagg agagctactg ctgtcattga
      301 cattcaacac gcaggcccca ctgaatcagc tgagtcagaa ggatcatggc agactcagcc
      361 acagcgagac attcagcgtc cacgttctct ttcaagtaga gccccatgcg gctttgtaag
      421 aggttggagg aacacgtcag acttggcctc cccagatgga gcgactaaag ctggggaaaa
      481 tcccagagca ctggtgtatc aggctggtgg ccatgttgct cttggcaata atttttctcc
      541 cgagcacgtt ctgtgacatt ggatctgtat ataattcttc ctatgaaact gtcatccctg
      601 agagactgcc aggcaagggg gggaaagacc ctggagggaa ggtgtcctac atgctattga
      661 tgcaaggcca aaagcagctg cttcacctcg aggtaaaggg acactaccct gagaataact
      721 tcccagtcta cagttaccac aatggcatcc tgaggcaaga aatgcctctc ctctcccagg
      781 actgccacta tgaaggctac atggaagggg tgccaggctc ctttgtttct gtcaacatct
      841 gttcaggcct caggggggtc ttgattaaag aggaaacatc ctatggcatt gagcccatgc
      901 tctcttccaa aaactttgaa catgtcctct acaccatgga gcatcagcct gtggtctcct
      961 gcagtgtcac tcccaaagac agccctgggg acaccagcca tccaccaagg agcaggaagc
     1021 ccgatgacct actggttctg actgactggt ggtcacacac caagtatgtg gagatgtttg
     1081 tggtggtcaa ccaccagcgg ttccagatgt ggggcagtaa catcaacgag acggtccagg
     1141 cagtaatgga catcattgct ctggccaaca gcttcactag ggggataaac acagaggtgg
     1201 tgctggtggg cctggaaatc tggacagagg gggacccgat agaggtccca gtggacctgc
     1261 agaccacact caggaatttc aacttctgga gacaggagaa actcgtgggc cgggtcaggc
     1321 acgatgtggc acacttgatc gtcgggcatc gcccaggaga gaacgagggc caggcgtttc
     1381 tccgtggtgc ctgttcgggt gagtttgcgg cggccgtgga ggccttccat catgaagatg
     1441 tcctcctgtt cgcggctctc atggcccacg agctcgggca caacctgggt atccagcacg
     1501 accacccgac ctgcacctgt ggtcccaagc acttctgcct catgggtgag aagatcggta
     1561 aggacagtgg cttcagcaac tgcagctctg accacttcct ccgtttcctc cacgaccaca
     1621 gaggggtgtg cctgcttgat gagcctgggc gccagagccg catgcgcaga gctgccaatt
     1681 gtgggaatgg tgtggtggag gacttggagc agtgtgactg tggcagtgac tgtgataaaa
     1741 gccagtgttg tgatgaaaat tgtaaactga agggcaactc agtgtgcagc actgaacttt
     1801 gctgttttaa atgtaacttt aaaaaggaag gagatgtttg ccgtcctgct gacggaccat
     1861 gtgacctgga agaatactgc aatgggacct ctgcagcatg tcccagtgac aggaaagccc
     1921 aggacggctc taagtgccac gaatccttct tgtgctttaa tggtcagtgc atggacccta
     1981 cctttcagtg ctctcgtatt tttgggcatg gttcaaggtc tgcctccgat tattgctaca
     2041 cctctctgaa ctcgagagga gaccagtttg gaaactgtgg ctcctcctct caatttccaa
     2101 aaaagtatac caagtgttca gataaaaatg taatgtgtgg gaaacttata tgtacagagg
     2161 tggccttcct gccacaaatc caaccgaaca acttgctgct ccaggtccct gagaccgagg
     2221 actggtgctg gagtgtagct gtgtttgaca tgagagattc cctccatgag gaatacgtga
     2281 aggacaacac ttactgtggc aaagataaag tctgtaaaaa ttccatttgt gaggacttca
     2341 ctccattctc atttccctgt agtccaagca aacaatgcaa caagcacggg gtgtgcaatg
     2401 acctggggaa ctgccactgc tccttcggct ttgcacctcc cgactgcaaa gaggaaggca
     2461 ctgggggcag tgtggacagt ggccctgctg ttaatctgtc aaatgacagc agtccagggc
     2521 cgaactccac ccaatccagc acagaggagc tgatccttaa cttaaagctg atcgtcctgg
     2581 ctgtcattct ggtgctcatg atactcttaa taatcatatg catcataagt gcctacacca
     2641 agtcagagac cgcttccgaa gcagggcctt cagagctaga ggagcttcca gaaggggaga
     2701 aggaagagca ggaggaggtc ctaccagaag aggctaaagg ggaggaggag gagttggagt
     2761 atgggaagga agaagcagaa gagcaaggag cagtagaaga ggaaggagca gaagaggcaa
     2821 acgaagaagc agcagcagaa aagaaagacg aagatgaaga agagggagag gaataagtgg
     2881 gggagataaa gccaataagt agccgagcct ctcacagccc tgagaatgag tctccaggaa
     2941 gcagaagctg tgggaagctg ccactctcag tgggcaaggg aggaaggagc cgtctgtcac
     3001 tagtgttcaa tggacaggtg tttacatact atttcagtac tttacatatt tcatttgaac
     3061 ttctcctata gctttggata ttcttgttct tgtatctttg ggctgatctt ttagtcacca
     3121 gaaaatgctt tcttccacat agattttttt ttgtatgcaa tatactatat tcctgaattt
     3181 ctcactgttc ccaggacttt catttcaagt aacaattacc tattatgtaa ggacaatttc
     3241 catgacattc attcttctaa cttgcccaaa aatatatata ttcaaggaca agtctttaaa
     3301 taaaactact actgttagac atgttttcaa gacccatgga
//
