LOCUS       NM_009615               4451 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 17 (Adam17),
            transcript variant 1, mRNA.
ACCESSION   NM_009615
VERSION     NM_009615.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Srinivas,A.N., Suresh,D., Vishwanath,P.M., Satish,S.,
            Santhekadur,P.K., Koka,S. and Kumar,D.P.
  TITLE     TACE inhibition: a promising therapeutic intervention against
            AATF-mediated steatohepatitis to hepatocarcinogenesis
  JOURNAL   Mol Oncol 18 (8), 1940-1957 (2024)
   PUBMED   38558505
  REMARK    GeneRIF: TACE inhibition: a promising therapeutic intervention
            against AATF-mediated steatohepatitis to hepatocarcinogenesis.
REFERENCE   3  (bases 1 to 4451)
  AUTHORS   Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M.,
            Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A.
  TITLE     Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes
            osteoclast differentiation
  JOURNAL   Cell Commun Signal 22 (1), 322 (2024)
   PUBMED   38863060
  REMARK    GeneRIF: Downregulation of the metalloproteinases ADAM10 or ADAM17
            promotes osteoclast differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Ding,H., Feng,Z. and Hu,K.
  TITLE     GRWD1 Over-Expression Promotes Gastric Cancer Progression by
            Activating Notch Signaling Pathway via Up-Regulation of ADAM17
  JOURNAL   Dig Dis Sci 69 (3), 821-834 (2024)
   PUBMED   38172445
  REMARK    GeneRIF: GRWD1 Over-Expression Promotes Gastric Cancer Progression
            by Activating Notch Signaling Pathway via Up-Regulation of ADAM17.
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Buxbaum,J.D., Liu,K.N., Luo,Y., Slack,J.L., Stocking,K.L.,
            Peschon,J.J., Johnson,R.S., Castner,B.J., Cerretti,D.P. and
            Black,R.A.
  TITLE     Evidence that tumor necrosis factor alpha converting enzyme is
            involved in regulated alpha-secretase cleavage of the Alzheimer
            amyloid protein precursor
  JOURNAL   J Biol Chem 273 (43), 27765-27767 (1998)
   PUBMED   9774383
REFERENCE   7  (bases 1 to 4451)
  AUTHORS   Amour,A., Slocombe,P.M., Webster,A., Butler,M., Knight,C.G.,
            Smith,B.J., Stephens,P.E., Shelley,C., Hutton,M., Knauper,V.,
            Docherty,A.J. and Murphy,G.
  TITLE     TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3
  JOURNAL   FEBS Lett 435 (1), 39-44 (1998)
   PUBMED   9755855
REFERENCE   8  (bases 1 to 4451)
  AUTHORS   Yamazaki,K., Mizui,Y., Sagane,K. and Tanaka,I.
  TITLE     Genetic mapping of mouse tumor necrosis factor-alpha converting
            enzyme (TACE) to chromosome 12
  JOURNAL   Genomics 49 (2), 336-337 (1998)
   PUBMED   9598327
REFERENCE   9  (bases 1 to 4451)
  AUTHORS   Moss,M.L., Jin,S.L., Milla,M.E., Bickett,D.M., Burkhart,W.,
            Carter,H.L., Chen,W.J., Clay,W.C., Didsbury,J.R., Hassler,D.,
            Hoffman,C.R., Kost,T.A., Lambert,M.H., Leesnitzer,M.A.,
            McCauley,P., McGeehan,G., Mitchell,J., Moyer,M., Pahel,G.,
            Rocque,W., Overton,L.K., Schoenen,F., Seaton,T., Su,J.L.,
            Becherer,J.D. et al.
  TITLE     Cloning of a disintegrin metalloproteinase that processes precursor
            tumour-necrosis factor-alpha
  JOURNAL   Nature 385 (6618), 733-736 (1997)
   PUBMED   9034191
  REMARK    Erratum:[Nature 1997 Apr 17;386(6626):738]
REFERENCE   10 (bases 1 to 4451)
  AUTHORS   Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L.,
            Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S.,
            Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R.,
            Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and
            Cerretti,D.P.
  TITLE     A metalloproteinase disintegrin that releases tumour-necrosis
            factor-alpha from cells
  JOURNAL   Nature 385 (6618), 729-733 (1997)
   PUBMED   9034190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC140457.3, BC094655.1 and
            AC156032.4.
            
            On Mar 27, 2013 this sequence version replaced NM_009615.5.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature enzyme that is involved
            in the proteolytic release of membrane-bound proteins in a process
            called ectodomain shedding. Mice lacking the encoded protein die in
            utero or fail to survive beyond one week of age. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms, some of which may undergo similar processing. [provided
            by RefSeq, May 2016].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC114999.1, AK137693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC140457.3         171883-171968
            87-2488             BC094655.1         1-2402
            2489-2489           AC156032.4         144066-144066       c
            2490-4154           BC094655.1         2404-4068
            4155-4451           AC156032.4         142104-142400       c
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.3 cM"
     gene            1..4451
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /note="a disintegrin and metallopeptidase domain 17"
                     /db_xref="GeneID:11491"
                     /db_xref="MGI:MGI:1096335"
     exon            1..297
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2684
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /EC_number="3.4.24.86"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; TNF-alpha converting enzyme; disintegrin and
                     metalloproteinase domain-containing protein 17; TNF-alpha
                     convertase"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 17 isoform 1 preproprotein"
                     /protein_id="NP_033745.4"
                     /db_xref="CCDS:CCDS25836.1"
                     /db_xref="GeneID:11491"
                     /db_xref="MGI:MGI:1096335"
                     /translation="MRRRLLILTTLVPFVLAPRPPEEAGSGSHPRLEKLDSLLSDYDI
                     LSLANIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGK
                     EESEYSVKWQNFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNVEPLWRFVNDTK
                     DKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEP
                     NPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYG
                     VQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSFDIAEEASKVCL
                     AHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPTVKKNIYLNSGLTSTKNYGK
                     TILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
                     SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTL
                     KPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTV
                     CLDLGKCKAGKCIPFCKREQELESCACVDTDNSCKVCCRNLSGPCVPYVDAEQKNLFL
                     RKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLI
                     FWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQ
                     ALQPAAMMPPVPAAPKLDHQRMDTIQEDPSTDSHADDDGFEKDPFPNSSTAAKSFEDL
                     TDHPVTRSEKAASFKLQRQSRVDSKETEC"
     exon            298..430
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            431..561
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            562..650
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            651..819
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            820..953
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1043
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1157
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1302
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1391
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1544
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1744
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1848
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1983
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2114
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2193
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2282
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2333
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..4451
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4127..4132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /note="hexamer: TATAAA"
     polyA_site      4154
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /note="major polyA site"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /note="hexamer: AATAAA"
     polyA_site      4280
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
     regulatory      4403..4408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /note="hexamer: AATAAA"
     polyA_site      4429
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
ORIGIN      
        1 gctgcggccg gaaacgagtt aagccgctct cagcgagcgc cgcctgcact tccggggacg
       61 tgagcctagc ttccctgtag gcggcgcggg agggagaagt ttgcagggcc gtgctgggaa
      121 gatcacctcc gctcccaatg tgagcagttt cccgaacgct ctttcggaga aggtttccca
      181 gagaggtggt ggacgggaac atgaggcggc gtctcctcat cctgaccact ttggtgcctt
      241 tcgtcctggc accccgacct ccggaggaag caggctctgg ctcccatccg cgacttgaga
      301 agcttgattc tttgctctca gactacgaca tcctctcctt agctaatatt cagcagcact
      361 ccataaggaa aagggatcta cagtctgcga cacacttaga aacattacta actttttcag
      421 ctttgaaaag acattttaaa ttatacttga catcaagtac cgaacgcttt tcacaaaact
      481 tgagagtcgt ggtggtggac gggaaagaag aaagcgagta cagcgtgaag tggcagaact
      541 tcttcagtgg tcacgtggtt ggtgagcctg actctagggt tctagcccac ataggagatg
      601 atgatgttac agtgagaatc aacacagatg gggcagaata taacgtagag ccactttgga
      661 ggtttgtcaa tgatactaaa gataaacgaa tgctggtgta taagtctgaa gatatcaagg
      721 atttttcacg tttgcagtct ccaaaagtat gtggttattt aaatgcagat agtgaagagc
      781 tgcttccaaa agggctcata gacagagagc catctgaaga gtttgttcgt cgagtgaaga
      841 gacgagctga acctaacccc ttgaagaata cttgtaaatt actggtggta gcagatcatc
      901 gattttataa atacatgggc cgtggagaag agagcaccac tacaaattac ttaatagagc
      961 taattgaccg agttgatgac atataccgga acacgtcgtg ggataatgca gggtttaaag
     1021 ggtatggagt gcagatagag cagattcgaa ttctcaagtc tccacaagag gtaaaacctg
     1081 gtgaaagaca cttcaatatg gcaaaaagtt tcccaaacga agagaaggat gcttgggatg
     1141 tgaagatgct attagagcaa tttagctttg atatagctga agaagcatct aaagtctgcc
     1201 tggctcatct tttcacgtac caggattttg atatgggaac tcttggatta gcttacgttg
     1261 gttctcccag agcaaacagt catggagggg tttgtccaaa agcttattac aacccaactg
     1321 tgaagaaaaa catctattta aatagtggtc tgactagtac taaaaattat ggcaaaacta
     1381 ttctcacaaa ggaagctgac ctggttacaa ctcatgaatt gggacataat tttggagcag
     1441 aacatgaccc tgatgggcta gcagaatgtg ccccaaatga ggaccaagga ggaaagtatg
     1501 tcatgtatcc catagctgtg agcggtgacc acgagaataa taagatgttt tcaaactgca
     1561 gtaaacagtc catctacaag accatagaaa gtaaggctca agagtgcttc caggagcgca
     1621 gcaacaaggt gtgtggcaac tccagggtgg atgaaggaga ggagtgtgac ccgggtatta
     1681 tgtacctgaa caacgacacc tgctgcaata gtgactgcac actgaagccg ggtgtgcagt
     1741 gcagtgatag gaacagtcct tgctgtaaaa actgtcagtt tgagacggcg cagaagaagt
     1801 gccaggaggc tattaatgct acatgcaaag gagtgtctta ctgcacaggg aatagcagtg
     1861 agtgcccccc acccggagat gctgaagatg acactgtgtg cttggacctt ggcaagtgca
     1921 aggctgggaa atgcatccct ttctgcaaga gggagcagga gctggagtcc tgcgcatgcg
     1981 ttgacactga caactcgtgc aaggtgtgct gcaggaacct ttctggcccg tgtgtgccgt
     2041 acgtcgatgc agagcaaaag aacttgtttt tgaggaaagg gaagccatgt acagtagggt
     2101 tttgcgacat gaatggcaaa tgtgagaaac gagtacagga cgtaattgag cgattttggg
     2161 atttcattga ccagctgagc atcaacactt ttgggaagtt tctggcagat aacatcgttg
     2221 ggtctgttct ggttttctcc ttgatatttt ggattccttt cagcattctt gtccactgtg
     2281 tggataagaa actggacaag cagtatgaat ccctgtctct gtttcatcac agtaacattg
     2341 agatgctgag cagcatggac tcagcatctg ttcgcatcat caagcccttt cctgcacccc
     2401 agactccagg tcgtctgcag gccctgcagc cagctgccat gatgccgcca gtacctgcag
     2461 ctccaaaact ggaccaccag aggatggaca ccatccagga agaccccagc acagactcac
     2521 atgcagatga tgacggtttt gagaaggacc ccttccccaa cagcagcaca gctgccaagt
     2581 cctttgagga tctcacagac cacccagtca ccaggagcga aaaggcggcc tcattcaagc
     2641 tgcagcgtca gagccgagtt gacagcaaag agacagagtg ctagtgggga accttggcct
     2701 gctctaggac atatacctgc agatgttcca tagagctgac ctgaatcaaa acatagatta
     2761 taatgatctg agaaacgggg aagcaactta gcagatgctg gtcatgtgct atgaccttca
     2821 catgacatcc tatgtatgta ggccctttga agaggtgagg taaatctggc ttatgtaagg
     2881 ctttcaggtt ttgggttttt cttttataat ctaaaatctc ctttgacctg tggtgcagaa
     2941 gcagaaagta aggctggacc ccgttcctgg tgacagtgct gttaagtctt cagtctgttt
     3001 ttctgtaccc tctgactaca gtgaagcact taacagtgag gataactgga acacagacat
     3061 acttgtttgt ttgttttgtt tttgtttttg tttttttttt tttgaccctc aactaaaaga
     3121 ggagcaagag aaacctgctt gtatgttgtc tccaaatgcg gcctgtcttg gcactgaatt
     3181 ctttgtagat ggagagacct gcctacactt agggccatct acattaagag cagtcctttc
     3241 caagaggaac agtttataga aacagccaca tgaacttcga gatggcctat taactgttca
     3301 gccccagatt cactgggcag tttttccatt ttacaaatgt gtcgtcttta aactgtttgc
     3361 cttaaaaaaa aaaatcaata ttgggctgga gagttggccc cacagttaag agcagttggt
     3421 ctcattctca gcacccacat ggtggctctc aactctgtaa ctccaatccc agaggagatg
     3481 acatcttctg aactctagga cacgaggcat acattggtgc aggcaaaaca aagccaagtg
     3541 ctgtaaaatg tggcaataac cacaaaacct atagtgcctc acagtatgga ctgagtggtg
     3601 aatagacact cttcccagaa ccacttctgg acaggccggg atgtgctggc tggctaggaa
     3661 gagggggtgg gagtgggaga gtggtgctgc catcggggcc cagccctaga agaactgacc
     3721 ttcagtctcg gcaagtagac acccacgtga cctctggctc tggtgcttca agatgttctg
     3781 tacttactgt gtgaggaata aatgccatta gcctgaattc tgatttctat aaattctagt
     3841 tataaatgct cttttcttct aagaattgca gtgtgctcac aagccaacac attttaacca
     3901 agataatttg taaactctga ggacagttaa ccaagcctgt gccttgtctc tcctgaggac
     3961 gcctgttaca ctaatacttg aatatatacc ttgtggtatt tgctcttttt actagtcatg
     4021 atagtcttgt attttaatta cactttgatg atttgctata gggagagtgg ggtgtgtggg
     4081 tatatgtatg aatgaaacag ttggcagaat ataagaaaac catttttata aaattgtgac
     4141 tttttaaacc aaaattgtct taattgtatt actttttttt tctttggcat gtacagaatt
     4201 aataagatgc tcagggcata ttctatagct gtggcattga tgatacctgc ctcagtcaat
     4261 aaatactgaa tatcaaagca gtggattgcg tatataacat ttccctgaaa aataagttag
     4321 taggtttttt gatcaataat catgaacaga agttaagctt ggaaaagaca tttaatcaat
     4381 ctcttgatgt ctgtgaatta ctaataaagc tacgcacatg ttcacagaat gtttgtggct
     4441 accaacatga a
//
