LOCUS       NM_010084               2361 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 18 (Adam18),
            transcript variant 1, mRNA.
ACCESSION   NM_010084
VERSION     NM_010084.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2361)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   2  (bases 1 to 2361)
  AUTHORS   Rowton,M., Ramos,P., Anderson,D.M., Rhee,J.M., Cunliffe,H.E. and
            Rawls,A.
  TITLE     Regulation of mesenchymal-to-epithelial transition by PARAXIS
            during somitogenesis
  JOURNAL   Dev Dyn 242 (11), 1332-1344 (2013)
   PUBMED   24038871
REFERENCE   3  (bases 1 to 2361)
  AUTHORS   Grayson,P. and Civetta,A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol Biol 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2361)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 2361)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 2361)
  AUTHORS   Zhu,G.Z., Lin,Y., Myles,D.G. and Primakoff,P.
  TITLE     Identification of four novel ADAMs with potential roles in
            spermatogenesis and fertilization
  JOURNAL   Gene 234 (2), 227-237 (1999)
   PUBMED   10395895
REFERENCE   7  (bases 1 to 2361)
  AUTHORS   Weskamp,G. and Blobel,C.P.
  TITLE     A family of cellular proteins related to snake venom disintegrins
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2748-2751 (1994)
   PUBMED   8146185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK076633.1, BY099176.1,
            AC138355.17 and AC114602.16.
            
            On Jun 30, 2009 this sequence version replaced NM_010084.1.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. This gene is expressed in a regulated
            fashion during early stages of spermatogenesis. The encoded
            preproprotein undergoes proteolytic processing to generate a
            mature, functional protein. This gene is located in a cluster of
            related ADAM genes on chromosome 8. [provided by RefSeq, May 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167405.1, AK076633.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AK076633.1         2-267
            267-411             BY099176.1         223-367
            412-554             AC138355.17        77230-77372
            555-603             AK076633.1         558-606
            604-626             AC138355.17        89102-89124
            627-700             AK076633.1         630-703
            701-704             AC138355.17        90762-90765
            705-1960            AK076633.1         709-1964
            1961-1961           AC114602.16        187754-187754       c
            1962-2357           AK076633.1         1966-2361
            2358-2361           AC114602.16        175106-175109       c
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 12.82 cM"
     gene            1..2361
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /note="a disintegrin and metallopeptidase domain 18"
                     /db_xref="GeneID:13524"
                     /db_xref="MGI:MGI:105986"
     exon            1..110
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2218
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 18; disintegrin and metalloproteinase
                     domain-containing protein 27; transmembrane
                     metalloproteinase-like, disintegrin-like, and
                     cysteine-rich protein III; disintegrin 3"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 18 preproprotein"
                     /protein_id="NP_034214.2"
                     /db_xref="CCDS:CCDS22195.1"
                     /db_xref="GeneID:13524"
                     /db_xref="MGI:MGI:105986"
                     /translation="MPLLFILAELAMLFARLDSEGICLHITVPQKIEPRKGGDAEGKV
                     TYVITIDGKPYSLHLRNHSFLSQNFLVYTYNETGSLYSDSSHFLAHCHYRGYVDEVPN
                     SIVTLSICSGLRGFLQLENVSYGIEPLESSARFEHIVYQVKSDSSMLAGNDSHVWQID
                     QLDKGHFNEQDKNHSQLLPQSLKLHIIVGKFLFDYMGSDIMAITQKIFQIIGLVNAML
                     TQLKLSVVLASLELWSDKNHISTDGNATDILQRLLDWKRDYLTLQSNEITHLLIYRRR
                     PKYIGAASPGEICSKSYVAGVGMYPEDIGLEGFSVVITQLIGLHIGLTYDDNIRNCSC
                     PSAPCIMQQGALSSSGKKTFSNCSLHDYMHYVSNFDTQCLGDLSNVHVLQPNQAVCGN
                     GIMEAGEECDCGNETECQFKECCDHETCRLKGSAQCGSGACCMPTCELSASGTPCRKA
                     VDPECDFTEYCDGSSSHCVPDTFALNGHLCRLGSAYCYNGRCQALNDQCVSLFGKGSQ
                     GASYACFEKVNSPRENLANCDSKDSYSVPCGQQDVLCGKLACFRPPKNYKSPSQSVVY
                     SYVHDSVCLSILPGLSMRSDGRDSAYVADGTVCGPQMYCINGTCKEVNFTGNDCNATK
                     KCKGNGICNNFGNCQCFPDYRPPDCNLQIGSPGGSIDDGNTLRTESAFATKRLSKNED
                     SWVILGFFIFLPFIVTFLVGIMKRNERKIVPQGEHKI"
     exon            111..187
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            188..243
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            244..322
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            323..399
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            400..568
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            569..634
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            635..706
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            707..873
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            874..955
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1095
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1279
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1375
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1574
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1680
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1867
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1948
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2063
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2221
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2361
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="Adam18"
                     /gene_synonym="Adam27; Dtgn3; Tmdc3; tMDCIII"
                     /note="major polyA site"
ORIGIN      
        1 gccccacggc tgccaacggt cttgagctcg gctgagcttc ttgcacttgg acccaaccat
       61 gcctctgctc ttcatacttg cggagcttgc catgctgttt gcccgcctcg attcggaagg
      121 aatatgcctg catatcacag tgccgcagaa gatagagcca cgcaagggcg gagatgcaga
      181 agggaaggtg acatacgtca ttaccattga cgggaagccc tactctctgc atctcaggaa
      241 ccactcattt ttatcccaga actttttggt ttacacatac aatgaaactg gatctttgta
      301 ttctgactca tcacactttt tggctcattg ccattaccga ggatatgttg atgaagtgcc
      361 aaattccatt gtgacactca gcatctgctc tggcctcagg ggattcctgc agttggaaaa
      421 tgtcagctat ggaattgaac cactggagtc ttcagcaagg tttgagcaca tagtttatca
      481 agtgaagagc gacagctcaa tgctagcagg aaatgacagc catgtttggc agatagacca
      541 gcttgataaa ggccatttca atgagcagga taaaaatcat tcacaactgt tacctcaaag
      601 tctaaaattg cacattatag tggggaaatt tttgtttgac tatatgggat ctgacattat
      661 ggccataaca cagaagattt tccagattat tggtcttgtt aacgctatgc tcactcagct
      721 gaaattgagt gttgtgttag cctccttgga attgtggtca gataaaaatc atatttctac
      781 tgacggaaat gctactgata ttttacaaag acttttggac tggaaacgag actatcttac
      841 cctgcagtcc aatgaaataa cacacttact catttacagg agacgcccga aatacatcgg
      901 agcggcatca ccaggtgaaa tatgcagtaa aagctatgtt gcgggtgttg gtatgtatcc
      961 agaagacata ggtttggagg gattctcagt ggttatcact caactgattg gccttcacat
     1021 aggattaaca tacgacgaca atattagaaa ttgttcctgt cccagcgctc catgcataat
     1081 gcagcaggga gcactgagtt ccagtgggaa gaagactttt agcaactgta gcttgcatga
     1141 ctacatgcac tatgtttcaa attttgacac gcagtgtctt ggtgacctgt caaatgtgca
     1201 tgtattgcaa ccaaatcaag ccgtgtgtgg caatggaatc atggaagctg gtgaggaatg
     1261 tgactgtggt aatgagacgg aatgtcaatt taaagagtgc tgcgaccatg aaacgtgcag
     1321 gctaaaaggc tcagcacaat gtggatctgg agcttgctgc atgcccacgt gtgagctgtc
     1381 agcatcaggc acgccctgta ggaaagctgt tgacccagag tgtgacttca cagaatattg
     1441 cgatggatcc tctagccact gtgttcctga cacctttgca ctgaacggcc atttgtgcag
     1501 gttgggatct gcatattgct acaatggaag atgccaggct ctcaatgacc aatgtgtcag
     1561 tttatttgga aaaggttctc aaggggcttc ctatgcctgt tttgaaaaag tgaattcacc
     1621 acgtgaaaat ctggcaaact gtgattctaa agactcgtac tcggtacctt gcggacagca
     1681 ggatgttctc tgtgggaaat tagcttgttt tcggccgccc aagaattata agagccctag
     1741 tcaatctgtg gtctattcct atgtccacga cagcgtgtgt ctgtccatac ttcctgggtt
     1801 gtctatgaga tcagatggca gagacagcgc atacgtggct gacggcactg tgtgtggacc
     1861 acaaatgtat tgtataaacg gaacctgcaa agaagttaat ttcacaggaa atgactgcaa
     1921 cgccactaag aagtgcaaag ggaatgggat atgtaataac tttggtaatt gccaatgctt
     1981 tcctgactac aggcctccag attgtaactt acagattgga tcaccggggg gcagcatcga
     2041 cgacgggaac actctcagaa ctgagtcggc ttttgctaca aagcgcctga gtaagaatga
     2101 ggacagctgg gtgatcctgg gcttcttcat ctttctgcct ttcatcgtaa ctttccttgt
     2161 tgggatcatg aagagaaacg aaaggaaaat cgtgcctcag ggagaacaca aaatatgagg
     2221 gccattcatt gcaccagaaa tcggccaagg aagctagcag ttgatggacc caaggaggaa
     2281 gtgtgtgttc taaccgctct gttaccggtg gatacacttt aaatctcaga cttttggaaa
     2341 ataaaactga tatatgcacg a
//
