LOCUS       NM_009616               6411 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus ADAM metallopeptidase domain 19 (Adam19), transcript
            variant 1, mRNA.
ACCESSION   NM_009616 XM_907895 XM_920638
VERSION     NM_009616.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6411)
  AUTHORS   Li,H., House,J.S., Nichols,C.E., Gruzdev,A., Ward,J.M., Li,J.L.,
            Wyss,A.B., Haque,E., Edin,M.L., Elmore,S.A., Mahler,B.W.,
            Degraff,L.M., Shi,M., Zeldin,D.C. and London,S.J.
  TITLE     Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up
            in a Mouse Knockout Model
  JOURNAL   Lung 202 (5), 659-672 (2024)
   PUBMED   39153120
  REMARK    GeneRIF: Adam19 Deficiency Impacts Pulmonary Function: Human GWAS
            Follow-up in a Mouse Knockout Model.
REFERENCE   2  (bases 1 to 6411)
  AUTHORS   Aydin,A., Klenk,C., Nemec,K., Isbilir,A., Martin,L.M., Zauber,H.,
            Rrustemi,T., Toka,H.R., Schuster,H., Gong,M., Stricker,S., Bock,A.,
            Bahring,S., Selbach,M., Lohse,M.J. and Luft,F.C.
  TITLE     ADAM19 cleaves the PTH receptor and associates with brachydactyly
            type E
  JOURNAL   Life Sci Alliance 7 (4), e202302400 (2024)
   PUBMED   38331475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6411)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6411)
  AUTHORS   Arai,H.N., Sato,F., Yamamoto,T., Woltjen,K., Kiyonari,H.,
            Yoshimoto,Y., Shukunami,C., Akiyama,H., Kist,R. and
            Sehara-Fujisawa,A.
  TITLE     Metalloprotease-Dependent Attenuation of BMP Signaling Restricts
            Cardiac Neural Crest Cell Fate
  JOURNAL   Cell Rep 29 (3), 603-616 (2019)
   PUBMED   31618630
REFERENCE   5  (bases 1 to 6411)
  AUTHORS   Kalyani,R., Lee,J.Y., Min,H., Yoon,H. and Kim,M.H.
  TITLE     Genes Frequently Coexpressed with Hoxc8 Provide Insight into the
            Discovery of Target Genes
  JOURNAL   Mol Cells 39 (5), 395-402 (2016)
   PUBMED   27025388
  REMARK    Erratum:[Mol Cells. 2017 Apr;40(4):314. doi:
            10.14348/molcells.2017.1311. PMID: 28486794]
REFERENCE   6  (bases 1 to 6411)
  AUTHORS   Kurisaki,T., Wakatsuki,S. and Sehara-Fujisawa,A.
  TITLE     Meltrin beta mini, a new ADAM19 isoform lacking metalloprotease and
            disintegrin domains, induces morphological changes in neuronal
            cells
  JOURNAL   FEBS Lett 532 (3), 419-422 (2002)
   PUBMED   12482604
  REMARK    GeneRIF: Meltrin beta-mini is a new isoform that induces neuron
            outgrowth in neuronal cells
REFERENCE   7  (bases 1 to 6411)
  AUTHORS   Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB
            (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb
            to mouse chromosome 11
  JOURNAL   Genomics 54 (1), 178-179 (1998)
   PUBMED   9806848
REFERENCE   8  (bases 1 to 6411)
  AUTHORS   Kurisaki,T., Masuda,A., Osumi,N., Nabeshima,Y. and
            Fujisawa-Sehara,A.
  TITLE     Spatially- and temporally-restricted expression of meltrin alpha
            (ADAM12) and beta (ADAM19) in mouse embryo
  JOURNAL   Mech Dev 73 (2), 211-215 (1998)
   PUBMED   9622634
REFERENCE   9  (bases 1 to 6411)
  AUTHORS   Inoue,D., Reid,M., Lum,L., Kratzschmar,J., Weskamp,G., Myung,Y.M.,
            Baron,R. and Blobel,C.P.
  TITLE     Cloning and initial characterization of mouse meltrin beta and
            analysis of the expression of four metalloprotease-disintegrins in
            bone cells
  JOURNAL   J Biol Chem 273 (7), 4180-4187 (1998)
   PUBMED   9461614
REFERENCE   10 (bases 1 to 6411)
  AUTHORS   Yagami-Hiromasa,T., Sato,T., Kurisaki,T., Kamijo,K., Nabeshima,Y.
            and Fujisawa-Sehara,A.
  TITLE     A metalloprotease-disintegrin participating in myoblast fusion
  JOURNAL   Nature 377 (6550), 652-656 (1995)
   PUBMED   7566181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL663031.15, CJ111383.1,
            AK147217.1 and CJ248266.1.
            
            On May 7, 2014 this sequence version replaced NM_009616.3.
            
            Summary: This gene encodes a cell surface glycoprotein and member
            of the ADAM (a disintegrin and metalloproteinase) family of
            endopeptidases. The encoded protein may play a role in the
            ectodomain shedding of neuregulin proteins. Homozygous knockout
            mice for this gene exhibit heart development defects and perinatal
            lethality. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that
            undergoes proteolytic processing to generate a mature protein
            product. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147217.1, D50410.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL663031.15        74345-74347
            4-81                CJ111383.1         4-81
            82-3857             AK147217.1         5-3780
            3858-4873           AK147217.1         3783-4798
            4874-6388           AK147217.1         4800-6314
            6389-6411           CJ248266.1         440-462
FEATURES             Location/Qualifiers
     source          1..6411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 27.54 cM"
     gene            1..6411
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /note="ADAM metallopeptidase domain 19"
                     /db_xref="GeneID:11492"
                     /db_xref="MGI:MGI:105377"
     exon            1..227
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            228..313
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            314..384
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            385..463
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            464..540
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            541..733
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            734..799
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            800..871
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1038
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1123
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1263
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1441
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1531
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1727
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1836
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2050
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2128
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2237
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2376
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2461
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2686
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2839
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..6395
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6372..6377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /note="hexamer: AACAAA"
     polyA_site      6391
                     /gene="Adam19"
                     /gene_synonym="MADDAM; Mltnb; MTLNB"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgtctg ggatgtgggc tgggtggctt ttaggccggc gtttgcttga aaacctccgc
       61 cgccgctagg ccgggggcag gcaatggcag gggatgtgtg attgcggaca gtgagagggc
      121 cgttgctatc atgcccgggc gcgcgggcgt cgcccggttc tgcttgctgg ctctcgctct
      181 gcagctacat tggccgctgg cggcgtgcga gccgggatgg accacaagag gaagccaaga
      241 aggtagccct ccgctacagc atgaactcat aatacctcag tggcggactt cagaaagccc
      301 tgggagagga aagcatccac tcagagcaga gctcagggtc atggctgaag ggcgagagct
      361 gatcctagac ctggagaaga acgagcacct ttttgctcca gcctacacag aaacctgcta
      421 cactgcaagt ggcaatcctc aaaccagcac gctgaagtct gaggatcact gcttttacca
      481 cgggactgtg agggacgtgg atgagtccag tgtcacgctc agcacctgcc ggggaattag
      541 aggactgatt atagtgagaa gtaacctcag ctacatcatc gagcccgtcc ctaacagcga
      601 cagccaacac cgtatttaca gatccgaaca tctcacgctg cccccgggga actgtgggtt
      661 cgagcactcc gggcccacct cgaaggactg ggcccttcag tttacacatc agaccaaaaa
      721 gcaacctcgc agaatgaaac gggaagatct acactctatg aagtacgtgg agctttacct
      781 ggtggctgat tatgcagagt ttcagaagaa tcgacatgac caggatgcca ccaaacgcaa
      841 gctcatggag attgccaact atgttgataa gttttaccgc tccctgaaca tccgaattgc
      901 acttgtcggc ttggaggtgt ggacgcatgg ggataagtgt gaagtttcag agaatcccta
      961 ctctaccctc tggtcctttc ttagttggag gcgcaagctg cttgctcaga agagccatga
     1021 caatgctcag ctaatcacgg gcaggtcctt ccaaggcacc accattggcc tggcccccct
     1081 catggccatg tgctccgtgt accagtctgg aggagttagc atggaccact ccgagaatgc
     1141 cattggtgta gcctccactg tggcccatga gattggccac aactttggca tgagccatga
     1201 ttctgcacac tgctgttctg ccagtgcagc cgatggcggc tgcatcatgg ccgccgccac
     1261 cgggcaccct ttccccaaag tgttcagttg gtgtaacagg aaggagctgg acaggtatct
     1321 gcagacagga ggagggatgt gtctctccaa catgccggac actaggacgc tgtatggagg
     1381 ccggaggtgt ggcaacgggt acctggaaga cggtgaagaa tgtgactgtg gagaagagga
     1441 ggaatgtaag aacccttgct gcaatgcctc caactgcact ctgaaggaag gggcagagtg
     1501 tgcccatggt tcctgctgcc accagtgcaa gctggtggct cctggaaccc agtgtcggga
     1561 gcaggttcgg caatgtgacc tccccgagtt ctgcaccggc aagtctcccc actgccccac
     1621 caactattat cagatggatg gcaccccctg cgagggtggc caggcctact gctacaacgg
     1681 catgtgcctc acttaccagg aacagtgcca gcagctgtgg ggacctggag cccggcctgc
     1741 cctcgatctt tgctttgaga gggtgaatgc tgctggtgac acctatggaa actgtggcaa
     1801 gggcttgaat ggccaataca ggaagtgcag tcccagggat gccaagtgtg ggaagattca
     1861 gtgccagagc acccaggccc ggcccctgga atccaacgca gtatctattg acaccaccat
     1921 caccttgaac gggaggcgga tccactgtcg gggcacccac gtctaccggg gtcctgagga
     1981 ggaggaaggg gaaggtgaca tgctggaccc agggctggtg atgactggaa ccaagtgtgg
     2041 ccacaaccat atttgcttcg aggggcagtg caggaacacc tccttctttg agacggaagg
     2101 ctgtgggaaa aagtgcaatg gccacggggt ctgcaacaac aacaagaact gtcattgctt
     2161 ccctggctgg tctccacctt tctgtaacac cccgggagat ggtggcagcg tcgacagtgg
     2221 tcctttgccc cctaagagtg tgggtcccgt gatcgctggg gtgttttcag ctctcttcgt
     2281 gttggcagtt ctggtgctac tgtgtcactg ctacagacag agccacaaac tgggcaaacc
     2341 ctcggctctc cctttcaagc tgcggcatca gttcagttgt cccttcaggg tatctcagag
     2401 tggtggaact ggccatgcca acccaacttt caagttgcag accccccagg gcaagcgaaa
     2461 ggtgactaac acccctgaat ccctccggaa gccgtcccac ccccctcccc ggccccctcc
     2521 agactacctg cgcgttgaat cgccacctgc accattgccg gcacatctga acagggctgc
     2581 tgggagctcc ccagaagctg gggctcgaat agaaagaaag gagtcagcca ggaggcctcc
     2641 cccaagccga cccatgcccc ctgcacctaa ctgcctactg tcccaggact tctccaggcc
     2701 tcgaccacct cagaaggcac tcccagccaa tccggtgcca ggccaaagga ccggtcccag
     2761 gtcaggaggc acctccctgc ttcagccccc tacttctggt cctcagcccc ccaggcctcc
     2821 agcagtgcct gttccaaagc tacccgagta ccgatcacag agggttggag caataattag
     2881 ctccaagatc tagaagtgtc gagaagtttc ttgttccgat ggaagactcc ggatgccatg
     2941 gaaggtccag aagaaagacg ccttctcacc catcctgaag ctttggcagc cttctggaac
     3001 gtccctcatc cccagaatct cccttcttac ccgagtgcct cctgcttcct ccgaggccca
     3061 gggggactca tatccaatgg ctcctaagtg tttgtcctgt gcaatataca gcccagggag
     3121 ggaagggaag cacggcgagg agggtgggaa aggttctccc tcagcccact agccaagagc
     3181 taccagcgat gctcagggaa ggcttgagct ggggtcctcc tctgcggagc ttggagaagg
     3241 tacccatcct ggtcctatgc tggcaggaac acacgcgagt gtcactgatt ggcctccttc
     3301 tgggatccca ggctgctgag gaagctactg ctacatccct accccaaggg gcttggtcaa
     3361 ggtgcctgtt cctggctctc tggctgcatg tgataagcca tgctcccctc ccctgccttt
     3421 cttcacattc ccactcccat atttacacgg gtcactctga ctcagacagg tactatttgt
     3481 aagtagcata gacagcaggg gggtggggtg gtcaacctgt gtcccctctg agccgttatg
     3541 ccaaaggtca ctaaggacat ttagaatccc catccatcca tccatccatc catccatcca
     3601 tccattcatc catccccagt gttccatgtg tcaccttctc cttttccagc atccctatcc
     3661 tatggtgctt tggtggtgaa ctatggcagt cctgacttgc tgatgaccat atgctggtga
     3721 cctacaaatc gggatcctgc catatggggt cgccactgga ctttctgcac tggatctcaa
     3781 gagcgttgag ccgagtgggc gtgtatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3841 gtgtgtgtgt gtgtgtgaaa gagacagagg caatgagaga gacagacatg caggcaggcc
     3901 gacagctctg catgtacttg tgttttacgg cctcaagcag aataagggac ctcctcctta
     3961 tttctgactc atatctaagt aaggttcccc aggacagcca cagttgtact gaggggggct
     4021 gacatgtttg gcatcctggc tatagtattg tatacacagg gccaccagcc ccgccctagt
     4081 ggtcagctct gaggggggac tggtgactct gaacagatcg atgtcaacag ccatggtgaa
     4141 ccagatctgg gcagggttcc ccaaactcta ttcaaccaga gttttatcac gcacctcatc
     4201 gggtctctcc tggttgctgc cccgaggtga tcgtcatgga aaatgctgag aaggtgggaa
     4261 tgggatgggg tggaccttct cttgcttggt gctccgctat ttggaacagt tcttacacat
     4321 ttgctgggcc tggcctctga gaggccatct tccaccccca gaaaggtgct aatggcactg
     4381 cagagggctc tctaggggcc tccccgcccc aacagcaagc agttgttagc tcttggaacc
     4441 ctccagagga agaggcaagc gtttgacttc ccctttacca cctgaggcct ccttatatct
     4501 cttcccagag taagctttgg gattgtagac atgtgggagc tatgacagac gtggcctggg
     4561 gtagaaagat ctcaggaaag cacctttctc cttttcaggg tgaccgtgct cttcacactc
     4621 tctgaggcct cagtccatgt cctatatcag tttctctttt gtgtgcttta ccaagtggcc
     4681 ggtgactaca ggccaccccg attctcacca caaagttaga aaccctccac tttctgtccc
     4741 ttgaaccata tcagaaaaag acccatttcc ttgctctttg gtaatcactt ctgttttttt
     4801 ctttttcatt actttgctac cacctccatc ccatgacatt atactgtgaa gtgtaagagg
     4861 acggggtttt tttaaacttg gtagaaatgt cggcagctgc tctacacaca acttcactca
     4921 aggctttgtt tccagaggcc agctaggctg tcacaggcag gaatcccttc ccatctgctt
     4981 tgtgaagggt cccatacagg tgtatctaga cttcaaggac agggtttgtc tcacaggatt
     5041 gtcacttagg agatgaaaga atattaccac atgaggagga ggggcagttg caacagaaca
     5101 ctttggtctt cctacaccaa gtctgtgagg gcatccaaga ctgaatgaaa gcgcttttct
     5161 tatgcataca atgtgagcaa gaacaagaac tgtttaaggc acctctgttc ccagccactg
     5221 aagagagacg tcagaagatg ttagaatagg tcaaagccaa ggctctggtg ggctgaggga
     5281 aggtttgtag ctgcgtttag tggtatacat ctttagtccc agcataggca ggtgaatctc
     5341 gagtttgaag ctagcctggt ctaaaaagga agttccaaga ctgccagggc cacacagagg
     5401 aaaaaaaaaa ccctctagaa aaacaaaaat gaagacagga tctcatgtat cgtagattgg
     5461 cctttaagtc actttaccaa ggatgatctt tgaactcctg agtacagact gcgggtgtgt
     5521 gctaccatgc tttatgtggc cctgggttca aacacagccc ttcatatgta tatagccaaa
     5581 cactctacaa ctgagctaca tcctccagcc taggctgtaa atgttttttg gagctagatt
     5641 agctgcctgc caaccttaga actgcaaagc cattcctgac ctgtaaacct cagctctcca
     5701 tctctataag aggtatagcc tgggctaata ccgtccaagt tacaactcct tgcttgcttt
     5761 ctgttccttc tagccttggt gacttccacc aggaagagaa taccccctct ctacccctgc
     5821 tccaagacac tgtagatgct agtgtcggag tgttctctgt aacgcgacag ttccttctgt
     5881 tgcaatagcc cccctgcaac actgcaataa tccttcagtg tctcccctgg gctcaattca
     5941 cttccttatt tgacaaagtg gaggtgagac ttgtattctt aaaattggag gctagttatt
     6001 ttgtcaaatg catgtaatga acagacccga aggaatcctc cacacacaag ccagggaaca
     6061 ccaactggaa aggtaccccg tcccagggaa gcctgctagg gagaggttct gtagaatccg
     6121 agcctagcac cccaaagtca tgcacccagt atcctcttgt atgactgtat atgtctatgt
     6181 ctgggatcca gggcaaatgt gaattttctt ttgatttggg agattgttca caggaagtag
     6241 tcctcccctc tcatgtcctc ctattgattg tttacaatat ttgtacatct atgcaaaata
     6301 cttgaatggg ccatggtgcc ttgttttttg ttgttgttgt tatttttttc tccttgtttg
     6361 tatttaatta aaacaaattg tcatgaggaa atgttaaaaa aaaaaaaaaa a
//
