LOCUS       NM_172126               3114 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 1a (Adam1a),
            mRNA.
ACCESSION   NM_172126
VERSION     NM_172126.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3114)
  AUTHORS   Grayson,P. and Civetta,A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol Biol 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3114)
  AUTHORS   Yamashita,M., Honda,A., Ogura,A., Kashiwabara,S., Fukami,K. and
            Baba,T.
  TITLE     Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is
            rescued by sperm exposure to uterine microenvironment
  JOURNAL   Genes Cells 13 (10), 1001-1013 (2008)
   PUBMED   18754795
REFERENCE   3  (bases 1 to 3114)
  AUTHORS   Nishimura,H., Kim,E., Nakanishi,T. and Baba,T.
  TITLE     Possible function of the ADAM1a/ADAM2 Fertilin complex in the
            appearance of ADAM3 on the sperm surface
  JOURNAL   J Biol Chem 279 (33), 34957-34962 (2004)
   PUBMED   15194697
  REMARK    GeneRIF: ADAM1a/ADAM2 Fertilin complex has roles in expression of
            ADAM3 on the cell surface of mouse sperm
REFERENCE   4  (bases 1 to 3114)
  AUTHORS   Kim,E., Nishimura,H. and Baba,T.
  TITLE     Differential localization of ADAM1a and ADAM1b in the endoplasmic
            reticulum of testicular germ cells and on the surface of epididymal
            sperm
  JOURNAL   Biochem Biophys Res Commun 304 (2), 313-319 (2003)
   PUBMED   12711316
  REMARK    GeneRIF: Localization of ADAM1a in the endoplasmic reticulum of
            testicular germ cells and on the surface of epididymal sperm.
REFERENCE   5  (bases 1 to 3114)
  AUTHORS   Nishimura,H., Kim,E., Fujimori,T., Kashiwabara,S., Kuroiwa,A.,
            Matsuda,Y. and Baba,T.
  TITLE     The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin alpha)
            gene, are localized on mouse chromosome 5
  JOURNAL   Gene 291 (1-2), 67-76 (2002)
   PUBMED   12095680
REFERENCE   6  (bases 1 to 3114)
  AUTHORS   Evans,J.P., Schultz,R.M. and Kopf,G.S.
  TITLE     Characterization of the binding of recombinant mouse sperm fertilin
            alpha subunit to mouse eggs: evidence for function as a cell
            adhesion molecule in sperm-egg binding
  JOURNAL   Dev Biol 187 (1), 94-106 (1997)
   PUBMED   9224677
REFERENCE   7  (bases 1 to 3114)
  AUTHORS   Cho,C., Turner,L., Primakoff,P. and Myles,D.G.
  TITLE     Genomic organization of the mouse fertilin beta gene that encodes
            an ADAM family protein active in sperm-egg fusion
  JOURNAL   Dev Genet 20 (4), 320-328 (1997)
   PUBMED   9254906
REFERENCE   8  (bases 1 to 3114)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   9  (bases 1 to 3114)
  AUTHORS   Wolfsberg,T.G., Straight,P.D., Gerena,R.L., Huovila,A.P.,
            Primakoff,P., Myles,D.G. and White,J.M.
  TITLE     ADAM, a widely distributed and developmentally regulated gene
            family encoding membrane proteins with a disintegrin and
            metalloprotease domain
  JOURNAL   Dev Biol 169 (1), 378-383 (1995)
   PUBMED   7750654
REFERENCE   10 (bases 1 to 3114)
  AUTHORS   Weskamp,G. and Blobel,C.P.
  TITLE     A family of cellular proteins related to snake venom disintegrins
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2748-2751 (1994)
   PUBMED   8146185
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC052093.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_172126.3.
            
            On Jun 10, 2003 this sequence version replaced NM_172126.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC052093.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3114
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.84 cM"
     gene            1..3114
                     /gene="Adam1a"
                     /gene_synonym="Adam1; Ftna"
                     /note="a disintegrin and metallopeptidase domain 1a"
                     /db_xref="GeneID:280668"
                     /db_xref="MGI:MGI:2429504"
     exon            1..3092
                     /gene="Adam1a"
                     /gene_synonym="Adam1; Ftna"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..2843
                     /gene="Adam1a"
                     /gene_synonym="Adam1; Ftna"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 1a; PH-30 alpha; ADAM 1a; fertilin subunit
                     alpha-a; fertilin alpha; a disintegrin and
                     metalloproteinase domain 1a (fertilin alpha)"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 1a precursor"
                     /protein_id="NP_742124.2"
                     /db_xref="CCDS:CCDS19637.1"
                     /db_xref="GeneID:280668"
                     /db_xref="MGI:MGI:2429504"
                     /translation="MSVAAAGRGFASSLSSPQIRRIALKEAKLTPHIWAALHWNLGLR
                     LVPSVRVGILVLLIFLPSTFCDIGSVYNSSYETVIPERLPGKGGKDPGGKVSYMLLMQ
                     GQKQLLHLEVKGHYPENNFPVYSYHNGILRQEMPLLSQDCHYEGYMEGVPGSFVSVNI
                     CSGLRGVLIKEETSYGIEPMLSSKNFEHVLYTMEHQPVVSCSVTPKDSPGDTSHPPRS
                     RKPDDLLVLTDWWSHTKYVEMFVVVNHQRFQMWGSNINETVQAVMDIIALANSFTRGI
                     NTEVVLVGLEIWTEGDPIEVPVDLQTTLRNFNFWRQEKLVGRVRHDVAHLIVGHRPGE
                     NEGQAFLRGACSGEFAAAVEAFHHEDVLLFAALMAHELGHNLGIQHDHPTCTCGPKHF
                     CLMGEKIGKDSGFSNCSSDHFLRFLHDHRGACLLDEPGRQSRMRRAANCGNGVVEDLE
                     ECDCGSDCDSHPCCSPTCTLKEGAQCSEGLCCYNCTFKKKGSLCRPAEDVCDLPEYCD
                     GSTQECPANSYMQDGTQCDRIYYCLGGWCKNPDKQCSRIYGYPARSAPEECYISVNTK
                     ANRFGNCGHPTSANFRYETCSDEDVFCGKLVCTDVRYLPKVKPLHSLLQVPYGEDWCW
                     SMDAYNITDVPDDGDVQSGTFCAPNKVCMEYICTGRGVLQYNCEPQEMCHGNGVCNNF
                     KHCHCDAGFAPPDCSSPGNGGSVDSGPVGKPADRHLSLSFLAEESPDDKMEDEEVNLK
                     VMVLVVPIFLVVLLCCLMLIAYLWSEVQEVVSPPSSSESSSSSSWSDSDSQ"
     regulatory      3055..3060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam1a"
                     /gene_synonym="Adam1; Ftna"
                     /note="hexamer: AATAGA"
     regulatory      3071..3076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam1a"
                     /gene_synonym="Adam1; Ftna"
                     /note="hexamer: AATAAA"
     polyA_site      3076
                     /gene="Adam1a"
                     /gene_synonym="Adam1; Ftna"
                     /note="major polyA site"
     polyA_site      3092
                     /gene="Adam1a"
                     /gene_synonym="Adam1; Ftna"
ORIGIN      
        1 ccagcatgac cactgtaaga atgaggaatg aggcaggaca acagagaact cttaattgtt
       61 cagagaaccc agagaacttt gtcccctccc ccgaaaccct gcagaatgtt gagtctgaaa
      121 gtatgagctg gttaacatgt caggggccca tgacctgtgg aggaggaaag atgatgtgac
      181 aagcacagaa ccggctgagc cactgtagat gcagggctca tctccatgaa tgtcaaagga
      241 acttaagcaa cactgaagct cctccacttg aaagaagccc ctgtgctgca catatccacc
      301 aaggccagga gaaagaaagg agagagacac agcctgagac cgcacagttt cttgggaagc
      361 tccccagtaa ggcacgggca caggtctggg tgcctgggtc tgggaaaagc agagagcact
      421 gccgctgatg gacagagatc ctccatcatc agcagtttgt tggagccatg tcagtggcag
      481 cagcggggag agggtttgcc tccagtctgt cttccccaca gatcaggcga atagccttaa
      541 aagaagctaa gctaacacct cacatctggg cggcactgca ctggaacttg ggactgagac
      601 tagtgccatc tgtcagagta gggattttgg tgctactgat ttttctcccg agcacgttct
      661 gtgacattgg atctgtatat aattcttcct atgaaactgt catccctgag agactgccag
      721 gcaagggggg gaaagaccct ggagggaagg tgtcctacat gctattgatg caaggccaaa
      781 agcagctgct tcacctcgag gtaaagggac actaccctga gaataacttc ccagtctaca
      841 gttaccacaa tggcatcctg aggcaagaaa tgcctctcct ctcccaggac tgccactatg
      901 aaggctacat ggaaggggtg ccaggctcct ttgtttctgt caacatctgt tcaggcctca
      961 ggggggtctt gattaaagag gaaacatcct atggcattga gcccatgctc tcttccaaaa
     1021 actttgaaca tgtcctctac accatggagc atcagcctgt ggtctcctgc agtgtcactc
     1081 ccaaagacag ccctggggac accagccatc caccaaggag caggaagccc gatgacctac
     1141 tggttctgac tgactggtgg tcacacacca agtatgtgga gatgtttgtg gtggtcaacc
     1201 accagcggtt ccagatgtgg ggcagtaaca tcaacgagac ggtccaggca gtaatggaca
     1261 tcattgctct ggccaacagc ttcactaggg ggataaacac agaggtggtg ctggtgggcc
     1321 tggaaatctg gacagagggg gacccgatag aggtcccagt ggacctgcag accacactca
     1381 ggaatttcaa cttctggaga caggagaaac tcgtgggccg ggtcaggcac gatgtggcac
     1441 acttgatcgt cgggcatcgc ccaggagaga acgagggcca ggcgtttctc cgtggtgcct
     1501 gttcgggtga gtttgcggcg gccgtggagg ccttccatca tgaagatgtc ctcctgttcg
     1561 cggctctcat ggcccacgag ctcgggcaca acctgggtat ccagcacgac cacccgacct
     1621 gcacctgtgg tcccaagcac ttctgcctca tgggtgagaa gatcggtaag gacagtggct
     1681 tcagcaactg cagctctgac cacttcctcc gtttcctcca tgaccacaga ggggcgtgcc
     1741 tgcttgatga gcctgggcgc cagagccgca tgcgcagagc tgccaattgt gggaatggtg
     1801 tggtggagga cttggaggag tgtgactgcg gcagtgactg tgacagtcac ccgtgctgtt
     1861 cgccaacatg tacgcttaag gagggtgcgc agtgcagtga gggactctgc tgctacaact
     1921 gtacattcaa gaagaaaggg agcttatgcc gtcctgctga ggatgtgtgt gaccttcccg
     1981 agtattgtga cggcagtact caggaatgcc ctgcaaacag ctacatgcag gatggcacac
     2041 agtgtgatag gatttattac tgcttggggg gttggtgtaa gaaccctgat aaacaatgtt
     2101 caaggatcta tgggtatcct gcaagatctg cccctgagga atgttacatt tcagttaata
     2161 ctaaggcgaa ccggtttgga aactgtggcc atcccacctc cgctaacttc agatatgaaa
     2221 catgttccga tgaggatgta ttttgtggga aactggtgtg tacagatgtt agatacctgc
     2281 ccaaagtcaa acccctacac tcactcctcc aggttcctta tggagaggac tggtgttgga
     2341 gtatggatgc ctataacatc acagatgtcc cggatgacgg agatgtacag agcggcacct
     2401 tctgtgcccc aaacaaagtc tgcatggagt atatctgcac tggtcgtggg gtgctccagt
     2461 acaactgtga gccacaggaa atgtgtcacg ggaatggagt gtgcaacaat ttcaagcact
     2521 gtcactgcga tgctggcttc gcccctcctg actgtagcag tccaggaaat ggggggagtg
     2581 tggacagtgg tcctgttggt aagcccgctg atcgacactt gagtctctct tttctggctg
     2641 aagagagtcc agatgataaa atggaggatg aagaggtaaa cctgaaagtg atggtgcttg
     2701 tggtccctat atttcttgtc gttttactgt gctgtctaat gctgatcgcc tacctctggt
     2761 ctgaagtaca agaagtagta tctccaccga gttcatcaga gtcttcgtct tcatcatcct
     2821 ggtcagactc tgactctcag tgaagtttta tttaagatcc tctcatggat cattgctatc
     2881 gatgtcttgt atttgcaggg caattttgcc taagtggatt ttagggcatg ctgttcagtg
     2941 taatgtgtgg tctatatact tgtgttgctc atctcagaaa caactggaat tatatcctga
     3001 atgatgttaa gggatctaaa tgttctaact tgccctgtca gctcctgttc ataaaataga
     3061 aggcatttta aataaatata aataataagg ccaaaaaaaa aaaaaaaaaa aaaa
//
